Joseph S Brunzelle

  • 3681 Citations
19962019

Research output per year

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Research Output

  • 3681 Citations
  • 90 Article
  • 2 Comment/debate
2019

Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity

Kalpage, H. A., Vaishnav, A., Liu, J., Varughese, A., Wan, J., Turner, A. A., Ji, Q., Zurek, M. P., Kapralov, A. A., Kagan, V. E., Brunzelle, J. S., Recanati, M. A., Grossman, L. I., Sanderson, T. H., Lee, I., Salomon, A. R., Edwards, B. F. P. & Hüttemann, M., Dec 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 13503-13514 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

Muzzarelli, K. M., Kuiper, B., Spellmon, N., Brunzelle, J., Hackett, J., Amblard, F., Zhou, S., Liu, P., Kovari, I. A., Yang, Z., Schinazi, R. F. & Kovari, L. C., Jan 1 2019, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

3 Scopus citations

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

Yan, Y., Edward Zhou, X., Novick, S. J., Shaw, S. J., Li, Y., Brunzelle, J. S., Hitoshi, Y., Griffin, P. R., Eric Xu, H. & Melcher, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 3, p. 953-967 15 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity

Cornett, E. M., Dickson, B. M., Krajewski, K., Spellmon, N., Umstead, A., Vaughan, R. M., Shaw, K. M., Versluis, P. P., Cowles, M. W., Brunzelle, J. S., Yang, Z., Vega, I. E., Sun, Z. W. & Rothbart, S. B., Nov 28 2018, In : Science Advances. 4, 11, eaav2623.

Research output: Contribution to journalArticle

4 Scopus citations

Crystal structure of Campylobacter jejuni peroxide regulator

Sarvan, S., Charih, F., Butcher, J., Brunzelle, J. S., Stintzi, A. & Couture, J. F., Jul 1 2018, In : FEBS Letters. 592, 13, p. 2351-2360 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Functional insights into the interplay between DNA interaction and metal coordination in ferric uptake regulators

Sarvan, S., Charih, F., Askoura, M., Butcher, J., Brunzelle, J. S., Stintzi, A. & Couture, J. F., Dec 1 2018, In : Scientific reports. 8, 1, 7140.

Research output: Contribution to journalArticle

5 Scopus citations

Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation

Haddad, J. F., Yang, Y., Takahashi, Y. H., Joshi, M., Chaudhary, N., Woodfin, A. R., Benyoucef, A., Yeung, S., Brunzelle, J. S., Skiniotis, G., Brand, M., Shilatifard, A. & Couture, J. F., Dec 4 2018, In : Structure. 26, 12, p. 1594-1603.e4

Research output: Contribution to journalArticle

3 Scopus citations

Structural Determinants of the Stereoinverting Activity of Pseudomonas stutzeri d -Phenylglycine Aminotransferase

Walton, C. J. W., Thiebaut, F., Brunzelle, J. S., Couture, J. F. & Chica, R. A., Sep 18 2018, In : Biochemistry. 57, 37, p. 5437-5446 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex

Qu, Q., Takahashi, Y., Yang, Y., Hu, H., Zhang, Y., Brunzelle, J. S., Couture, J. F., Shilatifard, A. & Skiniotis, G., Aug 23 2018, In : Cell. 174, 5, p. 1117-1126.e12

Research output: Contribution to journalArticle

20 Scopus citations
2017

Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination

Billon, P., Li, J., Lambert, J. P., Chen, Y., Tremblay, V., Brunzelle, J. S., Gingras, A. C., Verreault, A., Sugiyama, T., Couture, J. F. & Côté, J., Jan 5 2017, In : Molecular cell. 65, 1, p. 78-90 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex

Ma, H., Duan, J., Ke, J., He, Y., Gu, X., Xu, T. H., Yu, H., Wang, Y., Brunzelle, J. S., Jiang, Y., Rothbart, S. B., Xu, H. E., Li, J. & Melcher, K., Jun 2017, In : Science Advances. 3, 6, e1601217.

Research output: Contribution to journalArticle

23 Scopus citations

Molecular basis for the methylation specificity of ATXR5 for histone H3

Bergamin, E., Sarvan, S., Malette, J., Eram, M. S., Sylvain, Y., Mongeon, V., Joshi, M., Brunzelle, J. S., Michaels, S. D., Blais, A., Vedadi, M. & Couture, J. F., Jun 1 2017, In : Nucleic acids research. 45, 11, p. 6375-6387 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Novel aldo-keto reductases for the biocatalytic conversion of 3- hydroxybutanal to 1,3-butanediol: Structural and biochemical studies

Kim, T., Flick, R., Brunzelle, J. S., Singer, A., Evdokimova, E., Brown, G., Joo, J. C., Minasov, G., Anderson, W. F., Mahadevan, R., Savchenko, A. & Yakunin, A. F., Apr 1 2017, In : Applied and Environmental Microbiology. 83, 7, e03172-16.

Research output: Contribution to journalArticle

9 Scopus citations

Phosphorylation of cytochrome c threonine 28 regulates electron transport chain activity in kidney: Implications for amp kinase

Mahapatra, G., Varughese, A., Ji, Q., Lee, I., Liu, J., Vaishnav, A., Sinkler, C., Kapralov, A. A., Moraes, C. T., Sanderson, T. H., Stemmler, T. L., Grossman, L. I., Kagan, V. E., Brunzelle, J. S., Salomon, A. R., Edwards, B. F. P. & Hüttemann, M., Jan 6 2017, In : Journal of Biological Chemistry. 292, 1, p. 64-79 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF

Spellmon, N., Holcomb, J., Niu, A., Choudhary, V., Sun, X., Zhang, Y., Wan, J., Doughan, M., Hayden, S., Hachem, F., Brunzelle, J., Li, C. & Yang, Z., Apr 1 2017, In : Biochemical and Biophysical Research Communications. 485, 2, p. 529-534 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases

Pal, K., Bandyopadhyay, A., Zhou, X. E., Xu, Q., Marciano, D. P., Brunzelle, J. S., Yerrum, S., Griffin, P. R., Vande Woude, G., Melcher, K. & Xu, H. E., Jun 6 2017, In : Structure. 25, 6, p. 867-877.e3

Research output: Contribution to journalArticle

5 Scopus citations
2016

Ligand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividans

Gagné, D., Narayanan, C., Nguyen-Thi, N., Roux, L. D., Bernard, D. N., Brunzelle, J. S., Couture, J. F., Agarwal, P. K. & Doucet, N., Aug 2 2016, In : Biochemistry. 55, 30, p. 4184-4196 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation

Zhang, P., Chaturvedi, C. P., Tremblay, V., Cramet, M., Brunzelle, J. S., Skiniotis, G., Brand, M., Shilatifard, A. & Couture, J. F., Jan 15 2015, In : Genes and Development. 29, 2, p. 123-128 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Structural and functional study of D-Glucuronyl C5-epimerase

Qin, Y., Ke, J., Gu, X., Fang, J., Wang, W., Cong, Q., Li, J., Tan, J., Brunzelle, J. S., Zhang, C., Jiang, Y., Melcher, K., Li, J. P., Xu, H. E. & Ding, K., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 4620-4630 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors

Ke, J., Ma, H., Gu, X., Thelen, A., Brunzelle, J. S., Li, J., Xu, H. E. & Melcher, K., Jan 1 2015, In : Science Advances. 1, 6, 1500107.

Research output: Contribution to journalArticle

46 Scopus citations

Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling

Zhang, F., Yao, J., Ke, J., Zhang, L., Lam, V. Q., Xin, X. F., Zhou, X. E., Chen, J., Brunzelle, J., Griffin, P. R., Zhou, M., Xu, H. E., Melcher, K. & He, S. Y., Sep 10 2015, In : Nature. 525, 7568, p. 269-273 5 p.

Research output: Contribution to journalArticle

102 Scopus citations

The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops

Kuiper, B. D., Keusch, B. J., Dewdney, T. G., Chordia, P., Ross, K., Brunzelle, J. S., Kovari, I. A., MacArthur, R., Salimnia, H. & Kovari, L. C., Jul 1 2015, In : Biochemistry and Biophysics Reports. 2, p. 160-165 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex

Wan, B., Tang, T., Upton, H., Shuai, J., Zhou, Y., Li, S., Chen, J., Brunzelle, J. S., Zeng, Z., Collins, K., Wu, J. & Lei, M., Dec 1 2015, In : Nature Structural and Molecular Biology. 22, 12, p. 1023-1026 4 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014

Agonist ligands mediate the transcriptional response of nuclear receptor heterodimers through distinct stoichiometric assemblies with coactivators

Pavlin, M. R., Brunzelle, J. S. & Fernandez, E. J., Jan 1 2014, In : Journal of Biological Chemistry. 289, 36, p. 24771-24778 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Crystallographic analysis of NHERF1-PLCβ3 interaction provides structural basis for CXCR2 signaling in pancreatic cancer

Jiang, Y., Wang, S., Holcomb, J., Trescott, L., Guan, X., Hou, Y., Brunzelle, J., Sirinupong, N., Li, C. & Yang, Z., Apr 4 2014, In : Biochemical and Biophysical Research Communications. 446, 2, p. 638-643 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization

Holcomb, J., Jiang, Y., Guan, X., Trescott, L., Lu, G., Hou, Y., Wang, S., Brunzelle, J., Sirinupong, N., Li, C. & Yang, Z., May 30 2014, In : Biochemical and Biophysical Research Communications. 448, 2, p. 169-174 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Intersubunit communication in the dihydroorotase-aspartate transcarbamoylase complex of Aquifex aeolicus

Evans, H. G., Fernando, R., Vaishnav, A., Kotichukkala, M., Heyl, D., Hachem, F., Brunzelle, J. S., Edwards, B. F. P. & Evans, D. R., Jan 1 2014, In : Protein Science. 23, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Molecular basis for DPY-30 association to COMPASS-like and NURF complexes

Tremblay, V., Zhang, P., Chaturvedi, C. P., Thornton, J., Brunzelle, J. S., Skiniotis, G., Shilatifard, A., Brand, M. & Couture, J. F., Dec 2 2014, In : Structure. 22, 12, p. 1821-1830 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication

Jacob, Y., Bergamin, E., Donoghue, M. T. A., Mongeon, V., LeBlanc, C., Voigt, P., Underwood, C. J., Brunzelle, J. S., Michaels, S. D., Reinberg, D., Couture, J. F. & Martienssen, R. A., Jan 1 2014, In : Science. 343, 6176, p. 1249-1253 5 p.

Research output: Contribution to journalArticle

77 Scopus citations

Structural insights into estrogen receptor α methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation

Jiang, Y., Trescott, L., Holcomb, J., Zhang, X., Brunzelle, J., Sirinupong, N., Shi, X. & Yang, Z., Oct 9 2014, In : Journal of Molecular Biology. 426, 20, p. 3413-3425 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Structural insights into PDZ-mediated interaction of NHERF2 and LPA 2, a cellular event implicated in CFTR channel regulation

Holcomb, J., Jiang, Y., Lu, G., Trescott, L., Brunzelle, J., Sirinupong, N., Li, C., Naren, A. P. & Yang, Z., Mar 28 2014, In : Biochemical and Biophysical Research Communications. 446, 1, p. 399-403 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release

Kovari, L. C., Brunzelle, J. S., Lewis, K. T., Cho, W. J., Lee, J. S., Taatjes, D. J. & Jena, B. P., Jan 1 2014, In : Micron. 56, p. 37-43 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes

Liu, Z., Wang, Y., Yedidi, R. S., Dewdney, T. G., Reiter, S. J., Brunzelle, J. S., Kovari, I. A. & Kovari, L. C., Jan 18 2013, In : Biochemical and Biophysical Research Communications. 430, 3, p. 1022-1027 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: Mechanism of drug recognition and resistance

Liu, Z., Yedidi, R. S., Wang, Y., Dewdney, T. G., Reiter, S. J., Brunzelle, J. S., Kovari, I. A. & Kovari, L. C., Jul 26 2013, In : Biochemical and Biophysical Research Communications. 437, 2, p. 199-204 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Crystal structure of Saccharomyces cerevisiae Aro8, a putative α-aminoadipate aminotransferase

Bulfer, S. L., Brunzelle, J. S. & Trievel, R. C., Oct 1 2013, In : Protein Science. 22, 10, p. 1417-1424 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex

Liu, Z., Yedidi, R. S., Wang, Y., Dewdney, T. G., Reiter, S. J., Brunzelle, J. S., Kovari, I. A. & Kovari, L. C., Feb 8 2013, In : Biochemical and Biophysical Research Communications. 431, 2, p. 232-238 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease

Dewdney, T. G., Wang, Y., Liu, Z., Sharma, S. K., Reiter, S. J., Brunzelle, J. S., Kovari, I. A., Woster, P. M. & Kovari, L. C., Dec 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 23, p. 7430-7434 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

New conformational state of NHERF1-CXCR2 signaling complex captured by crystal lattice trapping

Jiang, Y., Lu, G., Trescott, L. R., Hou, Y., Guan, X., Wang, S., Stamenkovich, A., Brunzelle, J., Sirinupong, N., Li, C. & Yang, Z., Dec 10 2013, In : PloS one. 8, 12, e81904.

Research output: Contribution to journalArticle

5 Scopus citations

Structural basis for molecular recognition of folic acid by folate receptors

Chen, C., Ke, J., Edward Zhou, X., Yi, W., Brunzelle, J. S., Li, J., Yong, E. L., Xu, H. E. & Melcher, K., Jul 15 2013, In : Nature. 500, 7463, p. 486-489 4 p.

Research output: Contribution to journalArticle

288 Scopus citations

Structural basis for RNA recognition by a dimeric PPR-protein complex

Ke, J., Chen, R. Z., Ban, T., Zhou, X. E., Gu, X., Tan, M. H. E., Chen, C., Kang, Y., Brunzelle, J. S., Zhu, J. K., Melcher, K. & Xu, H. E., Dec 1 2013, In : Nature Structural and Molecular Biology. 20, 12, p. 1377-1382 6 p.

Research output: Contribution to journalArticle

66 Scopus citations

Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

Lu, G., Wu, Y., Jiang, Y., Wang, S., Hou, Y., Guan, X., Brunzelle, J., Sirinupong, N., Sheng, S., Li, C. & Yang, Z., Oct 2 2013, In : PloS one. 8, 10, e76219.

Research output: Contribution to journalArticle

13 Scopus citations

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium

Zheng, H., Beliavsky, A., Tchigvintsev, A., Brunzelle, J. S., Brown, G., Flick, R., Evdokimova, E., Wawrzak, Z., Mahadevan, R., Anderson, W. F., Savchenko, A. & Yakunin, A. F., Jun 1 2013, In : Proteins: Structure, Function and Bioinformatics. 81, 6, p. 1031-1041 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

The mononuclear metal center of type-I dihydroorotase from aquifex aeolicus

Edwards, B. F. P., Fernando, R., Martin, P. D., Grimley, E., Cordes, M., Vaishnav, A., Brunzelle, J. S., Evans, H. G. & Evans, D. R., Dec 9 2013, In : BMC Biochemistry. 14, 1, 36.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Crystal structure of the extracellular domain of human myelin protein zero

Liu, Z., Wang, Y., Yedidi, R. S., Brunzelle, J. S., Kovari, I. A., Sohi, J., Kamholz, J. & Kovari, L. C., Jan 1 2012, In : Proteins: Structure, Function and Bioinformatics. 80, 1, p. 307-313 7 p.

Research output: Contribution to journalComment/debate

12 Scopus citations

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds

Yedidi, R. S., Liu, Z., Wang, Y., Brunzelle, J. S., Kovari, I. A., Woster, P. M., Kovari, L. C. & Gupta, D., May 11 2012, In : Biochemical and Biophysical Research Communications. 421, 3, p. 413-417 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration

Zou, Y., Zhang, H., Brunzelle, J. S., Johannes, T. W., Woodyer, R., Hung, J. E., Nair, N., Van Der Donk, W. A., Zhao, H. & Nair, S. K., May 29 2012, In : Biochemistry. 51, 21, p. 4263-4270 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Higher desolvation energy reduces molecular recognition in multi-drug resistant HIV-1 protease

Wang, Y., Dewdney, T. G., Liu, Z., Reiter, S. J., Brunzelle, J. S., Kovari, I. A. & Kovari, L. C., May 31 2012, In : Biology. 1, 1, p. 81-93 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases

Soon, F. F., Ng, L. M., Zhou, X. E., West, G. M., Kovach, A., Tan, M. H. E., Suino-Powell, K. M., He, Y., Xu, Y., Chalmers, M. J., Brunzelle, J. S., Zhang, H., Yang, H., Jiang, H., Li, J., Yong, E. L., Cutler, S., Zhu, J. K., Griffin, P. R., Melcher, K. & 1 others, Xu, H. E., Jan 6 2012, In : Science. 335, 6064, p. 85-88 4 p.

Research output: Contribution to journalArticle

221 Scopus citations

Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers

Putcha, B. D. K., Wright, E., Brunzelle, J. S. & Fernandez, E. J., Apr 17 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6084-6087 4 p.

Research output: Contribution to journalArticle

30 Scopus citations

Structure and regulon of Campylobacter jejuni ferric uptake regulator fur define apo-Fur regulation

Butcher, J., Sarvan, S., Brunzelle, J. S., Couture, J. F. & Stintzi, A., Jun 19 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 10047-10052 6 p.

Research output: Contribution to journalArticle

77 Scopus citations