Joseph S Brunzelle

  • 3621 Citations
19962019
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Research Output 1996 2019

  • 3621 Citations
  • 90 Article
  • 2 Comment/debate
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Article
2019
1 Citation (Scopus)

Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity

Kalpage, H. A., Vaishnav, A., Liu, J., Varughese, A., Wan, J., Turner, A. A., Ji, Q., Zurek, M. P., Kapralov, A. A., Kagan, V. E., Brunzelle, J. S., Recanati, M. A., Grossman, L. I., Sanderson, T. H., Lee, I., Salomon, A. R., Edwards, B. F. P. & Hüttemann, M., Dec 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 13503-13514 12 p.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
Electron Transport Complex IV
Cytochromes c
Caspase 3
Serine
3 Citations (Scopus)

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease

Muzzarelli, K. M., Kuiper, B., Spellmon, N., Brunzelle, J., Hackett, J., Amblard, F., Zhou, S., Liu, P., Kovari, I. A., Yang, Z., Schinazi, R. F. & Kovari, L. C., Jan 1 2019, (Accepted/In press) In : Biochemistry.

Research output: Contribution to journalArticle

Norovirus
Antiviral Agents
Peptide Hydrolases
Pharmaceutical Preparations
Disease Outbreaks
2 Citations (Scopus)

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states

Yan, Y., Edward Zhou, X., Novick, S. J., Shaw, S. J., Li, Y., Brunzelle, J. S., Hitoshi, Y., Griffin, P. R., Eric Xu, H. & Melcher, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 3, p. 953-967 15 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Nucleotides
Pharmacology
Chemical activation
Phosphotransferases
2018
4 Citations (Scopus)

A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity

Cornett, E. M., Dickson, B. M., Krajewski, K., Spellmon, N., Umstead, A., Vaughan, R. M., Shaw, K. M., Versluis, P. P., Cowles, M. W., Brunzelle, J. S., Yang, Z., Vega, I. E., Sun, Z. W. & Rothbart, S. B., Nov 28 2018, In : Science Advances. 4, 11, eaav2623.

Research output: Contribution to journalArticle

Methyltransferases
Proteomics
Lysine
Methylation
Proteome
1 Citation (Scopus)

Crystal structure of Campylobacter jejuni peroxide regulator

Sarvan, S., Charih, F., Butcher, J., Brunzelle, J. S., Stintzi, A. & Couture, J. F., Jul 1 2018, In : FEBS Letters. 592, 13, p. 2351-2360 10 p.

Research output: Contribution to journalArticle

Campylobacter jejuni
Peroxides
Crystal structure
DNA
Proteins
4 Citations (Scopus)

Functional insights into the interplay between DNA interaction and metal coordination in ferric uptake regulators

Sarvan, S., Charih, F., Askoura, M., Butcher, J., Brunzelle, J. S., Stintzi, A. & Couture, J. F., Dec 1 2018, In : Scientific reports. 8, 1, 7140.

Research output: Contribution to journalArticle

Campylobacter jejuni
Metals
DNA
Regulator Genes
Gene Expression
3 Citations (Scopus)

Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation

Haddad, J. F., Yang, Y., Takahashi, Y. H., Joshi, M., Chaudhary, N., Woodfin, A. R., Benyoucef, A., Yeung, S., Brunzelle, J. S., Skiniotis, G., Brand, M., Shilatifard, A. & Couture, J. F., Dec 4 2018, In : Structure. 26, 12, p. 1594-1603.e4

Research output: Contribution to journalArticle

Personnel Selection
Epigenomics
Methylation
Chromatin
Enzymes

Structural Determinants of the Stereoinverting Activity of Pseudomonas stutzeri d -Phenylglycine Aminotransferase

Walton, C. J. W., Thiebaut, F., Brunzelle, J. S., Couture, J. F. & Chica, R. A., Sep 18 2018, In : Biochemistry. 57, 37, p. 5437-5446 10 p.

Research output: Contribution to journalArticle

Pseudomonas stutzeri
Transaminases
Amino Acids
Enzymes
Mutagenesis
17 Citations (Scopus)

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex

Qu, Q., Takahashi, Y., Yang, Y., Hu, H., Zhang, Y., Brunzelle, J. S., Couture, J. F., Shilatifard, A. & Skiniotis, G., Aug 23 2018, In : Cell. 174, 5, p. 1117-1126.e12

Research output: Contribution to journalArticle

Methyltransferases
Histones
Cryoelectron Microscopy
Proteins
Methylation
2017
15 Citations (Scopus)

Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination

Billon, P., Li, J., Lambert, J. P., Chen, Y., Tremblay, V., Brunzelle, J. S., Gingras, A. C., Verreault, A., Sugiyama, T., Couture, J. F. & Côté, J., Jan 5 2017, In : Molecular cell. 65, 1, p. 78-90 13 p.

Research output: Contribution to journalArticle

Genomic Instability
Homologous Recombination
Proliferating Cell Nuclear Antigen
Acetylation
DNA Damage
22 Citations (Scopus)

A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex

Ma, H., Duan, J., Ke, J., He, Y., Gu, X., Xu, T. H., Yu, H., Wang, Y., Brunzelle, J. S., Jiang, Y., Rothbart, S. B., Xu, H. E., Li, J. & Melcher, K., Jun 2017, In : Science Advances. 3, 6, e1601217.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Nucleosomes
Histones
Transducin
Indoleacetic Acids
7 Citations (Scopus)

Molecular basis for the methylation specificity of ATXR5 for histone H3

Bergamin, E., Sarvan, S., Malette, J., Eram, M. S., Sylvain, Y., Mongeon, V., Joshi, M., Brunzelle, J. S., Michaels, S. D., Blais, A., Vedadi, M. & Couture, J. F., Jun 1 2017, In : Nucleic acids research. 45, 11, p. 6375-6387 13 p.

Research output: Contribution to journalArticle

Histones
Methylation
S-Adenosylmethionine
Sequence Deletion
Genomic Instability
9 Citations (Scopus)

Novel aldo-keto reductases for the biocatalytic conversion of 3- hydroxybutanal to 1,3-butanediol: Structural and biochemical studies

Kim, T., Flick, R., Brunzelle, J. S., Singer, A., Evdokimova, E., Brown, G., Joo, J. C., Minasov, G., Anderson, W. F., Mahadevan, R., Savchenko, A. & Yakunin, A. F., Apr 1 2017, In : Applied and Environmental Microbiology. 83, 7, e03172-16.

Research output: Contribution to journalArticle

butanediol
acetaldehyde
Acetaldehyde
crystal structure
NADP (coenzyme)
13 Citations (Scopus)

Phosphorylation of cytochrome c threonine 28 regulates electron transport chain activity in kidney: Implications for amp kinase

Mahapatra, G., Varughese, A., Ji, Q., Lee, I., Liu, J., Vaishnav, A., Sinkler, C., Kapralov, A. A., Moraes, C. T., Sanderson, T. H., Stemmler, T. L., Grossman, L. I., Kagan, V. E., Brunzelle, J. S., Salomon, A. R., Edwards, B. F. P. & Hüttemann, M., Jan 6 2017, In : Journal of Biological Chemistry. 292, 1, p. 64-79 16 p.

Research output: Contribution to journalArticle

Phosphorylation
Threonine
Electron Transport
Cytochromes c
Phosphotransferases
2 Citations (Scopus)

Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF

Spellmon, N., Holcomb, J., Niu, A., Choudhary, V., Sun, X., Zhang, Y., Wan, J., Doughan, M., Hayden, S., Hachem, F., Brunzelle, J., Li, C. & Yang, Z., Apr 1 2017, In : Biochemical and Biophysical Research Communications. 485, 2, p. 529-534 6 p.

Research output: Contribution to journalArticle

Interleukin-8B Receptors
Rho Guanine Nucleotide Exchange Factors
Guanine Nucleotide Exchange Factors
Chemokine Receptors
PDZ Domains
5 Citations (Scopus)

Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases

Pal, K., Bandyopadhyay, A., Zhou, X. E., Xu, Q., Marciano, D. P., Brunzelle, J. S., Yerrum, S., Griffin, P. R., Vande Woude, G., Melcher, K. & Xu, H. E., Jun 6 2017, In : Structure. 25, 6, p. 867-877.e3

Research output: Contribution to journalArticle

Phosphotransferases
Leucine Zippers
Nuclear Pore
Mutation
Dimerization
2016
8 Citations (Scopus)

Ligand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividans

Gagné, D., Narayanan, C., Nguyen-Thi, N., Roux, L. D., Bernard, D. N., Brunzelle, J. S., Couture, J. F., Agarwal, P. K. & Doucet, N., Aug 2 2016, In : Biochemistry. 55, 30, p. 4184-4196 13 p.

Research output: Contribution to journalArticle

Streptomyces lividans
Fingers
Ligands
Thumb
Protein Engineering
2015
17 Citations (Scopus)

A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation

Zhang, P., Chaturvedi, C. P., Tremblay, V., Cramet, M., Brunzelle, J. S., Skiniotis, G., Brand, M., Shilatifard, A. & Couture, J. F., Jan 15 2015, In : Genes and Development. 29, 2, p. 123-128 6 p.

Research output: Contribution to journalArticle

Histones
Methylation
Lysine
Phosphorylation
Methyltransferases
19 Citations (Scopus)

Structural and functional study of D-Glucuronyl C5-epimerase

Qin, Y., Ke, J., Gu, X., Fang, J., Wang, W., Cong, Q., Li, J., Tan, J., Brunzelle, J. S., Zhang, C., Jiang, Y., Melcher, K., Li, J. P., Xu, H. E. & Ding, K., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 4620-4630 11 p.

Research output: Contribution to journalArticle

Racemases and Epimerases
Heparitin Sulfate
Biosynthesis
Enzymes
44 Citations (Scopus)

Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors

Ke, J., Ma, H., Gu, X., Thelen, A., Brunzelle, J. S., Li, J., Xu, H. E. & Melcher, K., Jan 1 2015, In : Science Advances. 1, 6, 1500107.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Indoleacetic Acids
Proteins
Transducin
Sequence Alignment
92 Citations (Scopus)

Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling

Zhang, F., Yao, J., Ke, J., Zhang, L., Lam, V. Q., Xin, X. F., Zhou, X. E., Chen, J., Brunzelle, J., Griffin, P. R., Zhou, M., Xu, H. E., Melcher, K. & He, S. Y., Sep 10 2015, In : Nature. 525, 7568, p. 269-273 5 p.

Research output: Contribution to journalArticle

Transcription Factors
Hormones
Plant Growth Regulators
SKP Cullin F-Box Protein Ligases
Mediator Complex
3 Citations (Scopus)

The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops

Kuiper, B. D., Keusch, B. J., Dewdney, T. G., Chordia, P., Ross, K., Brunzelle, J. S., Kovari, I. A., MacArthur, R., Salimnia, H. & Kovari, L. C., Jul 1 2015, In : Biochemistry and Biophysics Reports. 2, p. 160-165 6 p.

Research output: Contribution to journalArticle

Anchors
Peptide Hydrolases
Mutation
Conformations
Polyproteins
22 Citations (Scopus)

The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex

Wan, B., Tang, T., Upton, H., Shuai, J., Zhou, Y., Li, S., Chen, J., Brunzelle, J. S., Zeng, Z., Collins, K., Wu, J. & Lei, M., Dec 1 2015, In : Nature Structural and Molecular Biology. 22, 12, p. 1023-1026 4 p.

Research output: Contribution to journalArticle

Tetrahymena
Telomerase
Telomere
Holoenzymes
Single-Stranded DNA
2014
10 Citations (Scopus)

Agonist ligands mediate the transcriptional response of nuclear receptor heterodimers through distinct stoichiometric assemblies with coactivators

Pavlin, M. R., Brunzelle, J. S. & Fernandez, E. J., Jan 1 2014, In : Journal of Biological Chemistry. 289, 36, p. 24771-24778 8 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 1
Retinoid X Receptors
Cytoplasmic and Nuclear Receptors
Ligands
Transcription
9 Citations (Scopus)

Crystallographic analysis of NHERF1-PLCβ3 interaction provides structural basis for CXCR2 signaling in pancreatic cancer

Jiang, Y., Wang, S., Holcomb, J., Trescott, L., Guan, X., Hou, Y., Brunzelle, J., Sirinupong, N., Li, C. & Yang, Z., Apr 4 2014, In : Biochemical and Biophysical Research Communications. 446, 2, p. 638-643 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Tumors
Cells
Macromolecular Substances
PDZ Domains
5 Citations (Scopus)

Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization

Holcomb, J., Jiang, Y., Guan, X., Trescott, L., Lu, G., Hou, Y., Wang, S., Brunzelle, J., Sirinupong, N., Li, C. & Yang, Z., May 30 2014, In : Biochemical and Biophysical Research Communications. 448, 2, p. 169-174 6 p.

Research output: Contribution to journalArticle

Macromolecular Substances
Multiprotein Complexes
Dimerization
Chemokine Receptors
PDZ Domains
4 Citations (Scopus)

Intersubunit communication in the dihydroorotase-aspartate transcarbamoylase complex of Aquifex aeolicus

Evans, H. G., Fernando, R., Vaishnav, A., Kotichukkala, M., Heyl, D., Hachem, F., Brunzelle, J. S., Edwards, B. F. P. & Evans, D. R., Jan 1 2014, In : Protein Science. 23, 1, p. 100-109 10 p.

Research output: Contribution to journalArticle

Dihydroorotase
Aspartic Acid
Communication
NSC 224131
Enzymes
16 Citations (Scopus)

Molecular basis for DPY-30 association to COMPASS-like and NURF complexes

Tremblay, V., Zhang, P., Chaturvedi, C. P., Thornton, J., Brunzelle, J. S., Skiniotis, G., Shilatifard, A., Brand, M. & Couture, J. F., Dec 2 2014, In : Structure. 22, 12, p. 1821-1830 10 p.

Research output: Contribution to journalArticle

Histones
Cell Differentiation
Locus Control Region
Erythroid Cells
Nucleosomes
75 Citations (Scopus)

Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication

Jacob, Y., Bergamin, E., Donoghue, M. T. A., Mongeon, V., LeBlanc, C., Voigt, P., Underwood, C. J., Brunzelle, J. S., Michaels, S. D., Reinberg, D., Couture, J. F. & Martienssen, R. A., Jan 1 2014, In : Science. 343, 6176, p. 1249-1253 5 p.

Research output: Contribution to journalArticle

Heterochromatin
Histones
Methylation
Methyltransferases
Threonine
29 Citations (Scopus)

Structural insights into estrogen receptor α methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation

Jiang, Y., Trescott, L., Holcomb, J., Zhang, X., Brunzelle, J., Sirinupong, N., Shi, X. & Yang, Z., Oct 9 2014, In : Journal of Molecular Biology. 426, 20, p. 3413-3425 13 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Methylation
Estrogens
Substrate Specificity
Peptides
8 Citations (Scopus)

Structural insights into PDZ-mediated interaction of NHERF2 and LPA 2, a cellular event implicated in CFTR channel regulation

Holcomb, J., Jiang, Y., Lu, G., Trescott, L., Brunzelle, J., Sirinupong, N., Li, C., Naren, A. P. & Yang, Z., Mar 28 2014, In : Biochemical and Biophysical Research Communications. 446, 1, p. 399-403 5 p.

Research output: Contribution to journalArticle

Ligands
Macromolecular Substances
Drug Design
Substrates
Substrate Specificity
13 Citations (Scopus)

X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release

Kovari, L. C., Brunzelle, J. S., Lewis, K. T., Cho, W. J., Lee, J. S., Taatjes, D. J. & Jena, B. P., Jan 1 2014, In : Micron. 56, p. 37-43 7 p.

Research output: Contribution to journalArticle

Synaptic Vesicles
Neurotransmitter Agents
Cell Membrane
X-Rays
Lipoproteins
2013
7 Citations (Scopus)

Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes

Liu, Z., Wang, Y., Yedidi, R. S., Dewdney, T. G., Reiter, S. J., Brunzelle, J. S., Kovari, I. A. & Kovari, L. C., Jan 18 2013, In : Biochemical and Biophysical Research Communications. 430, 3, p. 1022-1027 6 p.

Research output: Contribution to journalArticle

Hydrogen
Hydrogen bonds
Molecules
Water
Pharmaceutical Preparations
3 Citations (Scopus)

Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: Mechanism of drug recognition and resistance

Liu, Z., Yedidi, R. S., Wang, Y., Dewdney, T. G., Reiter, S. J., Brunzelle, J. S., Kovari, I. A. & Kovari, L. C., Jul 26 2013, In : Biochemical and Biophysical Research Communications. 437, 2, p. 199-204 6 p.

Research output: Contribution to journalArticle

Lopinavir
Drug Resistance
Pharmaceutical Preparations
Multiple Drug Resistance
Peptide Hydrolases
10 Citations (Scopus)

Crystal structure of Saccharomyces cerevisiae Aro8, a putative α-aminoadipate aminotransferase

Bulfer, S. L., Brunzelle, J. S. & Trievel, R. C., Oct 1 2013, In : Protein Science. 22, 10, p. 1417-1424 8 p.

Research output: Contribution to journalArticle

kynurenine-oxoglutarate transaminase
Transaminases
Yeast
HEPES
Saccharomyces cerevisiae
4 Citations (Scopus)

Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex

Liu, Z., Yedidi, R. S., Wang, Y., Dewdney, T. G., Reiter, S. J., Brunzelle, J. S., Kovari, I. A. & Kovari, L. C., Feb 8 2013, In : Biochemical and Biophysical Research Communications. 431, 2, p. 232-238 7 p.

Research output: Contribution to journalArticle

Ritonavir
Drug Resistance
X-Rays
X rays
Pharmaceutical Preparations
1 Citation (Scopus)

Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease

Dewdney, T. G., Wang, Y., Liu, Z., Sharma, S. K., Reiter, S. J., Brunzelle, J. S., Kovari, I. A., Woster, P. M. & Kovari, L. C., Dec 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 23, p. 7430-7434 5 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Lopinavir
Catalytic Domain
Molecular Dynamics Simulation
Ligands
5 Citations (Scopus)

New conformational state of NHERF1-CXCR2 signaling complex captured by crystal lattice trapping

Jiang, Y., Lu, G., Trescott, L. R., Hou, Y., Guan, X., Wang, S., Stamenkovich, A., Brunzelle, J., Sirinupong, N., Li, C. & Yang, Z., Dec 10 2013, In : PloS one. 8, 12, e81904.

Research output: Contribution to journalArticle

Crystal lattices
trapping
crystals
Ligands
Crystals
280 Citations (Scopus)

Structural basis for molecular recognition of folic acid by folate receptors

Chen, C., Ke, J., Edward Zhou, X., Yi, W., Brunzelle, J. S., Li, J., Yong, E. L., Xu, H. E. & Melcher, K., Jul 15 2013, In : Nature. 500, 7463, p. 486-489 4 p.

Research output: Contribution to journalArticle

Folic Acid
Folic Acid Antagonists
Antibody Affinity
Membrane Glycoproteins
Drug Delivery Systems
65 Citations (Scopus)

Structural basis for RNA recognition by a dimeric PPR-protein complex

Ke, J., Chen, R. Z., Ban, T., Zhou, X. E., Gu, X., Tan, M. H. E., Chen, C., Kang, Y., Brunzelle, J. S., Zhu, J. K., Melcher, K. & Xu, H. E., Dec 1 2013, In : Nature Structural and Molecular Biology. 20, 12, p. 1377-1382 6 p.

Research output: Contribution to journalArticle

Thylakoids
RNA
Proteins
Brachypodium
Protein Splicing
13 Citations (Scopus)

Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

Lu, G., Wu, Y., Jiang, Y., Wang, S., Hou, Y., Guan, X., Brunzelle, J., Sirinupong, N., Sheng, S., Li, C. & Yang, Z., Oct 2 2013, In : PloS one. 8, 10, e76219.

Research output: Contribution to journalArticle

PDZ Domains
Chemokine Receptors
crystal structure
neutrophils
Neutrophils
12 Citations (Scopus)

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium

Zheng, H., Beliavsky, A., Tchigvintsev, A., Brunzelle, J. S., Brown, G., Flick, R., Evdokimova, E., Wawrzak, Z., Mahadevan, R., Anderson, W. F., Savchenko, A. & Yakunin, A. F., Jun 1 2013, In : Proteins: Structure, Function and Bioinformatics. 81, 6, p. 1031-1041 11 p.

Research output: Contribution to journalArticle

Succinate-Semialdehyde Dehydrogenase (NADP+)
Succinate-Semialdehyde Dehydrogenase
Salmonella
Salmonella typhimurium
NAD
6 Citations (Scopus)

The mononuclear metal center of type-I dihydroorotase from aquifex aeolicus

Edwards, B. F. P., Fernando, R., Martin, P. D., Grimley, E., Cordes, M., Vaishnav, A., Brunzelle, J. S., Evans, H. G. & Evans, D. R., Dec 9 2013, In : BMC Biochemistry. 14, 1, 36.

Research output: Contribution to journalArticle

Dihydroorotase
Metals
Zinc
Catalytic Domain
Ions
2012
7 Citations (Scopus)

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds

Yedidi, R. S., Liu, Z., Wang, Y., Brunzelle, J. S., Kovari, I. A., Woster, P. M., Kovari, L. C. & Gupta, D., May 11 2012, In : Biochemical and Biophysical Research Communications. 421, 3, p. 413-417 5 p.

Research output: Contribution to journalArticle

Antimalarials
Viruses
HIV-1
Peptide Hydrolases
Crystal structure
20 Citations (Scopus)

Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration

Zou, Y., Zhang, H., Brunzelle, J. S., Johannes, T. W., Woodyer, R., Hung, J. E., Nair, N., Van Der Donk, W. A., Zhao, H. & Nair, S. K., May 29 2012, In : Biochemistry. 51, 21, p. 4263-4270 8 p.

Research output: Contribution to journalArticle

Niacinamide
Regeneration
Crystal structure
NAD
Phosphites
7 Citations (Scopus)

Higher desolvation energy reduces molecular recognition in multi-drug resistant HIV-1 protease

Wang, Y., Dewdney, T. G., Liu, Z., Reiter, S. J., Brunzelle, J. S., Kovari, I. A. & Kovari, L. C., May 31 2012, In : Biology. 1, 1, p. 81-93 13 p.

Research output: Contribution to journalArticle

Molecular recognition
Human immunodeficiency virus 1
proteinases
drugs
energy
212 Citations (Scopus)

Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases

Soon, F. F., Ng, L. M., Zhou, X. E., West, G. M., Kovach, A., Tan, M. H. E., Suino-Powell, K. M., He, Y., Xu, Y., Chalmers, M. J., Brunzelle, J. S., Zhang, H., Yang, H., Jiang, H., Li, J., Yong, E. L., Cutler, S., Zhu, J. K., Griffin, P. R., Melcher, K. & 1 others, Xu, H. E., Jan 6 2012, In : Science. 335, 6064, p. 85-88 4 p.

Research output: Contribution to journalArticle

Molecular Mimicry
Abscisic Acid
Phosphoric Monoester Hydrolases
Phosphotransferases
Catalytic Domain
30 Citations (Scopus)

Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers

Putcha, B. D. K., Wright, E., Brunzelle, J. S. & Fernandez, E. J., Apr 17 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6084-6087 4 p.

Research output: Contribution to journalArticle

Thyroid Hormone Receptors
NSC 153174
Nuclear Receptor Coactivator 1
Thyronines
Hormones
76 Citations (Scopus)

Structure and regulon of Campylobacter jejuni ferric uptake regulator fur define apo-Fur regulation

Butcher, J., Sarvan, S., Brunzelle, J. S., Couture, J. F. & Stintzi, A., Jun 19 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 25, p. 10047-10052 6 p.

Research output: Contribution to journalArticle

Regulon
Campylobacter jejuni
Iron
DNA
Nucleic Acid Conformation
51 Citations (Scopus)

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases

Zhang, P., Lee, H., Brunzelle, J. S. & Couture, J. F., May 1 2012, In : Nucleic acids research. 40, 9, p. 4237-4246 10 p.

Research output: Contribution to journalArticle

Peptides
Proteins
Retinoblastoma Binding Proteins
Methyltransferases
Lysine