Grants per year
Personal profile
Research Interests
My research involves the substantiation that bone marrow derived cells have an immunoregulatory capacity that can influence the induction of clinical tolerance (the elimination of maintenance immunosuppressive drugs). This includes the development of sophisticated monitoring techniques to detect the immune status of the recipient and the appearance of these regulatory cells in the bone marrow, peripheral blood, and transplanted organ in the recipient. I am currently conducting a clinical trial at Northwestern in 20 such HLA-identical living donor kidney transplant recipients of donor stem cells, along with the transplanted organ, and following the recipient for the detection of these immune regulatory functions.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, Albert Einstein College
… → 1961
Research interests keywords
- Autoimmunity
- Immunology
- Kidney
- Microbiology
- Stem Cells
- Transplantation
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Grants
- 7 Finished
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Intergovernmental Personnel Act Agreement for Li Chen
Miller, J. (PD/PI)
2/1/10 → 12/31/10
Project: Research project
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Prot# KV-08-001: The Differential Effects of 3 Different Immunosuppressive Agents, Tacrolimus, Mycophenolate Mofetil and Sirolimus on the Generation of Tregs and DCregs in In Vitro MLR and T Cell Activation Assays
Gallon, L. (PD/PI), Levitsky, J. (Co-PD/PI), Mathew, J. (Co-PD/PI), Miller, J. (Co-PD/PI) & Tambur, A. R. (Co-PD/PI)
7/24/08 → 7/23/09
Project: Research project
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Agreement for ImmuKnow-Related Projects
Miller, J. (PD/PI), Baker, T. B. (Co-PD/PI) & Tambur, A. R. (Co-PD/PI)
6/30/08 → 6/30/09
Project: Research project
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Prot# 0468E6-4479 / Version 1.0: Immune Tolerance Profiles After Conversion from Tacrolimus to Sirolimus After Liver Transplantation
Levitsky, J. (PD/PI), Abecassis, M. M. (Co-PD/PI), Mathew, J. (Co-PD/PI), Miller, J. (Co-PD/PI) & Tambur, A. R. (Co-PD/PI)
5/8/08 → 5/8/11
Project: Research project
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Intergovernmental Personnel Act Agreement for C. Flaa
Miller, J. (PD/PI)
1/27/08 → 10/23/09
Project: Research project
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Differentiation of regulatory myeloid and T-cells from adult human hematopoietic stem cells after allogeneic stimulation
Mathew, J. M., Sanders, J. M., Cirocco, R., Miller, J. & Leventhal, J. R., 2024, In: Frontiers in immunology. 15, 1366972.Research output: Contribution to journal › Article › peer-review
Open Access -
The Importance of Bringing Transplantation Tolerance to the Clinic
Cosimi, A. B., Ascher, N. L., Emond, J. C., Kaufman, D. B., Madsen, J. C., Miller, J., Monaco, A. P., Montgomery, R. A., Newell, K. A., Sánchez-Fueyo, A., Sarwal, M. M., Scandling, J. D., Strober, S., Todo, S., Weir, M. R. & Sachs, D. H., May 1 2021, In: Transplantation. 105, 5, p. 935-940 6 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Transcriptomic studies in tolerance: Lessons learned and the path forward
Kurian, S. M., Whisenant, T. C., Mathew, J., Miller, J. & Leventhal, J. R., May 2018, In: Human Immunology. 79, 5, p. 395-401 7 p.Research output: Contribution to journal › Review article › peer-review
6 Scopus citations -
Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells
Leventhal, J. R., Miller, J., Mathew, J. M., Kurian, S., Tambur, A. R., Friedewald, J., Charrette, J. & Abecassis, M. M., May 2018, In: Human Immunology. 79, 5, p. 277-282 6 p.Research output: Contribution to journal › Review article › peer-review
Open Access18 Scopus citations -
Immunoregulatory effects of everolimus on in vitro alloimmune responses
Levitsky, J., Miller, J., Huang, X., Gallon, L., Leventhal, J. R. & Mathew, J. M., Jun 1 2016, In: PloS one. 11, 6, e0156535.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations