Grants per year
Personal profile
Research Interests
My research involves the substantiation that bone marrow derived cells have an immunoregulatory capacity that can influence the induction of clinical tolerance (the elimination of maintenance immunosuppressive drugs). This includes the development of sophisticated monitoring techniques to detect the immune status of the recipient and the appearance of these regulatory cells in the bone marrow, peripheral blood, and transplanted organ in the recipient. I am currently conducting a clinical trial at Northwestern in 20 such HLA-identical living donor kidney transplant recipients of donor stem cells, along with the transplanted organ, and following the recipient for the detection of these immune regulatory functions.
Education/Academic qualification
MD, Albert Einstein College
… → 1961
Research interests
- Autoimmunity
- Immunology
- Kidney
- Microbiology
- Stem Cells
- Transplantation
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Grants
- 6 Finished
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Prot# KV-08-001: The Differential Effects of 3 Different Immunosuppressive Agents, Tacrolimus, Mycophenolate Mofetil and Sirolimus on the Generation of Tregs and DCregs in In Vitro MLR and T Cell Activation Assays
Gallon, L., Levitsky, J., Mathew, J., Miller, J. & Roitberg-Tambur, A.
7/24/08 → 7/23/09
Project: Research project
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Agreement for ImmuKnow-Related Projects
Baker, T. B., Miller, J. & Roitberg-Tambur, A.
6/30/08 → 6/30/09
Project: Research project
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Prot# 0468E6-4479 / Version 1.0: Immune Tolerance Profiles After Conversion from Tacrolimus to Sirolimus After Liver Transplantation
Abecassis, M. M., Levitsky, J., Mathew, J., Miller, J. & Roitberg-Tambur, A.
5/8/08 → 5/8/11
Project: Research project
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Research Output
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Transcriptomic studies in tolerance: Lessons learned and the path forward
Kurian, S. M., Whisenant, T. C., Mathew, J., Miller, J. & Leventhal, J. R., May 2018, In: Human Immunology. 79, 5, p. 395-401 7 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells
Leventhal, J. R., Miller, J., Mathew, J. M., Kurian, S., Tambur, A. R., Friedewald, J., Charrette, J. & Abecassis, M. M., May 2018, In: Human Immunology. 79, 5, p. 277-282 6 p.Research output: Contribution to journal › Review article › peer-review
5 Scopus citations -
Immunoregulatory effects of everolimus on in vitro alloimmune responses
Levitsky, J., Miller, J., Huang, X., Gallon, L., Leventhal, J. R. & Mathew, J. M., Jun 1 2016, In: PloS one. 11, 6, e0156535.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Low incidence of acute rejection in hepatitis B virus positive liver transplant recipients and the impact of hepatitis B immunoglobulin
Veerappan, A., VanWagner, L. B., Mathew, J. M., Huang, X., Miller, J., Lapin, B. & Levitsky, J., Apr 1 2016, In: Human Immunology. 77, 4, p. 367-374 8 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Nonchimeric HLA-identical renal transplant tolerance: Regulatory immunophenotypic/genomic biomarkers
Leventhal, J. R., Mathew, J. M., Salomon, D. R., Kurian, S. M., Friedewald, J. J., Gallon, L., Konieczna, I., Tambur, A. R., Charette, J., Levitsky, J., Jie, C., Kanwar, Y. S., Abecassis, M. M. & Miller, J., Jan 1 2016, In: American Journal of Transplantation. 16, 1, p. 221-234 14 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations