Grants per year
Personal profile
Research Interests
My research involves the substantiation that bone marrow derived cells have an immunoregulatory capacity that can influence the induction of clinical tolerance (the elimination of maintenance immunosuppressive drugs). This includes the development of sophisticated monitoring techniques to detect the immune status of the recipient and the appearance of these regulatory cells in the bone marrow, peripheral blood, and transplanted organ in the recipient. I am currently conducting a clinical trial at Northwestern in 20 such HLA-identical living donor kidney transplant recipients of donor stem cells, along with the transplanted organ, and following the recipient for the detection of these immune regulatory functions.
Education/Academic qualification
MD, Albert Einstein College
… → 1961
Keywords
- Autoimmunity
- Immunology
- Kidney
- Microbiology
- Stem Cells
- Transplantation
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2007 2013
- 6 Finished
Prot# KV-08-001: The Differential Effects of 3 Different Immunosuppressive Agents, Tacrolimus, Mycophenolate Mofetil and Sirolimus on the Generation of Tregs and DCregs in In Vitro MLR and T Cell Activation Assays
Gallon, L., Levitsky, J., Mathew, J., Miller, J. & Roitberg-Tambur, A.
7/24/08 → 7/23/09
Project: Research project
Agreement for ImmuKnow-Related Projects
Baker, T. B., Miller, J. & Roitberg-Tambur, A.
6/30/08 → 6/30/09
Project: Research project
Research Output 1962 2018
1
Citation
(Scopus)
Transcriptomic studies in tolerance: Lessons learned and the path forward
Kurian, S. M., Whisenant, T. C., Mathew, J., Miller, J. & Leventhal, J. R., May 1 2018, In : Human Immunology. 79, 5, p. 395-401 7 p.Research output: Contribution to journal › Review article
Immunosuppression
Biomarkers
Graft Survival
Immunosuppressive Agents
Transplants
1
Citation
(Scopus)
Updated follow-up of a tolerance protocol in HLA-identical renal transplant pairs given donor hematopoietic stem cells
Leventhal, J. R., Miller, J., Mathew, J., Kurian, S., Roitberg-Tambur, A., Friedewald, J. J., Charrette, J. & Abecassis, M. M., May 1 2018, In : Human Immunology. 79, 5, p. 277-282 6 p.Research output: Contribution to journal › Review article
Hematopoietic Stem Cells
Tissue Donors
Transplants
Kidney
Biopsy
4
Citations
(Scopus)
Immunoregulatory effects of everolimus on in vitro alloimmune responses
Levitsky, J., Miller, J., Huang, X., Gallon, L., Leventhal, J. R. & Mathew, J. M., Jun 1 2016, In : PloS one. 11, 6, e0156535.Research output: Contribution to journal › Article
tacrolimus
Tacrolimus
organ transplantation
Sirolimus
in vitro studies
1
Citation
(Scopus)
Low incidence of acute rejection in hepatitis B virus positive liver transplant recipients and the impact of hepatitis B immunoglobulin
Veerappan, A., VanWagner, L. B., Mathew, J. M., Huang, X., Miller, J., Lapin, B. & Levitsky, J., Apr 1 2016, In : Human Immunology. 77, 4, p. 367-374 8 p.Research output: Contribution to journal › Article
Hepatitis B
Hepatitis B virus
Immunoglobulins
Liver
Incidence
28
Citations
(Scopus)
Nonchimeric HLA-identical renal transplant tolerance: Regulatory immunophenotypic/genomic biomarkers
Leventhal, J. R., Mathew, J. M., Salomon, D. R., Kurian, S. M., Friedewald, J. J., Gallon, L., Konieczna, I., Tambur, A. R., Charette, J., Levitsky, J., Jie, C., Kanwar, Y. S., Abecassis, M. M. & Miller, J., Jan 1 2016, In : American Journal of Transplantation. 16, 1, p. 221-234 14 p.Research output: Contribution to journal › Article
HLA Antigens
Biomarkers
Transcriptome
Transplants
Kidney