Grants per year
Personal profile
Research Interests
Professor Leonard’s research group works at the interface of systems biology and synthetic biology in order to probe and program the function of complex, multicellular systems to develop transformative biotechnologies and enable a new paradigm of design-driven medicine. Using the tools of synthetic biology, biomolecular engineering, computational systems biology, and gene therapy, they develop technologies including programmable cell-based “devices,” immune therapies for cancer and chronic disease, smart vaccines, biosensors for global health applications, and tools for advanced metabolic engineering. By bringing an engineering approach to the investigation, design, and construction of biological systems, the Leonard group is advancing the frontiers of design-driven medicine to address unmet medical needs and create safe, effective, and long-lasting treatment options that improve both quantity and quality of life.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Chemical Engineering, PhD, University of California at Berkeley
… → 2006
Chemical Engineering, BS, Stanford University
… → 2000
Research interests keywords
- Cancer
- Cellular engineering
- Gene therapy
- Immunology
- Protein engineering
- Synthetic biology
- Systems biology
- Computational and experimental systems biology
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Collaborations and top research areas from the last five years
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Plant DX - Phase II
Lucks, J. B., Gerardin, J., Jewett, M. C., Leonard, J. N. & Mangan, N. M.
Bill & Melinda Gates Foundation
8/23/22 → 6/9/24
Project: Research project
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NRT-URoL: Synthesizing Biology Across Scales – A Convergent Synthetic Biology Training Program
Lucks, J. B., Calkins, S. C., Jewett, M. C., Kamat, N. P., Karim, A. S., Tullman-Ercek, D., Leonard, J. N., Mangan, N. M., Prindle, A. & Tyo, K. E. J.
9/1/20 → 8/31/25
Project: Research project
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Supplementary Funding Subproject for Biotechnology Predoctoral Training Program
Leonard, J. N., Drane, D. L. & Goldberg, B. B.
National Institute of General Medical Sciences
7/1/19 → 6/30/24
Project: Research project
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Biotechnology Predoctoral Training Program
Leonard, J. N. & Lackner, L. L.
National Institute of General Medical Sciences
7/1/19 → 6/30/24
Project: Research project
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RAPID: Point-of-Need Detection of COVID-19 using CRISPR-Enabled Cell-Free Synthetic Biology
Lucks, J. B., Jewett, M. C. & Leonard, J. N.
5/1/20 → 4/30/22
Project: Research project
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Correction to: Elucidating Design Principles for Engineering Cell-Derived Vesicles to Inhibit SARS-CoV-2 Infection (Small, (2022), 18, 19, (2200125), 10.1002/smll.202200125)
Gunnels, T. F., Stranford, D. M., Mitrut, R. E., Kamat, N. P. & Leonard, J. N., Nov 3 2022, In: Small. 18, 44, 2205964.Research output: Contribution to journal › Comment/debate › peer-review
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Elucidating Design Principles for Engineering Cell-Derived Vesicles to Inhibit SARS-CoV-2 Infection
Gunnels, T. F., Stranford, D. M., Mitrut, R. E., Kamat, N. P. & Leonard, J. N., May 12 2022, In: Small. 18, 19, 2200125.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Erratum: GAMES: A Dynamic Model Development Workflow for Rigorous Characterization of Synthetic Genetic Systems (ACS Synth. Biol. (2022) 11: 2 (1009−1029) DOI: 10.1021/acssynbio.1c00528)
Dray, K. E., Muldoon, J. J., Mangan, N. M., Bagheri, N. & Leonard, J. N., Apr 15 2022, In: ACS synthetic biology. 11, 4, p. 1699-1704 6 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Fighting fire with fire: deploying complexity in computational modeling to effectively characterize complex biological systems
Prybutok, A. N., Cain, J. Y., Leonard, J. N. & Bagheri, N., Jun 2022, In: Current Opinion in Biotechnology. 75, 102704.Research output: Contribution to journal › Review article › peer-review
Open Access -
GAMES: A Dynamic Model Development Workflow for Rigorous Characterization of Synthetic Genetic Systems
Dray, K. E., Muldoon, J. J., Mangan, N. M., Bagheri, N. & Leonard, J. N., Feb 18 2022, In: ACS synthetic biology. 11, 2, p. 1009-1029 21 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations