Grants per year
Personal profile
Research Interests
Professor Leonard’s research group works at the interface of systems biology and synthetic biology in order to probe and program the function of complex, multicellular systems to develop transformative biotechnologies and enable a new paradigm of design-driven medicine. Using the tools of synthetic biology, biomolecular engineering, computational systems biology, and gene therapy, they develop technologies including programmable cell-based “devices,” immune therapies for cancer and chronic disease, smart vaccines, biosensors for global health applications, and tools for advanced metabolic engineering. By bringing an engineering approach to the investigation, design, and construction of biological systems, the Leonard group is advancing the frontiers of design-driven medicine to address unmet medical needs and create safe, effective, and long-lasting treatment options that improve both quantity and quality of life.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Chemical Engineering, PhD, University of California at Berkeley
… → 2006
Chemical Engineering, BS, Stanford University
… → 2000
Research interests keywords
- Cancer
- Cellular engineering
- Gene therapy
- Immunology
- Protein engineering
- Synthetic biology
- Systems biology
- Computational and experimental systems biology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Biotechnology Predoctoral Training Program
Leonard, J. N. (PD/PI) & Petersen, C. P. (Co-PD/PI)
National Institute of General Medical Sciences
7/1/24 → 6/30/29
Project: Research project
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Design-driven engineering of robust mammalian sense-and-respond functions: from parts to programs
Leonard, J. N. (PD/PI) & Mangan, N. M. (Co-PD/PI)
National Institute of Biomedical Imaging and Bioengineering
7/1/23 → 3/31/27
Project: Research project
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Plant DX - Phase II
Lucks, J. B. (PD/PI), Lucks, J. B. (PD/PI), Gerardin, J. (Co-PD/PI), Gerardin, J. (Co-PD/PI), Jewett, M. C. (Co-PD/PI), Jewett, M. C. (Co-PD/PI), Leonard, J. N. (Co-PD/PI), Leonard, J. N. (Co-PD/PI), Mangan, N. M. (Co-PD/PI) & Mangan, N. M. (Co-PD/PI)
Bill & Melinda Gates Foundation
8/23/22 → 8/31/25
Project: Research project
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NRT-URoL: Synthesizing Biology Across Scales – A Convergent Synthetic Biology Training Program
Lucks, J. B. (PD/PI), Lucks, J. B. (PD/PI), Calkins, S. C. (Co-PD/PI), Jewett, M. C. (Co-PD/PI), Kamat, N. P. (Co-PD/PI), Kamat, N. P. (Co-PD/PI), Kamat, N. P. (Co-PD/PI), Karim, A. S. (Co-PD/PI), Karim, A. S. (Co-PD/PI), Karim, A. S. (Co-PD/PI), Tullman-Ercek, D. (Co-PD/PI), Tullman-Ercek, D. (Co-PD/PI), Tullman-Ercek, D. (Co-PD/PI), Kamat, N. P. (Co-Investigator), Karim, A. S. (Co-Investigator), Tullman-Ercek, D. (Co-Investigator), Leonard, J. N. (Other), Leonard, J. N. (Other), Leonard, J. N. (Other), Mangan, N. M. (Other), Mangan, N. M. (Other), Mangan, N. M. (Other), Prindle, A. (Other), Prindle, A. (Other), Prindle, A. (Other), Tyo, K. (Other), Tyo, K. (Other) & Tyo, K. (Other)
9/1/20 → 8/31/25
Project: Research project
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Biotechnology Predoctoral Training Program
Leonard, J. N. (PD/PI), Leonard, J. N. (PD/PI), Leonard, J. N. (PD/PI), Lackner, L. L. (Co-PD/PI), Lackner, L. L. (Co-PD/PI) & Lackner, L. L. (Co-PD/PI)
National Institute of General Medical Sciences
7/1/19 → 9/30/24
Project: Research project
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Building Synthetic Biosensors Using Red Blood Cell Proteins
Dolberg, T. B., Gunnels, T. F., Ling, T., Sarnese, K. A., Crispino, J. D. & Leonard, J. N., Apr 19 2024, In: ACS synthetic biology. 13, 4, p. 1273-1289 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Deconstructing synthetic biology across scales: a conceptual approach for training synthetic biologists
Karim, A. S., Brown, D. M., Archuleta, C. M., Grannan, S., Aristilde, L., Goyal, Y., Leonard, J. N., Mangan, N. M., Prindle, A., Rocklin, G. J., Tyo, K. J., Zoloth, L. S., Jewett, M. C., Calkins, S. C., Kamat, N. P., Tullman-Ercek, D. & Lucks, J. B., Dec 2024, In: Nature communications. 15, 1, 5425.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
Peruzzi, J. A., Gunnels, T. F., Edelstein, H. I., Lu, P., Baker, D., Leonard, J. N. & Kamat, N. P., Dec 2024, In: Nature communications. 15, 1, 5618.Research output: Contribution to journal › Article › peer-review
Open Access -
Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells
Stranford, D. M., Simons, L. M., Berman, K. E., Cheng, L., DiBiase, B. N., Hung, M. E., Lucks, J. B., Hultquist, J. F. & Leonard, J. N., Apr 2024, In: Nature Biomedical Engineering. 8, 4, p. 397-414 18 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
HaloTag display enables quantitative single-particle characterisation and functionalisation of engineered extracellular vesicles
Mitrut, R. E., Stranford, D. M., DiBiase, B. N., Chan, J. M., Bailey, M. D., Luo, M., Harper, C. S., Meade, T. J., Wang, M. & Leonard, J. N., Jul 2024, In: Journal of Extracellular Vesicles. 13, 7, e12469.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Source Data for "Comparative evaluation of synthetic cytokines for enhancing production and performance of NK92 cell-based therapies"
Donahue, P. S. (Contributor), Mitrut, R. E. (Contributor) & Leonard, J. N. (Contributor), ZENODO, Jun 16 2023
DOI: 10.5281/zenodo.8047842, https://zenodo.org/record/8047842
Dataset