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Joshua N Leonard

  • 2592 Citations
19992024

Research output per year

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Personal profile

Research Interests

Professor Leonard’s research group works at the interface of systems biology and synthetic biology in order to probe and program the function of complex, multicellular systems to develop transformative biotechnologies and enable a new paradigm of design-driven medicine. Using the tools of synthetic biology, biomolecular engineering, computational systems biology, and gene therapy, they develop technologies including programmable cell-based “devices,” immune therapies for cancer and chronic disease, smart vaccines, biosensors for global health applications, and tools for advanced metabolic engineering. By bringing an engineering approach to the investigation, design, and construction of biological systems, the Leonard group is advancing the frontiers of design-driven medicine to address unmet medical needs and create safe, effective, and long-lasting treatment options that improve both quantity and quality of life.

Education/Academic qualification

Chemical Engineering, PhD, University of California, Berkeley

… → 2006

Chemical Engineering, BS, Stanford University

… → 2000

Research interests

  • Cancer
  • Cellular engineering
  • Gene therapy
  • Immunology
  • Protein engineering
  • Synthetic biology
  • Systems biology
  • Computational and experimental systems biology

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Grants

Biotechnology Predoctoral Training Program

Leonard, J. N.

National Institute of General Medical Sciences

7/1/19 → 6/30/24

Project: Research project

    • RoL: EAGER: DESYN-C3 Moving information across synthetic membranes via engineered sensors

    Kamat, N. P. & Leonard, J. N.

    National Science Foundation

    12/1/18 → 11/30/20

    Project: Research project

    • Design-driven engineering of robust mammalian sense-and-respond functions

    Bagheri, N. & Leonard, J. N.

    National Institute of Biomedical Imaging and Bioengineering

    8/1/18 → 4/30/22

    Project: Research project

    • Elucidating a novel regulator of inflammation: the TLR4-Inhibitory Complex (TIC)

    Bagheri, N. & Leonard, J. N.

    National Institute of Allergy and Infectious Diseases

    12/22/17 → 11/30/20

    Project: Research project

    • Collaborative Research: EAGER: Customized cell biosensors for interrogating cancer cell physiology

    Leonard, J. N.

    National Science Foundation

    9/1/17 → 8/31/20

    Project: Research project

    • Research Output

    Macrophages employ quorum licensing to regulate collective activation

    Muldoon, J. J., Chuang, Y., Bagheri, N. & Leonard, J. N., Dec 1 2020, In : Nature communications. 11, 1, 878.

    Research output: Contribution to journal › Article

    Open Access

    • The COMET toolkit for composing customizable genetic programs in mammalian cells

    Donahue, P. S., Draut, J. W., Muldoon, J. J., Edelstein, H. I., Bagheri, N. & Leonard, J. N., Dec 1 2020, In : Nature communications. 11, 1, 779.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop

    Li, K., Rodosthenous, R. S., Kashanchi, F., Gingeras, T., Gould, S. J., Kuo, L. S., Kurre, P., Lee, H., Leonard, J. N., Liu, H., Lombo, T. B., Momma, S., Nolan, J. P., Ochocinska, M. J., Pegtel, D. M., Sadovsky, Y., Sánchez-Madrid, F., Valdes, K. M., Vickers, K. C., Weaver, A. M. & 5 others, Witwer, K. W., Zeng, Y., Das, S., Raffai, R. L. & Howcroft, T. K., Apr 5 2018, In : JCI Insight. 3, 7

    Research output: Contribution to journal › Review article

    Open Access
    • 18 Scopus citations

    Development of novel metabolite-responsive transcription factors via transposon-mediated protein fusion

    Younger, A. K. D., Su, P. Y., Shepard, A. J., Udani, S. V., Cybulski, T. R., Tyo, K. E. J. & Leonard, J. N., Feb 1 2018, In : Protein Engineering, Design and Selection. 31, 2, p. 55-63 9 p.

    Research output: Contribution to journal › Article

    • 9 Scopus citations

    Enrichment of extracellular vesicle subpopulations via affinity chromatography

    Hung, M. E., Lenzini, S. B., Stranford, D. M. & Leonard, J. N., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 109-124 16 p. (Methods in Molecular Biology; vol. 1740).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    • 2 Scopus citations