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Research Output 1999 2018

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2018
6 Citations (Scopus)

Development of novel metabolite-responsive transcription factors via transposon-mediated protein fusion

Younger, A. K. D., Su, P. Y., Shepard, A. J., Udani, S. V., Cybulski, T. R., Tyo, K. E. J. & Leonard, J. N., Feb 1 2018, In : Protein Engineering, Design and Selection. 31, 2, p. 55-63 9 p.

Research output: Contribution to journalArticle

Transcription factors
Biosensing Techniques
Metabolites
Biosensors
Transcription Factors
2 Citations (Scopus)

Highly Stable, Ultrasmall Polymer-Grafted Nanobins (usPGNs) with Stimuli-Responsive Capability

Hong, B. J., Iscen, A., Chipre, A. J., Li, M. M., Lee, O. S., Leonard, J. N., Schatz, G. C. & Nguyen, S. T., Mar 1 2018, In : Journal of Physical Chemistry Letters. 9, 5, p. 1133-1139 7 p.

Research output: Contribution to journalArticle

carbopol 940
Cholesterol
stimuli
cholesterol
acrylic acid
2017
3 Citations (Scopus)

A Systematic Evaluation of Factors Affecting Extracellular Vesicle Uptake by Breast Cancer Cells

Stranford, D. M., Hung, M. E., Gargus, E. S., Shah, R. N. & Leonard, J. N., Nov 1 2017, In : Tissue Engineering - Part A. 23, 21-22, p. 1274-1282 9 p.

Research output: Contribution to journalArticle

Cells
Biomolecules
Breast Neoplasms
Hexadimethrine Bromide
Display devices

Building with intent: Technologies and principles for engineering mammalian cell-based therapies to sense and respond

Muldoon, J. J., Donahue, P. S., Dolberg, T. B. & Leonard, J. N., Dec 2017, In : Current Opinion in Biotechnology. 4, p. 127-133 7 p.

Research output: Contribution to journalArticle

Cell engineering
Cell- and Tissue-Based Therapy
Technology
Artificial Receptors
Signal transduction
2 Citations (Scopus)

Delivery of Biomolecules via Extracellular Vesicles: A Budding Therapeutic Strategy

Stranford, D. M. & Leonard, J. N., Jan 1 2017, In : Advances in Genetics. 98, p. 155-175 21 p.

Research output: Contribution to journalArticle

Therapeutics
Wound Healing
Nucleic Acids
Extracellular Vesicles
Membranes
17 Citations (Scopus)

Engineering Modular Biosensors to Confer Metabolite-Responsive Regulation of Transcription

Younger, A. K. D., Dalvie, N. C., Rottinghaus, A. G. & Leonard, J. N., Feb 17 2017, In : ACS Synthetic Biology. 6, 2, p. 311-325 15 p.

Research output: Contribution to journalArticle

Biosensing Techniques
Transcription
Metabolites
Biosensors
Maltose
1 Citation (Scopus)

Extended Concerted Rotation Technique Enhances the Sampling Efficiency of the Computational Peptide-Design Algorithm

Xiao, X., Wang, Y., Leonard, J. N. & Hall, C. K., Nov 14 2017, In : Journal of Chemical Theory and Computation. 13, 11, p. 5709-5720 12 p.

Research output: Contribution to journalArticle

Peptides
peptides
sampling
Sampling
RNA
4 Citations (Scopus)

Multiplexing Engineered Receptors for Multiparametric Evaluation of Environmental Ligands

Hartfield, R. M., Schwarz, K. A., Muldoon, J. J., Bagheri, N. & Leonard, J. N., Nov 17 2017, In : ACS synthetic biology. 6, 11, p. 2042-2055 14 p.

Research output: Contribution to journalArticle

Multiplexing
Transcription factors
Transcription Factors
Ligands
Artificial Receptors

Predicting the Dynamics and Heterogeneity of Genomic DNA Content within Bacterial Populations across Variable Growth Regimes

Du Lac, M., Scarpelli, A. H., Younger, A. K. D., Bates, D. G. & Leonard, J. N., Jul 21 2017, In : ACS synthetic biology. 6, 7, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

DNA
Growth
Population
Genes
Computing Methodologies
33 Citations (Scopus)

Rewiring human cellular input-output using modular extracellular sensors

Schwarz, K. A., Daringer, N. M., Dolberg, T. B. & Leonard, J. N., Feb 1 2017, In : Nature Chemical Biology. 13, 2, p. 202-209 8 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Interleukin-2
Cell Engineering
Biosensing Techniques
Immunosuppressive Agents
2016
5 Citations (Scopus)

Adding energy minimization strategy to peptide-design algorithm enables better search for RNA-binding peptides: Redesigned λ N peptide binds boxB RNA

Xiao, X., Hung, M. E., Leonard, J. N. & Hall, C. K., Oct 15 2016, In : Journal of computational chemistry. 37, 27, p. 2423-2435 13 p.

Research output: Contribution to journalArticle

Energy Minimization
Algorithm Design
RNA
Peptides
Strategy
31 Citations (Scopus)

A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery

Hung, M. E. & Leonard, J. N., May 13 2016, In : Journal of Extracellular Vesicles. 5, 13 p., 31027.

Research output: Contribution to journalArticle

RNA
Vesicular Stomatitis
Extracellular Vesicles
Prostatic Neoplasms
Glycoproteins
4 Citations (Scopus)

Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli

Chuang, Y., Hung, M. E., Cangelose, B. K. & Leonard, J. N., Nov 1 2016, In : Innate Immunity. 22, 8, p. 647-657 11 p.

Research output: Contribution to journalArticle

Interleukin-10
Macrophages
Phenotype
Immunosuppressive Agents
Interleukin-12
29 Citations (Scopus)

Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets

Liu, J. M. H., Zhang, J., Zhang, X., Hlavaty, K. A., Ricci, C. F., Leonard, J. N., Shea, L. D. & Gower, R. M., Feb 1 2016, In : Biomaterials. 80, p. 11-19 9 p.

Research output: Contribution to journalArticle

Scaffolds
Transforming Growth Factor beta
Biocompatible Materials
Inflammation
Biomaterials
2015
4 Citations (Scopus)

Contributions of unique intracellular domains to switchlike biosensing by Toll-like receptor 4

Daringer, N. M., Schwarz, K. A. & Leonard, J. N., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 8764-8777 14 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Toll-Like Receptors
Interleukin-1 Receptors
Ligands
Dimerization
3 Citations (Scopus)

Regulation of Bacterial Gene Expression by Protease-Alleviated Spatial Sequestration (PASS)

Pitner, R. A., Scarpelli, A. H. & Leonard, J. N., Sep 18 2015, In : ACS synthetic biology. 4, 9, p. 966-974 9 p.

Research output: Contribution to journalArticle

Bacterial Gene Expression Regulation
Gene expression
Synthetic Biology
Transcription factors
Peptide Hydrolases
9 Citations (Scopus)

Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune Networks

Wells, D. K., Chuang, Y., Knapp, L. M., Brockmann, D., Kath, W. L. & Leonard, J. N., Apr 1 2015, In : PLoS computational biology. 11, 4, e1004181.

Research output: Contribution to journalArticle

group behavior
Collective Behavior
tumor
Tumors
Tumor
71 Citations (Scopus)

Stabilization of exosome-targeting peptides via engineered glycosylation

Hung, M. E. & Leonard, J. N., Mar 27 2015, In : Journal of Biological Chemistry. 290, 13, p. 8166-8172 7 p.

Research output: Contribution to journalArticle

Exosomes
Glycosylation
Stabilization
Peptides
Display devices
2014
1 Citation (Scopus)

A systems biology approach to blood

Corey, S. J., Kimmel, M. & Leonard, J. N., Jan 1 2014, In : Advances in Experimental Medicine and Biology. 844

Research output: Contribution to journalArticle

Systems Biology
Blood
1 Citation (Scopus)

Engineered cell-based therapies: A vanguard of design-driven medicine

Dudek, R. M., Chuang, Y. & Leonard, J. N., Jan 1 2014, In : Advances in Experimental Medicine and Biology. 844, p. 369-391 23 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Medicine
Synthetic Biology
Systems Biology
Antigen Receptors
48 Citations (Scopus)

Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype

Boehler, R. M., Kuo, R., Shin, S., Goodman, A. G., Pilecki, M. A., Leonard, J. N. & Shea, L. D., Jan 1 2014, In : Biotechnology and Bioengineering. 111, 6, p. 1210-1221 12 p.

Research output: Contribution to journalArticle

Lentivirus
Macrophages
Interleukin-10
Anti-Inflammatory Agents
Polarization
36 Citations (Scopus)

Modular Extracellular sensor architecture for engineering mammalian cell-based devices

Daringer, N. M., Dudek, R. M., Schwarz, K. A. & Leonard, J. N., Jan 1 2014, In : ACS Synthetic Biology. 3, 12, p. 892-902 11 p.

Research output: Contribution to journalArticle

Cell engineering
Cell Engineering
Synthetic Biology
Ligands
Equipment and Supplies
42 Citations (Scopus)

Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression

Gower, R. M., Boehler, R. M., Azarin, S. M., Ricci, C. F., Leonard, J. N. & Shea, L. D., Feb 1 2014, In : Biomaterials. 35, 6, p. 2024-2031 8 p.

Research output: Contribution to journalArticle

Tissue Scaffolds
Macrophages
Tissue Engineering
Scaffolds (biology)
Tissue engineering

Systems hematology: An introduction

Corey, S. J., Kimmel, M. & Leonard, J. N., Jan 1 2014, In : Advances in Experimental Medicine and Biology. 844, p. 3-10 8 p.

Research output: Contribution to journalArticle

Hematology
Hematopoiesis
Blood
Stem cells
Stem Cells
2011
111 Citations (Scopus)

TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection

Jelinek, I., Leonard, J. N., Price, G. E., Brown, K. N., Meyer-Manlapat, A., Goldsmith, P. K., Wang, Y., Venzon, D., Epstein, S. L. & Segal, D. M., Feb 15 2011, In : Journal of Immunology. 186, 4, p. 2422-2429 8 p.

Research output: Contribution to journalArticle

Cross-Priming
Double-Stranded RNA
Oligonucleotides
Dendritic Cells
Antiviral Agents
2008
43 Citations (Scopus)

HIV Evades RNA Interference Directed at TAR by an Indirect Compensatory Mechanism

Leonard, J. N., Shah, P. S., Burnett, J. C. & Schaffer, D. V., Nov 13 2008, In : Cell Host and Microbe. 4, 5, p. 484-494 11 p.

Research output: Contribution to journalArticle

RNA Interference
HIV
Mutation
Antiviral Agents
Human Immunodeficiency Virus Proteins
92 Citations (Scopus)

Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis

Ricci, C., Pastukh, V., Leonard, J., Turrens, J., Wilson, G., Schaffer, D. & Schaffer, S. W., Feb 1 2008, In : American Journal of Physiology - Cell Physiology. 294, 2

Research output: Contribution to journalArticle

Mitochondrial DNA
Superoxides
DNA Damage
Apoptosis
Angiotensin II
462 Citations (Scopus)

Structural basis of toll-like receptor 3 signaling with double-stranded RNA

Liu, L., Botos, I., Wang, Y., Leonard, J. N., Shiloach, J., Segal, D. M. & Davies, D. R., Apr 18 2008, In : Science. 320, 5874, p. 379-381 3 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 3
Double-Stranded RNA
Interleukin-1 Receptors
Oligonucleotides
Base Pairing
146 Citations (Scopus)

The TLR3 signaling complex forms by cooperative receptor dimerization

Leonard, J. N., Ghirlando, R., Askins, J., Bell, J. K., Margulies, D. H., Davies, D. R. & Segal, D. M., Jan 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 1, p. 258-263 6 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Dimerization
Ligands
Oligonucleotides
Toll-Like Receptors
2007
15 Citations (Scopus)

Enhanced preparation of adeno-associated viral vectors by using high hydrostatic pressure to selectively inactivate helper adenovirus

Leonard, J. N., Ferstl, P., Delgado, A. & Schaffer, D. V., Aug 1 2007, In : Biotechnology and Bioengineering. 97, 5, p. 1170-1179 10 p.

Research output: Contribution to journalArticle

Dependovirus
Hydrostatic Pressure
Hydrostatic pressure
Viruses
Adenoviridae
22 Citations (Scopus)

High-throughput screening of gene function in stem cells using clonal microarrays

Ashton, R. S., Peltier, J., Fasano, C. A., O'Neill, A., Leonard, J., Temple, S., Schaffer, D. V. & Kane, R. S., Nov 1 2007, In : Stem Cells. 25, 11, p. 2928-2935 8 p.

Research output: Contribution to journalArticle

Stem Cells
Genes
Population
Libraries
Microtechnology
664 Citations (Scopus)

TLR3 deficiency in patients with herpes simplex encephalitis

Zhang, S. Y., Jouanguy, E., Ugolini, S., Smahi, A., Elain, G., Romero, P., Segal, D., Sancho-Shimizu, V., Lorenzo, L., Puel, A., Picard, C., Chapgier, A., Plancoulaine, S., Titeux, M., Cognet, C., Von Bernuth, H., Ku, C. L., Casrouge, A., Zhang, X. X., Barreiro, L. & 13 others, Leonard, J., Hamilton, C., Lebon, P., Héron, B., Vallée, L., Quintana-Murci, L., Hovnanian, A., Rozenberg, F., Vivier, E., Geissmann, F., Tardieu, M., Abel, L. & Casanova, J. L., Sep 14 2007, In : Science. 317, 5844, p. 1522-1527 6 p.

Research output: Contribution to journalArticle

Herpes Simplex Encephalitis
Human Herpesvirus 1
Central Nervous System
Cranial Nerves
Toll-Like Receptors
2005
53 Citations (Scopus)

Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape

Leonard, J. N. & Schaffer, D. V., Feb 1 2005, In : Journal of Virology. 79, 3, p. 1645-1654 10 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus
RNA Interference
RNA interference
Antiviral Agents
HIV