• 2675 Citations
19992020

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2020

Macrophages employ quorum licensing to regulate collective activation

Muldoon, J. J., Chuang, Y., Bagheri, N. & Leonard, J. N., Dec 1 2020, In : Nature communications. 11, 1, 878.

Research output: Contribution to journalArticle

Open Access

The COMET toolkit for composing customizable genetic programs in mammalian cells

Donahue, P. S., Draut, J. W., Muldoon, J. J., Edelstein, H. I., Bagheri, N. & Leonard, J. N., Dec 1 2020, In : Nature communications. 11, 1, 779.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Development of novel metabolite-responsive transcription factors via transposon-mediated protein fusion

Younger, A. K. D., Su, P. Y., Shepard, A. J., Udani, S. V., Cybulski, T. R., Tyo, K. E. J. & Leonard, J. N., Feb 1 2018, In : Protein Engineering, Design and Selection. 31, 2, p. 55-63 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Highly Stable, Ultrasmall Polymer-Grafted Nanobins (usPGNs) with Stimuli-Responsive Capability

Hong, B. J., Iscen, A., Chipre, A. J., Li, M. M., Lee, O. S., Leonard, J. N., Schatz, G. C. & Nguyen, S. T., Mar 1 2018, In : Journal of Physical Chemistry Letters. 9, 5, p. 1133-1139 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

A Systematic Evaluation of Factors Affecting Extracellular Vesicle Uptake by Breast Cancer Cells

Stranford, D. M., Hung, M. E., Gargus, E. S., Shah, R. N. & Leonard, J. N., Nov 2017, In : Tissue Engineering - Part A. 23, 21-22, p. 1274-1282 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Delivery of Biomolecules via Extracellular Vesicles: A Budding Therapeutic Strategy

Stranford, D. M. & Leonard, J. N., Jan 1 2017, In : Advances in Genetics. 98, p. 155-175 21 p.

Research output: Contribution to journalArticle

6 Scopus citations

Engineering Modular Biosensors to Confer Metabolite-Responsive Regulation of Transcription

Younger, A. K. D., Dalvie, N. C., Rottinghaus, A. G. & Leonard, J. N., Feb 17 2017, In : ACS synthetic biology. 6, 2, p. 311-325 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Extended Concerted Rotation Technique Enhances the Sampling Efficiency of the Computational Peptide-Design Algorithm

Xiao, X., Wang, Y., Leonard, J. N. & Hall, C. K., Nov 14 2017, In : Journal of Chemical Theory and Computation. 13, 11, p. 5709-5720 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Multiplexing Engineered Receptors for Multiparametric Evaluation of Environmental Ligands

Hartfield, R. M., Schwarz, K. A., Muldoon, J. J., Bagheri, N. & Leonard, J. N., Nov 17 2017, In : ACS synthetic biology. 6, 11, p. 2042-2055 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Predicting the Dynamics and Heterogeneity of Genomic DNA Content within Bacterial Populations across Variable Growth Regimes

Du Lac, M., Scarpelli, A. H., Younger, A. K. D., Bates, D. G. & Leonard, J. N., Jul 21 2017, In : ACS synthetic biology. 6, 7, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

Rewiring human cellular input-output using modular extracellular sensors

Schwarz, K. A., Daringer, N. M., Dolberg, T. B. & Leonard, J. N., Feb 1 2017, In : Nature Chemical Biology. 13, 2, p. 202-209 8 p.

Research output: Contribution to journalArticle

54 Scopus citations
2016

Adding energy minimization strategy to peptide-design algorithm enables better search for RNA-binding peptides: Redesigned λ N peptide binds boxB RNA

Xiao, X., Hung, M. E., Leonard, J. N. & Hall, C. K., Oct 15 2016, In : Journal of computational chemistry. 37, 27, p. 2423-2435 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery

Hung, M. E. & Leonard, J. N., May 13 2016, In : Journal of Extracellular Vesicles. 5, 13 p., 31027.

Research output: Contribution to journalArticle

47 Scopus citations

Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli

Chuang, Y., Hung, M. E., Cangelose, B. K. & Leonard, J. N., Nov 1 2016, In : Innate Immunity. 22, 8, p. 647-657 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets

Liu, J. M. H., Zhang, J., Zhang, X., Hlavaty, K. A., Ricci, C. F., Leonard, J. N., Shea, L. D. & Gower, R. M., Feb 1 2016, In : Biomaterials. 80, p. 11-19 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2015

Contributions of unique intracellular domains to switchlike biosensing by Toll-like receptor 4

Daringer, N. M., Schwarz, K. A. & Leonard, J. N., Apr 3 2015, In : Journal of Biological Chemistry. 290, 14, p. 8764-8777 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Regulation of Bacterial Gene Expression by Protease-Alleviated Spatial Sequestration (PASS)

Pitner, R. A., Scarpelli, A. H. & Leonard, J. N., Sep 18 2015, In : ACS synthetic biology. 4, 9, p. 966-974 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune Networks

Wells, D. K., Chuang, Y., Knapp, L. M., Brockmann, D., Kath, W. L. & Leonard, J. N., Apr 1 2015, In : PLoS computational biology. 11, 4, e1004181.

Research output: Contribution to journalArticle

10 Scopus citations

Stabilization of exosome-targeting peptides via engineered glycosylation

Hung, M. E. & Leonard, J. N., Mar 27 2015, In : Journal of Biological Chemistry. 290, 13, p. 8166-8172 7 p.

Research output: Contribution to journalArticle

89 Scopus citations
2014

A systems biology approach to blood

Corey, S. J., Kimmel, M. & Leonard, J. N., Jan 1 2014, In : Advances in experimental medicine and biology. 844

Research output: Contribution to journalArticle

1 Scopus citations

Engineered cell-based therapies: A vanguard of design-driven medicine

Dudek, R. M., Chuang, Y. & Leonard, J. N., Jan 1 2014, In : Advances in experimental medicine and biology. 844, p. 369-391 23 p.

Research output: Contribution to journalArticle

2 Scopus citations

Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype

Boehler, R. M., Kuo, R., Shin, S., Goodman, A. G., Pilecki, M. A., Leonard, J. N. & Shea, L. D., Jun 2014, In : Biotechnology and Bioengineering. 111, 6, p. 1210-1221 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

Modular Extracellular sensor architecture for engineering mammalian cell-based devices

Daringer, N. M., Dudek, R. M., Schwarz, K. A. & Leonard, J. N., Dec 19 2014, In : ACS synthetic biology. 3, 12, p. 892-902 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Modulation of leukocyte infiltration and phenotype in microporous tissue engineering scaffolds via vector induced IL-10 expression

Gower, R. M., Boehler, R. M., Azarin, S. M., Ricci, C. F., Leonard, J. N. & Shea, L. D., Feb 1 2014, In : Biomaterials. 35, 6, p. 2024-2031 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Systems hematology: An introduction

Corey, S. J., Kimmel, M. & Leonard, J. N., Jan 1 2014, In : Advances in experimental medicine and biology. 844, p. 3-10 8 p.

Research output: Contribution to journalArticle

2011

TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection

Jelinek, I., Leonard, J. N., Price, G. E., Brown, K. N., Meyer-Manlapat, A., Goldsmith, P. K., Wang, Y., Venzon, D., Epstein, S. L. & Segal, D. M., Feb 15 2011, In : Journal of Immunology. 186, 4, p. 2422-2429 8 p.

Research output: Contribution to journalArticle

121 Scopus citations
2008

HIV Evades RNA Interference Directed at TAR by an Indirect Compensatory Mechanism

Leonard, J. N., Shah, P. S., Burnett, J. C. & Schaffer, D. V., Nov 13 2008, In : Cell Host and Microbe. 4, 5, p. 484-494 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis

Ricci, C., Pastukh, V., Leonard, J., Turrens, J., Wilson, G., Schaffer, D. & Schaffer, S. W., Feb 1 2008, In : American Journal of Physiology - Cell Physiology. 294, 2

Research output: Contribution to journalArticle

100 Scopus citations

Structural basis of toll-like receptor 3 signaling with double-stranded RNA

Liu, L., Botos, I., Wang, Y., Leonard, J. N., Shiloach, J., Segal, D. M. & Davies, D. R., Apr 18 2008, In : Science. 320, 5874, p. 379-381 3 p.

Research output: Contribution to journalArticle

482 Scopus citations

The TLR3 signaling complex forms by cooperative receptor dimerization

Leonard, J. N., Ghirlando, R., Askins, J., Bell, J. K., Margulies, D. H., Davies, D. R. & Segal, D. M., Jan 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 1, p. 258-263 6 p.

Research output: Contribution to journalArticle

155 Scopus citations
2007

Enhanced preparation of adeno-associated viral vectors by using high hydrostatic pressure to selectively inactivate helper adenovirus

Leonard, J. N., Ferstl, P., Delgado, A. & Schaffer, D. V., Aug 1 2007, In : Biotechnology and Bioengineering. 97, 5, p. 1170-1179 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

High-throughput screening of gene function in stem cells using clonal microarrays

Ashton, R. S., Peltier, J., Fasano, C. A., O'Neill, A., Leonard, J., Temple, S., Schaffer, D. V. & Kane, R. S., Nov 1 2007, In : Stem Cells. 25, 11, p. 2928-2935 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

TLR3 deficiency in patients with herpes simplex encephalitis

Zhang, S. Y., Jouanguy, E., Ugolini, S., Smahi, A., Elain, G., Romero, P., Segal, D., Sancho-Shimizu, V., Lorenzo, L., Puel, A., Picard, C., Chapgier, A., Plancoulaine, S., Titeux, M., Cognet, C., Von Bernuth, H., Ku, C. L., Casrouge, A., Zhang, X. X., Barreiro, L. & 13 others, Leonard, J., Hamilton, C., Lebon, P., Héron, B., Vallée, L., Quintana-Murci, L., Hovnanian, A., Rozenberg, F., Vivier, E., Geissmann, F., Tardieu, M., Abel, L. & Casanova, J. L., Sep 14 2007, In : Science. 317, 5844, p. 1522-1527 6 p.

Research output: Contribution to journalArticle

715 Scopus citations
2005

Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape

Leonard, J. N. & Schaffer, D. V., Feb 1 2005, In : Journal of virology. 79, 3, p. 1645-1654 10 p.

Research output: Contribution to journalArticle

53 Scopus citations