Grants per year
Personal profile
Research Interests
The Hultquist lab specializes in the development and adaptation of high-throughput, quantitative, systems-based approaches for use in primary models of disease to better understand the host-pathogen relationship. Leveraging diverse expertise in primary cell models, proteomic profiling, and functional genomics, we work at the intersection of systems biology and infectious disease, defining host-pathogen interactions and their consequences for replication and pathogenesis. Through these efforts, we ultimately hope to strengthen the bridge from big data to targeted discovery to clinical application for the development of personalized, host-driven therapies and the advancement of human health.
Training Experience
2018 | Postdoctoral Fellowship, J. David Gladstone Institutes |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular Biology, PhD, University of Minnesota
… → 2013
Research interests keywords
- Big Data
- Genetic Engineering
- HIV Infection
- Infectious Diseases
- Infectious Diseases: Viral
- Molecular Biology
- Proteomics
- Systems Biology
- Virology
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Collaborations and top research areas from the last five years
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Viral and Host Dynamics during Pediatric COVID-19 and Respiratory Virus Co-Infection
Hultquist, J. F. (PD/PI), Evans, C. T. (Co-Investigator), Lorenzo Redondo, R. (Co-Investigator) & Ozer, E. A. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
7/22/24 → 5/31/29
Project: Research project
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Viral and host determinants of donor-specific anti-HIV/SIV immunity mediated by APOBEC3-enzyme
Hultquist, J. F. (PD/PI)
Texas Biomedical Research Institute, National Institute of Allergy and Infectious Diseases
6/21/24 → 4/30/29
Project: Research project
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A Functional Genomics Platform for the de novo Identification of Disease-relevant Alleles
Hultquist, J. F. (PD/PI)
National Center for Advancing Translational Sciences
3/15/24 → 3/31/26
Project: Research project
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Subproject Hultquist Advances in Multiplexed Diagnostic Platforms for Rapid Quantitative Detection of HIV, HBV, and HCV
Hultquist, J. F. (PD/PI), Dravid, V. P. (Co-Investigator) & Shekhawat, G. S. (Co-Investigator)
National Institute of Biomedical Imaging and Bioengineering
9/15/23 → 7/31/28
Project: Research project
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Exploring Small Molecule Inhibitors of PAF1C as No
Hultquist, J. F. (PD/PI)
National Institute of Allergy and Infectious Diseases
8/10/23 → 7/31/25
Project: Research project
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Evolution of the umbilical cord blood proteome across gestational development
Mithal, L. B., Lancki, N., Ling-Hu, T., Goo, Y. A., Otero, S., Rhodes, N. J., Cho, B. K., Grobman, W. A., Hultquist, J. F., Scholtens, D., Mestan, K. K. L. & Seed, P. C., Dec 2025, In: Scientific reports. 15, 1, 2233.Research output: Contribution to journal › Article › peer-review
Open Access -
Nanomechanical systems for the rapid detection of HIV-1 p24 antigen
Samuel, A. G., Cornish, D., Simons, L. M., Agarwal, D., Shekhawat, G. S., Hultquist, J. F. & Dravid, V. P., Jul 15 2025, In: Biosensors and Bioelectronics. 280, 117395.Research output: Contribution to journal › Article › peer-review
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Ribosome customization and functional diversification among P-stalk proteins regulate late poxvirus protein synthesis
Khalatyan, N., Cornish, D., Ferrell, A. J., Savas, J. N., Shen, P. S., Hultquist, J. F. & Walsh, D., Jan 28 2025, In: Cell reports. 44, 1, 115119.Research output: Contribution to journal › Article › peer-review
Open Access -
The impact of remdesivir on SARS-CoV-2 evolution in vivo
Ling-Hu, T., Simons, L. M., Rios-Guzman, E., Carvalho, A. M., Agnes, M. F. R., Alisoltanidehkordi, A., Ozer, E. A., Lorenzo-Redondo, R. & Hultquist, J. F., Feb 24 2025, In: JCI Insight. 10, 4, e182376.Research output: Contribution to journal › Article › peer-review
Open Access -
Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays
Inniss, N. L., Rzhetskaya, M., Ling-Hu, T., Lorenzo-Redondo, R., Bachta, K. E., Satchell, K. J. F. & Hultquist, J. F., Apr 2024, In: SLAS Discovery. 29, 3, 100145.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Crystal structure of Ebola virus VP30 C-terminus/RBBP6 peptide complex
Batra, J. (Contributor), Hultquist, J. F. (Contributor), Liu, D. (Contributor), Shtanko, O. (Contributor), Von Dollen, J. (Contributor), Satkamp, L. (Contributor), Jang, G. M. (Contributor), Luthra, P. (Contributor), Schwarz, T. M. (Contributor), Small, G. I. (Contributor), Arnett, E. (Contributor), Anantpadma, M. (Contributor), Reyes, A. (Contributor), Leung, D. W. (Contributor), Kaake, R. (Contributor), Haas, P. (Contributor), Schmidt, C. B. (Contributor), Schlesinger, L. S. (Contributor), LaCount, D. J. (Contributor), Davey, R. A. (Contributor), Amarasinghe, G. K. (Contributor), Basler, C. F. (Contributor) & Krogan, N. J. (Contributor), Protein Data Bank (PDB), Dec 12 2018
DOI: 10.2210/pdb6E5X/pdb, https://www.wwpdb.org/pdb?id=pdb_00006e5x
Dataset
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Virtual screening for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors
Fink, E. A. (Contributor), Bardine, C. (Contributor), Gahbauer, S. (Contributor), Singh, I. (Contributor), Detomasi, T. C. (Contributor), White, K. (Contributor), Gu, S. (Contributor), Wan, X. (Contributor), Chen, J. (Contributor), Ary, B. (Contributor), Glenn, I. (Contributor), O'Connell, J. (Contributor), O'Donnell, H. (Contributor), Fajtová, P. (Contributor), Lyu, J. (Contributor), Vigneron, S. (Contributor), Young, N. J. (Contributor), Kondratov, I. S. (Contributor), Alisoltani, A. (Contributor), Simons, L. M. (Contributor), Lorenzo-Redondo, R. (Contributor), Ozer, E. A. (Contributor), Hultquist, J. F. (Contributor), O'Donoghue, A. J. (Contributor), Moroz, Y. S. (Contributor), Taunton, J. (Contributor), Renslo, A. R. (Contributor), Irwin, J. J. (Contributor), García-Sastre, A. (Contributor), Shoichet, B. K. (Contributor) & Craik, C. S. (Contributor), Protein Data Bank (PDB), Jun 28 2023
DOI: 10.2210/pdb8DIE/pdb, https://www.wwpdb.org/pdb?id=pdb_00008die
Dataset
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N74D mutant of the HIV-1 capsid protein
Selyutina, A. (Contributor), Simons, L. M. (Contributor), Kirby, K. A. (Contributor), Bulnes-Ramos, A. (Contributor), Hu, P. (Contributor), Sarafianos, S. G. (Contributor), Hultquist, J. F. (Contributor) & Diaz-Griffero, F. (Contributor), Protein Data Bank (PDB), May 4 2022
DOI: 10.2210/pdb7MN0/pdb, https://www.wwpdb.org/pdb?id=pdb_00007mn0
Dataset
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Virtual screening for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors
Fink, E. A. (Contributor), Bardine, C. (Contributor), Gahbauer, S. (Contributor), Singh, I. (Contributor), Detomasi, T. C. (Contributor), White, K. (Contributor), Gu, S. (Contributor), Wan, X. (Contributor), Chen, J. (Contributor), Ary, B. (Contributor), Glenn, I. (Contributor), O'Connell, J. (Contributor), O'Donnell, H. (Contributor), Fajtová, P. (Contributor), Lyu, J. (Contributor), Vigneron, S. (Contributor), Young, N. J. (Contributor), Kondratov, I. S. (Contributor), Alisoltani, A. (Contributor), Simons, L. M. (Contributor), Lorenzo-Redondo, R. (Contributor), Ozer, E. A. (Contributor), Hultquist, J. F. (Contributor), O'Donoghue, A. J. (Contributor), Moroz, Y. S. (Contributor), Taunton, J. (Contributor), Renslo, A. R. (Contributor), Irwin, J. J. (Contributor), García-Sastre, A. (Contributor), Shoichet, B. K. (Contributor) & Craik, C. S. (Contributor), Protein Data Bank (PDB), Jun 28 2023
DOI: 10.2210/pdb8DIF/pdb, https://www.wwpdb.org/pdb?id=pdb_00008dif
Dataset
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Virtual screening for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors
Fink, E. A. (Contributor), Bardine, C. (Contributor), Gahbauer, S. (Contributor), Singh, I. (Contributor), Detomasi, T. C. (Contributor), White, K. (Contributor), Gu, S. (Contributor), Wan, X. (Contributor), Chen, J. (Contributor), Ary, B. (Contributor), Glenn, I. (Contributor), O'Connell, J. (Contributor), O'Donnell, H. (Contributor), Fajtová, P. (Contributor), Lyu, J. (Contributor), Vigneron, S. (Contributor), Young, N. J. (Contributor), Kondratov, I. S. (Contributor), Alisoltani, A. (Contributor), Simons, L. M. (Contributor), Lorenzo-Redondo, R. (Contributor), Ozer, E. A. (Contributor), Hultquist, J. F. (Contributor), O'Donoghue, A. J. (Contributor), Moroz, Y. S. (Contributor), Taunton, J. (Contributor), Renslo, A. R. (Contributor), Irwin, J. J. (Contributor), García-Sastre, A. (Contributor), Shoichet, B. K. (Contributor) & Craik, C. S. (Contributor), Protein Data Bank (PDB), Jun 28 2023
DOI: 10.2210/pdb8DIH/pdb, https://www.wwpdb.org/pdb?id=pdb_00008dih
Dataset