• 1519 Citations
20082020

Research output per year

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Personal profile

Research Interests

The Hultquist lab specializes in the development and adaptation of high-throughput, quantitative, systems-based approaches for use in primary models of disease to better understand the host-pathogen relationship. Leveraging diverse expertise in primary cell models, proteomic profiling, and functional genomics, we work at the intersection of systems biology and infectious disease, defining host-pathogen interactions and their consequences for replication and pathogenesis. Through these efforts, we ultimately hope to strengthen the bridge from big data to targeted discovery to clinical application for the development of personalized, host-driven therapies and the advancement of human health.

Training Experience

2018Postdoctoral Fellowship, J. David Gladstone Institutes

Education/Academic qualification

PhD, University of Minnesota

… → 2013

Research interests

  • Big Data
  • Genetic Engineering
  • HIV Infection
  • Infectious Diseases
  • Infectious Diseases: Viral
  • Molecular Biology
  • Proteomics
  • Systems Biology
  • Virology

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Grants

  • Research Output

    • 1519 Citations
    • 26 Article
    • 2 Comment/debate
    • 2 Review article
    • 1 Short survey

    A systems approach to infectious disease

    Eckhardt, M., Hultquist, J. F., Kaake, R. M., Hüttenhain, R. & Krogan, N. J., Jun 1 2020, In : Nature Reviews Genetics. 21, 6, p. 339-354 16 p.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core

    Selyutina, A., Persaud, M., Simons, L. M., Bulnes-Ramos, A., Buffone, C., Martinez-Lopez, A., Scoca, V., Di Nunzio, F., Hiatt, J., Marson, A., Krogan, N. J., Hultquist, J. F. & Diaz-Griffero, F., Mar 17 2020, In : Cell reports. 30, 11, p. 3766-3777.e6

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection

    Hüttenhain, R., Xu, J., Burton, L. A., Gordon, D. E., Hultquist, J. F., Johnson, J. R., Satkamp, L., Hiatt, J., Rhee, D. Y., Baek, K., Crosby, D. C., Frankel, A. D., Marson, A., Harper, J. W., Alpi, A. F., Schulman, B. A., Gross, J. D. & Krogan, N. J., Jul 10 2019, In : Cell Host and Microbe. 26, 1, p. 86-99.e7

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    CRISPR–Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV–host factor interactions

    Hultquist, J. F., Hiatt, J., Schumann, K., McGregor, M. J., Roth, T. L., Haas, P., Doudna, J. A., Marson, A. & Krogan, N. J., Jan 1 2019, In : Nature Protocols. 14, 1

    Research output: Contribution to journalArticle

  • 12 Scopus citations

    Large dataset enables prediction of repair after CRISPR–Cas9 editing in primary T cells

    Leenay, R. T., Aghazadeh, A., Hiatt, J., Tse, D., Roth, T. L., Apathy, R., Shifrut, E., Hultquist, J. F., Krogan, N., Wu, Z., Cirolia, G., Canaj, H., Leonetti, M. D., Marson, A., May, A. P. & Zou, J., Sep 1 2019, In : Nature biotechnology. 37, 9, p. 1034-1037 4 p.

    Research output: Contribution to journalArticle

  • 8 Scopus citations