Grants per year
Personal profile
Research Interests
The Hultquist lab specializes in the development and adaptation of high-throughput, quantitative, systems-based approaches for use in primary models of disease to better understand the host-pathogen relationship. Leveraging diverse expertise in primary cell models, proteomic profiling, and functional genomics, we work at the intersection of systems biology and infectious disease, defining host-pathogen interactions and their consequences for replication and pathogenesis. Through these efforts, we ultimately hope to strengthen the bridge from big data to targeted discovery to clinical application for the development of personalized, host-driven therapies and the advancement of human health.
Training Experience
2018 | Postdoctoral Fellowship, J. David Gladstone Institutes |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular Biology, PhD, University of Minnesota
… → 2013
Research interests keywords
- Big Data
- Genetic Engineering
- HIV Infection
- Infectious Diseases
- Infectious Diseases: Viral
- Molecular Biology
- Proteomics
- Systems Biology
- Virology
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Collaborations and top research areas from the last five years
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Viral and Host Dynamics during Pediatric COVID-19 and Respiratory Virus Co-Infection
Hultquist, J. F. (PD/PI), Evans, C. T. (Co-Investigator), Lorenzo Redondo, R. (Co-Investigator) & Ozer, E. A. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
7/22/24 → 5/31/29
Project: Research project
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A Functional Genomics Platform for the de novo Identification of Disease-relevant Alleles
Hultquist, J. F. (PD/PI)
National Center for Advancing Translational Sciences
3/15/24 → 3/31/26
Project: Research project
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Exploring Small Molecule Inhibitors of PAF1C as No
Hultquist, J. F. (PD/PI)
National Institute of Allergy and Infectious Diseases
8/10/23 → 7/31/25
Project: Research project
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Donor-specific anti-HIV/SIV immunity mediated by APOBEC3 enzymes
Hultquist, J. F. (PD/PI) & Hultquist, J. F. (PD/PI)
Texas Biomedical Research Institute, National Institute of Allergy and Infectious Diseases
4/1/23 → 3/31/25
Project: Research project
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Turning off HIV White Noise: Switching from Long-Lived to Short-Lived Reservoir
Martinelli, E. (PD/PI), Martinelli, E. (PD/PI), Goyal, Y. (Co-Investigator), Goyal, Y. (Co-Investigator), Hultquist, J. F. (Co-Investigator), Hultquist, J. F. (Co-Investigator), Lorenzo Redondo, R. (Co-Investigator), Lorenzo Redondo, R. (Co-Investigator), Shukla, V. (Co-Investigator) & Shukla, V. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
3/22/23 → 2/29/28
Project: Research project
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Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays
Inniss, N. L., Rzhetskaya, M., Ling-Hu, T., Lorenzo-Redondo, R., Bachta, K. E., Satchell, K. J. F. & Hultquist, J. F., Apr 2024, In: SLAS Discovery. 29, 3, 100145.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
COVID-19 outbreak and genomic investigation in an inpatient behavioral health unit
Rios-Guzman, E., Stancovici, A. G., Simons, L. M., Barajas, G., Glenn, K., Weber, R. T., Ozer, E. A., Lorenzo-Redondo, R., Hultquist, J. F. & Bolon, M. K., Apr 29 2024, In: Antimicrobial Stewardship and Healthcare Epidemiology. 4, 1, e62.Research output: Contribution to journal › Article › peer-review
Open Access -
CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells
Rathore, U., Haas, P., Kumar, V. E., Hiatt, J., Haas, K. M., Bouhaddou, M., Swaney, D. L., Stevenson, E., Zuliani-Alvarez, L., McGregor, M. J., Turner-Groth, A., Olwal, C. O., Bediako, Y., Braberg, H., Soucheray, M., Ott, M., Eckhardt, M., Hultquist, J. F., Marson, A. & Kaake, R. M. & 1 others, , Apr 2024, In: mBio. 15, 4Research output: Contribution to journal › Article › peer-review
Open Access -
Deviations in RSV epidemiological patterns and population structures in the United States following the COVID-19 pandemic
Rios-Guzman, E., Simons, L. M., Dean, T. J., Agnes, F., Pawlowski, A., Alisoltanidehkordi, A., Nam, H. H., Ison, M. G., Ozer, E. A., Lorenzo-Redondo, R. & Hultquist, J. F., Dec 2024, In: Nature communications. 15, 1, 3374.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
The NU SCRIPT Study Investigators, 2024, (Accepted/In press) In: Nature Immunology.Research output: Contribution to journal › Article › peer-review
Datasets
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Crystal structure of Ebola virus VP30 C-terminus/RBBP6 peptide complex
Batra, J. (Contributor), Hultquist, J. F. (Contributor), Liu, D. (Contributor), Shtanko, O. (Contributor), Von Dollen, J. (Contributor), Satkamp, L. (Contributor), Jang, G. M. (Contributor), Luthra, P. (Contributor), Schwarz, T. M. (Contributor), Small, G. I. (Contributor), Arnett, E. (Contributor), Anantpadma, M. (Contributor), Reyes, A. (Contributor), Leung, D. W. (Contributor), Kaake, R. (Contributor), Haas, P. (Contributor), Schmidt, C. B. (Contributor), Schlesinger, L. S. (Contributor), LaCount, D. J. (Contributor), Davey, R. A. (Contributor), Amarasinghe, G. K. (Contributor), Basler, C. F. (Contributor) & Krogan, N. J. (Contributor), Protein Data Bank (PDB), Dec 12 2018
DOI: 10.2210/pdb6E5X/pdb, https://www.wwpdb.org/pdb?id=pdb_00006e5x
Dataset
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Virtual screening for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors
Fink, E. A. (Contributor), Bardine, C. (Contributor), Gahbauer, S. (Contributor), Singh, I. (Contributor), Detomasi, T. C. (Contributor), White, K. (Contributor), Gu, S. (Contributor), Wan, X. (Contributor), Chen, J. (Contributor), Ary, B. (Contributor), Glenn, I. (Contributor), O'Connell, J. (Contributor), O'Donnell, H. (Contributor), Fajtová, P. (Contributor), Lyu, J. (Contributor), Vigneron, S. (Contributor), Young, N. J. (Contributor), Kondratov, I. S. (Contributor), Alisoltani, A. (Contributor), Simons, L. M. (Contributor), Lorenzo-Redondo, R. (Contributor), Ozer, E. A. (Contributor), Hultquist, J. F. (Contributor), O'Donoghue, A. J. (Contributor), Moroz, Y. S. (Contributor), Taunton, J. (Contributor), Renslo, A. R. (Contributor), Irwin, J. J. (Contributor), García-Sastre, A. (Contributor), Shoichet, B. K. (Contributor) & Craik, C. S. (Contributor), Protein Data Bank (PDB), Jun 28 2023
DOI: 10.2210/pdb8DIF/pdb, https://www.wwpdb.org/pdb?id=pdb_00008dif
Dataset
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Virtual screening for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors
Fink, E. A. (Contributor), Bardine, C. (Contributor), Gahbauer, S. (Contributor), Singh, I. (Contributor), Detomasi, T. C. (Contributor), White, K. (Contributor), Gu, S. (Contributor), Wan, X. (Contributor), Chen, J. (Contributor), Ary, B. (Contributor), Glenn, I. (Contributor), O'Connell, J. (Contributor), O'Donnell, H. (Contributor), Fajtová, P. (Contributor), Lyu, J. (Contributor), Vigneron, S. (Contributor), Young, N. J. (Contributor), Kondratov, I. S. (Contributor), Alisoltani, A. (Contributor), Simons, L. M. (Contributor), Lorenzo-Redondo, R. (Contributor), Ozer, E. A. (Contributor), Hultquist, J. F. (Contributor), O'Donoghue, A. J. (Contributor), Moroz, Y. S. (Contributor), Taunton, J. (Contributor), Renslo, A. R. (Contributor), Irwin, J. J. (Contributor), García-Sastre, A. (Contributor), Shoichet, B. K. (Contributor) & Craik, C. S. (Contributor), Protein Data Bank (PDB), Jun 28 2023
DOI: 10.2210/pdb8DIC/pdb, https://www.wwpdb.org/pdb?id=pdb_00008dic
Dataset
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Virtual screening for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors
Fink, E. A. (Contributor), Bardine, C. (Contributor), Gahbauer, S. (Contributor), Singh, I. (Contributor), Detomasi, T. C. (Contributor), White, K. (Contributor), Gu, S. (Contributor), Wan, X. (Contributor), Chen, J. (Contributor), Ary, B. (Contributor), Glenn, I. (Contributor), O'Connell, J. (Contributor), O'Donnell, H. (Contributor), Fajtová, P. (Contributor), Lyu, J. (Contributor), Vigneron, S. (Contributor), Young, N. J. (Contributor), Kondratov, I. S. (Contributor), Alisoltani, A. (Contributor), Simons, L. M. (Contributor), Lorenzo-Redondo, R. (Contributor), Ozer, E. A. (Contributor), Hultquist, J. F. (Contributor), O'Donoghue, A. J. (Contributor), Moroz, Y. S. (Contributor), Taunton, J. (Contributor), Renslo, A. R. (Contributor), Irwin, J. J. (Contributor), García-Sastre, A. (Contributor), Shoichet, B. K. (Contributor) & Craik, C. S. (Contributor), Protein Data Bank (PDB), Jun 28 2023
DOI: 10.2210/pdb8DIB/pdb, https://www.wwpdb.org/pdb?id=pdb_00008dib
Dataset
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Virtual screening for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors
Fink, E. A. (Contributor), Bardine, C. (Contributor), Gahbauer, S. (Contributor), Singh, I. (Contributor), Detomasi, T. C. (Contributor), White, K. (Contributor), Gu, S. (Contributor), Wan, X. (Contributor), Chen, J. (Contributor), Ary, B. (Contributor), Glenn, I. (Contributor), O'Connell, J. (Contributor), O'Donnell, H. (Contributor), Fajtová, P. (Contributor), Lyu, J. (Contributor), Vigneron, S. (Contributor), Young, N. J. (Contributor), Kondratov, I. S. (Contributor), Alisoltani, A. (Contributor), Simons, L. M. (Contributor), Lorenzo-Redondo, R. (Contributor), Ozer, E. A. (Contributor), Hultquist, J. F. (Contributor), O'Donoghue, A. J. (Contributor), Moroz, Y. S. (Contributor), Taunton, J. (Contributor), Renslo, A. R. (Contributor), Irwin, J. J. (Contributor), García-Sastre, A. (Contributor), Shoichet, B. K. (Contributor) & Craik, C. S. (Contributor), Protein Data Bank (PDB), Jul 5 2023
DOI: 10.2210/pdb8DID/pdb, https://www.wwpdb.org/pdb?id=pdb_00008did
Dataset