Justyna A Dobrowolska Zakaria

  • Source: Scopus
20062021

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Research Interests

Cerebral accumulation of amyloid-beta (Aß) peptides has a critical early role in Alzheimer’s disease (AD) pathogenesis. Cleavage of Amyloid Precursor Protein (APP) by ß-secretase (also called BACE1) produces the sAPPß fragment and this event must occur before Aß may be subsequently released from the APP C-terminal fragment. Although BACE1 levels are increased in AD brain, it is unclear whether BACE1 elevation leads to increased APP cleavage and Aß production in the human CNS. Our preliminary results suggest that newly generated sAPPß is increased in the CSF of amyloid-positive AD subjects. Using methods to measure sAPPß and sAPPa kinetic rates, we propose to determine if and by how much BACE1 activity is increased in late-onset AD (LOAD) subjects and in what subgroups of LOAD the shift toward increased BACE1 processing of APP occurs. We hypothesize that a subgroup of the LOAD and non-demented Amyloid+ populations overproduce Aß because of increased BACE1 activity. We anticipate that kinetic rates of sAPPß and sAPPa as biomarkers of BACE1 activity, together with kinetic rates of Aß isoforms, will allow differentiation of AD subgroups based on different pathogenic mechanisms.

Training Experience

2014Postdoctoral Fellowship, Washington University in St. Louis
2015Postdoctoral Fellowship, Nationwide Children's Hospital
2018Postdoctoral Fellowship, Northwestern University

Expertise related to UN Sustainable Devlopment Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Neuroscience, PhD, Washington University

… → 2013

Research interests

  • Alzheimer's Disease
  • Alzheimer's Drug
  • Cell Biology
  • Dementia
  • Molecular Biology
  • Neurobiology
  • Neuroscience
  • Proteomics

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