Karen K L Mestan

  • 1139 Citations
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Personal profile

Research Interests

Why do some premature infants experience adverse outcomes, while others do not? Dr. Mestan is an attending neonatologist at Lurie Children's Hospital and Northwestern University Feinberg School of Medicine, whose research focuses on identifying biochemical, environmental, and genetic markers for preterm birth and its complications. Understanding these markers and the scientific mechanisms behind them can lead to new approaches and therapies to prevent complications of preterm birth, such as chronic lung and heart problems, poor growth, and neurodevelopmental delays in early childhood.

Translational research in identifying biomarkers and mechanisms by which placental vascular dysfunction leads to neonatal lung disease and its long-term health sequelae.

Management and prevention of neonatal chronic lung diseases, such as bronchopulmonary dysplasia and neonatal pulmonary hypertension. Clinical care coordination for medically complex infants.

Certifications and Licenses

Neonatal-Perinatal Medicine

Training Experience

1999Residency, University of Chicago
2002Fellowship, University of Chicago

Education/Academic qualification

MD, Chicago Medical School

… → 1996

Research interests

  • Clinical Research
  • Developmental-Behavioral Pediatrics
  • Genomics
  • Lungs / Breathing Problems
  • Maternal-Child Health
  • Neonatology
  • Pediatrics
  • Stem Cells

Fingerprint Dive into the research topics where Karen K L Mestan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Fetal Blood Medicine & Life Sciences
Bronchopulmonary Dysplasia Medicine & Life Sciences
Premature Infants Medicine & Life Sciences
Gestational Age Medicine & Life Sciences
Mothers Medicine & Life Sciences
Pulmonary Hypertension Medicine & Life Sciences
Biomarkers Medicine & Life Sciences
Premature Birth Medicine & Life Sciences

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Grants 2011 2023

Pulmonary Hypertension
Blood Vessels
Bronchopulmonary Dysplasia
Fetal Blood
Bronchopulmonary Dysplasia
Alveolar Macrophages
Newborn Infant
Metabolic Bone Diseases
Bone Diseases

Research Output 2003 2018

1 Citation (Scopus)

An update on the diagnosis and management of bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension

Berkelhamer, S. K., Mestan, K. K. L. & Steinhorn, R., Nov 1 2018, In : Seminars in Perinatology. 42, 7, p. 432-443 12 p.

Research output: Contribution to journalReview article

Bronchopulmonary Dysplasia
Pulmonary Hypertension

Fetal cord blood and tissue immune responses to chronic placental inflammation and chorioamnionitis

Singh, A. M., Sherenian, M. G., Kim, K-Y. A., Erickson, K. A., Yang, A., Mestan, K. K. L., Ernst, L. M. & Kumar, R., Nov 19 2018, In : Allergy, Asthma and Clinical Immunology. 14, 1, 66.

Research output: Contribution to journalArticle

Fetal Blood
Live Birth
1 Citation (Scopus)

Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy

Liu, X., Hong, X., Tsai, H. J., Mestan, K. K., Shi, M., Kefi, A., Hao, K., Chen, Q., Wang, G., Caruso, D., Geng, H., Gao, Y., He, J., Kumar, R., Wang, H., Yu, Y., Bartell, T., Tan, X. D., Schleimer, R. P., Weeks, D. E. & 2 othersPongracic, J. A. & Wang, X., Mar 1 2018, In : Medicine (United States). 97, 9, e0043.

Research output: Contribution to journalArticle

Food Hypersensitivity
Genome-Wide Association Study
Egg Hypersensitivity

Umbilical Cord Blood Metabolomics Reveal Distict Signatures of Dyslipidemia Prior to Bronchopulmonary Dysplasia and Pulmonary Hypertension

La, F. M., Fahrmann, J., Grapov, D., Pedersen, T., Newman, JW., Fiehn, O., Underwood, MA., Mestan, KK., Steinhorn, R. & Wedgewood, S., Oct 2018, In : Am J Physiol Lung Cellular and Molecular Physiology (in press).

Research output: Contribution to journalArticle