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Karen K L Mestan

  • 1305 Citations
20032020

Research output per year

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Personal profile

Research Interests

Why do some premature infants experience adverse outcomes, while others do not? Dr. Mestan is an attending neonatologist at Lurie Children's Hospital and Northwestern University Feinberg School of Medicine, whose research focuses on identifying biochemical, environmental, and genetic markers for preterm birth and its complications. Understanding these markers and the scientific mechanisms behind them can lead to new approaches and therapies to prevent complications of preterm birth, such as chronic lung and heart problems, poor growth, and neurodevelopmental delays in early childhood.

Translational research in identifying biomarkers and mechanisms by which placental vascular dysfunction leads to neonatal lung disease and its long-term health sequelae.

Management and prevention of neonatal chronic lung diseases, such as bronchopulmonary dysplasia and neonatal pulmonary hypertension. Clinical care coordination for medically complex infants.

Certifications and Licenses

Neonatal-Perinatal Medicine

Training Experience

1999Residency, University of Chicago
2002Fellowship, University of Chicago

Education/Academic qualification

MD, Chicago Medical School

… → 1996

Research interests

  • Clinical Research
  • Developmental-Behavioral Pediatrics
  • Genomics
  • Lungs / Breathing Problems
  • Maternal-Child Health
  • Neonatology
  • Pediatrics
  • Stem Cells

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Grants

The Role of Placental Maternal Vascular Underperfusion in Neonatal Pulmonary Hypertension

Grobman, W. A., Mestan, K. K. L., Misharin, A. & Swaminathan, S.

Ann & Robert H. Lurie Children's Hospital of Chicago, National Heart, Lung, and Blood Institute

6/1/19 → 1/31/23

Project: Research project

    • The Role of Placental Maternal Vascular Underperfusion in Neonatal Pulmonary Hypertension

    Mestan, K. K. L.

    Northwestern University, National Institutes of Health

    2/15/18 → 1/31/23

    Project: Research project

    The Role of Placental Maternal Vascular Underperfusion in Neonatal Pulmonary Hypertension

    Mestan, K. K. L.

    Northwestern University, National Institutes of Health

    2/15/18 → 1/31/23

    Project: Research project

    The Role of Placental Maternal Vascular Underperfusion in Neonatal Pulmonary Hypertension

    Farrow, K. N., Grobman, W. A., Mestan, K. K. L., Misharin, A. & Swaminathan, S.

    National Heart, Lung, and Blood Institute

    2/15/18 → 6/1/19

    Project: Research project

    • Evaluation of Stem and Progenitor Cells from Umbilical Cord Blood and Tissues for Therapeutic Use in Premature Infants

    Chaudhury, S. & Mestan, K. K. L.

    ViaCord, LLC

    6/29/16 → 6/1/20

    Project: Research project

    Research Output

    The impact of placental pathology discordance in multiple gestation pregnancies on bronchopulmonary dysplasia-associated pulmonary hypertension

    Franklin, A., Yallapragada, S. G., Birkett, R., Grobman, W., Ernst, L. M. & Mestan, K., Jan 1 2020, In : Pulmonary Circulation. 10, 1

    Research output: Contribution to journal › Article

    Open Access

    • Cord blood alpha klotho is decreased in small for gestational age preterm infants with placental lesions of accelerated aging

    Franklin, A. D., Saqibuddin, J., Stephens, K., Birkett, R., Marsden, L., Ernst, L. M. & Mestan, K. K., Nov 2019, In : Placenta. 87, p. 1-7 7 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Racial differences in placental pathology among very preterm births

    Matoba, N., Yallapragada, S., Davis, M. M., Ernst, L. M., Collins, J. W. & Mestan, K. K., Aug 2019, In : Placenta. 83, p. 37-42 6 p.

    Research output: Contribution to journal › Article

    • Variations in Umbilical Cord Hematopoietic and Mesenchymal Stem Cells With Bronchopulmonary Dysplasia

    Chaudhury, S., Saqibuddin, J., Birkett, R., Falcon-Girard, K., Kraus, M., Ernst, L. M., Grobman, W. & Mestan, K. K., Nov 14 2019, In : Frontiers in Pediatrics. 7, 475.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    An update on the diagnoses and management of bronchopulmonary dyplasia (BPD)- associated pulmonary hypertension

    Berkelhamer, SK., Mestan, KK. & Steinhorn, R., Oct 2018, In : Seminars in Perinatology (in press).

    Research output: Contribution to journal › Article