Grants per year
Personal profile
Research Interests
Why do some premature infants experience adverse outcomes, while others do not? Dr. Mestan is an attending neonatologist at Lurie Children's Hospital and Northwestern University Feinberg School of Medicine, whose research focuses on identifying biochemical, environmental, and genetic markers for preterm birth and its complications. Understanding these markers and the scientific mechanisms behind them can lead to new approaches and therapies to prevent complications of preterm birth, such as chronic lung and heart problems, poor growth, and neurodevelopmental delays in early childhood.
Translational research in identifying biomarkers and mechanisms by which placental vascular dysfunction leads to neonatal lung disease and its long-term health sequelae.
Management and prevention of neonatal chronic lung diseases, such as bronchopulmonary dysplasia and neonatal pulmonary hypertension. Clinical care coordination for medically complex infants.
Certifications and Licenses
| Neonatal-Perinatal Medicine |
Training Experience
| 1999 | Residency, University of Chicago |
| 2002 | Fellowship, University of Chicago |
Education/Academic qualification
MD, Chicago Medical School
… → 1996
Research interests
- Clinical Research
- Developmental-Behavioral Pediatrics
- Genomics
- Lungs / Breathing Problems
- Maternal-Child Health
- Neonatology
- Pediatrics
- Stem Cells
Fingerprint Dive into the research topics where Karen K L Mestan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 20 Similar Profiles
Fetal Blood
Medicine & Life Sciences
Bronchopulmonary Dysplasia
Medicine & Life Sciences
Premature Infants
Medicine & Life Sciences
Gestational Age
Medicine & Life Sciences
Mothers
Medicine & Life Sciences
Pulmonary Hypertension
Medicine & Life Sciences
Biomarkers
Medicine & Life Sciences
Premature Birth
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2011 2023
The Role of Placental Maternal Vascular Underperfusion in Neonatal Pulmonary Hypertension
Farrow, K. N., Grobman, W. A., Mestan, K. K. L., Misharin, A. & Swaminathan, S.
National Heart, Lung, and Blood Institute
2/15/18 → 1/31/23
Project: Research project
Pulmonary Hypertension
Blood Vessels
Bronchopulmonary Dysplasia
Mothers
Fetal Blood
Developing a Humanized Mouse Model of Bronchopulmonary Dysplasia
Ann & Robert H. Lurie Children's Hospital of Chicago
4/1/16 → 9/30/17
Project: Research project
Bronchopulmonary Dysplasia
Monocytes
Alveolar Macrophages
Hyperoxia
Lung
Role of Iron in Fibroblast Growth Factor-23 Regulation in Neonates
Northwestern University, Northwestern Memorial Hospital
9/1/15 → 8/31/17
Project: Research project
Role of Iron in Fibroblast Growth Factor-23 Regulation in Neonates
Northwestern Memorial Hospital
9/1/15 → 8/31/17
Project: Research project
Iron
Newborn Infant
Rickets
Metabolic Bone Diseases
Bone Diseases
Cord Blood Biomarkers and 16S rRNA PCR for Early Diagnosis of Sepsis in Premature Infants
7/1/14 → 6/30/16
Project: Research project
Research Output 2003 2018
An update on the diagnoses and management of bronchopulmonary dyplasia (BPD)- associated pulmonary hypertension
Berkelhamer, SK., Mestan, KK. & Steinhorn, R., Oct 2018, In : Seminars in Perinatology (in press).Research output: Contribution to journal › Article
1
Citation
(Scopus)
An update on the diagnosis and management of bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension
Berkelhamer, S. K., Mestan, K. K. L. & Steinhorn, R., Nov 1 2018, In : Seminars in Perinatology. 42, 7, p. 432-443 12 p.Research output: Contribution to journal › Review article
Bronchopulmonary Dysplasia
Pulmonary Hypertension
Lung
Guidelines
Morbidity
Fetal cord blood and tissue immune responses to chronic placental inflammation and chorioamnionitis
Singh, A. M., Sherenian, M. G., Kim, K-Y. A., Erickson, K. A., Yang, A., Mestan, K. K. L., Ernst, L. M. & Kumar, R., Nov 19 2018, In : Allergy, Asthma and Clinical Immunology. 14, 1, 66.Research output: Contribution to journal › Article
Chorioamnionitis
Fetal Blood
Fetus
Inflammation
Live Birth
1
Citation
(Scopus)
Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy
Liu, X., Hong, X., Tsai, H. J., Mestan, K. K., Shi, M., Kefi, A., Hao, K., Chen, Q., Wang, G., Caruso, D., Geng, H., Gao, Y., He, J., Kumar, R., Wang, H., Yu, Y., Bartell, T., Tan, X. D., Schleimer, R. P., Weeks, D. E. & 2 others, Mar 1 2018, In : Medicine (United States). 97, 9, e0043.Research output: Contribution to journal › Article
Food Hypersensitivity
Genome-Wide Association Study
Mothers
Genes
Egg Hypersensitivity
Umbilical Cord Blood Metabolomics Reveal Distict Signatures of Dyslipidemia Prior to Bronchopulmonary Dysplasia and Pulmonary Hypertension
La, F. M., Fahrmann, J., Grapov, D., Pedersen, T., Newman, JW., Fiehn, O., Underwood, MA., Mestan, KK., Steinhorn, R. & Wedgewood, S., Oct 2018, In : Am J Physiol Lung Cellular and Molecular Physiology (in press).Research output: Contribution to journal › Article