Grants per year
Personal profile
Research Interests
My research interests focus on the intermediate filaments (IFs), which are cytoskeletal structures that are crucial for maintaining the structural integrity of cells and tissues. In general, my lab focuses on the non-mechanical roles for the IF cytoskeleton such as how IFs regulate cell migration and cell survival, and the mechanisms by which IFs are a scaffold for stress-activated kinases and adaptor proteins. We investigated whether micromechanical forces, such as shear stress and stretch, had an effect on the keratin intermediate filament (IF) network in alveolar epithelial cells. We demonstrated that these forces resulted in altered keratin IF expression in alveolar epithelial type II (ATII) cells. This work impacted the field of intermediate filament biology as it describes a mechanism by which mechanical forces and signaling molecules, such as ROS, can lead to the disassembly of the keratin IF network. More recently, we have been examining vimentin, a type III intermediate filament, that acts as a scaffold for the assembly and activation of the NLRP3 inflammasome. The existing paradigm for NOD-like receptor (NLR) signaling is that NLR proteins interact with an apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) and or a CARD domain to form a multi-protein complex called the “inflammasome”. We revealed that optimal localization and activity of the inflammasome requires the vimentin IF network, which suggests a broad biologic role for vimentin in the regulation of NLR proteins in the lung.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Illinois at Chicago
… → 1998
Research interests keywords
- Aging
- Cell Biology
- Cytoskeleton
- Immunology
- Interstitial Lung Disease
- Lung Cancer / Chest Cancer
- Lung Injury
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Collaborations and top research areas from the last five years
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Mechanisms of Alveolar Homeostasis, Injury, Regeneration, and Fibrosis
University of Michigan, National Heart, Lung, and Blood Institute
3/1/22 → 2/28/25
Project: Research project
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Mechanisms of Recovery from Viral Pneumonia
National Heart, Lung, and Blood Institute
9/15/21 → 7/31/26
Project: Research project
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Role of TGFß/BMP Antagonism in Regeneration of the Alveolar Epithelium After Lung Injury
University of Michigan, National Heart, Lung, and Blood Institute
6/1/21 → 5/31/24
Project: Research project
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Training Program In Lung Sciences
Ridge, K. M., Sznajder, J. I., Budinger, G. S. & Wunderink, R. G.
National Heart, Lung, and Blood Institute
7/1/19 → 6/30/24
Project: Research project
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Gigaxonin is required for intermediate filament transport
Renganathan, B., Zewe, J. P., Cheng, Y., Paumier, J. M., Kittisopikul, M., Ridge, K. M., Opal, P. & Gelfand, V. I., May 2023, In: FASEB Journal. 37, 5, e22886.Research output: Contribution to journal › Article › peer-review
Open Access -
Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10
Yang, J., Hou, C., Wang, H., Perez, E. A., Do-Umehara, H. C., Dong, H., Arunagiri, V., Tong, F., Van Scoyk, M., Cho, M., Liu, X., Ge, X., Winn, R. A., Ridge, K. M., Wang, X., Chandel, N. S. & Liu, J., Feb 28 2023, In: Cancer Letters. 555, 216025.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancer
Berr, A. L., Wiese, K., dos Santos, G., Koch, C. M., Anekalla, K. R., Kidd, M., Davis, J. M., Cheng, Y., Hu, Y. S. & Ridge, K. M., Jun 16 2023, In: Oncogene. 42, 25, p. 2074-2087 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Age-related Differences in the Nasal Mucosal Immune Response to SARS-CoV-2
Koch, C. M., Prigge, A. D., Anekalla, K. R., Shukla, A., Do Umehara, H. C., Setar, L., Chavez, J., Abdala-Valencia, H., Politanska, Y., Markov, N. S., Hahn, G. R., Heald-Sargent, T., Sanchez-Pinto, L. N., Muller, W. J., Singer, B. D., Misharin, A. V., Ridge, K. M. & Coates, B. M., Feb 2022, In: American journal of respiratory cell and molecular biology. 66, 2, p. 206-222 17 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Aging is associated with a systemic length-associated transcriptome imbalance
Stoeger, T., Grant, R. A., McQuattie-Pimentel, A. C., Anekalla, K. R., Liu, S. S., Tejedor-Navarro, H., Singer, B. D., Abdala-Valencia, H., Schwake, M., Tetreault, M. P., Perlman, H., Balch, W. E., Chandel, N. S., Ridge, K. M., Sznajder, J. I., Morimoto, R. I., Misharin, A. V., Budinger, G. R. S. & Nunes Amaral, L. A., Dec 2022, In: Nature Aging. 2, 12, p. 1191-1206 16 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations
Datasets
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Additional file 3: of Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A. (Creator), Balderas-Martínez, Y. I. (Contributor), Buendía-Roldan, I. (Contributor), Abdala-Valencia, H. (Creator), Nam, K. (Contributor), Jain, M. (Creator), Bhorade, S. (Creator), Bharat, A. (Creator), Reyfman, P. A. (Creator), Ridge, K. M. (Creator), Pardo, A. (Creator), Sznajder, J. I. (Creator), Budinger, G. S. (Contributor), Misharin, A. (Creator), Selman, M. (Creator), Ridge, K. (Creator), Pardo, A. (Creator) & Selman, M. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7386359, https://springernature.figshare.com/articles/Additional_file_3_of_Inflammatory_pathways_are_upregulated_in_the_nasal_epithelium_in_patients_with_idiopathic_pulmonary_fibrosis/7386359
Dataset
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Additional file 8: of Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A. (Creator), Balderas-Martínez, Y. I. (Contributor), Buendía-Roldan, I. (Contributor), Abdala-Valencia, H. (Creator), Nam, K. (Contributor), Jain, M. (Creator), Bhorade, S. (Creator), Bharat, A. (Creator), Reyfman, P. A. (Creator), Ridge, K. M. (Creator), Pardo, A. (Creator), Sznajder, J. I. (Creator), Budinger, G. S. (Contributor), Misharin, A. (Creator), Selman, M. (Creator), Ridge, K. (Creator), Pardo, A. (Creator) & Selman, M. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7386437, https://springernature.figshare.com/articles/Additional_file_8_of_Inflammatory_pathways_are_upregulated_in_the_nasal_epithelium_in_patients_with_idiopathic_pulmonary_fibrosis/7386437
Dataset
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Additional file 1: of Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A. (Creator), Balderas-Martínez, Y. I. (Contributor), Buendía-Roldan, I. (Contributor), Abdala-Valencia, H. (Creator), Nam, K. (Contributor), Jain, M. (Creator), Bhorade, S. (Creator), Bharat, A. (Creator), Reyfman, P. A. (Creator), Ridge, K. M. (Creator), Pardo, A. (Creator), Sznajder, J. I. (Creator), Budinger, G. S. (Contributor), Misharin, A. (Creator), Selman, M. (Creator), Ridge, K. (Creator), Pardo, A. (Creator) & Selman, M. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7386323, https://springernature.figshare.com/articles/Additional_file_1_of_Inflammatory_pathways_are_upregulated_in_the_nasal_epithelium_in_patients_with_idiopathic_pulmonary_fibrosis/7386323
Dataset
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Additional file 2: of Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A. (Creator), Balderas-Martínez, Y. I. (Contributor), Buendía-Roldan, I. (Contributor), Abdala-Valencia, H. (Creator), Nam, K. (Contributor), Jain, M. (Creator), Bhorade, S. (Creator), Bharat, A. (Creator), Reyfman, P. A. (Creator), Ridge, K. M. (Creator), Pardo, A. (Creator), Sznajder, J. I. (Creator), Budinger, G. S. (Contributor), Misharin, A. (Creator), Selman, M. (Creator), Ridge, K. (Creator), Pardo, A. (Creator) & Selman, M. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7386341, https://springernature.figshare.com/articles/Additional_file_2_of_Inflammatory_pathways_are_upregulated_in_the_nasal_epithelium_in_patients_with_idiopathic_pulmonary_fibrosis/7386341
Dataset
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Additional file 5: of Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A. (Creator), Balderas-Martínez, Y. I. (Contributor), Buendía-Roldan, I. (Contributor), Abdala-Valencia, H. (Creator), Nam, K. (Contributor), Jain, M. (Creator), Bhorade, S. (Creator), Bharat, A. (Creator), Reyfman, P. A. (Creator), Ridge, K. M. (Creator), Pardo, A. (Creator), Sznajder, J. I. (Creator), Budinger, G. S. (Contributor), Misharin, A. (Creator) & Selman, M. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7386386, https://springernature.figshare.com/articles/Additional_file_5_of_Inflammatory_pathways_are_upregulated_in_the_nasal_epithelium_in_patients_with_idiopathic_pulmonary_fibrosis/7386386
Dataset