Grants per year
Personal profile
Research Interests
My research interests focus on the intermediate filaments (IFs), which are cytoskeletal structures that are crucial for maintaining the structural integrity of cells and tissues. In general, my lab focuses on the non-mechanical roles for the IF cytoskeleton such as how IFs regulate cell migration and cell survival, and the mechanisms by which IFs are a scaffold for stress-activated kinases and adaptor proteins. We investigated whether micromechanical forces, such as shear stress and stretch, had an effect on the keratin intermediate filament (IF) network in alveolar epithelial cells. We demonstrated that these forces resulted in altered keratin IF expression in alveolar epithelial type II (ATII) cells. This work impacted the field of intermediate filament biology as it describes a mechanism by which mechanical forces and signaling molecules, such as ROS, can lead to the disassembly of the keratin IF network. More recently, we have been examining vimentin, a type III intermediate filament, that acts as a scaffold for the assembly and activation of the NLRP3 inflammasome. The existing paradigm for NOD-like receptor (NLR) signaling is that NLR proteins interact with an apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) and or a CARD domain to form a multi-protein complex called the “inflammasome”. We revealed that optimal localization and activity of the inflammasome requires the vimentin IF network, which suggests a broad biologic role for vimentin in the regulation of NLR proteins in the lung.
Education/Academic qualification
PhD, University of Illinois at Chicago
… → 1998
Research interests
- Aging
- Cell Biology
- Cytoskeleton
- Immunology
- Interstitial Lung Disease
- Lung Cancer / Chest Cancer
- Lung Injury
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Network
Grants
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Training Program In Lung Sciences
Budinger, G. S., Ridge, K. M., Sznajder, J. I. & Wunderink, R. G.
National Heart, Lung, and Blood Institute
7/1/19 → 6/30/24
Project: Research project
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Ridge Research Core B Subproject for Institution # SP0044258
National Institute of General Medical Sciences
9/1/18 → 7/31/22
Project: Research project
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Project 2 - Role of Intermediate Filaments in Acute Lung Injury
Goldman, R., Ridge, K. M., Ridge, K. M., Shumaker, D. K. & Stehlik, C.
National Heart, Lung, and Blood Institute
9/1/15 → 6/30/21
Project: Research project
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Pathophysiology of Acute Lung Injury
Budinger, G. S., Chandel, N., Dada, L., Goldman, R., Horvath, C. M., Lecuona, E., Perlman, H. R., Ridge, K. M., Stehlik, C., Sznajder, J. I. & Wunderink, R. G.
National Heart, Lung, and Blood Institute
9/1/15 → 6/30/21
Project: Research project
Research Output
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Age-dependent differences in t-cell responses to influenza a virus
Prigge, A. D., Ma, R., Coates, B. M., Singer, B. D. & Ridge, K. M., Oct 2020, In: American journal of respiratory cell and molecular biology. 63, 4, p. 415-423 9 p.Research output: Contribution to journal › Review article › peer-review
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Epithelial cell–specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice
Do-Umehara, H. C., Chen, C., Zhang, Q., Misharin, A. V., Abdala-Valencia, H., Casalino-Matsuda, S. M., Reyfman, P. A., Anekalla, K. R., Gonzalez-Gonzalez, F. J., Sala, M. A., Peng, C., Wu, P., Wong, C. C. L., Kalhan, R., Bharat, A., Perlman, H., Ridge, K. M., Sznajder, J. I., Sporn, P. H. S., Chandel, N. S. & 6 others, , Aug 2020, In: Science Advances. 6, 33, eabb7238.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection
Brazee, P. L., Morales-Nebreda, L., Magnani, N. D., Garcia, J. G. N., Misharin, A. V., Ridge, K. M., Budinger, G. R. S., Iwai, K., Dada, L. A. & Sznajder, J. I., Mar 2 2020, In: Journal of Clinical Investigation. 130, 3, p. 1301-1314 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis
Kim, S. J., Cheresh, P., Jablonski, R. P., Rachek, L., Yeldandi, A., Piseaux-Aillon, R., Ciesielski, M. J., Ridge, K., Gottardi, C., Lam, A. P., Pardo, A., Selman, M., Natarajan, V. & Kamp, D. W., May 1 2020, In: American journal of physiology. Lung cellular and molecular physiology. 318, 5, p. L1084-L1096Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The cGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease
Ma, R., Ortiz Serrano, T. P., Davis, J., Prigge, A. D. & Ridge, K. M., Oct 1 2020, In: FASEB Journal. 34, 10, p. 13156-13170 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access