If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2019

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations
2018

Future research directions in pneumonia

Dela Cruz, C. S., Wunderink, R. G., Christiani, D. C., Cormier, S. A., Crothers, K., Doerschuk, C. M., Evans, S. E., Goldstein, D. R., Khatri, P., Kobzik, L., Kolls, J. K., Levy, B. D., Metersky, M. L., Niederman, M. S., Nusrat, R., Orihuela, C. J., Peyrani, P., Prince, A. S., Ramírez, J. A., Ridge, K. M. & 9 others, Sethi, S., Suratt, B. T., Sznajder, J. I., Tsalik, E. L., Walkey, A. J., Yende, S., Aggarwal, N. R., Caler, E. V. & Mizgerd, J. P., Jul 15 2018, In : American journal of respiratory and critical care medicine. 198, 2, p. 256-263 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Inflammatory monocytes drive influenza A virus-mediated lung injury in juvenile mice

Coates, B. M., Staricha, K. L., Koch, C. M., Cheng, Y., Shumaker, D. K., Budinger, G. R. S., Perlman, H., Misharin, A. V. & Ridge, K. M., Apr 1 2018, In : Journal of Immunology. 200, 7, p. 2391-2404 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis

Sala, M. A., Balderas-Martínez, Y. I., Buendía-Roldan, I., Abdala-Valencia, H., Nam, K., Jain, M., Bhorade, S., Bharat, A., Reyfman, P. A., Ridge, K. M., Pardo, A., Sznajder, J. I., Budinger, G. R. S., Misharin, A. V. & Selman, M., Nov 26 2018, In : Respiratory Research. 19, 1, 233.

Research output: Contribution to journalArticle

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C-I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Oct 11 2018, In : Cell Metabolism.

Research output: Contribution to journalArticle

8 Scopus citations

Vimentin expression is required for the development of EMT-related renal fibrosis following unilateral ureteral obstruction in mice

Wang, Z., Divanyan, A., Jourd’heuil, F. L., Goldman, R. D., Ridge, K. M., Jourd’heuil, D. & Lopez-Soler, R. I., Oct 2018, In : American Journal of Physiology - Renal Physiology. 315, 4, p. F769-F780

Research output: Contribution to journalArticle

6 Scopus citations
2017

FXYD5 is an essential mediator of the inflammatory response during lung injury

Brazee, P. L., Soni, P. N., Tokhtaeva, E., Magnani, N., Yemelyanov, A., Perlman, H. R., Ridge, K. M., Sznajder, J. I., Vagin, O. & Dada, L. A., Jun 1 2017, In : Frontiers in immunology. 8, JUN, 623.

Research output: Contribution to journalArticle

8 Scopus citations

Inhibition of the NOD-like receptor protein 3 inflammasome is protective in juvenile influenza a virus infection

Coates, B. M., Staricha, K. L., Ravindran, N., Koch, C. M., Cheng, Y., Davis, J. M., Shumaker, D. K. & Ridge, K. M., Jul 10 2017, In : Frontiers in immunology. 8, JUL, 782.

Research output: Contribution to journalArticle

21 Scopus citations
11 Scopus citations

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

161 Scopus citations

SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis

Jablonski, R. P., Kim, S. J., Cheresh, P., Williams, D. B., Morales-Nebreda, L., Cheng, Y., Yeldandi, A., Bhorade, S., Pardo, A., Selman, M., Ridge, K., Gius, D., Budinger, G. R. S. & Kamp, D. W., Jun 2017, In : FASEB Journal. 31, 6, p. 2520-2532 13 p.

Research output: Contribution to journalArticle

26 Scopus citations
2016

Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage

Kim, S. J., Cheresh, P., Jablonski, R. P., Morales-Nebreda, L., Cheng, Y., Hogan, E., Yeldandi, A., Chi, M., Piseaux, R., Ridge, K., Michael Hart, C., Chandel, N., Scott Budinger, G. R. & Kamp, D. W., Dec 1 2016, In : Free Radical Biology and Medicine. 101, p. 482-490 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits

Tokhtaeva, E., Sun, H., Deiss-Yehiely, N., Wen, Y., Soni, P. N., Gabrielli, N. M., Marcus, E. A., Ridge, K. M., Sachs, G., Vazquez-Levin, M., Sznajder, J. I., Vagin, O. & Dada, L. A., Jun 15 2016, In : Journal of cell science. 129, 12, p. 2394-2406 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice

Cheresh, P., Morales-Nebreda, L., Kim, S. J., Yeldandi, A., Williams, D. B., Cheng, Y., Mutlu, G. M., Scott Budinger, G. R., Ridge, K., Schumacker, P. T., Bohr, V. A. & Kamp, D. W., Jan 1 2015, In : American journal of respiratory cell and molecular biology. 52, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Influenza virus-induced lung injury: Pathogenesis and implications for treatment

Herold, S., Becker, C., Ridge, K. M. & Budinger, G. R. S., May 1 2015, In : European Respiratory Journal. 45, 5, p. 1463-1478 16 p.

Research output: Contribution to journalArticle

72 Scopus citations

Lung-specific loss of a3 laminin worsens bleomycin-induced pulmonary fibrosis

Morales-Nebreda, L. I., Rogel, M. R., Eisenberg, J. L., Hamill, K. J., Soberanes, S., Nigdelioglu, R., Chi, M., Cho, T., Radigan, K. A., Ridge, K. M., Misharin, A. V., Woychek, A., Hopkinson, S., Perlman, H., Mutlu, G. M., Pardo, A., Selman, M., Jones, J. C. R. & Scott Budinger, G. R., Apr 1 2015, In : American journal of respiratory cell and molecular biology. 52, 4, p. 503-512 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation

Zhang, Q., Kuang, H., Chen, C., Yan, J., Do-Umehara, H. C., Liu, X. Y., Dada, L., Ridge, K. M., Chandel, N. S. & Liu, J., May 28 2015, In : Nature Immunology. 16, 5, p. 458-466 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Vimentin regulates activation of the NLRP3 inflammasome

Dos Santos, G., Rogel, M. R., Baker, M. A., Troken, J. R., Urich, D., Morales-Nebreda, L., Sennello, J. A., Kutuzov, M. A., Sitikov, A., Davis, J. M., Lam, A. P., Cheresh, P., Kamp, D., Shumaker, D. K., Budinger, G. R. S. & Ridge, K. M., Mar 12 2015, In : Nature communications. 6, 6574.

Research output: Contribution to journalArticle

85 Scopus citations
2014

Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling

Weisel, F. C., Kloepping, C., Pichl, A., Sydykov, A., Kojonazarov, B., Wilhelm, J., Roth, M., Ridge, K. M., Igarashi, K., Nishimura, K., Maison, W., Wackendorff, C., Klepetko, W., Jaksch, P., Ghofrani, H. A., Grimminger, F., Seeger, W., Schermuly, R. T., Weissmann, N. & Kwapiszewska, G., Apr 8 2014, In : Circulation. 129, 14, p. 1510-1523 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury

Morales-Nebreda, L., Chi, M., Lecuona, E., Chandel, N. S., Dada, L. A., Ridge, K., Soberanes, S., Nigdelioglu, R., Sznajder, J. I., Mutlu, G. M., Budinger, G. R. S. & Radigan, K. A., Dec 1 2014, In : Journal of Virological Methods. 209, p. 116-120 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells

Kim, S. J., Cheresh, P., Williams, D., Cheng, Y., Ridge, K., Schumacker, P. T., Weitzman, S., Bohr, V. A. & Kamp, D. W., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 6165-6176 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Structure and biomechanics of the endothelial transcellular circumferential invasion array in tumor invasion

Arvanitis, C., Khuon, S., Spann, R., Ridge, K. M. & Chew, T. L., Feb 24 2014, In : PloS one. 9, 2, e89758.

Research output: Contribution to journalArticle

11 Scopus citations
2013

Asbestos-induced alveolar epithelial cell apoptosis: The role of endoplasmic reticulum stress response

Kamp, D. W., Liu, G., Cheresh, P., Kim, S. J., Mueller, A., Lam, A. P., Trejo, H., Williams, D., Tulasiram, S., Baker, M., Ridge, K., Chandel, N. S. & Beri, R., Dec 1 2013, In : American journal of respiratory cell and molecular biology. 49, 6, p. 892-901 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ

Do-Umehara, H. C., Chen, C., Urich, D., Zhou, L., Qiu, J., Jang, S., Zander, A., Baker, M. A., Eilers, M., Sporn, P. H. S., Ridge, K. M., Sznajder, J. I., Budinger, G. R. S., Mutlu, G. M., Lin, A. & Liu, J., May 1 2013, In : Nature Immunology. 14, 5, p. 461-469 9 p.

Research output: Contribution to journalArticle

46 Scopus citations
2012

Particulate matter air pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway

Soberanes, S., Gonzalez, A., Urich, D., Chiarella, S. E., Radigan, K. A., Osornio-Vargas, A., Joseph, J., Kalyanaraman, B., Ridge, K. M., Chandel, N. S., Mutlu, G. M., De Vizcaya-Ruiz, A. & Budinger, G. R. S., Apr 19 2012, In : Scientific reports. 2, 275.

Research output: Contribution to journalArticle

58 Scopus citations
2011

Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells

Rogel, M. R., Soni, P. N., Troken, J. R., Sitikov, A., Trejo, H. E. & Ridge, K. M., Nov 1 2011, In : FASEB Journal. 25, 11, p. 3873-3883 11 p.

Research output: Contribution to journalArticle

63 Scopus citations
2010

Mitochondrial reactive oxygen species are required for hypoxia-induced degradation of keratin intermediate filaments

Na, N., Chandel, N. S., Litvan, J. & Ridge, K. M., Mar 1 2010, In : FASEB Journal. 24, 3, p. 799-809 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2009

Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution

Soberanes, S., Urich, D., Baker, C. M., Burgess, Z., Chiarella, S. E., Bell, E. L., Ghio, A. J., De Vizcaya-Ruiz, A., Liu, J., Ridge, K. M., Kamp, D. W., Chandel, N. S., Schumacker, P. T., Mutlu, G. M. & Budinger, G. R. S., Jan 23 2009, In : Journal of Biological Chemistry. 284, 4, p. 2176-2186 11 p.

Research output: Contribution to journalArticle

91 Scopus citations

Proapoptotic Noxa is required for particulate matterinduced cell death and lung inflammation

Urich, D., Soberanes, S., Burgess, Z., Chiarella, S. E., Ghio, A. J., Ridge, K. M., Kamp, D. W., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Jul 1 2009, In : FASEB Journal. 23, 7, p. 2055-2064 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C ζ

Sivaramakrishnan, S., Schneider, J. L., Sitikov, A., Goldman, R. D. & Ridge, K. M., Jun 1 2009, In : Molecular biology of the cell. 20, 11, p. 2755-2765 11 p.

Research output: Contribution to journalArticle

51 Scopus citations
2008

Micromechanical properties of keratin intermediate filament networks

Sivaramakrishnan, S., DeGiulio, J. V., Lorand, L., Goldman, R. D. & Ridge, K. M., Jan 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 3, p. 889-894 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

Overexpression of the Na-K-ATPase α2-subunit improves lung liquid clearance during ventilation-induced lung injury

Adir, Y., Welch, L. C., Dumasius, V., Factor, P., Sznajder, J. I. & Ridge, K. M., Jun 1 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 6, p. L1233-L1237

Research output: Contribution to journalArticle

16 Scopus citations

Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells

Jaitovich, A., Mehta, S., Na, N., Ciechanover, A., Goldman, R. D. & Ridge, K. M., Sep 12 2008, In : Journal of Biological Chemistry. 283, 37, p. 25348-25355 8 p.

Research output: Contribution to journalArticle

36 Scopus citations
2006

Differential binding of plasminogen, plasmin, and Angiostatin4.5 to cell surface β-actin: Implications for cancer-mediated angiogenesis

Wang, H., Doll, J. A., Jiang, K., Cundiff, D. L., Czarnecki, J. S., Wilson, M., Ridge, K. M. & Soff, G. A., Jul 15 2006, In : Cancer Research. 66, 14, p. 7211-7215 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Laminin-311 (laminin-6) fiber assembly by type I-like alveolar cells

DeBiase, P. J., Lane, K., Budinger, S., Ridge, K., Wilson, M. & Jones, J. C. R., Jun 1 2006, In : Journal of Histochemistry and Cytochemistry. 54, 6, p. 665-672 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Proapoptotic Bid is required for pulmonary fibrosis

Budinger, G. R. S., Mutlu, G. M., Eisenbart, J., Fuller, A. C., Bellmeyer, A. A., Baker, C. M., Wilson, M., Ridge, K., Barrett, T. A., Lee, V. Y. & Chandel, N. S., Mar 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 12, p. 4604-4609 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
45 Scopus citations
2005

Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption

Myrianthefs, P. M., Briva, A., Lecuona, E., Dumasius, V., Rutschman, D. H., Ridge, K. M., Baltopoulos, G. J. & Sznajder, J. I., Jun 1 2005, In : American journal of respiratory and critical care medicine. 171, 11, p. 1267-1271 5 p.

Research output: Contribution to journalArticle

20 Scopus citations
98 Scopus citations
2004

Augmentation of Endogenous Dopamine Production Increases Lung Liquid Clearance

Adir, Y., Azzam, Z. S., Lecuona, E., Leal, S., Pesce, L., Dumasius, V., Bertorello, A. M., Factor, P., Young, J. B., Ridge, K. M. & Sznajder, J. I., Mar 15 2004, In : American Journal of Respiratory and Critical Care Medicine. 169, 6, p. 757-763 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Leukotriene D4 Activates Alveolar Epithelial Na,K-ATPase and Increases Alveolar Fluid Clearance

Sloniewsky, D. E., Ridge, K. M., Adir, Y., Fries, F. P., Briva, A., Sznajder, J. I. & Sporn, P. H. S., Feb 1 2004, In : American Journal of Respiratory and Critical Care Medicine. 169, 3, p. 407-412 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity

Azzam, Z. S., Adir, Y., Crespo, A., Comellas, A., Lecuona, E., Dada, L. A., Krivoy, N., Rutschman, D. H., Sznajder, J. I. & Ridge, K. M., Oct 1 2004, In : American journal of respiratory and critical care medicine. 170, 7, p. 730-736 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
2003

Alveolar type 1 cells express the α2 Na,K-ATPase, which contributes to lung liquid clearance

Ridge, K. M., Olivera, W. G., Saldias, F., Azzam, Z., Horowitz, S., Rutschman, D. H., Dumasius, V., Factor, P. & Sznajder, J. I., Mar 7 2003, In : Circulation research. 92, 4, p. 453-460 8 p.

Research output: Contribution to journalArticle

98 Scopus citations
212 Scopus citations

Na,K-ATPase Gene Transfer Increases Liquid Clearance during Ventilation-induced Lung Injury

Adir, Y., Factor, P., Dumasius, V., Ridge, K. M. & Sznajder, J. I., Dec 15 2003, In : American journal of respiratory and critical care medicine. 168, 12, p. 1445-1448 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

Pulmonary lymphatics and edema accumulation after brief lung injury

Schraufnagel, D. E., Agaram, N. P., Faruqui, A., Jain, S., Jain, L., Ridge, K. M. & Sznajder, J. I., May 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 5 28-5

Research output: Contribution to journalArticle

20 Scopus citations

The GTP-binding protein RhoA mediates Na,K-ATpase exocytosis in alveolar epithelial cells

Lecuona, E., Ridge, K., Pesce, L., Batlle, D. & Sznajder, J. I., Sep 1 2003, In : Molecular biology of the cell. 14, 9, p. 3888-3897 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
2002
29 Scopus citations

Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-ε and -δ

Ridge, K. M., Dada, L., Lecuona, E., Bertorello, A. M., Katz, A. I., Mochly-Rosen, D. & Sznajder, J. I., Apr 25 2002, In : Molecular Biology of the Cell. 13, 4, p. 1381-1389 9 p.

Research output: Contribution to journalArticle

89 Scopus citations
2001

Alveolar fluid reabsorption is impaired by increased left atrial pressures in rats

Saldías, F. J., Azzam, Z. S., Ridge, K. M., Yeldandi, A., Rutschman, D. H., Schraufnagel, D. & Sznajder, J. I., Oct 1 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 3 25-3

Research output: Contribution to journalArticle

48 Scopus citations