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Research Output 1989 2019

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2019
38 Citations (Scopus)

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
Single-Cell Analysis
Pulmonary Fibrosis
Lung
RNA Sequence Analysis
Alveolar Macrophages
2018
12 Citations (Scopus)

Future research directions in pneumonia

Dela Cruz, C. S., Wunderink, R. G., Christiani, D. C., Cormier, S. A., Crothers, K., Doerschuk, C. M., Evans, S. E., Goldstein, D. R., Khatri, P., Kobzik, L., Kolls, J. K., Levy, B. D., Metersky, M. L., Niederman, M. S., Nusrat, R., Orihuela, C. J., Peyrani, P., Prince, A. S., Ramírez, J. A., Ridge, K. M. & 9 others, Sethi, S., Suratt, B. T., Sznajder, J. I., Tsalik, E. L., Walkey, A. J., Yende, S., Aggarwal, N. R., Caler, E. V. & Mizgerd, J. P., Jul 15 2018, In : American journal of respiratory and critical care medicine. 198, 2, p. 256-263 8 p.

Research output: Contribution to journalArticle

Pneumonia
Lung
Direction compound
National Heart, Lung, and Blood Institute (U.S.)
Adult Respiratory Distress Syndrome
14 Citations (Scopus)

Inflammatory monocytes drive influenza A virus-mediated lung injury in juvenile mice

Coates, B. M., Staricha, K. L., Koch, C. M., Cheng, Y., Shumaker, D. K., Budinger, G. R. S., Perlman, H., Misharin, A. V. & Ridge, K. M., Apr 1 2018, In : Journal of Immunology. 200, 7, p. 2391-2404 14 p.

Research output: Contribution to journalArticle

Influenza A virus
Lung Injury
Human Influenza
Monocytes
Inflammasomes

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis

Sala, M. A., Balderas-Martínez, Y. I., Buendía-Roldan, I., Abdala-Valencia, H., Nam, K., Jain, M., Bhorade, S., Bharat, A., Reyfman, P. A., Ridge, K. M., Pardo, A., Sznajder, J. I., Budinger, G. R. S., Misharin, A. V. & Selman, M., Nov 26 2018, In : Respiratory Research. 19, 1, 233.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Nasal Mucosa
Nose
Up-Regulation
RNA Sequence Analysis
6 Citations (Scopus)

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C-I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Oct 11 2018, In : Cell Metabolism.

Research output: Contribution to journalArticle

Metformin
Air Pollution
Electron Transport
Particulate Matter
Alveolar Macrophages
6 Citations (Scopus)

Vimentin expression is required for the development of EMT-related renal fibrosis following unilateral ureteral obstruction in mice

Wang, Z., Divanyan, A., Jourd’heuil, F. L., Goldman, R. D., Ridge, K. M., Jourd’heuil, D. & Lopez-Soler, R. I., Oct 2018, In : American Journal of Physiology - Renal Physiology. 315, 4, p. F769-F780

Research output: Contribution to journalArticle

Ureteral Obstruction
Epithelial-Mesenchymal Transition
Vimentin
Fibrosis
Kidney
2017
7 Citations (Scopus)

FXYD5 is an essential mediator of the inflammatory response during lung injury

Brazee, P. L., Soni, P. N., Tokhtaeva, E., Magnani, N., Yemelyanov, A., Perlman, H. R., Ridge, K. M., Sznajder, J. I., Vagin, O. & Dada, L. A., Jun 1 2017, In : Frontiers in immunology. 8, JUN, 623.

Research output: Contribution to journalArticle

Lung Injury
Lipopolysaccharides
CC Chemokines
Cytokines
Ligands
18 Citations (Scopus)

Inhibition of the NOD-like receptor protein 3 inflammasome is protective in juvenile influenza a virus infection

Coates, B. M., Staricha, K. L., Ravindran, N., Koch, C. M., Cheng, Y., Davis, J. M., Shumaker, D. K. & Ridge, K. M., Jul 10 2017, In : Frontiers in immunology. 8, JUL, 782.

Research output: Contribution to journalArticle

Inflammasomes
Influenza A virus
Virus Diseases
Orthomyxoviridae
Proteins
11 Citations (Scopus)
Alveolar Epithelial Cells
Mitochondrial DNA
Oxidants
DNA Damage
Apoptosis
150 Citations (Scopus)

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

Alveolar Macrophages
Fibrosis
Macrophages
Lung
Monocytes
23 Citations (Scopus)

SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis

Jablonski, R. P., Kim, S. J., Cheresh, P., Williams, D. B., Morales-Nebreda, L., Cheng, Y., Yeldandi, A., Bhorade, S., Pardo, A., Selman, M., Ridge, K., Gius, D., Budinger, G. R. S. & Kamp, D. W., Jun 2017, In : FASEB Journal. 31, 6, p. 2520-2532 13 p.

Research output: Contribution to journalArticle

Sirtuin 3
Alveolar Epithelial Cells
Mitochondrial DNA
DNA Damage
Fibrosis
2016
17 Citations (Scopus)

Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage

Kim, S. J., Cheresh, P., Jablonski, R. P., Morales-Nebreda, L., Cheng, Y., Hogan, E., Yeldandi, A., Chi, M., Piseaux, R., Ridge, K., Michael Hart, C., Chandel, N., Scott Budinger, G. R. & Kamp, D. W., Dec 1 2016, In : Free Radical Biology and Medicine. 101, p. 482-490 9 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Mitochondrial DNA
Catalase
Transgenic Mice
DNA Damage
8 Citations (Scopus)

The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits

Tokhtaeva, E., Sun, H., Deiss-Yehiely, N., Wen, Y., Soni, P. N., Gabrielli, N. M., Marcus, E. A., Ridge, K. M., Sachs, G., Vazquez-Levin, M., Sznajder, J. I., Vagin, O. & Dada, L. A., Jun 15 2016, In : Journal of cell science. 129, 12, p. 2394-2406 13 p.

Research output: Contribution to journalArticle

Dimerization
Cell Adhesion
Glycosylation
Mutagenesis
Adhesives
2015
19 Citations (Scopus)

Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice

Cheresh, P., Morales-Nebreda, L., Kim, S. J., Yeldandi, A., Williams, D. B., Cheng, Y., Mutlu, G. M., Scott Budinger, G. R., Ridge, K., Schumacker, P. T., Bohr, V. A. & Kamp, D. W., Jan 1 2015, In : American journal of respiratory cell and molecular biology. 52, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Alveolar Epithelial Cells
Pulmonary Fibrosis
Asbestos
Knockout Mice
68 Citations (Scopus)

Influenza virus-induced lung injury: Pathogenesis and implications for treatment

Herold, S., Becker, C., Ridge, K. M. & Budinger, G. R. S., May 1 2015, In : European Respiratory Journal. 45, 5, p. 1463-1478 16 p.

Research output: Contribution to journalArticle

Lung Injury
Orthomyxoviridae
Human Influenza
Viral Tropism
Alveolar Epithelial Cells
10 Citations (Scopus)

Lung-specific loss of a3 laminin worsens bleomycin-induced pulmonary fibrosis

Morales-Nebreda, L. I., Rogel, M. R., Eisenberg, J. L., Hamill, K. J., Soberanes, S., Nigdelioglu, R., Chi, M., Cho, T., Radigan, K. A., Ridge, K. M., Misharin, A. V., Woychek, A., Hopkinson, S., Perlman, H., Mutlu, G. M., Pardo, A., Selman, M., Jones, J. C. R. & Scott Budinger, G. R., Apr 1 2015, In : American journal of respiratory cell and molecular biology. 52, 4, p. 503-512 10 p.

Research output: Contribution to journalArticle

Pulmonary Fibrosis
Bleomycin
Laminin
Lung
Fibrosis
37 Citations (Scopus)

The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation

Zhang, Q., Kuang, H., Chen, C., Yan, J., Do-Umehara, H. C., Liu, X. Y., Dada, L., Ridge, K. M., Chandel, N. S. & Liu, J., May 28 2015, In : Nature Immunology. 16, 5, p. 458-466 9 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Phosphotransferases
Neoplasms
Homeostasis
Inflammasomes
84 Citations (Scopus)

Vimentin regulates activation of the NLRP3 inflammasome

Dos Santos, G., Rogel, M. R., Baker, M. A., Troken, J. R., Urich, D., Morales-Nebreda, L., Sennello, J. A., Kutuzov, M. A., Sitikov, A., Davis, J. M., Lam, A. P., Cheresh, P., Kamp, D., Shumaker, D. K., Budinger, G. R. S. & Ridge, K. M., Mar 12 2015, In : Nature communications. 6, 6574.

Research output: Contribution to journalArticle

Inflammasomes
Vimentin
lungs
fibrosis
Interleukin-1
2014
11 Citations (Scopus)

Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling

Weisel, F. C., Kloepping, C., Pichl, A., Sydykov, A., Kojonazarov, B., Wilhelm, J., Roth, M., Ridge, K. M., Igarashi, K., Nishimura, K., Maison, W., Wackendorff, C., Klepetko, W., Jaksch, P., Ghofrani, H. A., Grimminger, F., Seeger, W., Schermuly, R. T., Weissmann, N. & Kwapiszewska, G., Apr 8 2014, In : Circulation. 129, 14, p. 1510-1523 14 p.

Research output: Contribution to journalArticle

Adenosylmethionine Decarboxylase
Pulmonary Hypertension
Lung
Early Growth Response Protein 1
Vascular Remodeling
9 Citations (Scopus)

Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury

Morales-Nebreda, L., Chi, M., Lecuona, E., Chandel, N. S., Dada, L. A., Ridge, K., Soberanes, S., Nigdelioglu, R., Sznajder, J. I., Mutlu, G. M., Budinger, G. R. S. & Radigan, K. A., Dec 1 2014, In : Journal of Virological Methods. 209, p. 116-120 5 p.

Research output: Contribution to journalArticle

Intranasal Administration
Acute Lung Injury
Influenza A virus
Orthomyxoviridae
Viral Load
47 Citations (Scopus)

Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells

Kim, S. J., Cheresh, P., Williams, D., Cheng, Y., Ridge, K., Schumacker, P. T., Weitzman, S., Bohr, V. A. & Kamp, D. W., Feb 28 2014, In : Journal of Biological Chemistry. 289, 9, p. 6165-6176 12 p.

Research output: Contribution to journalArticle

Aconitate Hydratase
Alveolar Epithelial Cells
Mitochondria
Mitochondrial DNA
Oxidants
11 Citations (Scopus)

Structure and biomechanics of the endothelial transcellular circumferential invasion array in tumor invasion

Arvanitis, C., Khuon, S., Spann, R., Ridge, K. M. & Chew, T. L., Feb 24 2014, In : PloS one. 9, 2, e89758.

Research output: Contribution to journalArticle

Biomechanics
Endothelial cells
myosin
Biomechanical Phenomena
endothelial cells
2013
34 Citations (Scopus)

Asbestos-induced alveolar epithelial cell apoptosis: The role of endoplasmic reticulum stress response

Kamp, D. W., Liu, G., Cheresh, P., Kim, S. J., Mueller, A., Lam, A. P., Trejo, H., Williams, D., Tulasiram, S., Baker, M., Ridge, K., Chandel, N. S. & Beri, R., Dec 1 2013, In : American journal of respiratory cell and molecular biology. 49, 6, p. 892-901 10 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Endoplasmic Reticulum Stress
Asbestos
Apoptosis
Endoplasmic Reticulum
46 Citations (Scopus)

Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ

Do-Umehara, H. C., Chen, C., Urich, D., Zhou, L., Qiu, J., Jang, S., Zander, A., Baker, M. A., Eilers, M., Sporn, P. H. S., Ridge, K. M., Sznajder, J. I., Budinger, G. R. S., Mutlu, G. M., Lin, A. & Liu, J., May 1 2013, In : Nature Immunology. 14, 5, p. 461-469 9 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Inflammation
Lipopolysaccharides
Histone Deacetylase 1
Mortality
2012
57 Citations (Scopus)

Particulate matter air pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway

Soberanes, S., Gonzalez, A., Urich, D., Chiarella, S. E., Radigan, K. A., Osornio-Vargas, A., Joseph, J., Kalyanaraman, B., Ridge, K. M., Chandel, N. S., Mutlu, G. M., De Vizcaya-Ruiz, A. & Budinger, G. R. S., Apr 19 2012, In : Scientific Reports. 2, 275.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Particulate Matter
Air Pollution
Methyltransferases
Methylation
2011
63 Citations (Scopus)

Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells

Rogel, M. R., Soni, P. N., Troken, J. R., Sitikov, A., Trejo, H. E. & Ridge, K. M., Nov 1 2011, In : FASEB Journal. 25, 11, p. 3873-3883 11 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Vimentin
Repair
Wounds and Injuries
Cell Movement
2010
22 Citations (Scopus)

Mitochondrial reactive oxygen species are required for hypoxia-induced degradation of keratin intermediate filaments

Na, N., Chandel, N. S., Litvan, J. & Ridge, K. M., Mar 1 2010, In : FASEB Journal. 24, 3, p. 799-809 11 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Keratins
Alveolar Epithelial Cells
Reactive Oxygen Species
Degradation
2009
90 Citations (Scopus)

Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution

Soberanes, S., Urich, D., Baker, C. M., Burgess, Z., Chiarella, S. E., Bell, E. L., Ghio, A. J., De Vizcaya-Ruiz, A., Liu, J., Ridge, K. M., Kamp, D. W., Chandel, N. S., Schumacker, P. T., Mutlu, G. M. & Budinger, G. R. S., Jan 23 2009, In : Journal of Biological Chemistry. 284, 4, p. 2176-2186 11 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Particulate Matter
Electron Transport Complex III
Air Pollution
Cell death
25 Citations (Scopus)

Proapoptotic Noxa is required for particulate matterinduced cell death and lung inflammation

Urich, D., Soberanes, S., Burgess, Z., Chiarella, S. E., Ghio, A. J., Ridge, K. M., Kamp, D. W., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Jul 1 2009, In : FASEB Journal. 23, 7, p. 2055-2064 10 p.

Research output: Contribution to journalArticle

Noxae
Cell death
Pneumonia
Cell Death
Alveolar Epithelial Cells
51 Citations (Scopus)

Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C ζ

Sivaramakrishnan, S., Schneider, J. L., Sitikov, A., Goldman, R. D. & Ridge, K. M., Jun 1 2009, In : Molecular biology of the cell. 20, 11, p. 2755-2765 11 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Keratins
Protein Kinase C
Phosphorylation
Alveolar Epithelial Cells
2008
65 Citations (Scopus)

Micromechanical properties of keratin intermediate filament networks

Sivaramakrishnan, S., DeGiulio, J. V., Lorand, L., Goldman, R. D. & Ridge, K. M., Jan 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 3, p. 889-894 6 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Keratins
Alveolar Epithelial Cells
Epithelial Cells
Cell Nucleus
16 Citations (Scopus)

Overexpression of the Na-K-ATPase α2-subunit improves lung liquid clearance during ventilation-induced lung injury

Adir, Y., Welch, L. C., Dumasius, V., Factor, P., Sznajder, J. I. & Ridge, K. M., Jun 1 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 6, p. L1233-L1237

Research output: Contribution to journalArticle

Lung Injury
Ventilation
Lung
Artificial Respiration
sodium-translocating ATPase
35 Citations (Scopus)

Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells

Jaitovich, A., Mehta, S., Na, N., Ciechanover, A., Goldman, R. D. & Ridge, K. M., Sep 12 2008, In : Journal of Biological Chemistry. 283, 37, p. 25348-25355 8 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Proteasome Endopeptidase Complex
Keratins
Ubiquitin
Shear stress
2006
25 Citations (Scopus)

Differential binding of plasminogen, plasmin, and Angiostatin4.5 to cell surface β-actin: Implications for cancer-mediated angiogenesis

Wang, H., Doll, J. A., Jiang, K., Cundiff, D. L., Czarnecki, J. S., Wilson, M., Ridge, K. M. & Soff, G. A., Jul 15 2006, In : Cancer Research. 66, 14, p. 7211-7215 5 p.

Research output: Contribution to journalArticle

Plasminogen
Kringles
Fibrinolysin
Actins
Neoplasms
12 Citations (Scopus)

Laminin-311 (laminin-6) fiber assembly by type I-like alveolar cells

DeBiase, P. J., Lane, K., Budinger, S., Ridge, K., Wilson, M. & Jones, J. C. R., Jun 1 2006, In : Journal of Histochemistry and Cytochemistry. 54, 6, p. 665-672 8 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Laminin
Actin Cytoskeleton
Integrins
Myosin-Light-Chain Kinase
78 Citations (Scopus)

Proapoptotic Bid is required for pulmonary fibrosis

Budinger, G. R. S., Mutlu, G. M., Eisenbart, J., Fuller, A. C., Bellmeyer, A. A., Baker, C. M., Wilson, M., Ridge, K., Barrett, T. A., Lee, V. Y. & Chandel, N. S., Mar 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 12, p. 4604-4609 6 p.

Research output: Contribution to journalArticle

Pulmonary Fibrosis
Bleomycin
Alveolar Epithelial Cells
Cell Death
Bronchoalveolar Lavage Fluid
45 Citations (Scopus)
Adrenergic Receptors
Superoxide Dismutase
Adenosine Triphosphatases
Rats
Fluids
2005
20 Citations (Scopus)

Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption

Myrianthefs, P. M., Briva, A., Lecuona, E., Dumasius, V., Rutschman, D. H., Ridge, K. M., Baltopoulos, G. J. & Sznajder, J. I., Jun 1 2005, In : American journal of respiratory and critical care medicine. 171, 11, p. 1267-1271 5 p.

Research output: Contribution to journalArticle

Alkalosis
Critical Illness
Respiratory Alkalosis
Hypocapnia
Lung
98 Citations (Scopus)
Keratin-8
Alveolar Epithelial Cells
Phosphorylation
Intermediate Filaments
Keratins
2004
16 Citations (Scopus)

Augmentation of Endogenous Dopamine Production Increases Lung Liquid Clearance

Adir, Y., Azzam, Z. S., Lecuona, E., Leal, S., Pesce, L., Dumasius, V., Bertorello, A. M., Factor, P., Young, J. B., Ridge, K. M. & Sznajder, J. I., Mar 15 2004, In : American Journal of Respiratory and Critical Care Medicine. 169, 6, p. 757-763 7 p.

Research output: Contribution to journalArticle

Dopamine
Lung
Tyrosine
Diet
Levodopa
33 Citations (Scopus)

Leukotriene D4 Activates Alveolar Epithelial Na,K-ATPase and Increases Alveolar Fluid Clearance

Sloniewsky, D. E., Ridge, K. M., Adir, Y., Fries, F. P., Briva, A., Sznajder, J. I. & Sporn, P. H. S., Feb 1 2004, In : American Journal of Respiratory and Critical Care Medicine. 169, 3, p. 407-412 6 p.

Research output: Contribution to journalArticle

Leukotriene D4
Alveolar Epithelial Cells
Lung
Acute Lung Injury
Adult Respiratory Distress Syndrome
23 Citations (Scopus)

Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity

Azzam, Z. S., Adir, Y., Crespo, A., Comellas, A., Lecuona, E., Dada, L. A., Krivoy, N., Rutschman, D. H., Sznajder, J. I. & Ridge, K. M., Oct 1 2004, In : American Journal of Respiratory and Critical Care Medicine. 170, 7, p. 730-736 7 p.

Research output: Contribution to journalArticle

Norepinephrine
Adrenergic Receptors
Adrenergic Agonists
Adrenergic Antagonists
Octopamine
2003
97 Citations (Scopus)

Alveolar type 1 cells express the α2 Na,K-ATPase, which contributes to lung liquid clearance

Ridge, K. M., Olivera, W. G., Saldias, F., Azzam, Z., Horowitz, S., Rutschman, D. H., Dumasius, V., Factor, P. & Sznajder, J. I., Mar 7 2003, In : Circulation research. 92, 4, p. 453-460 8 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Lung
Active Biological Transport
Adenoviridae
sodium-translocating ATPase
211 Citations (Scopus)
Alveolar Epithelial Cells
Endocytosis
Reactive Oxygen Species
Antioxidants
Phosphorylation
28 Citations (Scopus)

Na,K-ATPase Gene Transfer Increases Liquid Clearance during Ventilation-induced Lung Injury

Adir, Y., Factor, P., Dumasius, V., Ridge, K. M. & Sznajder, J. I., Dec 15 2003, In : American journal of respiratory and critical care medicine. 168, 12, p. 1445-1448 4 p.

Research output: Contribution to journalArticle

Lung Injury
Ventilation
Lung
Genes
Epithelium
20 Citations (Scopus)

Pulmonary lymphatics and edema accumulation after brief lung injury

Schraufnagel, D. E., Agaram, N. P., Faruqui, A., Jain, S., Jain, L., Ridge, K. M. & Sznajder, J. I., May 1 2003, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 5 28-5

Research output: Contribution to journalArticle

Tidal Volume
Lung Injury
Pulmonary Edema
Edema
Blood Vessels
38 Citations (Scopus)

The GTP-binding protein RhoA mediates Na,K-ATpase exocytosis in alveolar epithelial cells

Lecuona, E., Ridge, K., Pesce, L., Batlle, D. & Sznajder, J. I., Sep 1 2003, In : Molecular biology of the cell. 14, 9, p. 3888-3897 10 p.

Research output: Contribution to journalArticle

rhoA GTP-Binding Protein
Alveolar Epithelial Cells
Exocytosis
Isoproterenol
rho-Associated Kinases
2002
29 Citations (Scopus)
Alveolar Epithelial Cells
ras Proteins
Protein Kinase C
Dopamine
Proto-Oncogene Proteins c-raf
89 Citations (Scopus)

Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-ε and -δ

Ridge, K. M., Dada, L., Lecuona, E., Bertorello, A. M., Katz, A. I., Mochly-Rosen, D. & Sznajder, J. I., Apr 25 2002, In : Molecular Biology of the Cell. 13, 4, p. 1381-1389 9 p.

Research output: Contribution to journalArticle

Exocytosis
Protein Kinase C
Dopamine
Alveolar Epithelial Cells
Membranes
2001
48 Citations (Scopus)

Alveolar fluid reabsorption is impaired by increased left atrial pressures in rats

Saldías, F. J., Azzam, Z. S., Ridge, K. M., Yeldandi, A., Rutschman, D. H., Schraufnagel, D. & Sznajder, J. I., Oct 1 2001, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 3 25-3

Research output: Contribution to journalArticle

Atrial Pressure
Active Biological Transport
Lung
Pulmonary Circulation
Permeability