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Karla J. F. Satchell

  • 3462 Citations
1993 …2022

Research output per year

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Personal profile

Research Interests

My research focuses on the role of secreted protein toxins on bacterial pathogenesis. The toxins we study are members of the MARTX family and are produced by Vibrio cholerae, a pathogen important for the diarrheal disease cholera, and Vibrio vulnificus, a pathogen that causes septicemia and necrotizing fasciitis from seafood consumption as well as wound infections. Our group studies the mechanism of action of these toxins using a combination of cell biology, biochemistry, and structural biology. In addition, we investigate the role of these toxins in pathogenesis using animal and tissue culture models with focus on mechanisms of tissue damage and evasion of innate immune clearance.

Training Experience

1997Postdoctoral Fellowship, University of Pittsburgh
2000Postdoctoral Fellowship, Harvard Medical School

Education/Academic qualification

PhD, University of Washington

… → 1996

Research interests

  • Bacterial Pathogenesis
  • Biochemistry: Proteins
  • Cellular Microbiology
  • Cytoskeleton
  • Global Health
  • Immunology
  • Infectious Diseases: Bacteria
  • Structural Biology

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Grants

Support for the Lakeside Conference on Bacterial Toxins and Effectors to be held October 4-7, 2020 in Lake Geneva, WI

Satchell, K. J. F.

Burroughs Wellcome Fund

11/1/19 → 10/31/20

Project: Research project

    • Subproject for Sanford Burnham

    Satchell, K. J. F.

    National Institute of Allergy and Infectious Diseases

    9/1/17 → 8/31/22

    Project: Research project

    • Subproject for University of Virginia

    Satchell, K. J. F.

    National Institute of Allergy and Infectious Diseases

    9/1/17 → 8/31/22

    Project: Research project

    • Subproject for University of Chicago

    Satchell, K. J. F.

    National Institute of Allergy and Infectious Diseases

    9/1/17 → 8/31/22

    Project: Research project

    • Subproject for University of Calgary

    Satchell, K. J. F.

    National Institute of Allergy and Infectious Diseases

    9/1/17 → 8/31/22

    Project: Research project

    • Research Output

    Direct cloning method for expression of recombinant proteins with an inositol hexakisphosphate inducible self-cleaving tag

    Kwon, K., Biancucci, M., Woida, P. J. & Satchell, K. J. F., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 163-179 17 p. (Methods in Molecular Biology; vol. 2091).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    • N-terminal autoprocessing and acetylation of multifunctional-autoprocessing repeats-in-toxins (MARTX) Makes Caterpillars Floppy-like effector is stimulated by adenosine diphosphate (ADP)-Ribosylation Factor 1 in advance of Golgi fragmentation

    Herrera, A., Muroski, J., Sengupta, R., Nguyen, H. H., Agarwal, S., Ogorzalek Loo, R. R., Mattoo, S., Loo, J. A. & Satchell, K. J. F., Feb 1 2020, In : Cellular Microbiology. 22, 2, e13133.

    Research output: Contribution to journal › Article

    • Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment

    Rosas-Lemus, M., Minasov, G., Shuvalova, L., Wawrzak, Z., Kiryukhina, O., Mih, N., Jaroszewski, L., Palsson, B., Godzik, A. & Satchell, K. J. F., Mar 1 2020, In : Protein Science. 29, 3, p. 711-722 12 p.

    Research output: Contribution to journal › Article

    • Correction: Additive function of vibrio vulnificus martxvv and vvha cytolysins promotes rapid growth and epithelial tissue necrosis during intestinal infection(PLoS Pathog 8(3), e1002581, 10.1371/journal.ppat.1002581

    Jeong, H. G. & Satchell, K. J. F., Jun 1 2019, In : PLoS pathogens. 15, 6, e1007895.

    Research output: Contribution to journal › Comment/debate

    Open Access

    • Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

    Zhu, Y., Zou, X., Dean, A. E., Brien, J. O., Gao, Y., Tran, E. L., Park, S. H., Liu, G., Kieffer, M. B., Jiang, H., Stauffer, M. E., Hart, R., Quan, S., Satchell, K. J. F., Horikoshi, N., Bonini, M. & Gius, D., Dec 1 2019, In : Nature communications. 10, 1, 2399.

    Research output: Contribution to journal › Article

    Open Access
    • 4 Scopus citations