Grants per year
Personal profile
Research Interests
My research focuses on the role of secreted protein toxins on bacterial pathogenesis. The toxins we study are members of the MARTX family and are produced by Vibrio cholerae, a pathogen important for the diarrheal disease cholera, and Vibrio vulnificus, a pathogen that causes septicemia and necrotizing fasciitis from seafood consumption as well as wound infections. Our group studies the mechanism of action of these toxins using a combination of cell biology, biochemistry, and structural biology. In addition, we investigate the role of these toxins in pathogenesis using animal and tissue culture models with focus on mechanisms of tissue damage and evasion of innate immune clearance.
Training Experience
| 1997 | Postdoctoral Fellowship, University of Pittsburgh |
| 2000 | Postdoctoral Fellowship, Harvard Medical School |
Education/Academic qualification
PhD, University of Washington
… → 1996
Research interests
- Bacterial Pathogenesis
- Biochemistry: Proteins
- Cellular Microbiology
- Cytoskeleton
- Global Health
- Immunology
- Infectious Diseases: Bacteria
- Structural Biology
Fingerprint Dive into the research topics where Karla J. F. Satchell is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 2 Similar Profiles
Vibrio cholerae
Medicine & Life Sciences
Vibrio vulnificus
Medicine & Life Sciences
Cholera Toxin
Medicine & Life Sciences
Bacterial Toxins
Medicine & Life Sciences
Cysteine Proteases
Medicine & Life Sciences
Actins
Medicine & Life Sciences
Virulence
Medicine & Life Sciences
Virulence Factors
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2002 2022
A bacterial toxin that cleaves Ras: a translational study to provide insights into breast cancer biology and treatment
Northwestern Memorial Hospital
9/1/18 → 8/31/19
Project: Research project
Bacterial Toxins
Neoplasms
Breast Neoplasms
Triple Negative Breast Neoplasms
Mutation
Subproject for Sanford Burnham
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
Subproject for Base Option Quantities 1 and 4
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
Subproject for University of Texas Southwestern
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
Option 3
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
Research Output 1993 2019
Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter
Zhu, Y., Zou, X., Dean, A. E., Brien, J. O., Gao, Y., Tran, E. L., Park, S. H., Liu, G., Kieffer, M. B., Jiang, H., Stauffer, M. E., Hart, R., Quan, S., Satchell, K. J. F., Horikoshi, N., Bonini, M. & Gius, D. R., Dec 1 2019, In : Nature communications. 10, 1, 2399.Research output: Contribution to journal › Article
Open Access
acetylation
Acetylation
Detoxification
inorganic peroxides
lysine
1
Citation
(Scopus)
RRSP and RID effector domains dominate the virulence impact of vibrio vulnificus MARTX toxin
Gavin, H. E. & Satchell, K. J. F., Feb 23 2019, In : Journal of Infectious Diseases. 219, 6, p. 889-897 9 p.Research output: Contribution to journal › Article
Vibrio vulnificus
Virulence
Infection
Phagocytosis
ras Proteins
4
Citations
(Scopus)
Coordinated delivery and function of bacterial MARTX toxin effectors
Woida, P. J. & Satchell, K. J. F., Jan 1 2018, In : Molecular Microbiology. 107, 2, p. 133-141 9 p.Research output: Contribution to journal › Review article
Virulence Factors
Secretory Pathway
Eukaryotic Cells
Infection
Cytosol
3
Citations
(Scopus)
Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43
Kam, C. Y., Dubash, A. D., Magistrati, E., Polo, S., Satchell, K. J. F., Sheikh, F., Lampe, P. D. & Green, K. J., Sep 1 2018, In : Journal of Cell Biology. 217, 9, p. 3219-3235 17 p.Research output: Contribution to journal › Article
Desmoplakins
Connexin 43
Gap Junctions
Cardiomyopathies
RNA Sequence Analysis
1
Citation
(Scopus)
Draft genome sequences of two Vibrio parahaemolyticus strains associated with gastroenteritis after raw seafood ingestion in Colorado
Trinh, S. A., Leyn, S. A., Rodionov, I. D., Godzik, A. & Satchell, K. J. F., Jan 1 2018, In : Genome Announcements. 6, 3, e01387-17.Research output: Contribution to journal › Article
Vibrio parahaemolyticus
Seafood
Gastroenteritis
Centers for Disease Control and Prevention (U.S.)
Eating