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Personal profile

Research Interests

My research focuses on the role of secreted protein toxins on bacterial pathogenesis. The toxins we study are members of the MARTX family and are produced by Vibrio cholerae, a pathogen important for the diarrheal disease cholera, and Vibrio vulnificus, a pathogen that causes septicemia and necrotizing fasciitis from seafood consumption as well as wound infections. Our group studies the mechanism of action of these toxins using a combination of cell biology, biochemistry, and structural biology. In addition, we investigate the role of these toxins in pathogenesis using animal and tissue culture models with focus on mechanisms of tissue damage and evasion of innate immune clearance.

Training Experience

1997Postdoctoral Fellowship, University of Pittsburgh
2000Postdoctoral Fellowship, Harvard Medical School

Education/Academic qualification

PhD, University of Washington

… → 1996

Keywords

  • Bacterial Pathogenesis
  • Biochemistry: Proteins
  • Cellular Microbiology
  • Cytoskeleton
  • Global Health
  • Immunology
  • Infectious Diseases: Bacteria
  • Structural Biology

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Grants 2002 2022

Bacterial Toxins
Neoplasms
Breast Neoplasms
Triple Negative Breast Neoplasms
Mutation
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins

Research Output 1993 2019

RRSP and RID effector domains dominate the virulence impact of vibrio vulnificus MARTX toxin

Gavin, H. E. & Satchell, K. J. F., Feb 23 2019, In : Journal of Infectious Diseases. 219, 6, p. 889-897 9 p.

Research output: Contribution to journalArticle

Vibrio vulnificus
Virulence
Infection
Phagocytosis
ras Proteins
4 Citations (Scopus)

Coordinated delivery and function of bacterial MARTX toxin effectors

Woida, P. J. & Satchell, K. J. F., Jan 1 2018, In : Molecular Microbiology. 107, 2, p. 133-141 9 p.

Research output: Contribution to journalReview article

Virulence Factors
Secretory Pathway
Eukaryotic Cells
Infection
Cytosol
2 Citations (Scopus)

Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43

Kam, C. Y., Dubash, A. D., Magistrati, E., Polo, S., Satchell, K. J. F., Sheikh, F., Lampe, P. D. & Green, K. J., Sep 1 2018, In : Journal of Cell Biology. 217, 9, p. 3219-3235 17 p.

Research output: Contribution to journalArticle

Desmoplakins
Connexin 43
Gap Junctions
Cardiomyopathies
RNA Sequence Analysis
1 Citation (Scopus)

Draft genome sequences of two Vibrio parahaemolyticus strains associated with gastroenteritis after raw seafood ingestion in Colorado

Trinh, S. A., Leyn, S. A., Rodionov, I. D., Godzik, A. & Satchell, K. J. F., Jan 1 2018, In : Genome Announcements. 6, 3, e01387-17.

Research output: Contribution to journalArticle

Vibrio parahaemolyticus
Seafood
Gastroenteritis
Centers for Disease Control and Prevention (U.S.)
Eating

Engineered Bacteria for Cholera Prophylaxis

Satchell, K. J. F., Aug 8 2018, In : Cell Host and Microbe. 24, 2, p. 192-194 3 p.

Research output: Contribution to journalShort survey

Immunization Programs
Translational Medical Research
Cholera
Probiotics
Animal Models