If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

My research focuses on the role of secreted protein toxins on bacterial pathogenesis. The toxins we study are members of the MARTX family and are produced by Vibrio cholerae, a pathogen important for the diarrheal disease cholera, and Vibrio vulnificus, a pathogen that causes septicemia and necrotizing fasciitis from seafood consumption as well as wound infections. Our group studies the mechanism of action of these toxins using a combination of cell biology, biochemistry, and structural biology. In addition, we investigate the role of these toxins in pathogenesis using animal and tissue culture models with focus on mechanisms of tissue damage and evasion of innate immune clearance.

Training Experience

1997Postdoctoral Fellowship, University of Pittsburgh
2000Postdoctoral Fellowship, Harvard Medical School

Education/Academic qualification

PhD, University of Washington

… → 1996

Research interests

  • Bacterial Pathogenesis
  • Biochemistry: Proteins
  • Cellular Microbiology
  • Cytoskeleton
  • Global Health
  • Immunology
  • Infectious Diseases: Bacteria
  • Structural Biology

Fingerprint Dive into the research topics where Karla J. F. Satchell is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Vibrio cholerae Medicine & Life Sciences
Vibrio vulnificus Medicine & Life Sciences
Cholera Toxin Medicine & Life Sciences
Bacterial Toxins Medicine & Life Sciences
Cysteine Proteases Medicine & Life Sciences
Actins Medicine & Life Sciences
Virulence Medicine & Life Sciences
Virulence Factors Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2002 2022

vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins
vaccine development
drug resistance
life cycle (organisms)
pathogenesis
proteins

Research Output 1993 2019

Open Access
Vibrio vulnificus
Cytotoxins
Necrosis
Epithelium
Growth
1 Citation (Scopus)

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Zhu, Y., Zou, X., Dean, A. E., Brien, J. O., Gao, Y., Tran, E. L., Park, S. H., Liu, G., Kieffer, M. B., Jiang, H., Stauffer, M. E., Hart, R., Quan, S., Satchell, K. J. F., Horikoshi, N., Bonini, M. & Gius, D. R., Dec 1 2019, In : Nature communications. 10, 1, 2399.

Research output: Contribution to journalArticle

Open Access
acetylation
Acetylation
Detoxification
inorganic peroxides
lysine
1 Citation (Scopus)

RRSP and RID effector domains dominate the virulence impact of vibrio vulnificus MARTX toxin

Gavin, H. E. & Satchell, K. J. F., Feb 23 2019, In : Journal of Infectious Diseases. 219, 6, p. 889-897 9 p.

Research output: Contribution to journalArticle

Vibrio vulnificus
Virulence
Infection
Phagocytosis
ras Proteins
4-Hydroxybenzoate-3-Monooxygenase
Oxygenases
Pseudomonas putida
pseudomonas
adenines
5 Citations (Scopus)

Coordinated delivery and function of bacterial MARTX toxin effectors

Woida, P. J. & Satchell, K. J. F., Jan 1 2018, In : Molecular Microbiology. 107, 2, p. 133-141 9 p.

Research output: Contribution to journalReview article

Virulence Factors
Secretory Pathway
Eukaryotic Cells
Infection
Cytosol