Grants per year
Personal profile
Research Interests
My research focuses on the role of secreted protein toxins on bacterial pathogenesis. The toxins we study are members of the MARTX family and are produced by Vibrio cholerae, a pathogen important for the diarrheal disease cholera, and Vibrio vulnificus, a pathogen that causes septicemia and necrotizing fasciitis from seafood consumption as well as wound infections. Our group studies the mechanism of action of these toxins using a combination of cell biology, biochemistry, and structural biology. In addition, we investigate the role of these toxins in pathogenesis using animal and tissue culture models with focus on mechanisms of tissue damage and evasion of innate immune clearance.
Training Experience
| 1997 | Postdoctoral Fellowship, University of Pittsburgh |
| 2000 | Postdoctoral Fellowship, Harvard Medical School |
Education/Academic qualification
PhD, University of Washington
… → 1996
Research interests
- Bacterial Pathogenesis
- Biochemistry: Proteins
- Cellular Microbiology
- Cytoskeleton
- Global Health
- Immunology
- Infectious Diseases: Bacteria
- Structural Biology
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Grants
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Acquisition of an MD3-UP microdiffractometer for macromolecular crystallography
Anderson, S. M., Brister, K., Brunzelle, J. S., Mondragon, A., O'Halloran, T. V., Pinkett, H. W., Rosenzweig, A. C., Satchell, K. J. F. & Wawrzak, Z.
Office of the Director, National Institutes of Health
8/26/20 → 8/25/21
Project: Research project
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Acquisition of an Eiger2 X 16M pixel array detector for macromolecular crystallography
Anderson, S. M., Brister, K., Brunzelle, J. S., Mondragon, A., O'Halloran, T. V., Pinkett, H. W., Rosenzweig, A. C., Satchell, K. J. F. & Wawrzak, Z.
Office of the Director, National Institutes of Health
8/15/20 → 8/14/21
Project: Research project
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Vibrio vulnificus toxin-receptor interactions
National Institute of Allergy and Infectious Diseases
6/19/20 → 5/31/22
Project: Research project
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Subproject for Sanford Burnham
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
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Options 1,2,4
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
Research Output
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A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant
Allen, J. P., Ozer, E. A., Minasov, G., Shuvalova, L., Kiryukhina, O., Satchell, K. J. F. & Hauser, A. R., Mar 24 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 12, p. 6811-6821 11 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth
Vidimar, V., Beilhartz, G. L., Park, M., Biancucci, M., Kieffer, M. B., Gius, D. R., Melnyk, R. A. & Satchell, K. J. F., Jul 21 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 29, p. 16938-16948 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Anthrax Protective Antigen Retargeted with Single-Chain Variable Fragments Delivers Enzymes to Pancreatic Cancer Cells
Loftis, A. R., Santos, M. S., Truex, N. L., Biancucci, M., Satchell, K. J. F. & Pentelute, B. L., Oct 1 2020, In: ChemBioChem. 21, 19, p. 2772-2776 5 p.Research output: Contribution to journal › Article › peer-review
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Cellular microbiology: Bacterial toxin interference drives understanding of eukaryotic cell function
Lemichez, E., Popoff, M. R. & Satchell, K. J. F., Apr 1 2020, In: Cellular Microbiology. 22, 4, e13178.Research output: Contribution to journal › Review article › peer-review
Open Access -
Comparison of metal-bound and unbound structures of aminopeptidase B proteins from Escherichia coli and Yersinia pestis
Minasov, G., Lam, M. R., Rosas-Lemus, M., Sławek, J., Woinska, M., Shabalin, I. G., Shuvalova, L. A., Palsson, B., Godzik, A., Minor, W. & Satchell, K. J. F., Jul 1 2020, In: Protein Science. 29, 7, p. 1618-1628 11 p.Research output: Contribution to journal › Article › peer-review