Grants per year
Personal profile
Research Interests
My research focuses on the role of secreted protein toxins on bacterial pathogenesis. The toxins we study are members of the MARTX family and are produced by Vibrio cholerae, a pathogen important for the diarrheal disease cholera, and Vibrio vulnificus, a pathogen that causes septicemia and necrotizing fasciitis from seafood consumption as well as wound infections. Our group studies the mechanism of action of these toxins using a combination of cell biology, biochemistry, and structural biology. In addition, we investigate the role of these toxins in pathogenesis using animal and tissue culture models with focus on mechanisms of tissue damage and evasion of innate immune clearance.
Training Experience
| 1997 | Postdoctoral Fellowship, University of Pittsburgh |
| 2000 | Postdoctoral Fellowship, Harvard Medical School |
Education/Academic qualification
PhD, University of Washington
… → 1996
Research interests
- Bacterial Pathogenesis
- Biochemistry: Proteins
- Cellular Microbiology
- Cytoskeleton
- Global Health
- Immunology
- Infectious Diseases: Bacteria
- Structural Biology
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Grants
Support for the Lakeside Conference on Bacterial Toxins and Effectors to be held October 4-7, 2020 in Lake Geneva, WI
11/1/19 → 10/31/20
Project: Research project
Subproject for Sanford Burnham
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
Options 1,2,4
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
Subproject for Purdue University
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
Subproject for University of Texas Southwestern
National Institute of Allergy and Infectious Diseases
9/1/17 → 8/31/22
Project: Research project
Research Output
A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant
Allen, J. P., Ozer, E. A., Minasov, G., Shuvalova, L., Kiryukhina, O., Satchell, K. J. F. & Hauser, A. R., Mar 24 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 12, p. 6811-6821 11 p.Research output: Contribution to journal › Article
Cellular microbiology: Bacterial toxin interference drives understanding of eukaryotic cell function
Lemichez, E., Popoff, M. R. & Satchell, K. J. F., Apr 1 2020, In : Cellular Microbiology. 22, 4, e13178.Research output: Contribution to journal › Review article
Open Access
Direct cloning method for expression of recombinant proteins with an inositol hexakisphosphate inducible self-cleaving tag
Kwon, K., Biancucci, M., Woida, P. J. & Satchell, K. J. F., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 163-179 17 p. (Methods in Molecular Biology; vol. 2091).Research output: Chapter in Book/Report/Conference proceeding › Chapter
N-terminal autoprocessing and acetylation of multifunctional-autoprocessing repeats-in-toxins (MARTX) Makes Caterpillars Floppy-like effector is stimulated by adenosine diphosphate (ADP)-Ribosylation Factor 1 in advance of Golgi fragmentation
Herrera, A., Muroski, J., Sengupta, R., Nguyen, H. H., Agarwal, S., Ogorzalek Loo, R. R., Mattoo, S., Loo, J. A. & Satchell, K. J. F., Feb 1 2020, In : Cellular Microbiology. 22, 2, e13133.Research output: Contribution to journal › Article
Soluble angiotensin-converting enzyme 2: A potential approach for coronavirus infection therapy?
Batlle, D., Wysocki, J. & Satchell, K., Mar 1 2020, In : Clinical science. 134, 5, p. 543-545 3 p.Research output: Contribution to journal › Article
Open Access
36
Scopus
citations