Grants per year
Personal profile
Research Interests
My research focuses on the role of secreted protein toxins on bacterial pathogenesis. The toxins we study are members of the MARTX family and are produced by Vibrio cholerae, a pathogen important for the diarrheal disease cholera, and Vibrio vulnificus, a pathogen that causes septicemia and necrotizing fasciitis from seafood consumption as well as wound infections. Our group studies the mechanism of action of these toxins using a combination of cell biology, biochemistry, and structural biology. In addition, we investigate the role of these toxins in pathogenesis using animal and tissue culture models with focus on mechanisms of tissue damage and evasion of innate immune clearance.
Training Experience
| 1997 | Postdoctoral Fellowship, University of Pittsburgh |
| 2000 | Postdoctoral Fellowship, Harvard Medical School |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Microbiology, University of Washington
… → 1996
Research interests keywords
- Bacterial Pathogenesis
- Biochemistry: Proteins
- Cellular Microbiology
- Cytoskeleton
- Global Health
- Immunology
- Infectious Diseases: Bacteria
- Structural Biology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Covid Related
Satchell, K. J. (PD/PI)
National Institute of Allergy and Infectious Diseases
9/1/22 → 8/31/27
Project: Research project
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Centers for Research on Structural Biology of Infectious Diseases
Satchell, K. J. (PD/PI) & Satchell, K. J. (PD/PI)
National Institute of Allergy and Infectious Diseases
9/1/22 → 8/31/27
Project: Research project
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Option Quantities 4-5
Satchell, K. J. (PD/PI)
National Institute of Allergy and Infectious Diseases
9/1/22 → 8/31/27
Project: Research project
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Option Quantities 1-3
Satchell, K. J. (PD/PI)
National Institute of Allergy and Infectious Diseases
9/1/22 → 8/31/27
Project: Research project
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Structure-based functional annotation of microbial genomes
Satchell, K. J. (PD/PI), Satchell, K. J. (PD/PI), Minasov, G. (Other) & Minasov, G. (Other)
University of Michigan, National Institute of Allergy and Infectious Diseases
8/1/22 → 7/31/26
Project: Research project
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Structural analysis of extracellular ATP-independent chaperones of streptococcal species and protein substrate interactions
Agbavor, C., Torres, M., Inniss, N. L., Latimer, S., Minasov, G., Shuvalova, L., Wawrzak, Z., Borek, D., Otwinowski, Z., Stogios, P. J., Savchenko, A., Anderson, W. F., Satchell, K. J. F. & Cahoon, L. A., Feb 2025, In: mSphere. 10, 2Research output: Contribution to journal › Article › peer-review
Open Access -
Torsional twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains
Rosas-Lemus, M., Minasov, G., Brunzelle, J. S., Taha, T. Y., Lemak, S., Yin, S., Shuvalova, L., Rosecrans, J., Khanna, K., Seifert, H. S., Savchenko, A., Stogios, P. J., Ott, M. & Satchell, K. J. F., Mar 2025, In: Protein Science. 34, 3, e70050.Research output: Contribution to journal › Article › peer-review
Open Access -
Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays
Inniss, N. L., Rzhetskaya, M., Ling-Hu, T., Lorenzo-Redondo, R., Bachta, K. E., Satchell, K. J. F. & Hultquist, J. F., Apr 2024, In: SLAS Discovery. 29, 3, 100145.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Bactericidal effectors of the Stenotrophomonas maltophilia type IV secretion system: functional definition of the nuclease TfdA and structural determination of TfcB
Cobe, B. L., Dey, S., Minasov, G., Inniss, N., Satchell, K. J. F. & Cianciotto, N. P., Jul 2024, In: mBio. 15, 7Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Control of biofilm formation by an Agrobacterium tumefaciens pterin-binding periplasmic protein conserved among diverse Proteobacteria
Greenwich, J. L., Eagan, J. L., Feirer, N., Boswinkle, K., Minasov, G., Shuvalova, L., Inniss, N. L., Raghavaiah, J., Ghosh, A. K., Satchell, K. J. F., Allen, K. D. & Fuqua, C., Jun 1 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 25, p. 2-10 9 p., e2319903121.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations
Datasets
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Actin dimer cross-linked by V. cholerae MARTX toxin and complexed with Gelsolin-segment 1
Kudryashov, D. S. (Contributor), Oztug Durer, Z. A. (Contributor), Ytterberg, A. J. (Contributor), Sawaya, M. R. (Contributor), Pashkov, I. (Contributor), Prochazkova, K. (Contributor), Yeates, T. O. (Contributor), Ogorzalek Loo, R. R. (Contributor), Loo, J. A. (Contributor), Fullner Satchell, K. J. (Contributor) & Reisler, E. (Contributor), Protein Data Bank (PDB), Mar 25 2008
DOI: 10.2210/pdb3CJB/pdb, https://www.wwpdb.org/pdb?id=pdb_00003cjb
Dataset
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2.75 Angstrom Crystal Structure of Galactarate Dehydratase from Escherichia coli.
Rosas-Lemus, M. (Contributor), Minasov, G. (Contributor), Shuvalova, L. (Contributor), Wawrzak, Z. (Contributor), Kiryukhina, O. (Contributor), Mih, N. (Contributor), Jaroszewski, L. (Contributor), Palsson, B. (Contributor), Godzik, A. (Contributor) & Satchell, K. J. F. (Contributor), Protein Data Bank (PDB), Nov 6 2019
DOI: 10.2210/pdb6U7L/pdb, https://www.wwpdb.org/pdb?id=pdb_00006u7l
Dataset
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The structure of a sensor domain of a histidine kinase (VxrA) from Vibrio cholerae O1 biovar eltor str. N16961, 2nd form
Tan, K. (Contributor), Teschler, J. K. (Contributor), Wu, R. (Contributor), Jedrzejczak, R. P. (Contributor), Zhou, M. (Contributor), Shuvalova, L. A. (Contributor), Endres, M. J. (Contributor), Welk, L. F. (Contributor), Kwon, K. (Contributor), Anderson, W. F. (Contributor), Satchell, K. J. F. (Contributor), Yildiz, F. H. (Contributor) & Joachimiak, A. (Contributor), Protein Data Bank (PDB), Oct 14 2020
DOI: 10.2210/pdb7KB3/pdb, https://www.wwpdb.org/pdb?id=pdb_00007kb3
Dataset
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THE STRUCTURE OF A SENSOR DOMAIN OF A HISTIDINE KINASE (VxrA) FROM VIBRIO CHOLERAE O1 BIOVAR ELTOR STR. N16961, D238-T240 deletion mutant
Tan, K. (Contributor), Teschler, J. K. (Contributor), Wu, R. (Contributor), Jedrzejczak, R. P. (Contributor), Zhou, M. (Contributor), Shuvalova, L. A. (Contributor), Endres, M. J. (Contributor), Welk, L. F. (Contributor), Kwon, K. (Contributor), Anderson, W. F. (Contributor), Satchell, K. J. F. (Contributor), Yildiz, F. H. (Contributor) & Joachimiak, A. (Contributor), Protein Data Bank (PDB), Oct 14 2020
DOI: 10.2210/pdb7KB9/pdb, https://www.wwpdb.org/pdb?id=pdb_00007kb9
Dataset
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THE STRUCTURE OF A SENSOR DOMAIN OF A HISTIDINE KINASE (VxrA) FROM VIBRIO CHOLERAE O1 BIOVAR ELTOR STR. N16961, N239 deletion mutant
Tan, K. (Contributor), Teschler, J. K. (Contributor), Wu, R. (Contributor), Jedrzejczak, R. P. (Contributor), Zhou, M. (Contributor), Shuvalova, L. A. (Contributor), Endres, M. J. (Contributor), Welk, L. F. (Contributor), Kwon, K. (Contributor), Anderson, W. F. (Contributor), Satchell, K. J. F. (Contributor), Yildiz, F. H. (Contributor) & Joachimiak, A. (Contributor), Protein Data Bank (PDB), Jan 27 2021
DOI: 10.2210/pdb7LA6/pdb, https://www.wwpdb.org/pdb?id=pdb_00007la6
Dataset