Grants per year
Personal profile
Research Interests
My research focuses on the role of secreted protein toxins on bacterial pathogenesis. The toxins we study are members of the MARTX family and are produced by Vibrio cholerae, a pathogen important for the diarrheal disease cholera, and Vibrio vulnificus, a pathogen that causes septicemia and necrotizing fasciitis from seafood consumption as well as wound infections. Our group studies the mechanism of action of these toxins using a combination of cell biology, biochemistry, and structural biology. In addition, we investigate the role of these toxins in pathogenesis using animal and tissue culture models with focus on mechanisms of tissue damage and evasion of innate immune clearance.
Training Experience
| 1997 | Postdoctoral Fellowship, University of Pittsburgh |
| 2000 | Postdoctoral Fellowship, Harvard Medical School |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Microbiology, University of Washington
… → 1996
Research interests keywords
- Bacterial Pathogenesis
- Biochemistry: Proteins
- Cellular Microbiology
- Cytoskeleton
- Global Health
- Immunology
- Infectious Diseases: Bacteria
- Structural Biology
Fingerprint
Dive into the research topics where Karla J Satchell is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Support of the 29th Annual Midwest Microbial Pathogenesis Conference (MMPC)
Satchell, K. J., Seifert, H. & Yap, M. F.
3/1/23 → 12/31/23
Project: Research project
-
SP0071158 University of California-Riverside
National Institute of Allergy and Infectious Diseases
9/1/22 → 8/31/27
Project: Research project
-
SP0071158 University of Texas SW
National Institute of Allergy and Infectious Diseases
9/1/22 → 8/31/27
Project: Research project
-
SP0071158 Purdue University
National Institute of Allergy and Infectious Diseases
9/1/22 → 8/31/27
Project: Research project
-
SP0071158 University of Chicago
National Institute of Allergy and Infectious Diseases
9/1/22 → 8/31/27
Project: Research project
-
A Structural Systems Biology Approach to High-Risk CG23 Klebsiella pneumoniae
Inniss, N. L., Kochan, T. J., Minasov, G., Wawrzak, Z., Chang, C., Tan, K., Shuvalova, L., Kiryukhina, O., Pshenychnyi, S., Wu, R., Dubrovska, I., Babnigg, G., Endres, M., Anderson, W. F., Hauser, A. R., Joachimiak, A. & Satchell, K. J. F., Feb 2023, In: Microbiology Resource Announcements. 12, 2Research output: Contribution to journal › Article › peer-review
Open Access -
Actin Cross-Linking Effector Domain of the Vibrio vulnificus F-Type MARTX Toxin Dominates Disease Progression During Intestinal Infection
Woida, P. J., Kitts, G., Shee, S., Godzik, A. & Satchell, K. J. F., Apr 2022, In: Infection and immunity. 90, 4Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
A Genomic Island of Vibrio cholerae Encodes a Three- Component Cytotoxin with Monomer and Protomer Forms Structurally Similar to Alpha-Pore-Forming Toxins
Herrera, A., Kim, Y., Chen, J., Jedrzejczak, R., Shukla, S., Maltseva, N., Joachimiak, G., Welk, L., Wiersum, G., Jaroszewski, L., Godzik, A., Joachimiak, A. & Satchell, K. J. F., May 2022, In: Journal of bacteriology. 204, 5Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Assessment of Virological Contributions to COVID-19 Outcomes in a Longitudinal Cohort of Hospitalized Adults
Simons, L. M., Lorenzo-Redondo, R., Gibson, M., Kinch, S. L., Vandervaart, J. P., Reiser, N. L., Eren, M., Lux, E., McNally, E. M., Tambur, A. R., Vaughan, D. E., Bachta, K. E. R., Demonbreun, A. R., Satchell, K. J. F., Achenbach, C. J., Ozer, E. A., Ison, M. G. & Hultquist, J. F., Mar 2022, In: Open Forum Infectious Diseases. 9, 3, ofac027.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling
Woida, P. J. & Satchell, K. J. F., Feb 16 2022, In: Frontiers in Cell and Developmental Biology. 10, 837691.Research output: Contribution to journal › Review article › peer-review
Open Access
Datasets
-
Additional file 2: Table S1. of New ligation independent cloning vectors for expression of recombinant proteins with a self-cleaving CPD/6xHis-tag
Biancucci, M. (Creator), Dolores, J. S. (Contributor), Wong, J. (Creator), Grimshaw, S. (Creator), Anderson, W. F. (Creator), Satchell, K. J. (Creator) & Kwon, K. (Contributor), figshare, 2017
DOI: 10.6084/m9.figshare.c.3659012_d1.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_Table_S1_of_New_ligation_independent_cloning_vectors_for_expression_of_recombinant_proteins_with_a_self-cleaving_CPD_6xHis-tag/4523495/1
Dataset
-
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
Devkota, K. (Creator), Schapira, M. (Creator), Perveen, S. (Creator), Khalili Yazdi, A. (Creator), Li, F. (Creator), Chau, I. (Creator), Ghiabi, P. (Creator), Hajian, T. (Creator), Loppnau, P. (Creator), Bolotokova, A. (Creator), Satchell, K. J. (Creator), Wang, K. (Creator), Li, D. (Creator), Liu, J. (Creator), Smil, D. (Creator), Luo, M. (Creator), Jin, J. (Creator), Fish, P. V. (Creator), Brown, P. J. (Creator) & Vedadi, M. (Creator), SAGE Journals, 2021
DOI: 10.25384/sage.c.5495157.v1, https://sage.figshare.com/collections/Probing_the_SAM_Binding_Site_of_SARS-CoV-2_Nsp14_In_Vitro_Using_SAM_Competitive_Inhibitors_Guides_Developing_Selective_Bisubstrate_Inhibitors/5495157/1
Dataset
-
New ligation independent cloning vectors for expression of recombinant proteins with a self-cleaving CPD/6xHis-tag
Biancucci, M. (Creator), Dolores, J. S. (Contributor), Wong, J. (Creator), Grimshaw, S. (Creator), Anderson, W. F. (Creator), Satchell, K. J. (Creator) & Kwon, K. (Contributor), figshare, 2017
DOI: 10.6084/m9.figshare.c.3659012, https://figshare.com/collections/New_ligation_independent_cloning_vectors_for_expression_of_recombinant_proteins_with_a_self-cleaving_CPD_6xHis-tag/3659012
Dataset
-
New ligation independent cloning vectors for expression of recombinant proteins with a self-cleaving CPD/6xHis-tag
Biancucci, M. (Creator), Dolores, J. S. (Contributor), Wong, J. (Creator), Grimshaw, S. (Creator), Anderson, W. F. (Creator), Satchell, K. J. (Creator) & Kwon, K. (Contributor), figshare, 2017
DOI: 10.6084/m9.figshare.c.3659012.v1, https://figshare.com/collections/New_ligation_independent_cloning_vectors_for_expression_of_recombinant_proteins_with_a_self-cleaving_CPD_6xHis-tag/3659012/1
Dataset
-
Additional file 1: Figure S1. of New ligation independent cloning vectors for expression of recombinant proteins with a self-cleaving CPD/6xHis-tag
Biancucci, M. (Creator), Dolores, J. S. (Contributor), Wong, J. (Creator), Grimshaw, S. (Creator), Anderson, W. F. (Creator), Satchell, K. J. (Creator) & Kwon, K. (Contributor), figshare, 2017
DOI: 10.6084/m9.figshare.c.3659012_d2, https://figshare.com/articles/Additional_file_1_Figure_S1_of_New_ligation_independent_cloning_vectors_for_expression_of_recombinant_proteins_with_a_self-cleaving_CPD_6xHis-tag/4523513
Dataset