Grants per year
Personal profile
Education/Academic qualification
PhD, University of Chicago
… → 2006
Fingerprint Dive into the research topics where Katherine Rose Sadleir is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 11 Similar Profiles
Alzheimer Disease
Medicine & Life Sciences
Amyloid
Medicine & Life Sciences
Amyloid Plaques
Medicine & Life Sciences
Amyloid Precursor Protein Secretases
Medicine & Life Sciences
Amyloid beta-Protein Precursor
Medicine & Life Sciences
Alzheimer disease
Agriculture & Biology
Peptide Initiation Factors
Medicine & Life Sciences
Presynaptic Terminals
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2013 2024
BACE1 as a Therapeutic Target for Alzheimer's Disease
Sadleir, K. R. & Vassar, R. J.
8/1/19 → 4/30/24
Project: Research project
Alzheimer Disease
Therapeutics
Pathology
Amyloid
Knockout Mice
Interaction of the microbiome with astrocytes and amyloid pathology
Sadleir, K. R. & Vassar, R. J.
10/25/18 → 12/31/21
Project: Research project
Microbiota
Amyloid
Astrocytes
Pathology
Microglia
Structural characterization of Aβ strain variation in AD mouse models
Sadleir, K. R., Savas, J. N., Vassar, R. J., Sadleir, K. R. & Vassar, R. J.
University Of Southern California, National Institute on Aging
9/30/18 → 5/31/23
Project: Research project
Pathology
Brain
Nitrogen
Amyloid beta-Peptides
Amyloid
A test of the calcium hypothesis of Alzheimers disease
Disterhoft, J. F., Sadleir, K. R. & Vassar, R. J.
8/15/18 → 5/31/20
Project: Research project
Alzheimer Disease
Calcium
Doxycycline
Buffers
Neurites
Gene Therapy for Alzheimer’s Disease
Sadleir, K. R. & Vassar, R. J.
Harvard University, National Institute on Aging
8/15/18 → 4/30/20
Project: Research project
Dependovirus
Genetic Therapy
Alzheimer Disease
Amyloid
Pathology
Research Output 2008 2019
Modeling genetic diversity in Alzheimer’s disease
Sadleir, K. R. & Vassar, R. J., Mar 1 2019, In : Lab animal. 48, 3, p. 87-88 2 p.Research output: Contribution to journal › Comment/debate
Alzheimer disease
Alzheimer Disease
animal models
genetic variation
RPS23RG1 May Prevent Ubiquitin-Proteosomal Degradation of Postsynaptic Densities-93 and -95 to Protect Synaptic Function: Implications for Alzheimer's Disease
Sadleir, K. R. & Vassar, R. J., Aug 1 2019, In : Biological psychiatry. 86, 3, p. 164-166 3 p.Research output: Contribution to journal › Comment/debate
Post-Synaptic Density
Ubiquitin
Alzheimer Disease
Differential neurotoxicity related to tetracycline transactivator and TDP-43 expression in conditional TDP-43 mouse model of frontotemporal lobar degeneration
Kukreja, L., Shahidehpour, R., Kim, G., Keegan, J., Sadleir, K. R., Russell, T., Csernansky, J., Mesulam, M., Vassar, R. J., Wang, L., Dong, H. & Geula, C., Jul 4 2018, In : Journal of Neuroscience. 38, 27, p. 6045-6062 18 p.Research output: Contribution to journal › Article
Frontotemporal Lobar Degeneration
Trans-Activators
DNA-Binding Proteins
Tetracycline
Atrophy
1
Citation
(Scopus)
ER stress is not elevated in the 5XFAD mouse model of Alzheimer’s disease
Sadleir, K. R., Popovic, J. & Vassar, R., Jan 1 2018, In : Journal of Biological Chemistry. 293, 48, p. 18434-18443 10 p.Research output: Contribution to journal › Article
Endoplasmic Reticulum Stress
Amyloid beta-Protein Precursor
Presenilin-1
Alzheimer Disease
Unfolded Protein Response
21
Citations
(Scopus)
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease
Rocchi, A., Yamamoto, S., Ting, T., Fan, Y., Sadleir, K., Wang, Y., Zhang, W., Huang, S., Levine, B., Vassar, R. & He, C., Aug 1 2017, In : PLoS Genetics. 13, 8, e1006962.Research output: Contribution to journal › Article
autophagy
cognition
Autophagy
amyloid
Alzheimer disease