Katherine Rose Sadleir

  • 584 Citations
20082024
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Personal profile

Education/Academic qualification

PhD, University of Chicago

… → 2006

Fingerprint Dive into the research topics where Katherine Rose Sadleir is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Alzheimer Disease Medicine & Life Sciences
Amyloid Medicine & Life Sciences
Amyloid Plaques Medicine & Life Sciences
Amyloid Precursor Protein Secretases Medicine & Life Sciences
Amyloid beta-Protein Precursor Medicine & Life Sciences
Alzheimer disease Agriculture & Biology
Peptide Initiation Factors Medicine & Life Sciences
Presynaptic Terminals Medicine & Life Sciences

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Grants 2013 2024

Alzheimer Disease
Therapeutics
Pathology
Amyloid
Knockout Mice
Microbiota
Amyloid
Astrocytes
Pathology
Microglia
Alzheimer Disease
Calcium
Doxycycline
Buffers
Neurites
Dependovirus
Genetic Therapy
Alzheimer Disease
Amyloid
Pathology

Research Output 2008 2019

  • 584 Citations
  • 12 Article
  • 3 Comment/debate

Modeling genetic diversity in Alzheimer’s disease

Sadleir, K. R. & Vassar, R. J., Mar 1 2019, In : Lab animal. 48, 3, p. 87-88 2 p.

Research output: Contribution to journalComment/debate

Alzheimer disease
Alzheimer Disease
animal models
genetic variation
Post-Synaptic Density
Ubiquitin
Alzheimer Disease

Differential neurotoxicity related to tetracycline transactivator and TDP-43 expression in conditional TDP-43 mouse model of frontotemporal lobar degeneration

Kukreja, L., Shahidehpour, R., Kim, G., Keegan, J., Sadleir, K. R., Russell, T., Csernansky, J. G., Mesulam, M-M., Vassar, R. J., Wang, L., Dong, H. & Geula, C., Jul 4 2018, In : Journal of Neuroscience. 38, 27, p. 6045-6062 18 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Trans-Activators
DNA-Binding Proteins
Tetracycline
Atrophy
1 Citation (Scopus)

ER stress is not elevated in the 5XFAD mouse model of Alzheimer’s disease

Sadleir, K. R., Popovic, J. & Vassar, R. J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 48, p. 18434-18443 10 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Amyloid beta-Protein Precursor
Presenilin-1
Alzheimer Disease
Unfolded Protein Response
21 Citations (Scopus)

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Rocchi, A., Yamamoto, S., Ting, T., Fan, Y., Sadleir, K., Wang, Y., Zhang, W., Huang, S., Levine, B., Vassar, R. & He, C., Aug 1 2017, In : PLoS Genetics. 13, 8, e1006962.

Research output: Contribution to journalArticle

autophagy
cognition
Autophagy
amyloid
Alzheimer disease