Grants per year
Personal profile
Education/Academic qualification
Molecular Genetics and Cell Biology, PhD, University of Chicago
… → 2006
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Vasculo-neuronal pathophysiological interface in Alzheimer’s and Atherosclerosis
Arispe, L. (PD/PI), Vassar, R. J. (PD/PI), Cuddy, L. K. (Other) & Sadleir, K. R. (Other)
National Institute of Neurological Disorders and Stroke
9/18/24 → 8/31/27
Project: Research project
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Exploring annexin A6 for the prevention of dystrophic neurites and tau seeding and spreading in Alzheimer's disease
Sadleir, K. R. (PD/PI), Vassar, R. J. (PD/PI), Contractor, A. (Co-Investigator), Demonbreun, A. R. (Co-Investigator) & McNally, E. M. (Co-Investigator)
1/1/24 → 12/31/28
Project: Research project
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Alzheimer’s Disease Tau Consortium: The role of Aß-induced membrane damage in tau pathology
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Sadleir, K. R. (Co-PD/PI), Sadleir, K. R. (Co-PD/PI) & Sadleir, K. R. (Co-PD/PI)
Alzheimer's Disease Research Foundation
12/12/22 → 2/11/25
Project: Research project
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BACE1 as a Therapeutic Target for Alzheimer's Disease
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Sadleir, K. R. (Other), Sadleir, K. R. (Other) & Sadleir, K. R. (Other)
8/1/19 → 6/30/24
Project: Research project
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Interaction of the microbiome with astrocytes and amyloid pathology
Vassar, R. J. (PD/PI) & Sadleir, K. R. (Co-Investigator)
10/25/18 → 12/31/23
Project: Research project
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Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging
Paudel, B., Jeong, S. Y., Martinez, C. P., Rickman, A., Haluck-Kangas, A., Bartom, E. T., Fredriksen, K., Affaneh, A., Kessler, J. A., Mazzulli, J. R., Murmann, A. E., Rogalski, E., Geula, C., Ferreira, A., Heckmann, B. L., Green, D. R., Sadleir, K. R., Vassar, R. & Peter, M. E., Dec 2024, In: Nature communications. 15, 1, 264.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice
Sasmita, A. O., Depp, C., Nazarenko, T., Sun, T., Siems, S. B., Ong, E. C., Nkeh, Y. B., Böhler, C., Yu, X., Bues, B., Evangelista, L., Mao, S., Morgado, B., Wu, Z., Ruhwedel, T., Subramanian, S., Börensen, F., Overhoff, K., Spieth, L. & Berghoff, S. A. & 15 others, , Sep 2024, In: Nature neuroscience. 27, 9, p. 1668-1674 7 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Connections between ApoE, sleep, and Aβ and tau pathologies in Alzheimer's disease
Sadleir, K. R. & Vassar, R., Jul 17 2023, In: Journal of Clinical Investigation. 133, 14, e171838.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
Chandra, S., Di Meco, A., Dodiya, H. B., Popovic, J., Cuddy, L. K., Weigle, I. Q., Zhang, X., Sadleir, K., Sisodia, S. S. & Vassar, R., Dec 2023, In: Molecular neurodegeneration. 18, 1, 45.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Aberrant glial activation and synaptic defects in CaMKIIα-iCre and nestin-Cre transgenic mouse models
Alia, A. O., Jeon, S., Popovic, J., Salvo, M. A., Sadleir, K. R., Vassar, R. & Cuddy, L. K., Dec 2022, In: Scientific reports. 12, 1, 22099.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations
Datasets
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The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
Weigle, I. Q. (Creator), Dodiya, H. B. (Creator), Sadleir, K. R. (Creator), Popovic, J. (Creator), Zhang, X. (Creator), Di Meco, A. (Creator), Chandra, S. (Creator), Vassar, R. J. (Creator), Sisodia, S. S. (Creator) & Cuddy, L. K. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.6730690.v1, https://springernature.figshare.com/collections/The_gut_microbiome_regulates_astrocyte_reaction_to_A_amyloidosis_through_microglial_dependent_and_independent_mechanisms/6730690/1
Dataset
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Additional file 12 of The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
Chandra, S. (Creator), Di Meco, A. (Creator), Dodiya, H. B. (Creator), Popovic, J. (Creator), Cuddy, L. K. (Creator), Weigle, I. Q. (Creator), Zhang, X. (Creator), Sadleir, K. (Creator), Sisodia, S. S. (Creator) & Vassar, R. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.26988553.v1, https://springernature.figshare.com/articles/dataset/Additional_file_12_of_The_gut_microbiome_regulates_astrocyte_reaction_to_A_amyloidosis_through_microglial_dependent_and_independent_mechanisms/26988553/1
Dataset
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Additional file 11 of The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
Chandra, S. (Creator), Di Meco, A. (Creator), Dodiya, H. B. (Creator), Popovic, J. (Creator), Cuddy, L. K. (Creator), Weigle, I. Q. (Creator), Zhang, X. (Creator), Sadleir, K. (Creator), Sisodia, S. S. (Creator) & Vassar, R. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.26988550.v1, https://springernature.figshare.com/articles/dataset/Additional_file_11_of_The_gut_microbiome_regulates_astrocyte_reaction_to_A_amyloidosis_through_microglial_dependent_and_independent_mechanisms/26988550/1
Dataset
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Additional file 10 of The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
Chandra, S. (Creator), Di Meco, A. (Creator), Dodiya, H. B. (Creator), Popovic, J. (Creator), Cuddy, L. K. (Creator), Weigle, I. Q. (Creator), Zhang, X. (Creator), Sadleir, K. (Creator), Sisodia, S. S. (Creator) & Vassar, R. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.26988547.v1, https://springernature.figshare.com/articles/dataset/Additional_file_10_of_The_gut_microbiome_regulates_astrocyte_reaction_to_A_amyloidosis_through_microglial_dependent_and_independent_mechanisms/26988547/1
Dataset