Grants per year
Personal profile
Research Interests
intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis
Our laboratory is interested in the function and regulation of intercellular
junction molecules in desmosomes and adherens junctions that act to mediate cell-cell adhesion and attachment of the cytoskeleton to the cell surface. Defects in junctional components caused by mutation or post-translational modification result in a variety of pathologies ranging from skin and cardiac disease to cancer. In addition, junction-associated molecules are involved in non-junctional functions such as signaling in development and differentiation. The lab uses a multi-faceted approach to dissect the function of cadherins, armadillo and plakin family junction components including but not limited to collaborative atomic structure determinations, molecular genetics, live cell imaging and trangenic mouse approaches.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Cell & Developmental Biology, PhD, Washington University
… → 1982
Research interests keywords
- Cell Adhesion Mechanisms
- Cell Biology
- Cutaneous Biology
- Cytoskeleton
- Molecular Genetics
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Intercellular junctions and cell polarity
Troyanovsky, S. M., Godsel, L. M. & Green, K. J.
National Institute of General Medical Sciences
12/15/22 → 11/30/26
Project: Research project
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Function of Desmoglein 1/Pemphigus Foliaceus Antigen
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/15/22 → 7/31/27
Project: Research project
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Desmoplakin Assembly and Function in Epidermis
National Institute of Arthritis and Musculoskeletal and Skin Diseases
6/1/21 → 5/31/26
Project: Research project
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Keratinocyte contributions to inflammatory skin disease-Desmoglein 1 loss as a model
2/15/21 → 2/14/24
Project: Research project
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Meeting report - Desmosome dysfunction and disease: Alpine desmosome disease meeting
Spindler, V., Gerull, B., Green, K. J., Kowalczyk, A. P., Leube, R., Marian, A. J., Milting, H., Müller, E. J., Niessen, C., Payne, A. S., Schlegel, N., Schmidt, E., Strnad, P., Tikkanen, R., Vielmuth, F. & Waschke, J., Jan 2023, In: Journal of cell science. 136, 1, jcs260832.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells
Wang, J., Fu, Y., Huang, W., Biswas, R., Banerjee, A., Broussard, J. A., Zhao, Z., Wang, D., Bjerke, G., Raghavan, S., Yan, J., Green, K. J. & Yi, R., May 30 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, e2220635120.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Polarity signaling balances epithelial contractility and mechanical resistance
Rübsam, M., Püllen, R., Tellkamp, F., Bianco, A., Peskoller, M., Bloch, W., Green, K. J., Merkel, R., Hoffmann, B., Wickström, S. A. & Niessen, C. M., Dec 2023, In: Scientific reports. 13, 1, 7743.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Retromer Chaperones: Potential Therapeutics for Treatment of Skin Disease?
Hegazy, M. & Green, K. J., Sep 2023, In: Journal of Investigative Dermatology. 143, 9, p. 1634-1637 4 p.Research output: Contribution to journal › Comment/debate › peer-review
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Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis
Roth-Carter, Q. R., Burks, H. E., Ren, Z., Koetsier, J. L., Tsoi, L. C., Harms, P. W., Xing, X., Kirma, J., Harmon, R. M., Godsel, L. M., Perl, A. L., Gudjonsson, J. E. & Green, K. J., 2023, In: JCI Insight. 8, 16, e168955.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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1LM7 : Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Weis, W. I. (Contributor), Choi, H. (Contributor), Park-Snyder, S. (Contributor), Pascoe, L. T. (Contributor) & Green, K. J. (Contributor), RCSB-PDB, 2002
DOI: 10.2210/pdb1lm7/pdb, https://www.rcsb.org/structure/1LM7
Dataset
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1LM5 : Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Choi, H. (Contributor), Park-Snyder, S. (Contributor), Pascoe, L. T. (Contributor), Green, K. J. (Contributor) & Weis, W. I. (Contributor), RCSB-PDB, 2002
DOI: 10.2210/pdb1lm5/pdb, https://www.rcsb.org/structure/1LM5
Dataset