Kathleen Janee Green

  • 10568 Citations
1981 …2024
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Personal profile

Research Interests

intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis

Our laboratory is interested in the function and regulation of intercellular junction molecules in desmosomes and adherens junctions that act to mediate cell-cell adhesion and attachment of the cytoskeleton to the cell surface. Defects in junctional components caused by mutation or post-translational modification result in a variety of pathologies ranging from skin and cardiac disease to cancer. In addition, junction-associated molecules are involved in non-junctional functions such as signaling in development and differentiation. The lab uses a multi-faceted approach to dissect the function of cadherins, armadillo and plakin family junction components including but not limited to collaborative atomic structure determinations, molecular genetics, live cell imaging and trangenic mouse approaches.

Education/Academic qualification

PhD, Washington University

… → 1982

Keywords

  • Cell Adhesion Mechanisms
  • Cell Biology
  • Cutaneous Biology
  • Cytoskeleton
  • Molecular Genetics

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Grants 2000 2024

Desmoglein 1
Melanocytes
Keratinocytes
Melanoma
Communication
Desmoplakins
Desmosomes
Post Translational Protein Processing
Intermediate Filaments
Cardiomegaly
Desmoplakins
Rho Guanine Nucleotide Exchange Factors
Cardiac Myocytes
Desmosomes
Actins
Desmoglein 1
Morphogenesis
Epidermal Growth Factor Receptor
Epidermis
Cell Membrane

Research Output 1981 2019

1 Citation (Scopus)

Loss-of-function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype

Maruthappu, T., Posafalvi, A., Castelletti, S., Delaney, P. J., Syrris, P., O'Toole, E. A., Green, K. J., Elliott, P. M., Lambiase, P. D., Tinker, A., McKenna, W. J. & Kelsell, D. P., Jan 1 2019, (Accepted/In press) In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Desmoplakins
Cardiomyopathies
Hair
Phenotype
Skin
10 Citations (Scopus)

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective

Rübsam, M., Broussard, J. A., Wickström, S. A., Nekrasova, O., Green, K. J. & Niessen, C. M., Nov 1 2018, In : Cold Spring Harbor perspectives in biology. 10, 11

Research output: Contribution to journalReview article

Adherens Junctions
Desmosomes
Mechanics
Morphogenesis
Intercellular Junctions
2 Citations (Scopus)

Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43

Kam, C. Y., Dubash, A. D., Magistrati, E., Polo, S., Satchell, K. J. F., Sheikh, F., Lampe, P. D. & Green, K. J., Sep 1 2018, In : Journal of Cell Biology. 217, 9, p. 3219-3235 17 p.

Research output: Contribution to journalArticle

Desmoplakins
Connexin 43
Gap Junctions
Cardiomyopathies
RNA Sequence Analysis
3 Citations (Scopus)

Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination

Nekrasova, O., Harmon, R. M., Broussard, J. A., Koetsier, J. L., Godsel, L. M., Fitz, G. N., Gardel, M. L. & Green, K. J., Dec 1 2018, In : Nature communications. 9, 1, 1053.

Research output: Contribution to journalArticle

Desmosomal Cadherins
Desmoglein 1
Cortactin
Keratinocytes
Delamination
2 Citations (Scopus)

Epithelial barrier dysfunction in desmoglein-1 deficiency

Polivka, L., Hadj-Rabia, S., Bal, E., Leclerc-Mercier, S., Madrange, M., Hamel, Y., Bonnet, D., Mallet, S., Lepidi, H., Ovaert, C., Barbet, P., Dupont, C., Neven, B., Munnich, A., Godsel, L. M., Campeotto, F., Weil, R., Laplantine, E., Marchetto, S., Borg, J. P. & 6 othersWeis, W. I., Casanova, J. L., Puel, A., Green, K. J., Bodemer, C. & Smahi, A., Aug 1 2018, In : Journal of Allergy and Clinical Immunology. 142, 2, p. 702-706.e7

Research output: Contribution to journalArticle

Desmoglein 1