Grants per year
Personal profile
Research Interests
intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis
Our laboratory is interested in the function and regulation of intercellular
junction molecules in desmosomes and adherens junctions that act to mediate cell-cell adhesion and attachment of the cytoskeleton to the cell surface. Defects in junctional components caused by mutation or post-translational modification result in a variety of pathologies ranging from skin and cardiac disease to cancer. In addition, junction-associated molecules are involved in non-junctional functions such as signaling in development and differentiation. The lab uses a multi-faceted approach to dissect the function of cadherins, armadillo and plakin family junction components including but not limited to collaborative atomic structure determinations, molecular genetics, live cell imaging and trangenic mouse approaches.
Education/Academic qualification
PhD, Washington University St. Louis
… → 1982
Research interests
- Cell Adhesion Mechanisms
- Cell Biology
- Cutaneous Biology
- Cytoskeleton
- Molecular Genetics
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Grants
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Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and Melanoma
Godsel, L. M., Green, K. J. & Johnson, J. L. P.
2/1/19 → 1/31/24
Project: Research project
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AKAP-mediated desmoplakin modification: impact on cardiac desmosomes and hypertrophic signaling (19POST34370124)
1/1/19 → 12/31/20
Project: Research project
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The Robert H. Lurie Comprehensive Cancer Center
Agulnik, M., Awatramani, R., Backman, V., Benson III, A. B., Carthew, R. W., Cella, D., Chakravarti, D., Chandel, N., Crispino, J. D., Cristofanilli, M., Eklund, E. A., Frankfurt, O., Gordon, L. I., Green, K. J., Hahn, E. A., Horbinski, C. M., Horvath, C. M., Hussain, M., James, C. D., Kelleher, N. L., Khan, S. A., LaBonne, C., Larson, A. C., Matei, D. E., Meade, T. J., Mondragon, A., Mrksich, M., Munshi, H. G., Murphy, A. B., Penedo, F. J., Perlman, H. R., Peter, M. E., Platanias, L. C., Rademaker, A. W., Rappoport, J. Z., Rosenzweig, A. C., Scheidt, K. A., Simon, M. A., Sosman, J. A., Spring, B., Wei, J., Weiss, E. L., Woloschak, G. E., Obeng, R. & Hitsman, B. L.
8/10/18 → 7/31/23
Project: Research project
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Function of Desmoglein 1/Pemphigus Foliaceus Antigen
Green, K. J., Johnson, J. L. P. & Nekrasova, O.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/1/17 → 8/31/22
Project: Research project
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Carcinogenesis Training Program
Crispino, J. D. & Green, K. J.
7/1/17 → 6/30/22
Project: Research project
Research Output
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Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling
Arnette, C. R., Roth-Carter, Q. R., Koetsier, J. L., Broussard, J. A., Burks, H. E., Cheng, K., Amadi, C., Gerami, P., Johnson, J. L. & Green, K. J., Mar 1 2020, In: Pigment Cell and Melanoma Research. 33, 2, p. 305-317 13 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Proximity Ligation Assay for Detecting Protein-Protein Interactions and Protein Modifications in Cells and Tissues in Situ
Hegazy, M., Cohen-Barak, E., Koetsier, J. L., Najor, N. A., Arvanitis, C., Sprecher, E., Green, K. J. & Godsel, L. M., Dec 1 2020, In: Current Protocols in Cell Biology. 89, 1, p. e115Research output: Contribution to journal › Article › peer-review
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Scaling up single-cell mechanics to multicellular tissues - The role of the intermediate filament-desmosome network
Broussard, J. A., Jaiganesh, A., Zarkoob, H., Conway, D. E., Dunn, A. R., Espinosa, H. D., Janmey, P. A. & Green, K. J., Mar 16 2020, In: Journal of cell science. 133, 6, 228031.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
The Role of Desmoglein 1 in Gap Junction Turnover Revealed through the Study of SAM Syndrome
Cohen-Barak, E., Godsel, L. M., Koetsier, J. L., Hegazy, M., Kushnir-Grinbaum, D., Hammad, H., Danial-Farran, N., Harmon, R., Khayat, M., Bochner, R., Peled, A., Rozenblat, M., Krausz, J., Sarig, O., Johnson, J. L., Ziv, M., Shalev, S. A., Sprecher, E. & Green, K. J., Mar 2020, In: Journal of Investigative Dermatology. 140, 3, p. 556-567.e9Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Tracing the Evolutionary Origin of Desmosomes
Green, K. J., Roth-Carter, Q., Niessen, C. M. & Nichols, S. A., May 18 2020, In: Current Biology. 30, 10, p. R535-R543Research output: Contribution to journal › Short survey › peer-review
Open Access2 Scopus citations