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Kathleen Janee Green

  • 11192 Citations
1981 …2020

Research output per year

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Personal profile

Research Interests

intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis

Our laboratory is interested in the function and regulation of intercellular junction molecules in desmosomes and adherens junctions that act to mediate cell-cell adhesion and attachment of the cytoskeleton to the cell surface. Defects in junctional components caused by mutation or post-translational modification result in a variety of pathologies ranging from skin and cardiac disease to cancer. In addition, junction-associated molecules are involved in non-junctional functions such as signaling in development and differentiation. The lab uses a multi-faceted approach to dissect the function of cadherins, armadillo and plakin family junction components including but not limited to collaborative atomic structure determinations, molecular genetics, live cell imaging and trangenic mouse approaches.

Education/Academic qualification

PhD, Washington University St. Louis

… → 1982

Research interests

  • Cell Adhesion Mechanisms
  • Cell Biology
  • Cutaneous Biology
  • Cytoskeleton
  • Molecular Genetics

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Grants

Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and Melanoma

Godsel, L. M., Green, K. J. & Johnson, J. L. P.

National Cancer Institute

2/1/19 → 1/31/24

Project: Research project

    • AKAP-mediated desmoplakin modification: impact on cardiac desmosomes and hypertrophic signaling (19POST34370124)

    Green, K. J.

    American Heart Association

    1/1/19 → 12/31/20

    Project: Research project

    • The Robert H. Lurie Comprehensive Cancer Center

    Agulnik, M., Awatramani, R., Backman, V., Benson III, A. B., Carthew, R. W., Cella, D., Chakravarti, D., Chandel, N., Crispino, J. D., Cristofanilli, M., Eklund, E. A., Frankfurt, O., Gordon, L. I., Green, K. J., Hahn, E. A., Horbinski, C. M., Horvath, C. M., Hussain, M., James, C. D., Kelleher, N. L., Khan, S. A., LaBonne, C., Larson, A. C., Matei, D. E., Meade, T. J., Mondragon, A., Mrksich, M., Munshi, H. G., Murphy, A. B., Penedo, F. J., Perlman, H. R., Peter, M. E., Platanias, L. C., Rademaker, A. W., Rappoport, J. Z., Rosenzweig, A. C., Scheidt, K. A., Simon, M. A., Sosman, J. A., Spring, B., Wei, J., Weiss, E. L. & Woloschak, G. E.

    National Cancer Institute

    8/10/18 → 7/31/23

    Project: Research project

    • Cardiomyocyte Mechanotransduction through Desmoplakin/RhoGEF Ect2 Interaction

    Green, K. J.

    American Heart Association

    7/1/18 → 6/30/20

    Project: Research project

    • Function of Desmoglein 1/Pemphigus Foliaceus Antigen

    Green, K. J., Johnson, J. L. P. & Nekrasova, O.

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    9/1/17 → 8/31/22

    Project: Research project

    • Research Output

    Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling

    Arnette, C. R., Roth-Carter, Q. R., Koetsier, J. L., Broussard, J. A., Burks, H. E., Cheng, K., Amadi, C., Gerami, P., Johnson, J. L. & Green, K. J., Mar 1 2020, In : Pigment Cell and Melanoma Research. 33, 2, p. 305-317 13 p.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Scaling up single-cell mechanics to multicellular tissues - the role of the intermediate filament-desmosome network

    Broussard, J. A., Jaiganesh, A., Zarkoob, H., Conway, D. E., Dunn, A. R., Espinosa, H. D., Janmey, P. A. & Green, K. J., Mar 16 2020, In : Journal of cell science. 133, 6

    Research output: Contribution to journal › Review article

    Open Access
    • 1 Scopus citations

    The Role of Desmoglein 1 in Gap Junction Turnover Revealed through the Study of SAM Syndrome

    Cohen-Barak, E., Godsel, L. M., Koetsier, J. L., Hegazy, M., Kushnir-Grinbaum, D., Hammad, H., Danial-Farran, N., Harmon, R., Khayat, M., Bochner, R., Peled, A., Rozenblat, M., Krausz, J., Sarig, O., Johnson, J. L., Ziv, M., Shalev, S. A., Sprecher, E. & Green, K. J., Mar 2020, In : Journal of Investigative Dermatology. 140, 3, p. 556-567.e9

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Tracing the Evolutionary Origin of Desmosomes

    Green, K. J., Roth-Carter, Q., Niessen, C. M. & Nichols, S. A., May 18 2020, In : Current Biology. 30, 10, p. R535-R543

    Research output: Contribution to journal › Short survey

    Open Access

    • Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert panel report

    Elliott, P. M., Anastasakis, A., Asimaki, A., Basso, C., Bauce, B., Brooke, M. A., Calkins, H., Corrado, D., Duru, F., Green, K. J., Judge, D. P., Kelsell, D., Lambiase, P. D., McKenna, W. J., Pilichou, K., Protonotarios, A., Saffitz, J. E., Syrris, P., Tandri, H., Te Riele, A. & 3 others, Thiene, G., Tsatsopoulou, A. & van Tintelen, J. P., Jan 1 2019, In : European Journal of Heart Failure. 21, 8, p. 955-964 10 p.

    Research output: Contribution to journal › Article

    • 8 Scopus citations