Personal profile

Research Interests

intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis

Our laboratory is interested in the function and regulation of intercellular junction molecules in desmosomes and adherens junctions that act to mediate cell-cell adhesion and attachment of the cytoskeleton to the cell surface. Defects in junctional components caused by mutation or post-translational modification result in a variety of pathologies ranging from skin and cardiac disease to cancer. In addition, junction-associated molecules are involved in non-junctional functions such as signaling in development and differentiation. The lab uses a multi-faceted approach to dissect the function of cadherins, armadillo and plakin family junction components including but not limited to collaborative atomic structure determinations, molecular genetics, live cell imaging and trangenic mouse approaches.

Keywords

  • Molecular Genetics
  • Cell Adhesion Mechanisms
  • Cutaneous Biology
  • Cytoskeleton
  • Cell Biology

Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 19 Similar Profiles
Desmosomes Medicine & Life Sciences
Desmoplakins Medicine & Life Sciences
Intermediate Filaments Medicine & Life Sciences
Proteins Medicine & Life Sciences
Cadherins Medicine & Life Sciences
gamma Catenin Medicine & Life Sciences
Adhesives Medicine & Life Sciences
Desmoglein 1 Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1981 2017

Epidermolytic Ichthyosis Sine Epidermolysis

Eskin-Schwartz, M., Drozhdina, M., Sarig, O., Gat, A., Jackman, T., Isakov, O., Shomron, N., Samuelov, L., Malchin, N., Peled, A., Vodo, D., Hovnanian, A., Ruzicka, T., Koshkin, S., Harmon, R. M., Koetsier, J. L., Green, K. J., Paller, A. S. & Sprecher, E. Jan 17 2017 In : American Journal of Dermatopathology.

Research output: Contribution to journalArticle

Epidermolytic Hyperkeratosis
Mutation
Keratins
Epidermis
Histology

Intermediate filaments and the plasma membrane

Jones, J. C. R., Kam, C. Y., Harmon, R. M., Woychek, A. V., Hopkinson, S. B. & Green, K. J. Jan 1 2017 In : Cold Spring Harbor Perspectives in Biology. 9, 1, a025866

Research output: Contribution to journalArticle

Edema Disease of Swine
Aldicarb
Cell membranes
Molecules
Intermediate Filaments

SVEP1 plays a crucial role in epidermal differentiation

Samuelov, L. , Li, Q. , Bochner, R. , Najor, N. A. , Albrecht, L. , Malchin, N. , Goldsmith, T. , Grafi-Cohen, M. , Vodo, D. , Fainberg, G. , Meilik, B. , Goldberg, I. , Warshauer, E. , Rogers, T. , Edie, S. , Ishida-Yamamoto, A. , Burzenski, L. , Erez, N. , Murray, S. A. , Irvine, A. D. & 5 others Shultz, L., Green, K. J., Uitto, J., Sprecher, E. & Sarig, O. 2017 In : Experimental Dermatology.

Research output: Contribution to journalArticle

Cell adhesion
Keratinocytes
Skin
Cell Adhesion
Down-Regulation

Cadherins in cancer

Albrecht, L. V., Green, K. J. & Dubash, A. D. Jan 1 2016 The Cadherin Superfamily: Key Regulators of Animal Development and Physiology. Springer Japan, p. 363-397 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cadherins
Neoplasms
Cell Adhesion
Library Catalogs
Cell adhesion

Degrees of Freedom: Your Future in Biomedical Research

Green, K. J. & Niessen, C. M. 2016 In : Journal of Investigative Dermatology. 136, 6, p. 1073-1076 4 p.

Research output: Contribution to journalEditorial