Personal profile

Research Interests

intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis

Our laboratory is interested in the function and regulation of intercellular junction molecules in desmosomes and adherens junctions that act to mediate cell-cell adhesion and attachment of the cytoskeleton to the cell surface. Defects in junctional components caused by mutation or post-translational modification result in a variety of pathologies ranging from skin and cardiac disease to cancer. In addition, junction-associated molecules are involved in non-junctional functions such as signaling in development and differentiation. The lab uses a multi-faceted approach to dissect the function of cadherins, armadillo and plakin family junction components including but not limited to collaborative atomic structure determinations, molecular genetics, live cell imaging and trangenic mouse approaches.

Keywords

  • Molecular Genetics
  • Cell Adhesion Mechanisms
  • Cutaneous Biology
  • Cytoskeleton
  • Cell Biology

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Desmosomes Medicine & Life Sciences
Desmoplakins Medicine & Life Sciences
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Cadherins Medicine & Life Sciences
gamma Catenin Medicine & Life Sciences
Desmosomal Cadherins Medicine & Life Sciences
Intercellular Junctions Medicine & Life Sciences

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Research Output 1981 2017

A rim-and-spoke hypothesis to explain the biomechanical roles for cytoplasmic intermediate filament networks

Quinlan, R. A., Schwarz, N., Windoffer, R., Richardson, C., Hawkins, T., Broussard, J. A., Green, K. J. & Leube, R. E. 2017 In : Journal of Cell Science. 130, 20, p. 3437-3445 9 p.

Research output: Research - peer-reviewArticle

Intermediate Filaments
Keratins
Cytoskeleton
Cell Membrane
Desmosomes

Epidermal growth factor receptor neddylation is regulated by a desmosomal-COP9 (Constitutive photomorphogenesis 9) signalosome complex

Najor, N. A., Fitz, G. N., Koetsier, J. L., Godsel, L. M., Albrecht, L. V., Harmon, R. & Green, K. J. Sep 11 2017 In : eLife. 6, e22599

Research output: Research - peer-reviewArticle

Epidermal Growth Factor Receptor
COP9 signalosome complex
Desmosomes
Desmosomal Cadherins
Desmoplakins

Epidermolytic ichthyosis sine epidermolysis

Eskin-Schwartz, M., Drozhdina, M., Sarig, O., Gat, A., Jackman, T., Isakov, O., Shomron, N., Samuelov, L., Malchin, N., Peled, A., Vodo, D., Hovnanian, A., Ruzicka, T., Koshkin, S., Harmon, R. M., Koetsier, J. L., Green, K. J., Paller, A. S. & Sprecher, E. Jun 1 2017 In : American Journal of Dermatopathology. 39, 6, p. 440-444 5 p.

Research output: Research - peer-reviewArticle

Epidermolytic Hyperkeratosis
Mutation
Keratins
Epidermis
Names
2 Citations

Intermediate filaments and the plasma membrane

Jones, J. C. R., Kam, C. Y., Harmon, R. M., Woychek, A. V., Hopkinson, S. B. & Green, K. J. Jan 1 2017 In : Cold Spring Harbor Perspectives in Biology. 9, 1, a025866

Research output: Research - peer-reviewArticle

Cell membranes
Adhesion
Molecules
Intermediate Filaments
Cell Membrane
Energy Transfer
Microscopy
Research Design
Energy transfer
Microscopic examination