Grants per year
Personal profile
Research Interests
intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis
Our laboratory is interested in the function and regulation of intercellular
junction molecules in desmosomes and adherens junctions that act to mediate cell-cell adhesion and attachment of the cytoskeleton to the cell surface. Defects in junctional components caused by mutation or post-translational modification result in a variety of pathologies ranging from skin and cardiac disease to cancer. In addition, junction-associated molecules are involved in non-junctional functions such as signaling in development and differentiation. The lab uses a multi-faceted approach to dissect the function of cadherins, armadillo and plakin family junction components including but not limited to collaborative atomic structure determinations, molecular genetics, live cell imaging and trangenic mouse approaches.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Cell & Developmental Biology, PhD, Washington University
… → 1982
Research interests keywords
- Cell Adhesion Mechanisms
- Cell Biology
- Cutaneous Biology
- Cytoskeleton
- Molecular Genetics
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Collaborations and top research areas from the last five years
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Core B Subproject
Green, K. J. (Co-Investigator) & Perez White, B. E. (Co-Investigator)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
8/1/24 → 6/30/29
Project: Research project
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Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and Melanoma
Green, K. J. (PD/PI), Godsel, L. M. (Co-Investigator), Ren, Z. (Co-Investigator) & Tong, X. (Co-Investigator)
3/15/24 → 2/28/29
Project: Research project
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CCSG Senior Leadership
Platanias, L. C. (PD/PI), Abdulkadir, S. A. (Other), Cella, D. (Other), Green, K. J. (Other) & Hussain, M. (Other)
8/1/23 → 7/31/25
Project: Research project
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Intercellular junctions and cell polarity
Troyanovsky, S. M. (PD/PI), Troyanovsky, S. M. (PD/PI), Godsel, L. M. (Co-Investigator), Godsel, L. M. (Co-Investigator), Green, K. J. (Co-Investigator) & Green, K. J. (Co-Investigator)
National Institute of General Medical Sciences
12/15/22 → 11/30/26
Project: Research project
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Function of Desmoglein 1/Pemphigus Foliaceus Antigen
Green, K. J. (PD/PI), Green, K. J. (PD/PI), Godsel, L. M. (Co-Investigator) & Godsel, L. M. (Co-Investigator)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/15/22 → 7/31/27
Project: Research project
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Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis
Green, K. J., Pokorny, J. & Jarrell, B., Nov 2024, In: BioEssays. 46, 11, 2400135.Research output: Contribution to journal › Review article › peer-review
Open Access -
Desmosomes at a glance
Perl, A. L., Pokorny, J. L. & Green, K. J., 2024, In: Journal of cell science. 137, 12, jcs261899.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Pumping the Breaks on Acantholytic Skin Disorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey–Hailey, and Grover Disease
Harmon, R. M., Ayers, J. L., McCarthy, E. F., Kowalczyk, A. P., Green, K. J. & Simpson, C. L., 2024, (Accepted/In press) In: Journal of Investigative Dermatology.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Susceptibility to innate immune activation in genetically mediated myocarditis
Selgrade, D. F., Fullenkamp, D. E., Chychula, I. A., Li, B., Dellefave-Castillo, L., Dubash, A. D., Ohiri, J., Monroe, T. O., Blancard, M., Tomar, G., Holgren, C., Burridge, P. W., George, A. L., Demonbreun, A. R., Puckelwartz, M. J., George, S. A., Efimov, I. R., Green, K. J. & McNally, E. M., Jul 1 2024, In: Journal of Clinical Investigation. 134, 13, e180254.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis
Nanavati, B. N., Noordstra, I., Lwin, A. K. O., Brooks, J. W., Rae, J., Parton, R. G., Verma, S., Duszyc, K., Green, K. J. & Yap, A. S., Sep 9 2024, In: Current Biology. 34, 17, p. 4081-4090.e5Research output: Contribution to journal › Article › peer-review
2 Scopus citations
Datasets
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1LM5 : Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Choi, H.-J. (Contributor), Park-Snyder, S. (Contributor), Pascoe, L. T. (Contributor), Green, K. J. (Contributor) & Weis, W. I. (Contributor), RCSB-PDB, 2002
DOI: 10.2210/pdb1lm5/pdb, https://www.rcsb.org/structure/1LM5
Dataset
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1LM7 : Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Weis, W. I. (Contributor), Choi, H.-J. (Contributor), Park-Snyder, S. (Contributor), Pascoe, L. T. (Contributor) & Green, K. J. (Contributor), RCSB-PDB, 2002
DOI: 10.2210/pdb1lm7/pdb, https://www.rcsb.org/structure/1LM7
Dataset