Kazuo Fushimi

  • 1452 Citations
1990 …2023
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Personal profile

Education/Academic qualification

PhD, Okayama University

… → 1998

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p53 Genes Medicine & Life Sciences
Fibroblasts Medicine & Life Sciences
Cells Chemical Compounds
Alternative Splicing Medicine & Life Sciences
Cell Line Medicine & Life Sciences
RNA Precursors Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Genes Medicine & Life Sciences

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Grants 2011 2023

Dementia
RNA-Binding Protein FUS
Alzheimer Disease
Frontotemporal Lobar Degeneration
Molecular Biology
RNA-Binding Proteins
Alzheimer Disease
Tauopathies
Gene Regulatory Networks
Neurons
TDP-43 Proteinopathies
Mitochondria
Frontotemporal Dementia
Neurodegenerative Diseases
Frontotemporal Lobar Degeneration
Lung Neoplasms
Neoplasms
Animal Models
Deubiquitinating Enzymes
High-Throughput Nucleotide Sequencing

Research Output 1990 2019

  • 1452 Citations
  • 28 Article
  • 2 Chapter
  • 2 Review article
1 Citation (Scopus)

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

Wang, P., Deng, J., Dong, J., Liu, J., Bigio, E. H., Mesulam, M-M., Wang, T., Sun, L., Wang, L., Lee, A. Y. L., McGee, W. A., Chen, X., Fushimi, K., Zhu, L. & Wu, J., May 1 2019, In : PLoS genetics. 15, 5, e1007947.

Research output: Contribution to journalArticle

Open Access
TDP-43 Proteinopathies
unfolded protein response
Unfolded Protein Response
Mitochondrial Proteins
animal models
5 Citations (Scopus)

FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models

Deng, J., Wang, P., Chen, X., Cheng, H., Liu, J., Fushimi, K., Zhu, L. & Wu, J., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. E9678-E9686

Research output: Contribution to journalArticle

Unfolded Protein Response
Mitochondrial Proteins
Sarcoma
Animal Models
Adenosine Triphosphate
16 Citations (Scopus)

PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration

Chen, Y., Deng, J., Wang, P., Yang, M., Chen, X., Zhu, L., Liu, J., Lu, B., Shen, Y., Fushimi, K., Xu, Q. & Wu, J. Y., Jan 1 2016, In : Human molecular genetics. 25, 23, p. 5059-5068 10 p.

Research output: Contribution to journalArticle

Sarcoma
Amyotrophic Lateral Sclerosis
Diptera
Genes
Phenotype
44 Citations (Scopus)

FUS Interacts with HSP60 to Promote Mitochondrial Damage

Deng, J., Yang, M., Chen, Y., Chen, X., Liu, J., Sun, S., Cheng, H., Li, Y., Bigio, E. H., Mesulam, M-M., Xu, Q., Du, S., Fushimi, K., Zhu, L. & Wu, J., Jan 1 2015, In : PLoS genetics. 11, 9, e1005357.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
nuclear proteins
defect
Nuclear Proteins
chaperonins
22 Citations (Scopus)

USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration

Huang, Z., Wen, P., Kong, R., Cheng, H., Zhang, B., Quan, C., Bian, Z., Chen, M., Zhang, Z., Chen, X., Du, X., Liu, J., Zhu, L., Fushimi, K., Hua, D. & Wu, J., Apr 15 2015, In : International Journal of Cancer. 136, 8, p. 1792-1802 11 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Cell Movement
Colorectal Neoplasms
Down-Regulation
Tumor Suppressor Genes