• 2692 Citations
20052019

Research output per year

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Personal profile

Research Interests

Microbes must cope with harsh, rapidly changing environments to survive. To do this, microbes have developed sophisticated mechanisms to (a) sense the changes in the environment, and (b) respond quickly to these changes to protect itself from harm or capitalize on an opportunity. Professor Tyo's lab seeks to rewire these fundamental input/output relationships to program cells to do useful things for mankind in a paradigm called synthetic biology.

Synthetic biology offers a disruptive technology that has vast potential to impact the most important facets of our lives. The way we diagnose diseases, the drugs we use, the fuels we put in our cars, the plastic that is used in our potato chip bag - we have the opportunity to improve the sustainability of our lifestyle. And by reducing costs, we can make aspects of our lifestyle available to those who could not otherwise afford it. His lab hopes to offer technical contributions that, simply put, make the world a better place.

Education/Academic qualification

Chemical Engineering, PhD, Massachusetts Institute of Technology

… → 2008

Chemical Engineering, MS, Massachusetts Institute of Technology

… → 2003

Chemical Engineering, BS, West Virginia University

… → 2001

Research interests

  • Global health
  • Metabolic engineering
  • Synthetic biology

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Grants

  • Research Output

    Bayesian inference of metabolic kinetics from genome-scale multiomics data

    John, P. C. S., Strutz, J., Broadbelt, L. J., Tyo, K. E. J. & Bomble, Y. J., Jan 1 2019, In : PLoS computational biology. 15, 11, e1007424.

    Research output: Contribution to journalArticle

    Open Access
  • Chemically inducible chromosomal evolution (CIChE) for multicopy metabolic pathway engineering

    Love, A. M., Biggs, B. W., Tyo, K. E. J. & Ajikumar, P. K., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc, p. 37-45 9 p. (Methods in Molecular Biology; vol. 1927).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 1 Scopus citations

    Kinetic ensemble model of gas fermenting Clostridium autoethanogenum for improved ethanol production

    Greene, J., Daniell, J., Köpke, M., Broadbelt, L. & Tyo, K. E. J., Aug 15 2019, In : Biochemical Engineering Journal. 148, p. 46-56 11 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Metabolic in silico network expansions to predict and exploit enzyme promiscuity

    Jeffryes, J., Strutz, J., Henry, C. & Tyo, K. E. J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc, p. 11-21 11 p. (Methods in Molecular Biology; vol. 1927).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Metabolic kinetic modeling provides insight into complex biological questions, but hurdles remain

    Strutz, J., Martin, J., Greene, J., Broadbelt, L. & Tyo, K., Oct 2019, In : Current Opinion in Biotechnology. 59, p. 24-30 7 p.

    Research output: Contribution to journalReview article

  • 2 Scopus citations