Krishan Kumar

  • 494 Citations
20052018
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Personal profile

Research Interests

Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal malignancy with dense stromal matrix. The central focus of my research is studying the role and regulation of dense stromal matrix in tumor progression and therapy resistance in PDAC. Overall my research goals are to delineate the molecular basis of PDAC to identify novel approaches for pancreatic cancer treatment.

Education/Academic qualification

PhD, University of Rostock

… → 2004

Keywords

  • Chemotherapy
  • Chromatin
  • Molecular Genetics
  • Fibrosis
  • Epigenetics
  • Cancer Biology
  • Pancreatic Cancer
  • Metabolism

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Research Output 2005 2018

  • 494 Citations
  • 18 Article
  • 1 Chapter

Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells

Ebine, K., Kumar, K., Pham, T. N., Shields, M. A., Collier, K. A., Shang, M., DeCant, B. T., Urrutia, R., Hwang, R. F., Grimaldo, S., Principe, D. R., Grippo, P. J., Bentrem, D. J. & Munshi, H. G., Dec 1 2018, In : Scientific Reports. 8, 1, 13225.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
Interferon Regulatory Factor-1
Interferon-gamma
Adenocarcinoma
Stromal Cells
5 Citations
Collagen
Cells
Cell adhesion
Cadherins
Neoplasms

Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression

Chow, C. R., Ebine, K., Hattaway, H. Z., Kumar, K. & Munshi, H. G., Aug 30 2016, Conquering RAS: From Biology to Cancer Therapy. Elsevier Inc., p. 119-131 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreatic Neoplasms
Epithelial-Mesenchymal Transition
Neoplasm Metastasis
Neoplastic Stem Cells
Neoplasms
12 Citations

Differential regulation of ZEB1 and EMT by MAPK-interacting protein kinases (MNK) and eIF4E in pancreatic cancer

Kumar, K., Chow, C. R., Ebine, K., Arslan, A. D., Kwok, B., Bentrem, D. J., Eckerdt, F. D., Platanias, L. C. & Munshi, H. G., Feb 1 2016, In : Molecular Cancer Research. 14, 2, p. 216-227 12 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Pancreatic Neoplasms
Protein Kinases
Adenocarcinoma
Messenger RNA
1 Citations

Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasia

Ebine, K., Chow, C. R., Decant, B. T., Hattaway, H. Z., Grippo, P. J., Kumar, K. & Munshi, H. G., Jul 1 2016, In : Scientific Reports. 6, 29133.

Research output: Contribution to journalArticle

Gastropoda
Metaplasia
Pancreatic Neoplasms
Acinar Cells
Transforming Growth Factor alpha