Krishan Kumar

  • 594 Citations
20052020
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Personal profile

Research Interests

Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal malignancy with dense stromal matrix. The central focus of my research is studying the role and regulation of dense stromal matrix in tumor progression and therapy resistance in PDAC. Overall my research goals are to delineate the molecular basis of PDAC to identify novel approaches for pancreatic cancer treatment.

Education/Academic qualification

PhD, University of Rostock

… → 2004

Research interests

  • Cancer Biology
  • Chemotherapy
  • Chromatin
  • Epigenetics
  • Fibrosis
  • Metabolism
  • Molecular Genetics
  • Pancreatic Cancer

Fingerprint Dive into the research topics where Krishan Kumar is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Pancreatic Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Adenocarcinoma Medicine & Life Sciences
Epithelial-Mesenchymal Transition Medicine & Life Sciences
Collagen Medicine & Life Sciences
Genes Medicine & Life Sciences
African Americans Medicine & Life Sciences
Microsatellite Instability Medicine & Life Sciences

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Grants 2017 2020

Hyaluronic Acid
Pancreatic Neoplasms
Adenocarcinoma
Neoplasms
Hyaluronoglucosaminidase

Research Output 2005 2019

  • 594 Citations
  • 20 Article
  • 1 Chapter
1 Citation (Scopus)

Induction of MNK kinase–dependent eIF4E phosphorylation by inhibitors targeting BET proteins limits efficacy of BET inhibitors

Pham, T. N. D., Kumar, K., DeCant, B. T., Shang, M., Munshi, S. Z., Matsangou, M., Ebine, K. & Munshi, H. G., Feb 2019, In : Molecular cancer therapeutics. 18, 2, p. 235-244 10 p.

Research output: Contribution to journalArticle

Protein Transport
Phosphorylation
Neoplasms
p38 Mitogen-Activated Protein Kinases
Proteolysis

Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1

Pham, T. N. D., Stempel, S., Shields, M. A., Spaulding, C., Kumar, K., Bentrem, D. J., Matsangou, M. & Munshi, H. G., Sep 2 2019, In : International journal of molecular sciences. 20, 17

Research output: Contribution to journalArticle

Open Access
Quercetin
inhibitors
Tumors
tumors
Proteins
7 Citations (Scopus)

Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells

Ebine, K., Kumar, K., Pham, T. N., Shields, M. A., Collier, K. A., Shang, M., DeCant, B. T., Urrutia, R., Hwang, R. F., Grimaldo, S., Principe, D. R., Grippo, P. J., Bentrem, D. J. & Munshi, H. G., Dec 1 2018, In : Scientific reports. 8, 1, 13225.

Research output: Contribution to journalArticle

Pancreatic Stellate Cells
Interferon Regulatory Factor-1
Interferons
Adenocarcinoma
Stromal Cells
6 Citations (Scopus)
G12-G13 GTP-Binding Protein alpha Subunits
Collagen
Cells
Cell adhesion
Cadherins

Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression

Chow, C. R., Ebine, K., Hattaway, H. Z., Kumar, K. & Munshi, H. G., Aug 30 2016, Conquering RAS: From Biology to Cancer Therapy. Elsevier Inc, p. 119-131 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreatic Neoplasms
Epithelial-Mesenchymal Transition
Neoplasm Metastasis
Neoplastic Stem Cells
Neoplasms