Grants per year
Personal profile
Research Interests
My research interests are in the areas of healthcare epidemiology and infection prevention and control, particularly Clostridium difficile infections. I am exploring various aspects of C. difficile infection, including clinical and molecular epidemiology, diagnosis, antibiotic resistance, and host immune response. The primary aims of my K23-funded translational research are to optimize the diagnosis of C. difficile infection by validating several existing and emerging diagnostic testing strategies in children with the ultimate goal of accurately differentiating C. difficile colonization and infection. Other areas of investigation includes the use of whole genome sequencing to assess antibiotic resistance determinants and virulence factors of emerging strains of C. difficile, namely DH/NAP11/106, as well as identifying transmission and evolution of C. difficile clones in a pediatric population.
Healthcare epidemiology; infection prevention and control; Clostridium difficile; bacterial genomics
All areas of pediatric infectious diseases, with a particular interest in healthcare-associated infections, Clostridium difficile infection, and infections caused by antibiotic resistant organisms.
Training Experience
| 2010 | Residency, University of Chicago Hospitals |
| 2014 | Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
Education/Academic qualification
MSCI, Northwestern University Feinberg School of Medicine
… → 2015
MD, Saint Louis University
… → 2006
Research interests
- Bacteriology
- Epidemiology
- Genomics
- Infectious Diseases
- Microbiology
- Molecular Diagnostics
- Pediatrics
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Grants
Clostridium innocuum as an emerging multidrug-resistant antibiotic-associated diarrheal pathogen
National Institute of Allergy and Infectious Diseases
1/24/19 → 3/31/21
Project: Research project
IMPLEMENTING DIAGNOSTIC STEWARDSHIP TO REDUCE ANTIBIOTIC USE AND RESISTANCE IN CRITICALLY ILL CHILDREN
5/1/18 → 5/1/20
Project: Research project
Optimizing the diagnosis of pediatric Clostridium difficile infection
National Institute of Allergy and Infectious Diseases
2/15/16 → 1/31/21
Project: Research project
Optimizing the diagnosis of pediatric Clostridium difficile infection
National Institute of Allergy and Infectious Diseases
2/15/16 → 1/31/21
Project: Research project
Research Output
Association Between Children's Hospital Visitor Restrictions and Healthcare-Associated Viral Respiratory Infections: A Quasi-Experimental Study
Forkpa, H., Rupp, A. H., Shulman, S. T., Patel, S. J., Gray, E. L., Zheng, X., Bovee, M. & Kociolek, L. K., Apr 30 2020, In : Journal of the Pediatric Infectious Diseases Society. 9, 2, p. 240-243 4 p.Research output: Contribution to journal › Article
1
Scopus
citations
Natural Clostridioides difficile Toxin Immunization in Colonized Infants
Kociolek, L. K., Espinosa, R. O., Gerding, D. N., Hauser, A. R., Ozer, E. A., Budz, M., Balaji, A., Chen, X., Tanz, R. R., Yalcinkaya, N., Conner, M. E., Savidge, T. & Kelly, C. P., May 6 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 70, 10, p. 2095-2102 8 p.Research output: Contribution to journal › Article
3
Scopus
citations
An Infectious Diseases Perspective on Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children
Cotter, J. M., Nicholson, M. R. & Kociolek, L. K., Dec 1 2019, In : Journal of the Pediatric Infectious Diseases Society. 8, 6, p. 580-584 5 p.Research output: Contribution to journal › Article
1
Scopus
citations
Clostridioides difficile whole-genome sequencing reveals limited within-host genetic diversity in a pediatric cohort
Balaji, A., Ozer, E. A. & Kociolek, L. K., Jan 1 2019, In : Journal of Clinical Microbiology. 57, 9, e00559-19.Research output: Contribution to journal › Article
Erratum: Oral vancomycin may be associated with earlier symptom resolution than metronidazole for hospitalized children with nonsevere clostridioides difficile infections (Open Forum Infectious Diseases (2019) (ofz492) DOI: 10.1093/ofid/ofz492)
Yin, J., Kociolek, L. K., Same, R. G., Hsu, A. J., Amoah, J. & Tamma, P. D., Dec 1 2019, In : Open Forum Infectious Diseases. 7, 2, ofaa041.Research output: Contribution to journal › Comment/debate
Open Access