Larry Kenneth Kociolek

  • 209 Citations
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Personal profile

Research Interests

My research interests are in the areas of healthcare epidemiology and infection prevention and control, particularly Clostridium difficile infections. I am exploring various aspects of C. difficile infection, including clinical and molecular epidemiology, diagnosis, antibiotic resistance, and host immune response. The primary aims of my K23-funded translational research are to optimize the diagnosis of C. difficile infection by validating several existing and emerging diagnostic testing strategies in children with the ultimate goal of accurately differentiating C. difficile colonization and infection. Other areas of investigation includes the use of whole genome sequencing to assess antibiotic resistance determinants and virulence factors of emerging strains of C. difficile, namely DH/NAP11/106, as well as identifying transmission and evolution of C. difficile clones in a pediatric population.

Healthcare epidemiology; infection prevention and control; Clostridium difficile; bacterial genomics

All areas of pediatric infectious diseases, with a particular interest in healthcare-associated infections, Clostridium difficile infection, and infections caused by antibiotic resistant organisms.

Training Experience

2010Residency, University of Chicago Hospitals
2014Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital)

Education/Academic qualification

MSCI, Northwestern University Feinberg School of Medicine

… → 2015

MD, Saint Louis University

… → 2006

Research interests

  • Bacteriology
  • Epidemiology
  • Genomics
  • Infectious Diseases
  • Microbiology
  • Molecular Diagnostics
  • Pediatrics

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  • 3 Similar Profiles
Clostridium difficile Medicine & Life Sciences
Clostridium Infections Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Anti-Bacterial Agents Medicine & Life Sciences
DNA Restriction Enzymes Medicine & Life Sciences
Infection Control Medicine & Life Sciences
Infection Medicine & Life Sciences
Genome Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2012 2021

Research Output 2006 2019

  • 209 Citations
  • 39 Article
  • 4 Review article
  • 3 Comment/debate
  • 1 Chapter
1 Citation (Scopus)
Clostridium Infections
Clostridium difficile
1 Citation (Scopus)
Clostridium difficile
Clostridium Infections
Health Personnel
Communicable Diseases

Lack of false-positive results for Clostridioides difficile toxins A and B using two commercial enzyme immunoassays in pediatric patients

Balaji, A. B., Sichel, J. S. & Kociolek, L. K., Jul 1 2019, In : Infection Control and Hospital Epidemiology. 40, 7, p. 825-826 2 p.

Research output: Contribution to journalComment/debate

Immunoenzyme Techniques
3 Citations (Scopus)
Clostridium difficile
Clostridium Infections
Delivery of Health Care
Community Health Services
6 Citations (Scopus)

Comparative genomics analysis of Clostridium difficile epidemic strain DH/NAP11/106

Kociolek, L. K., Gerding, D. N., Hecht, D. W. & Ozer, E. A., Apr 1 2018, In : Microbes and Infection. 20, 4, p. 245-253 9 p.

Research output: Contribution to journalArticle

Clostridium difficile
DNA Restriction Enzymes
Clostridium Infections