Larry Kenneth Kociolek

  • 305 Citations

Research output per year

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Personal profile

Research Interests

My research interests are in the areas of healthcare epidemiology and infection prevention and control, particularly Clostridium difficile infections. I am exploring various aspects of C. difficile infection, including clinical and molecular epidemiology, diagnosis, antibiotic resistance, and host immune response. The primary aims of my K23-funded translational research are to optimize the diagnosis of C. difficile infection by validating several existing and emerging diagnostic testing strategies in children with the ultimate goal of accurately differentiating C. difficile colonization and infection. Other areas of investigation includes the use of whole genome sequencing to assess antibiotic resistance determinants and virulence factors of emerging strains of C. difficile, namely DH/NAP11/106, as well as identifying transmission and evolution of C. difficile clones in a pediatric population.

Healthcare epidemiology; infection prevention and control; Clostridium difficile; bacterial genomics

All areas of pediatric infectious diseases, with a particular interest in healthcare-associated infections, Clostridium difficile infection, and infections caused by antibiotic resistant organisms.

Training Experience

2010Residency, University of Chicago Hospitals
2014Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital)

Education/Academic qualification

MSCI, Northwestern University Feinberg School of Medicine

… → 2015

MD, Saint Louis University

… → 2006

Research interests

  • Bacteriology
  • Epidemiology
  • Genomics
  • Infectious Diseases
  • Microbiology
  • Molecular Diagnostics
  • Pediatrics

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Research Output

  • 1 Scopus citations

    Natural Clostridioides difficile Toxin Immunization in Colonized Infants

    Kociolek, L. K., Espinosa, R. O., Gerding, D. N., Hauser, A. R., Ozer, E. A., Budz, M., Balaji, A., Chen, X., Tanz, R. R., Yalcinkaya, N., Conner, M. E., Savidge, T. & Kelly, C. P., May 6 2020, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 70, 10, p. 2095-2102 8 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    An Infectious Diseases Perspective on Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children

    Cotter, J. M., Nicholson, M. R. & Kociolek, L. K., Dec 1 2019, In : Journal of the Pediatric Infectious Diseases Society. 8, 6, p. 580-584 5 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations
  • Open Access