Larry Kenneth Kociolek

  • 278 Citations
20062021

Research output per year

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Personal profile

Research Interests

My research interests are in the areas of healthcare epidemiology and infection prevention and control, particularly Clostridium difficile infections. I am exploring various aspects of C. difficile infection, including clinical and molecular epidemiology, diagnosis, antibiotic resistance, and host immune response. The primary aims of my K23-funded translational research are to optimize the diagnosis of C. difficile infection by validating several existing and emerging diagnostic testing strategies in children with the ultimate goal of accurately differentiating C. difficile colonization and infection. Other areas of investigation includes the use of whole genome sequencing to assess antibiotic resistance determinants and virulence factors of emerging strains of C. difficile, namely DH/NAP11/106, as well as identifying transmission and evolution of C. difficile clones in a pediatric population.

Healthcare epidemiology; infection prevention and control; Clostridium difficile; bacterial genomics

All areas of pediatric infectious diseases, with a particular interest in healthcare-associated infections, Clostridium difficile infection, and infections caused by antibiotic resistant organisms.

Training Experience

2010Residency, University of Chicago Hospitals
2014Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital)

Education/Academic qualification

MSCI, Northwestern University Feinberg School of Medicine

… → 2015

MD, Saint Louis University

… → 2006

Research interests

  • Bacteriology
  • Epidemiology
  • Genomics
  • Infectious Diseases
  • Microbiology
  • Molecular Diagnostics
  • Pediatrics

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Grants

Research Output

  • 278 Citations
  • 38 Article
  • 4 Review article
  • 3 Comment/debate
  • 1 Chapter

An Infectious Diseases Perspective on Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children

Cotter, J. M., Nicholson, M. R. & Kociolek, L. K., Dec 27 2019, In : Journal of the Pediatric Infectious Diseases Society. 8, 6, p. 580-584 5 p.

Research output: Contribution to journalArticle

  • 1 Scopus citations
  • Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition

    FMT Special Interest Group of the North American Society of Pediatric Gastroenterology Hepatology, Nutrition, the European Society for Pediatric Gastroenterology Hepatology, Nutrition, Jan 1 2019, In : Journal of pediatric gastroenterology and nutrition. 68, 1, p. 130-143 14 p.

    Research output: Contribution to journalArticle

  • 19 Scopus citations
  • 2 Scopus citations

    Lack of false-positive results for Clostridioides difficile toxins A and B using two commercial enzyme immunoassays in pediatric patients

    Balaji, A. B., Sichel, J. S. & Kociolek, L. K., Jul 1 2019, In : Infection Control and Hospital Epidemiology. 40, 7, p. 825-826 2 p.

    Research output: Contribution to journalComment/debate