Grants per year
Personal profile
Research Interests
My research interests are in the areas of healthcare epidemiology and infection prevention and control, particularly Clostridium difficile infections. I am exploring various aspects of C. difficile infection, including clinical and molecular epidemiology, diagnosis, antibiotic resistance, and host immune response. The primary aims of my K23-funded translational research are to optimize the diagnosis of C. difficile infection by validating several existing and emerging diagnostic testing strategies in children with the ultimate goal of accurately differentiating C. difficile colonization and infection. Other areas of investigation includes the use of whole genome sequencing to assess antibiotic resistance determinants and virulence factors of emerging strains of C. difficile, namely DH/NAP11/106, as well as identifying transmission and evolution of C. difficile clones in a pediatric population.
Healthcare epidemiology; infection prevention and control; Clostridium difficile; bacterial genomics
All areas of pediatric infectious diseases, with a particular interest in healthcare-associated infections, Clostridium difficile infection, and infections caused by antibiotic resistant organisms.
Training Experience
| 2010 | Residency, University of Chicago Hospitals |
| 2014 | Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
Education/Academic qualification
MSCI, Northwestern University Feinberg School of Medicine
… → 2015
MD, Saint Louis University
… → 2006
Research interests
- Bacteriology
- Epidemiology
- Genomics
- Infectious Diseases
- Microbiology
- Molecular Diagnostics
- Pediatrics
Fingerprint Dive into the research topics where Larry Kenneth Kociolek is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 3 Similar Profiles
Clostridium difficile
Medicine & Life Sciences
Clostridium Infections
Medicine & Life Sciences
Pediatrics
Medicine & Life Sciences
Anti-Bacterial Agents
Medicine & Life Sciences
DNA Restriction Enzymes
Medicine & Life Sciences
Infection Control
Medicine & Life Sciences
Infection
Medicine & Life Sciences
Genome
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2012 2021
Clostridium innocuum as an emerging multidrug-resistant antibiotic-associated diarrheal pathogen
Ann & Robert H. Lurie Children's Hospital of Chicago, National Institute of Allergy and Infectious Diseases
1/24/19 → 12/31/20
Project: Research project
Clostridium
Clostridium difficile
Diarrhea
Anti-Bacterial Agents
Clostridium Infections
Optimizing the diagnosis of pediatric Clostridium difficile infection
Ann & Robert H. Lurie Children's Hospital of Chicago, National Institute of Allergy and Infectious Diseases
2/1/17 → 1/31/21
Project: Research project
Clostridium Infections
Clostridium difficile
Pediatrics
Nucleic Acid Amplification Techniques
Immunoenzyme Techniques
Optimizing the diagnosis of pediatric Clostridium difficile infection
National Institute of Allergy and Infectious Diseases
2/15/16 → 1/31/21
Project: Research project
The Role of Clostridium Difficile Colonization in the Induction of Antibody Responses in Infants
The Gerber Companies Foundation
7/7/14 → 12/31/18
Project: Research project
Research Output 2006 2019
4
Citations
(Scopus)
Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition
and the FMT Special Interest Group of the North American Society of Pediatric Gastroenterology Hepatology, Nutrition, the European Society for Pediatric Gastroenterology Hepatology, Nutrition, Jan 1 2019, In : Journal of pediatric gastroenterology and nutrition. 68, 1, p. 130-143 14 p.Research output: Contribution to journal › Article
Clostridium Infections
Clostridium difficile
Gastroenterology
Joints
Pediatrics
1
Citation
(Scopus)
Healthcare provider diagnostic testing practices for identification of Clostridioides (Clostridium) difficile in children: An Emerging Infections Network survey
Kociolek, L. K., Kutty, P. K., Polgreen, P. M. & Beekmann, S. E., Mar 1 2019, In : Infection Control and Hospital Epidemiology. 40, 3, p. 276-280 5 p.Research output: Contribution to journal › Article
Clostridium difficile
Clostridium Infections
Health Personnel
Infection
Communicable Diseases
Lack of false-positive results for Clostridioides difficile toxins A and B using two commercial enzyme immunoassays in pediatric patients
Balaji, A. B., Sichel, J. S. & Kociolek, L. K., Jul 1 2019, In : Infection Control and Hospital Epidemiology. 40, 7, p. 825-826 2 p.Research output: Contribution to journal › Comment/debate
Immunoenzyme Techniques
Pediatrics
Risk factors for Clostridioides (Clostridium) difficile infection following solid organ transplantation in children
Ochfeld, E., Balmert, L. C., Patel, S. J., Muller, W. J. & Kociolek, L. K., Jan 1 2019, In : Transplant Infectious Disease. e13149.Research output: Contribution to journal › Article
Clostridium Infections
Clostridium difficile
Organ Transplantation
Transplants
Polymerase Chain Reaction
4
Citations
(Scopus)
Clostridium difficile whole genome sequencing reveals limited transmission among symptomatic children: A single-center analysis
Kociolek, L. K., Gerding, D. N., Espinosa, R. O., Patel, S. J., Shulman, S. T. & Ozer, E. A., Jul 2 2018, In : Clinical Infectious Diseases. 67, 2, p. 229-234 6 p.Research output: Contribution to journal › Article
Clostridium difficile
Clostridium Infections
Genome
Delivery of Health Care
Community Health Services