Laura Dada

  • 1932 Citations
1987 …2020

Research output per year

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Personal profile

Research Interests

The major goal of our research is to study the role of the Na,K-ATPase subunits in the regulation of alveolar epithelial function in normal and hypoxic conditions. We will shift the emphasis from the transport function of the Na,K-ATPase to its important role in stabilizing intercellular junctions and hence in alveolar epithelial integrity. Hypoxemia and injury of the alveolar-capillary barrier might result not only in a decrease in Na,K-ATPase activity but also in weakening interactions between the Na,K-ATPase ß1 subunits in neighboring cells. We will determine the molecular mechanisms regulating these ß1:ß1 interactions and design strategies to strengthen them as a way to enhance the function of the alveolar epithelial barrier. We are also interested in the role of FXYD5, which regulates cell-cell adhesion and the integrity of the alveolar epithelium by inhibiting the intercellular interaction between the Na,K-ATPase ß1 subunits of neighboring cells in a competitive mode. Given the fact that FXYD proteins are expressed and interact with the Na,K-ATPase in a tissue-specific way, understanding the molecular mechanisms of FXYD5-mediated regulation of ß1:ß1 interactions and thus alveolar epithelial barrier function may lead to novel, more effective treatment of acute lung injury.

Education/Academic qualification

PhD, Universidad de Buenos Aires

… → 1996

Research interests

  • Biochemistry: Proteins
  • Cell Adhesion Mechanisms
  • Cell Biology
  • Molecular Biology
  • Respiratory Diseases
  • Signal Transduction

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Grants

Research Output

Hypercapnia impairs Na,K-ATPase function by inducing endoplasmic reticulum retention of the β-subunit of the enzyme in alveolar epithelial cells

Kryvenko, V., Wessendorf, M., Morty, R. E., Herold, S., Seeger, W., Vagin, O., Dada, L. A., Sznajder, J. I. & Vadász, I., Feb 2 2020, In : International journal of molecular sciences. 21, 4, 1467.

Research output: Contribution to journalArticle

Open Access
  • Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection

    Brazee, P. L., Morales-Nebreda, L., Magnani, N. D., Garcia, J. G. N., Misharin, A. V., Ridge, K. M., Budinger, G. R. S., Iwai, K., Dada, L. A. & Sznajder, J. I., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1301-1314 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

    Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, Berdnikovs, S. & Sznajder, J. I., Dec 1 2019, In : Scientific reports. 9, 1, 18251.

    Research output: Contribution to journalArticle

    Open Access
  • Influenza A virus infection induces muscle wasting via IL-6 regulation of the E3 ubiquitin ligase atrogin-1

    Radigan, K. A., Nicholson, T. T., Welch, L. C., Chi, M., Amarelle, L., Angulo, M., Shigemura, M., Shigemura, A., Runyan, C. E., Morales-Nebreda, L., Perlman, H., Ceco, E., Lecuona, E., Dada, L. A., Misharin, A. V., Mutlu, G. M., Sznajder, J. I. & Scott Budinger, G. R., Jan 15 2019, In : Journal of Immunology. 202, 2, p. 484-493 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Splice wars: The role of MLCK isoforms in ventilation-induced lung injury

    Brazee, P. L. & Dada, L. A., May 1 2018, In : American journal of respiratory cell and molecular biology. 58, 5, p. 549-550 2 p.

    Research output: Contribution to journalEditorial

    1 Scopus citations