Laura Dada

  • 1858 Citations
1987 …2020
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Personal profile

Research Interests

The major goal of our research is to study the role of the Na,K-ATPase subunits in the regulation of alveolar epithelial function in normal and hypoxic conditions. We will shift the emphasis from the transport function of the Na,K-ATPase to its important role in stabilizing intercellular junctions and hence in alveolar epithelial integrity. Hypoxemia and injury of the alveolar-capillary barrier might result not only in a decrease in Na,K-ATPase activity but also in weakening interactions between the Na,K-ATPase ß1 subunits in neighboring cells. We will determine the molecular mechanisms regulating these ß1:ß1 interactions and design strategies to strengthen them as a way to enhance the function of the alveolar epithelial barrier. We are also interested in the role of FXYD5, which regulates cell-cell adhesion and the integrity of the alveolar epithelium by inhibiting the intercellular interaction between the Na,K-ATPase ß1 subunits of neighboring cells in a competitive mode. Given the fact that FXYD proteins are expressed and interact with the Na,K-ATPase in a tissue-specific way, understanding the molecular mechanisms of FXYD5-mediated regulation of ß1:ß1 interactions and thus alveolar epithelial barrier function may lead to novel, more effective treatment of acute lung injury.

Education/Academic qualification

PhD, University of Buenos Aires

… → 1996

Research interests

  • Biochemistry: Proteins
  • Cell Adhesion Mechanisms
  • Cell Biology
  • Molecular Biology
  • Respiratory Diseases
  • Signal Transduction

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  • 3 Similar Profiles
Endocytosis Medicine & Life Sciences
Alveolar Epithelial Cells Medicine & Life Sciences
Adrenocorticotropic Hormone Medicine & Life Sciences
Adenosine Triphosphatases Chemical Compounds
Lung Injury Medicine & Life Sciences
Zona Fasciculata Medicine & Life Sciences
Ubiquitination Medicine & Life Sciences
Reactive Oxygen Species Medicine & Life Sciences

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Grants 2004 2020

Research Output 1987 2019

1 Citation (Scopus)

Influenza A virus infection induces muscle wasting via IL-6 regulation of the E3 ubiquitin ligase atrogin-1

Radigan, K. A., Nicholson, T. T., Welch, L. C., Chi, M., Amarelle, L., Angulo, M., Shigemura, M., Shigemura, A., Runyan, C. E., Morales-Nebreda, L., Perlman, H. R., Ceco, E., Lecuona, E., Dada, L., Misharin, A., Mutlu, G. M., Sznajder, J. I. & Budinger, GR. S., Jan 15 2019, In : Journal of Immunology. 202, 2, p. 484-493 10 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Influenza A virus
Virus Diseases
Interleukin-6
Human Influenza
1 Citation (Scopus)

Splice wars: The role of MLCK isoforms in ventilation-induced lung injury

Brazee, P. L. & Dada, L., May 1 2018, In : American journal of respiratory cell and molecular biology. 58, 5, p. 549-550 2 p.

Research output: Contribution to journalEditorial

Myosin-Light-Chain Kinase
Calcium-Binding Proteins
Alternative Splicing
Lung Injury
Ventilation
1 Citation (Scopus)

Ubiquitin-proteasome signaling in lung injury

Magnani, N. D., Dada, L. & Sznajder, J. I., Aug 1 2018, In : Translational Research. 198, p. 29-39 11 p.

Research output: Contribution to journalReview article

Ubiquitination
Lung Injury
Proteasome Endopeptidase Complex
Ubiquitin
Proteins
6 Citations (Scopus)

Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion

Zhou, Q., Dai, J., Chen, T., Dada, L., Zhang, X., Zhang, W., DeCamp Jr, M. M., Winn, R. A., Sznajder, J. I. & Zhou, G., Oct 1 2017, In : Cellular Signalling. 38, p. 49-59 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Protein Kinase C
Down-Regulation
Lung Neoplasms
Non-Small Cell Lung Carcinoma
6 Citations (Scopus)

FXYD5 is an essential mediator of the inflammatory response during lung injury

Brazee, P. L., Soni, P. N., Tokhtaeva, E., Magnani, N., Yemelyanov, A., Perlman, H. R., Ridge, K. M., Sznajder, J. I., Vagin, O. & Dada, L., Jun 1 2017, In : Frontiers in immunology. 8, JUN, 623.

Research output: Contribution to journalArticle

Lung Injury
Lipopolysaccharides
CC Chemokines
Cytokines
Ligands