Grants per year
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Research Interests
The major goal of our research is to study the role of the Na,K-ATPase subunits in the regulation of alveolar epithelial function in normal and hypoxic conditions. We will shift the emphasis from the transport function of the Na,K-ATPase to its important role in stabilizing intercellular junctions and hence in alveolar epithelial integrity. Hypoxemia and injury of the alveolar-capillary barrier might result not only in a decrease in Na,K-ATPase activity but also in weakening interactions between the Na,K-ATPase ß1 subunits in neighboring cells. We will determine the molecular mechanisms regulating these ß1:ß1 interactions and design strategies to strengthen them as a way to enhance the function of the alveolar epithelial barrier. We are also interested in the role of FXYD5, which regulates cell-cell adhesion and the integrity of the alveolar epithelium by inhibiting the intercellular interaction between the Na,K-ATPase ß1 subunits of neighboring cells in a competitive mode. Given the fact that FXYD proteins are expressed and interact with the Na,K-ATPase in a tissue-specific way, understanding the molecular mechanisms of FXYD5-mediated regulation of ß1:ß1 interactions and thus alveolar epithelial barrier function may lead to novel, more effective treatment of acute lung injury.
Education/Academic qualification
Biochemistry, PhD, Universidad de Buenos Aires
… → 1996
Research interests keywords
- Biochemistry: Proteins
- Cell Adhesion Mechanisms
- Cell Biology
- Molecular Biology
- Respiratory Diseases
- Signal Transduction
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Collaborations and top research areas from the last five years
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Alveolar epithelial stress-induced polyploidization in lung injury and repair
Gottardi, C., Dada, L. & Misharin, A.
National Heart, Lung, and Blood Institute
5/15/22 → 4/30/26
Project: Research project
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Core C: The Cell Phenotyping and Mouse Core
Abdala-Valencia, H., Dada, L., Han, S. & Misharin, A.
National Heart, Lung, and Blood Institute
9/15/21 → 7/31/26
Project: Research project
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Project 3: Targeting linear ubiquitination to attenuate inflammation and promote repair after viral pneumonia
Dada, L., Sznajder, J. I. & Budinger, G. S.
National Heart, Lung, and Blood Institute
9/15/21 → 7/31/26
Project: Research project
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Role of the Na K ATPase Beta 1 subunit in alveolar epithelial integrity
National Heart, Lung, and Blood Institute
6/1/16 → 11/30/17
Project: Research project
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Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells
Dada, L. A., Welch, L. C., Magnani, N. D., Ren, Z., Han, H., Brazee, P. L., Celli, D., Flozak, A. S., Weng, A., Herrerias, M. M., Kryvenko, V., Vadász, I., Runyan, C. E., Abdala-Valencia, H., Shigemura, M., Casalino-Matsuda, S. M., Misharin, A. V., Budinger, G. R. S., Gottardi, C. J. & Sznajder, J. I., Feb 22 2023, In: JCI Insight. 8, 4, e159331.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Mitochondrial integrated stress response controls lung epithelial cell fate
Han, S. H., Lee, M., Shin, Y., Giovanni, R., Chakrabarty, R. P., Herrerias, M. M., Dada, L. A., Flozak, A. S., Reyfman, P. A., Khuder, B., Reczek, C. R., Gao, L., Lopéz-Barneo, J., Gottardi, C. J., Budinger, G. R. S. & Chandel, N. S., Aug 24 2023, In: Nature. 620, 7975, p. 890-897 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Lung Injury Induces Alveolar Type 2 Cell Hypertrophy and Polyploidy with Implications for Repair and Regeneration
Weng, A., Maciel Herrerias, M., Watanabe, S., Welch, L. C., Flozak, A. S., Grant, R. A., Aillon, R. P., Dada, L. A., Han, S., Hinchcliff, M. E., Misharin, A. V., Budinger, G. R. S. & Gottardi, C. J., May 2022, In: American journal of respiratory cell and molecular biology. 66, 5, p. 564-576 13 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Dysregulation of ion transport in the lung epithelium infected with SARS-CoV-2
Dada, L. A., Vagin, O. & Sznajder, J. I., Jun 2021, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 320, 6Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Maturation of the Na,K-ATPase in the Endoplasmic Reticulum in Health and Disease
Kryvenko, V., Vagin, O., Dada, L. A., Sznajder, J. I. & Vadász, I., Dec 2021, In: Journal of Membrane Biology. 254, 5-6, p. 447-457 11 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations