Grants per year
Personal profile
Research Interests
The major goal of our research is to study the role of the Na,K-ATPase subunits in the regulation of alveolar epithelial function in normal and hypoxic conditions. We will shift the emphasis from the transport function of the Na,K-ATPase to its important role in stabilizing intercellular junctions and hence in alveolar epithelial integrity. Hypoxemia and injury of the alveolar-capillary barrier might result not only in a decrease in Na,K-ATPase activity but also in weakening interactions between the Na,K-ATPase ß1 subunits in neighboring cells. We will determine the molecular mechanisms regulating these ß1:ß1 interactions and design strategies to strengthen them as a way to enhance the function of the alveolar epithelial barrier. We are also interested in the role of FXYD5, which regulates cell-cell adhesion and the integrity of the alveolar epithelium by inhibiting the intercellular interaction between the Na,K-ATPase ß1 subunits of neighboring cells in a competitive mode. Given the fact that FXYD proteins are expressed and interact with the Na,K-ATPase in a tissue-specific way, understanding the molecular mechanisms of FXYD5-mediated regulation of ß1:ß1 interactions and thus alveolar epithelial barrier function may lead to novel, more effective treatment of acute lung injury.
Education/Academic qualification
PhD, Universidad de Buenos Aires
… → 1996
Research interests
- Biochemistry: Proteins
- Cell Adhesion Mechanisms
- Cell Biology
- Molecular Biology
- Respiratory Diseases
- Signal Transduction
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Grants
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Project 1 - Role of LUBAC and Na K-ATPase in Acute Lung Injury
Dada, L., Lecuona, E., Sznajder, J. I. & Sznajder, J. I.
National Heart, Lung, and Blood Institute
9/1/15 → 6/30/21
Project: Research project
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Pathophysiology of Acute Lung Injury
Budinger, G. S., Chandel, N., Dada, L., Goldman, R., Horvath, C. M., Lecuona, E., Perlman, H. R., Ridge, K. M., Stehlik, C., Sznajder, J. I. & Wunderink, R. G.
National Heart, Lung, and Blood Institute
9/1/15 → 6/30/21
Project: Research project
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Role of the Na K ATPase Beta 1 subunit in alveolar epithelial integrity
National Heart, Lung, and Blood Institute
6/1/16 → 11/30/17
Project: Research project
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Role and Regulation of Sodium, Potasium ATPase in Lung
Dada, L., Gelfand, V. I., Lecuona, E. & Sznajder, J. I.
National Heart, Lung, and Blood Institute
4/1/16 → 3/31/19
Project: Research project
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The deleterious effects of hypercapnia on the lungs
Dada, L., Lecuona, E. & Sznajder, J. I.
National Heart, Lung, and Blood Institute
12/1/14 → 6/30/19
Project: Research project
Research Output
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Hypercapnia impairs Na,K-ATPase function by inducing endoplasmic reticulum retention of the β-subunit of the enzyme in alveolar epithelial cells
Kryvenko, V., Wessendorf, M., Morty, R. E., Herold, S., Seeger, W., Vagin, O., Dada, L. A., Sznajder, J. I. & Vadász, I., Feb 2 2020, In: International journal of molecular sciences. 21, 4, 1467.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection
Brazee, P. L., Morales-Nebreda, L., Magnani, N. D., Garcia, J. G. N., Misharin, A. V., Ridge, K. M., Budinger, G. R. S., Iwai, K., Dada, L. A. & Sznajder, J. I., Mar 2 2020, In: Journal of Clinical Investigation. 130, 3, p. 1301-1314 14 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans
Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, , Dec 1 2019, In: Scientific reports. 9, 1, 18251.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Influenza A virus infection induces muscle wasting via IL-6 regulation of the E3 ubiquitin ligase atrogin-1
Radigan, K. A., Nicholson, T. T., Welch, L. C., Chi, M., Amarelle, L., Angulo, M., Shigemura, M., Shigemura, A., Runyan, C. E., Morales-Nebreda, L., Perlman, H., Ceco, E., Lecuona, E., Dada, L. A., Misharin, A. V., Mutlu, G. M., Sznajder, J. I. & Scott Budinger, G. R., Jan 15 2019, In: Journal of Immunology. 202, 2, p. 484-493 10 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Splice wars: The role of MLCK isoforms in ventilation-induced lung injury
Brazee, P. L. & Dada, L. A., May 1 2018, In: American journal of respiratory cell and molecular biology. 58, 5, p. 549-550 2 p.Research output: Contribution to journal › Editorial › peer-review
1 Scopus citations