Grants per year
Personal profile
Research Interests
In the Lackner Lab, we study how mitochondria are positioned in cells. Central to mitochondrial positioning are molecular tethers, which function to anchor mitochondria to specific cellular sites. While tethering of mitochondria is observed in cells from yeast to neurons, very little is known about this positioning mechanism. Using multidisciplinary biochemical, cytological, and genetic approaches, we are working to elucidate the molecular mechanism, regulation, and physiological significance of mitochondrial tethering.
Education/Academic qualification
PhD, Case Western Reserve University
… → 2005
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- 9 Similar Profiles
Mitochondria
Medicine & Life Sciences
Mitochondrial Dynamics
Medicine & Life Sciences
Dynamins
Medicine & Life Sciences
Organelles
Medicine & Life Sciences
Membranes
Medicine & Life Sciences
Dyneins
Medicine & Life Sciences
Proteins
Medicine & Life Sciences
Yeasts
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2011 2022
Investigating the regulation and functions of a mitochondrial membrane contact site
1/1/19 → 12/31/20
Project: Research project
Mitochondrial Membranes
Organelles
5'-N-methylcarboxamideadenosine
Homeostasis
Microfluidics
Saccharomyces Cerevisiae
Expertise
Microscopy
Investigating the molecular mechanism of mitochondrial tethering
National Institute of General Medical Sciences
4/1/17 → 2/28/22
Project: Research project
Mitochondria
Homeostasis
Yeasts
Mitochondrial Dynamics
Organized Financing
Equipment Supplement for Investigating the molecular mechanism of mitochondrial tethering
National Institute of General Medical Sciences
4/1/17 → 2/28/22
Project: Research project
Mitochondria
Equipment and Supplies
Homeostasis
Yeasts
Mitochondrial Dynamics
Services for Principles of organelle copy number homeostasis
Gordon E. and Betty I. Moore Foundation
8/18/17 → 4/30/19
Project: Research project
Homeostasis
Microfluidics
Saccharomyces Cerevisiae
Expertise
Microscopy
Research Output 2002 2019
3
Citations
(Scopus)
A conserved mechanism for mitochondria-dependent dynein anchoring
Kraft, L. M. & Lackner, L. L., Jan 1 2019, In : Molecular biology of the cell. 30, 5, p. 691-702 12 p.Research output: Contribution to journal › Article
Open Access
Dyneins
Mitochondria
Schizosaccharomyces
Saccharomyces cerevisiae
Cell Membrane
8
Citations
(Scopus)
Coming together to define membrane contact sites
Scorrano, L., De Matteis, M. A., Emr, S., Giordano, F., Hajnóczky, G., Kornmann, B., Lackner, L. L., Levine, T. P., Pellegrini, L., Reinisch, K., Rizzuto, R., Simmen, T., Stenmark, H., Ungermann, C. & Schuldiner, M., Dec 1 2019, In : Nature communications. 10, 1, 1287.Research output: Contribution to journal › Article
Open Access
organelles
Organelles
streamlining
communication
Cytology
3
Citations
(Scopus)
The Expanding and Unexpected Functions of Mitochondria Contact Sites
Lackner, L. L., Jul 1 2019, In : Trends in Cell Biology. 29, 7, p. 580-590 11 p.Research output: Contribution to journal › Review article
Mitochondria
Organelles
3
Citations
(Scopus)
Aberrant Drp1-mediated mitochondrial division presents in humans with variable outcomes
Whitley, B. N., Lam, C., Cui, H., Haude, K., Bai, R., Escobar, L., Hamilton, A., Brady, L., Tarnopolsky, M. A., Dengle, L., Picker, J., Lincoln, S., Lackner, L. L., Glass, I. A. & Hoppins, S., Jan 1 2018, In : Human molecular genetics. 27, 21, p. 3710-3719 10 p.Research output: Contribution to journal › Article
Dynamins
Mitochondrial Dynamics
Proteins
Organelles
Mutation
2
Citations
(Scopus)
Direct membrane binding and self-interaction contribute to Mmr1 function in mitochondrial inheritance
Chen, W. T., Ping, H. A. & Lackner, L. L., Sep 15 2018, In : Molecular biology of the cell. 29, 19, p. 2346-2357 12 p.Research output: Contribution to journal › Article
Mitochondrial Genes
Mitochondria
Membranes
Phospholipids
Liposomes