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Laura Lynn Lackner

  • 3225 Citations
20022020

Research output per year

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Personal profile

Research Interests

In the Lackner Lab, we study how mitochondria are positioned in cells. Central to mitochondrial positioning are molecular tethers, which function to anchor mitochondria to specific cellular sites. While tethering of mitochondria is observed in cells from yeast to neurons, very little is known about this positioning mechanism. Using multidisciplinary biochemical, cytological, and genetic approaches, we are working to elucidate the molecular mechanism, regulation, and physiological significance of mitochondrial tethering.

Education/Academic qualification

PhD, Case Western Reserve University

… → 2005

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Grants

Investigating the regulation and functions of a mitochondrial membrane contact site

Lackner, L. L.

American Heart Association

1/1/19 → 12/31/20

Project: Research project

    • Principles of organelle copy number homeostasis

    Lackner, L. L.

    Research Corporation

    11/1/18 → 10/31/20

    Project: Research project

    • Equipment Supplement for Investigating the molecular mechanism of mitochondrial tethering

    Lackner, L. L.

    National Institute of General Medical Sciences

    4/1/17 → 2/28/22

    Project: Research project

    • Investigating the molecular mechanism of mitochondrial tethering

    Lackner, L. L.

    National Institute of General Medical Sciences

    4/1/17 → 2/28/22

    Project: Research project

    • Principles of organelle copy number homeostasis

    Lackner, L. L.

    Gordon E. and Betty I. Moore Foundation

    8/18/17 → 4/30/19

    Project: Research project

    • Research Output

    • 3225 Citations
    • 24 Article
    • 5 Review article
    • 2 Chapter
    • 1 Short survey

    Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology

    Abrisch, R. G., Gumbin, S. C., Wisniewski, B. T., Lackner, L. L. & Voeltz, G. K., Apr 6 2020, In : The Journal of cell biology. 219, 4

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    The multifunctional nature of mitochondrial contact site proteins

    Harper, C. S., White, A. J. & Lackner, L. L., Aug 2020, In : Current Opinion in Cell Biology. 65, p. 58-65 8 p.

    Research output: Contribution to journal › Review article

    • 1 Scopus citations

    A conserved mechanism for mitochondria-dependent dynein anchoring

    Kraft, L. M. & Lackner, L. L., 2019, In : Molecular biology of the cell. 30, 5, p. 691-702 12 p.

    Research output: Contribution to journal › Article

    Open Access
    • 6 Scopus citations

    Coming together to define membrane contact sites

    Scorrano, L., De Matteis, M. A., Emr, S., Giordano, F., Hajnóczky, G., Kornmann, B., Lackner, L. L., Levine, T. P., Pellegrini, L., Reinisch, K., Rizzuto, R., Simmen, T., Stenmark, H., Ungermann, C. & Schuldiner, M., Dec 1 2019, In : Nature communications. 10, 1, 1287.

    Research output: Contribution to journal › Article

    Open Access
    • 54 Scopus citations

    In vitro and in vivo assays for mitochondrial fission and fusion

    Hoppins, S., Lackner, L. L., Lee, J. E. & Mears, J. A., Jan 1 2019, (Accepted/In press) Methods in Cell Biology. Academic Press Inc, (Methods in Cell Biology).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter