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Personal profile

Research Interests

In the Lackner Lab, we study how mitochondria are positioned in cells. Central to mitochondrial positioning are molecular tethers, which function to anchor mitochondria to specific cellular sites. While tethering of mitochondria is observed in cells from yeast to neurons, very little is known about this positioning mechanism. Using multidisciplinary biochemical, cytological, and genetic approaches, we are working to elucidate the molecular mechanism, regulation, and physiological significance of mitochondrial tethering.

Education/Academic qualification

PhD, Case Western Reserve University

… → 2005

Fingerprint Dive into the research topics where Laura Lynn Lackner is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 9 Similar Profiles
Mitochondria Medicine & Life Sciences
Mitochondrial Dynamics Medicine & Life Sciences
Dynamins Medicine & Life Sciences
Organelles Medicine & Life Sciences
Membranes Medicine & Life Sciences
Dyneins Medicine & Life Sciences
Proteins Medicine & Life Sciences
Yeasts Medicine & Life Sciences

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Grants 2011 2022

Mitochondrial Membranes
Organelles
5'-N-methylcarboxamideadenosine
Homeostasis
Microfluidics
Saccharomyces Cerevisiae
Expertise
Microscopy
Mitochondria
Homeostasis
Yeasts
Mitochondrial Dynamics
Organized Financing
Mitochondria
Equipment and Supplies
Homeostasis
Yeasts
Mitochondrial Dynamics
Homeostasis
Microfluidics
Saccharomyces Cerevisiae
Expertise
Microscopy

Research Output 2002 2019

  • 2834 Citations
  • 23 Article
  • 4 Review article
  • 1 Chapter
  • 1 Short survey
3 Citations (Scopus)

A conserved mechanism for mitochondria-dependent dynein anchoring

Kraft, L. M. & Lackner, L. L., Jan 1 2019, In : Molecular biology of the cell. 30, 5, p. 691-702 12 p.

Research output: Contribution to journalArticle

Open Access
Dyneins
Mitochondria
Schizosaccharomyces
Saccharomyces cerevisiae
Cell Membrane
8 Citations (Scopus)

Coming together to define membrane contact sites

Scorrano, L., De Matteis, M. A., Emr, S., Giordano, F., Hajnóczky, G., Kornmann, B., Lackner, L. L., Levine, T. P., Pellegrini, L., Reinisch, K., Rizzuto, R., Simmen, T., Stenmark, H., Ungermann, C. & Schuldiner, M., Dec 1 2019, In : Nature communications. 10, 1, 1287.

Research output: Contribution to journalArticle

Open Access
organelles
Organelles
streamlining
communication
Cytology
3 Citations (Scopus)

The Expanding and Unexpected Functions of Mitochondria Contact Sites

Lackner, L. L., Jul 1 2019, In : Trends in Cell Biology. 29, 7, p. 580-590 11 p.

Research output: Contribution to journalReview article

Mitochondria
Organelles
3 Citations (Scopus)

Aberrant Drp1-mediated mitochondrial division presents in humans with variable outcomes

Whitley, B. N., Lam, C., Cui, H., Haude, K., Bai, R., Escobar, L., Hamilton, A., Brady, L., Tarnopolsky, M. A., Dengle, L., Picker, J., Lincoln, S., Lackner, L. L., Glass, I. A. & Hoppins, S., Jan 1 2018, In : Human molecular genetics. 27, 21, p. 3710-3719 10 p.

Research output: Contribution to journalArticle

Dynamins
Mitochondrial Dynamics
Proteins
Organelles
Mutation
2 Citations (Scopus)

Direct membrane binding and self-interaction contribute to Mmr1 function in mitochondrial inheritance

Chen, W. T., Ping, H. A. & Lackner, L. L., Sep 15 2018, In : Molecular biology of the cell. 29, 19, p. 2346-2357 12 p.

Research output: Contribution to journalArticle

Mitochondrial Genes
Mitochondria
Membranes
Phospholipids
Liposomes