Grants per year
Personal profile
Research Interests
In the Lackner Lab, we study how mitochondria are positioned in cells. Central to mitochondrial positioning are molecular tethers, which function to anchor mitochondria to specific cellular sites. While tethering of mitochondria is observed in cells from yeast to neurons, very little is known about this positioning mechanism. Using multidisciplinary biochemical, cytological, and genetic approaches, we are working to elucidate the molecular mechanism, regulation, and physiological significance of mitochondrial tethering.
Education/Academic qualification
PhD, Case Western Reserve University
… → 2005
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Collaborations and top research areas from the last five years
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Investigating the role of PI4P and membrane contact sites in mitochondrial dynamics
Lackner, L. L. (PD/PI)
1/1/25 → 12/31/26
Project: Research project
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Interdisciplinary investigation of functional asymmetry and topological restructuring in mitochondrial networks during cellular aging
Lackner, L. L. (PD/PI)
9/20/24 → 8/31/25
Project: Research project
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Equipment Supplement - Investigating the molecular mechanism and function of mitochondrial tethering
Lackner, L. L. (PD/PI)
National Institute of General Medical Sciences
3/1/22 → 2/28/26
Project: Research project
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Investigating the molecular mechanism and function of mitochondrial tethering
Lackner, L. L. (PD/PI) & Lackner, L. L. (PD/PI)
National Institute of General Medical Sciences
3/1/22 → 2/28/26
Project: Research project
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Biotechnology Predoctoral Training Program
Leonard, J. N. (PD/PI), Leonard, J. N. (PD/PI), Leonard, J. N. (PD/PI), Lackner, L. L. (Co-PD/PI), Lackner, L. L. (Co-PD/PI) & Lackner, L. L. (Co-PD/PI)
National Institute of General Medical Sciences
7/1/19 → 9/30/24
Project: Research project
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Mitochondria–ER–PM contacts regulate mitochondrial division and PI(4)P distribution
Casler, J. C., Harper, C. S., White, A. J., Anderson, H. L. & Lackner, L. L., Sep 2 2024, In: Journal of Cell Biology. 223, 9, e202308144.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Significantly reduced, but balanced, rates of mitochondrial fission and fusion are sufficient to maintain the integrity of yeast mitochondrial DNA
Wisniewski, B. T., Casler, J. C. & Lackner, L. L., Dec 1 2024, In: Molecular biology of the cell. 35, 12, p. br25Research output: Contribution to journal › Article › peer-review
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Temporal control of contact site formation reveals a relationship between mitochondrial division and Num1-mediated mitochondrial tethering
Harper, C. S., Casler, J. C. & Lackner, L. L., Oct 1 2023, In: Molecular biology of the cell. 34, 11, p. ar108Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Hierarchical integration of mitochondrial and nuclear positioning pathways by the Num1 EF hand
Anderson, H. L., Casler, J. C. & Lackner, L. L., Feb 1 2022, In: Molecular biology of the cell. 33, 2, ar20.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Loss of Num1-mediated cortical dynein anchoring negatively impacts respiratory growth
White, A. J., Harper, C. S., Rosario, E. M., Dietz, J. V., Addis, H. G., Fox, J. L., Khalimonchuk, O. & Lackner, L. L., Nov 2022, In: Journal of cell science. 135, 21, jcs259980.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations