Grants per year
Personal profile
Research Interests
In the Lackner Lab, we study how mitochondria are positioned in cells. Central to mitochondrial positioning are molecular tethers, which function to anchor mitochondria to specific cellular sites. While tethering of mitochondria is observed in cells from yeast to neurons, very little is known about this positioning mechanism. Using multidisciplinary biochemical, cytological, and genetic approaches, we are working to elucidate the molecular mechanism, regulation, and physiological significance of mitochondrial tethering.
Education/Academic qualification
PhD, Case Western Reserve University
… → 2005
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Investigating the molecular mechanism and function of mitochondrial tethering
National Institute of General Medical Sciences
3/1/22 → 2/28/26
Project: Research project
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Biotechnology Predoctoral Training Program
Leonard, J. N. & Lackner, L. L.
National Institute of General Medical Sciences
7/1/19 → 6/30/24
Project: Research project
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Investigating the molecular mechanism of mitochondrial tethering
National Institute of General Medical Sciences
4/1/17 → 2/28/23
Project: Research project
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Equipment Supplement for Investigating the molecular mechanism of mitochondrial tethering
National Institute of General Medical Sciences
4/1/17 → 2/28/23
Project: Research project
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Investigating the regulation and functions of a mitochondrial membrane contact site
1/1/19 → 12/31/20
Project: Research project
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Hierarchical integration of mitochondrial and nuclear positioning pathways by the Num1 EF hand
Anderson, H. L., Casler, J. C. & Lackner, L. L., Feb 1 2022, In: Molecular biology of the cell. 33, 2, p. ar20Research output: Contribution to journal › Article › peer-review
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Cnm1: A bridge between mitochondria and nuclear ER
Casler, J. C. & Lackner, L. L., Nov 1 2021, In: Journal of Cell Biology. 220, 11, e202109021.Research output: Contribution to journal › Article › peer-review
Open Access -
Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology
Abrisch, R. G., Gumbin, S. C., Wisniewski, B. T., Lackner, L. L. & Voeltz, G. K., 2020, In: Journal of Cell Biology. 219, 4, e201911122.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
In vitro and in vivo assays for mitochondrial fission and fusion
Hoppins, S., Lackner, L. L., Lee, J. E. & Mears, J. A., 2020, Mitochondria, 3rd Edition. Pon, L. A. & Schon, E. A. (eds.). Academic Press Inc, p. 491-518 28 p. (Methods in Cell Biology; vol. 155).Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Scopus citations -
The multifunctional nature of mitochondrial contact site proteins
Harper, C. S., White, A. J. & Lackner, L. L., Aug 2020, In: Current Opinion in Cell Biology. 65, p. 58-65 8 p.Research output: Contribution to journal › Review article › peer-review
6 Scopus citations