Laura Lynn Lackner

Associate Professor, Molecular Biosciences
Interdisciplinary Biological Sciences PhD Program

EmailLaura.Lackner@northwestern.edu

Source: Scopus

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Personal profile

Research Interests

In the Lackner Lab, we study how mitochondria are positioned in cells. Central to mitochondrial positioning are molecular tethers, which function to anchor mitochondria to specific cellular sites. While tethering of mitochondria is observed in cells from yeast to neurons, very little is known about this positioning mechanism. Using multidisciplinary biochemical, cytological, and genetic approaches, we are working to elucidate the molecular mechanism, regulation, and physiological significance of mitochondrial tethering.

Education/Academic qualification

PhD, Case Western Reserve University

… → 2005

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2 Active
5 Finished

Equipment Supplement for Investigating the molecular mechanism of mitochondrial tethering
Lackner, L. L.
National Institute of General Medical Sciences
4/1/17 → 2/28/22
Project: Research project
Investigating the molecular mechanism of mitochondrial tethering
Lackner, L. L.
National Institute of General Medical Sciences
4/1/17 → 2/28/22
Project: Research project
Investigating the regulation and functions of a mitochondrial membrane contact site
Lackner, L. L.
American Heart Association
1/1/19 → 12/31/20
Project: Research project
Principles of organelle copy number homeostasis
Lackner, L. L.
Research Corporation
11/1/18 → 10/31/20
Project: Research project
Services for Principles of organelle copy number homeostasis
Lackner, L. L.
Gordon E. and Betty I. Moore Foundation
8/18/17 → 4/30/19
Project: Research project

3595 Citations
24 Article
5 Review article
2 Chapter
1 Short survey

Fission and fusion machineries converge at ER contact sites to regulate mitochondrial morphology
Abrisch, R. G., Gumbin, S. C., Wisniewski, B. T., Lackner, L. L. & Voeltz, G. K., 2020, In: Journal of Cell Biology. 219, 4, e201911122.
Research output: Contribution to journal › Article › peer-review

Open Access
25 Scopus citations
In vitro and in vivo assays for mitochondrial fission and fusion
Hoppins, S., Lackner, L. L., Lee, J. E. & Mears, J. A., 2020, Methods in Cell Biology. Pon, L. A. & Schon, E. A. (eds.). Academic Press Inc, p. 491-518 28 p. (Methods in Cell Biology; vol. 155).
Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations
The multifunctional nature of mitochondrial contact site proteins
Harper, C. S., White, A. J. & Lackner, L. L., Aug 2020, In: Current Opinion in Cell Biology. 65, p. 58-65 8 p.
Research output: Contribution to journal › Review article › peer-review
3 Scopus citations
A conserved mechanism for mitochondria-dependent dynein anchoring
Kraft, L. M. & Lackner, L. L., 2019, In: Molecular biology of the cell. 30, 5, p. 691-702 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
7 Scopus citations
Coming together to define membrane contact sites
Scorrano, L., De Matteis, M. A., Emr, S., Giordano, F., Hajnóczky, G., Kornmann, B., Lackner, L. L., Levine, T. P., Pellegrini, L., Reinisch, K., Rizzuto, R., Simmen, T., Stenmark, H., Ungermann, C. & Schuldiner, M., Dec 1 2019, In: Nature communications. 10, 1, 1287.
Research output: Contribution to journal › Article › peer-review

Open Access
102 Scopus citations