Lauren M Pachman

  • 7425 Citations
1967 …2019
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Personal profile

Research Interests

Dr. Pachman's translational team studies Juvenile Myositis (JM), an often chronic pediatric systemic vasculopathy associated with skin inflammation and proximal muscle weakness of unknown etiology. Her laboratory has identified genetic, immunologic and environmental factors that play a role in the onset of symptoms and govern outcome. RNASeq, miRNA and Gene expression micro array studies of untreated children's diagnostic muscle biopsies identified massive dysregulation of IFN-a induced genes in JDM. Epigenetic and miRNA studies of diagnostic muscle biopsies indicate critical differences associated with disease duration. Dr. Pachman’s search for clinically useful biomarkers of immune activation has identified CD3- natural killer cells and von Willebrand factor antigen, released from damaged endothelial cells, as well as proteomic markers associated with disease activity. Current investigations focus on genetic differences (RNASeq; miRNA) between induced pluripotent stem cells from monozygotic twins discordant for JM and a healthy control This is of relevance for with chronic inflammation, for there is progressive endothelial damage reflected by loss of nailfold capillary end row loops (we have developed a quantitative system of nailfold capillary analysis) associated with impaired drug absorption, such as oral prednisone. Her lab maintains a patient-derived CureJM Registry now available in REDCap as well as a JM Repository containing diagnostic muscle and skin biopsies, sequential sera, peripheral blood lymphocytes and dystrophic calcifications samples keyed the bio-informatics system for over 600 children with Juvenile Myositis. In summary, this intensive research effort broadens the clinical, genetic and immunological characterization of the child with JM, which will be a critical aid to guide current therapy and may lead to novel targeted interventions.

1. Immunogenetics of Juvenile Dermatomyositis associated with individual Myositis Specific Antibodies and a range of disease activity. 2. Biomarkers--proteomic and genetic of disease activity and response to therapy

Juvenile Myositis (JM) environmental factors that impact on disease outcome JM: biomarkers of immunogentic disease activity before and after therapy, leading to discovery of new ways to effectively treat this often chronic disease.

Certifications and Licenses

Allergy & Immunology
Pediatrics

Training Experience

1962Internship, Philadelphia General Hospital
1964Residency, Columbia Presbyterian Medical Center

Education/Academic qualification

MD, University of Chicago

… → 1961

Research interests

  • Autoimmunity
  • Epidemiology
  • Immune Regulation
  • Immunogenetics
  • Inflammation
  • Pediatric Rheumatology
  • Proteomics
  • Vascular Biology

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  • 2 Similar Profiles
Myositis Medicine & Life Sciences
Juvenile Arthritis Medicine & Life Sciences
Dermatomyositis Medicine & Life Sciences
Muscles Medicine & Life Sciences
Juvenile dermatomyositis Medicine & Life Sciences
Preschool Children Medicine & Life Sciences
Serum Medicine & Life Sciences
Autoantibodies Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2012 2018

Research Output 1967 2019

2 Citations (Scopus)

Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups

Rothwell, S., Chinoy, H., Lamb, J. A., Miller, F. W., Rider, L. G., Wedderburn, L. R., McHugh, N. J., Mammen, A. L., Betteridge, Z. E., Tansley, S. L., Bowes, J., Vencovský, J. I., Deakin, C. T., Dankó, K., Vidya, L., Selva-O'Callaghan, A., Pachman, L. M., Reed, A. M., Molberg, Y., Benveniste, O. & 13 others, Mathiesen, P. R., Radstake, T. R. D. J., Doria, A., De Bleecker, J., Lee, A. T., Hanna, M. G., Machado, P. M., Ollier, W. E., Gregersen, P. K., Padyukov, L., O'Hanlon, T. P., Cooper, R. G. & Lundberg, I. E., Jul 1 2019, In : Annals of the Rheumatic Diseases. 78, 7, p. 996-1002 7 p.

Research output: Contribution to journalArticle

Open Access
Myositis
HLA Antigens
Autoantibodies
Major Histocompatibility Complex
Haplotypes
Open Access
Agammaglobulinemia
Autoimmune Diseases
Pediatrics
Central Nervous System Diseases
Immunoglobulins
4 Citations (Scopus)
Antibodies
Juvenile dermatomyositis
6 Citations (Scopus)

Development of a consensus core dataset in juvenile dermatomyositis for clinical use to inform research

McCann, L. J., Pilkington, C. A., Huber, A. M., Ravelli, A., Appelbe, D., Kirkham, J. J., Williamson, P. R., Aggarwal, A., Christopher-Stine, L., Constantin, T., Feldman, B. M., Lundberg, I., Maillard, S., Mathiesen, P., Murphy, R., Pachman, L. M., Reed, A. M., Rider, L. G., Van Royen-Kerkof, A., Russo, R. & 3 others, Spinty, S., Wedderburn, L. R. & Beresford, M. W., Feb 1 2018, In : Annals of the Rheumatic Diseases. 77, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

Consensus
Myositis
Research
Pediatrics
Electronic mail

Dysregulated NK cell PLCγ2 signaling and activity in juvenile dermatomyositis

Throm, A. A., Alinger, J. B., Pingel, J. T., Daugherty, A. L., Pachman, L. M. & French, A. R., Nov 15 2018, In : JCI insight. 3, 22

Research output: Contribution to journalArticle

Phospholipases
Natural Killer Cells
Calcium
Phosphorylation
Phosphoproteins