Lauren M Pachman

  • 7655 Citations
1967 …2020

Research output per year

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Personal profile

Research Interests

Dr. Pachman's translational team studies Juvenile Myositis (JM), an often chronic pediatric systemic vasculopathy associated with skin inflammation and proximal muscle weakness of unknown etiology. Her laboratory has identified genetic, immunologic and environmental factors that play a role in the onset of symptoms and govern outcome. RNASeq, miRNA and Gene expression micro array studies of untreated children's diagnostic muscle biopsies identified massive dysregulation of IFN-a induced genes in JDM. Epigenetic and miRNA studies of diagnostic muscle biopsies indicate critical differences associated with disease duration. Dr. Pachman’s search for clinically useful biomarkers of immune activation has identified CD3- natural killer cells and von Willebrand factor antigen, released from damaged endothelial cells, as well as proteomic markers associated with disease activity. Current investigations focus on genetic differences (RNASeq; miRNA) between induced pluripotent stem cells from monozygotic twins discordant for JM and a healthy control This is of relevance for with chronic inflammation, for there is progressive endothelial damage reflected by loss of nailfold capillary end row loops (we have developed a quantitative system of nailfold capillary analysis) associated with impaired drug absorption, such as oral prednisone. Her lab maintains a patient-derived CureJM Registry now available in REDCap as well as a JM Repository containing diagnostic muscle and skin biopsies, sequential sera, peripheral blood lymphocytes and dystrophic calcifications samples keyed the bio-informatics system for over 600 children with Juvenile Myositis. In summary, this intensive research effort broadens the clinical, genetic and immunological characterization of the child with JM, which will be a critical aid to guide current therapy and may lead to novel targeted interventions.

1. Immunogenetics of Juvenile Dermatomyositis associated with individual Myositis Specific Antibodies and a range of disease activity. 2. Biomarkers--proteomic and genetic of disease activity and response to therapy

Juvenile Myositis (JM) environmental factors that impact on disease outcome JM: biomarkers of immunogentic disease activity before and after therapy, leading to discovery of new ways to effectively treat this often chronic disease.

Certifications and Licenses

Allergy & Immunology

Training Experience

1962Internship, Philadelphia General Hospital
1964Residency, Columbia Presbyterian Medical Center

Education/Academic qualification

MD, The University of Chicago

… → 1961

Research interests

  • Autoimmunity
  • Epidemiology
  • Immune Regulation
  • Immunogenetics
  • Inflammation
  • Pediatric Rheumatology
  • Proteomics
  • Vascular Biology

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Research Output

Neutrophil Extracellular Traps in Tissue and Periphery in Juvenile Dermatomyositis

Duvvuri, B., Pachman, L. M., Morgan, G., Khojah, A. M., Klein-Gitelman, M., Curran, M. L., Doty, S. & Lood, C., Feb 1 2020, In : Arthritis and Rheumatology. 72, 2, p. 348-358 11 p.

Research output: Contribution to journalArticle

  • 2 Scopus citations

    Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups

    Rothwell, S., Chinoy, H., Lamb, J. A., Miller, F. W., Rider, L. G., Wedderburn, L. R., McHugh, N. J., Mammen, A. L., Betteridge, Z. E., Tansley, S. L., Bowes, J., Vencovský, J. I., Deakin, C. T., Dankó, K., Vidya, L., Selva-O'Callaghan, A., Pachman, L. M., Reed, A. M., Molberg, Y., Benveniste, O. & 13 others, Mathiesen, P. R., Radstake, T. R. D. J., Doria, A., De Bleecker, J., Lee, A. T., Hanna, M. G., Machado, P. M., Ollier, W. E., Gregersen, P. K., Padyukov, L., O'Hanlon, T. P., Cooper, R. G. & Lundberg, I. E., Jul 1 2019, In : Annals of the Rheumatic Diseases. 78, 7, p. 996-1002 7 p.

    Research output: Contribution to journalArticle

    Open Access
  • 8 Scopus citations
    Open Access
  • 2 Scopus citations
    8 Scopus citations

    Development of a consensus core dataset in juvenile dermatomyositis for clinical use to inform research

    McCann, L. J., Pilkington, C. A., Huber, A. M., Ravelli, A., Appelbe, D., Kirkham, J. J., Williamson, P. R., Aggarwal, A., Christopher-Stine, L., Constantin, T., Feldman, B. M., Lundberg, I., Maillard, S., Mathiesen, P., Murphy, R., Pachman, L. M., Reed, A. M., Rider, L. G., Van Royen-Kerkof, A., Russo, R. & 3 others, Spinty, S., Wedderburn, L. R. & Beresford, M. W., Feb 2018, In : Annals of the Rheumatic Diseases. 77, 2, p. 241-250 10 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations