Personal profile

Research Interests

Dr. Wakschlag's research is focused on translational approaches to elucidating mechanisms and phenomenology of early emerging disruptive behavior. The Developmental Mechanisms Program emphasizes developmentally-based measurement science including novel observational methodologies for use at varying developmental periods. The centerpiece of this work is NIMH-funded measurement development of tools for characterizing the phenotype of disruptive behavior in preschoolers in a manner distinct from the normative misbehavior of early childhood. This includes a completed study to validate the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS), a standardized laboratory observation method for assessing clinically salient behavior in preschoolers; and the study designed to validate the Multidimensional Assessment of Preschool Disruptive Behavior (MAP-DB)- a paper-and pencil measure of four dimensions of disruptive behavior theorized to comprise its defining features: i.e., Temper Loss, Noncompliance, Aggression and Low Concern for Others. Dr. Wakschlag’s work on mechanisms of psychopathology has a central focus on prenatal origins of health and disease. This is exemplified by her NIDA-funded work on prenatal smoking as a putative mechanism in pathways to disruptive behavior. This program of research has focused on elucidating exposure-related phenotypes across developmental periods and identifying how exposure interacts with biologic and social risk in these pathways. She and her colleagues discovered an interaction of exposure and the MAOA genotype with varying patterns by sex, and modification of exposure effects by early responsive parenting.


  • Maternal-Child Health
  • Developmental-Behavioral Pediatrics
  • Psychology
  • Outcome measures
  • Psychometrics
  • Tobacco Control
  • Developmental Neurobiology
  • Developmental Psychopathology
  • Prenatal Environment and Developmental Outcomes
  • Developmental Origins of Disease
  • Gene x Environment Interactions
  • Child and Adolescent psychiatry
  • Disruptive/antisocial Behavior
  • Developmental Alterations
  • Developmental Methods

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  • 29 Similar Profiles
Problem Behavior Medicine & Life Sciences
Smoking Medicine & Life Sciences
Mothers Medicine & Life Sciences
Pregnancy Medicine & Life Sciences
Parenting Medicine & Life Sciences
Attention Deficit and Disruptive Behavior Disorders Medicine & Life Sciences
Preschool Children Medicine & Life Sciences
Psychopathology Medicine & Life Sciences

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Research Output 1991 2017

6 Citations

Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products

England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., Lanphear, B., Leslie, F., Pauly, J. R., Neiderhiser, J., Rubinstein, M., Slotkin, T. A., Spindel, E., Stroud, L. & Wakschlag, L. Jan 1 2017 In : Neuroscience and Biobehavioral Reviews. 72, p. 176-189 14 p.

Research output: Research - peer-reviewReview article

Tobacco Products
Adolescent Development
Impulsive Behavior
1 Citations

Evidence of Non-Linear Associations between Frustration-Related Prefrontal Cortex Activation and the Normal: Abnormal Spectrum of Irritability in Young Children

Grabell, A. S., Li, Y., Barker, J. W., Wakschlag, L. S., Huppert, T. J. & Perlman, S. B. Mar 18 2017 (Accepted/In press) In : Journal of Abnormal Child Psychology. p. 1-11 11 p.

Research output: Research - peer-reviewArticle

Prefrontal Cortex
Linear Models
3 Citations
Substance-Related Disorders
Impulsive Behavior
Social Sciences

Specific and social fears in children and adolescents: Separating normative fears from problem indicators and phobias

Laporte, P. P., Pan, P. M., Hoffmann, M. S., Wakschlag, L. S., Rohde, L. A., Miguel, E. C., Pine, D. S., Manfro, G. G. & Salum, G. A. Jan 1 2017 In : Revista Brasileira de Psiquiatria. 39, 2, p. 118-125 8 p.

Research output: Research - peer-reviewArticle

Phobic Disorders
ROC Curve
Specific Phobia
Differential Threshold

The Family Socialization Interview—Revised (FSI-R): a Comprehensive Assessment of Parental Disciplinary Behaviors

O’Dor, S. L., Grasso, D. J., Forbes, D., Bates, J. E., McCarthy, K. J., Wakschlag, L. S. & Briggs-Gowan, M. J. Apr 1 2017 In : Prevention Science. 18, 3, p. 292-304 13 p.

Research output: Research - peer-reviewArticle

Child Development