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Personal profile

Research Interests

As a developmental/clinical psychologist, Dr. Wakschlag's scientific focus is on how early development (from the prenatal-preschool period) shapes mental health pathways. One major line of inquiry is characterizing the phenotype of emergent mental health problems in early childhood. She and her collaborators have generated the first “developmentally-sensitive toolkit” specifically designed to enhance early identification of mental health problems, via by empirically-based differentiation of the normative misbehavior of early childhood from the onset of disruptive behavior at preschool age. Currently, these tools are being used to pinpoint corollary neurodevelopmental atypicalities, with work underway to ready the tools for clinical use. Most recently, this work has focused on the neurodevelopment of irritability as a shared substrate of common childhood-onset mental disorders. The second major focus of her research is elucidating prenatal origins of disease pathways. In particular, this work focuses on causal modeling of prenatal smoking “effects” on disruptive behavior. This includes the development of novel methods for multi-level characterization of adverse prenatal environments, investigating prenatal environment x gene interactions, and pinpointing the developmental sequence of exposure-related neurobehavioral vulnerabilities from infancy-adolescence. Examination of prenatal smoking effects “within psychosocial context,” has led her to a burgeoning emphasis on the role of early life stress in these pathways. Increasingly her work in this area aims to discover the patterns of brain:behavior atypicality associated with adverse prenatal exposures. The long term goal of these efforts is to serve as an impetus for moving the “dial” of mental health prevention much earlier in the disease sequence, by providing well characterized neurodevelopmental phenotypes of disease susceptibility to serve as core prevention targets.

Education/Academic qualification

PhD, University of Chicago

… → 1992

Social Work, MA, The University of Chicago

… → 1983

Psychology, BA, Barnard College

… → 1980

Research interests

  • Child and Adolescent Psychiatry
  • Developmental Alterations
  • Developmental Methods
  • Developmental Origins of Disease
  • Developmental Psychopathology
  • Disruptive/Antisocial Behavior
  • Gene-Environment Interactions
  • Prenatal Environment and Developmental Outcomes

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Smoking Medicine & Life Sciences
Mothers Medicine & Life Sciences
Parenting Medicine & Life Sciences
Pregnancy Medicine & Life Sciences
Attention Deficit and Disruptive Behavior Disorders Medicine & Life Sciences
Preschool Children Medicine & Life Sciences
Psychopathology Medicine & Life Sciences
Conduct Disorder Medicine & Life Sciences

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Grants 2010 2024

Neurosciences
Parent-Child Relations
Manuscripts
Research Personnel
Therapeutics

Research Output 1991 2019

1 Citation (Scopus)

Cognitive flexibility-related prefrontal activation in preschoolers: A biological approach to temperamental effortful control

Quiñones-Camacho, L. E., Fishburn, F. A., Camacho, M. C., Wakschlag, L. S. & Perlman, S. B., Aug 1 2019, In : Developmental Cognitive Neuroscience. 38, 100651.

Research output: Contribution to journalArticle

Open Access
Temperament
Neuronal Plasticity
Near-Infrared Spectroscopy
Brain
Prefrontal Cortex
2 Citations (Scopus)

Differentiating typical from atypical perpetration of sibling-directed aggression during the preschool years

Dirks, M. A., Recchia, H. E., Estabrook, C. R., Howe, N., Petitclerc, A., Burns, J. L., Briggs-Gowan, M. J. & Wakschlag, L. S., Mar 1 2019, In : Journal of Child Psychology and Psychiatry and Allied Disciplines. 60, 3, p. 267-276 10 p.

Research output: Contribution to journalArticle

Aggression
Siblings
Biomarkers
Poverty
Hispanic Americans
Mental Disorders
Mental Health
Primary Health Care
Population
Delivery of Health Care
2 Citations (Scopus)

Irritability uniquely predicts prefrontal cortex activation during preschool inhibitory control among all temperament domains: A LASSO approach

Fishburn, F. A., Hlutkowsky, C. O., Bemis, L. M., Huppert, T. J., Wakschlag, L. S. & Perlman, S. B., Jan 1 2019, In : Neuroimage. 184, p. 68-77 10 p.

Research output: Contribution to journalArticle

Temperament
Prefrontal Cortex
Frustration
Near-Infrared Spectroscopy
Executive Function
2 Citations (Scopus)
Child Behavior
Checklist
Information Storage and Retrieval
Problem Behavior
Aggression