Personal profile

Research Interests

Dr. Wakschlag's research is focused on translational approaches to elucidating mechanisms and phenomenology of early emerging disruptive behavior. The Developmental Mechanisms Program emphasizes developmentally-based measurement science including novel observational methodologies for use at varying developmental periods. The centerpiece of this work is NIMH-funded measurement development of tools for characterizing the phenotype of disruptive behavior in preschoolers in a manner distinct from the normative misbehavior of early childhood. This includes a completed study to validate the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS), a standardized laboratory observation method for assessing clinically salient behavior in preschoolers; and the study designed to validate the Multidimensional Assessment of Preschool Disruptive Behavior (MAP-DB)- a paper-and pencil measure of four dimensions of disruptive behavior theorized to comprise its defining features: i.e., Temper Loss, Noncompliance, Aggression and Low Concern for Others. Dr. Wakschlag’s work on mechanisms of psychopathology has a central focus on prenatal origins of health and disease. This is exemplified by her NIDA-funded work on prenatal smoking as a putative mechanism in pathways to disruptive behavior. This program of research has focused on elucidating exposure-related phenotypes across developmental periods and identifying how exposure interacts with biologic and social risk in these pathways. She and her colleagues discovered an interaction of exposure and the MAOA genotype with varying patterns by sex, and modification of exposure effects by early responsive parenting.

Keywords

  • Maternal-Child Health
  • Developmental-Behavioral Pediatrics
  • Psychology
  • Outcome measures
  • Psychometrics
  • Tobacco Control
  • Developmental Neurobiology
  • Developmental Psychopathology
  • Prenatal Environment and Developmental Outcomes
  • Developmental Origins of Disease
  • Gene x Environment Interactions
  • Child and Adolescent psychiatry
  • Disruptive/antisocial Behavior
  • Developmental Alterations
  • Developmental Methods

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Tobacco Products Medicine & Life Sciences

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Research Output 1991 2017

1 Citations

Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products

England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., Lanphear, B., Leslie, F., Pauly, J. R., Neiderhiser, J., Rubinstein, M., Slotkin, T. A., Spindel, E., Stroud, L. & Wakschlag, L. Jan 1 2017 In : Neuroscience and Biobehavioral Reviews. 72, p. 176-189 14 p.

Research output: Contribution to journalReview article

Nicotine
Tobacco Products
Health
Adolescent Development
Impulsive Behavior

Evidence of Non-Linear Associations between Frustration-Related Prefrontal Cortex Activation and the Normal: Abnormal Spectrum of Irritability in Young Children

Grabell, A. S., Li, Y., Barker, J. W., Wakschlag, L. S., Huppert, T. J. & Perlman, S. B. Mar 18 2017 In : Journal of Abnormal Child Psychology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Frustration
Prefrontal Cortex
Emotions
Neuroimaging
Linear Models
empathy
Substance-Related Disorders
initiation
assessment
process

Specific and social fears in children and adolescents: Separating normative fears from problem indicators and phobias

Laporte, P. P., Pan, P. M., Hoffmann, M. S., Wakschlag, L. S., Rohde, L. A., Miguel, E. C., Pine, D. S., Manfro, G. G. & Salum, G. A. 2017 In : Revista Brasileira de Psiquiatria. 39, 2, p. 118-125 8 p.

Research output: Contribution to journalArticle

Phobic Disorders
Fear
ROC Curve
Differential Threshold
Mental Disorders

The Family Socialization Interview—Revised (FSI-R): a Comprehensive Assessment of Parental Disciplinary Behaviors

O’Dor, S. L., Grasso, D. J., Forbes, D., Bates, J. E., McCarthy, K. J., Wakschlag, L. S. & Briggs-Gowan, M. J. Apr 1 2017 In : Prevention Science. 18, 3, p. 292-304 13 p.

Research output: Contribution to journalArticle

Socialization
Interviews
Parenting
Child Development
Psychopathology