Grants per year
Personal profile
Research Interests
Dr. Cooper received his PhD in Electrical and Computer Engineering from Ohio State University in 2009. He joined the Biomedical Informatics faculty at Emory University in 2012 where he was jointly appointed with Biomedical Engineering at Georgia Institute of Technology. He joined the department of pathology at Northwestern in 2019 as an Associate Professor and Director of Computational Pathology.
My lab focuses on the applications of machine learning in cancer and fundamental research in machine learning. We develop algorithms to predict clinical outcomes from genomic, imaging, and histopathology data, and to extract quantitative descriptions of tissue microenvironments from digital pathology images. Our work has produced a number of software tools that enable researchers to manage large and complex datasets and to interact with these data using machine learning algorithms. Our goal is to improve the quality of predictions used in clinical management and to provide investigators with new insights in cancer biology. Our research has been funded by NLM, NCI, NIBIB, NINDS, and industry and foundation sources.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Electrical Engineering and Computer Science, Ohio State University
… → 2009
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Collaborations and top research areas from the last five years
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Element B + Subcontracts
Becker, S. (PD/PI), D'Aquila, R. T. (PD/PI), Yancy, C. W. (PD/PI), Alshurafa, N. (Other), Ameer, G. A. (Other), Beidas, R. S. (Other), Blanco, I. (Other), Bradley, C. D. (Other), Brawley, C. (Other), Brown, O. E. (Other), Brown, C. H. (Other), Cameron, K. A. (Other), Carnethon, M. R. (Other), Cooper, L. A. D. (Other), Feinstein, M. J. (Other), Franklin, P. D. (Other), Helseth, S. A. (Other), Hill, V. B. (Other), Holmes, K. (Other), Kalhan, R. (Other), Khan, S. S. (Other), Kho, A. N. (Other), Li, D. H. (Other), Liebovitz, D. M. (Other), Luo, Y. (Other), Macapagal, K. (Other), O'Brien, M. J. (Other), Passman, R. S. (Other), Perreault, E. (Other), Peters, A. T. (Other), Pickens, C. I. (Other), Rasmussen-Torvik, L. J. (Other), Rivnay, J. (Other), Rosenberg, S. R. (Other), Schauer, J. M. (Other), Scott, K. (Other), Scott, E. A. (Other), Simon, M. A. (Other), Skolarus, L. E. (Other), Spring, B. (Other), Starren, J. (Other), Tandon, D. (Other), Walunas, T. L. (Other), Welty, L. J. (Other), Woitowich, N. C. (Other) & Wolf, M. (Other)
National Center for Advancing Translational Sciences
9/1/24 → 7/31/31
Project: Research project
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Atlascope: Composable Visualization Tools for Multiscale Integrative Biology
Cooper, L. A. D. (PD/PI)
Kitware, Inc, National Cancer Institute
9/15/23 → 9/14/25
Project: Research project
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Enabling Next Generation Machine Learning for Large Scale Image Analysis
Cooper, L. A. D. (PD/PI)
RNET Technologies, Inc., National Institute of Biomedical Imaging and Bioengineering
6/1/23 → 5/31/25
Project: Research project
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Epigenetic study of oral HPV infection-associated oral cancer in people living with HIV in Nigeria
Hou, L. (PD/PI), Hou, L. (PD/PI), Murphy, R. L. (PD/PI), Murphy, R. L. (PD/PI), Cooper, L. A. D. (Co-Investigator), Wang, J. (Co-Investigator), Wang, J. (Co-Investigator), Wei, J.-J. (Co-Investigator), Wei, J.-J. (Co-Investigator), Zheng, Y. (Co-Investigator) & Zheng, Y. (Co-Investigator)
9/16/22 → 8/31/26
Project: Research project
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Improved whole-brain spectroscopic MRI for radiation therapy planning
Cooper, L. A. D. (PD/PI) & Cooper, L. A. D. (PD/PI)
Emory University, National Cancer Institute
5/5/22 → 4/30/27
Project: Research project
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A population-level digital histologic biomarker for enhanced prognosis of invasive breast cancer
Amgad, M., Hodge, J. M., Elsebaie, M. A. T., Bodelon, C., Puvanesarajah, S., Gutman, D. A., Siziopikou, K. P., Goldstein, J. A., Gaudet, M. M., Teras, L. R. & Cooper, L. A. D., Jan 2024, In: Nature Medicine. 30, 1, p. 85-97 13 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Automated Deep Learning-Based Diagnosis and Molecular Characterization of Acute Myeloid Leukemia Using Flow Cytometry
Lewis, J. E., Cooper, L. A. D., Jaye, D. L. & Pozdnyakova, O., Jan 2024, In: Modern Pathology. 37, 1, 100373.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Focused active learning for histopathological image classification
Schmidt, A., Morales-Álvarez, P., Cooper, L. A., Newberg, L. A., Enquobahrie, A., Molina, R. & Katsaggelos, A. K., Jul 2024, In: Medical Image Analysis. 95, 103162.Research output: Contribution to journal › Article › peer-review
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Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer
Jahangir, C. A., Page, D. B., Broeckx, G., Gonzalez, C. A., Burke, C., Murphy, C., Reis-Filho, J. S., Ly, A., Harms, P. W., Gupta, R. R., Vieth, M., Hida, A. I., Kahila, M., Kos, Z., van Diest, P. J., Verbandt, S., Thagaard, J., Khiroya, R., Abduljabbar, K. & Acosta Haab, G. & 117 others, , Mar 2024, In: Journal of Pathology. 262, 3, p. 271-288 18 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Learning from crowds for automated histopathological image segmentation
López-Pérez, M., Morales-Álvarez, P., Cooper, L. A. D., Felicelli, C., Goldstein, J., Vadasz, B., Molina, R. & Katsaggelos, A. K., Mar 2024, In: Computerized Medical Imaging and Graphics. 112, 102327.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Metadata supporting data files in the published article: Pitfalls in Assessing Stromal Tumor Infiltrating Lymphocytes (sTILs) in Breast Cancer
Kos, Z. (Creator), Roblin, E. (Creator), Kim, R. S. (Creator), Michiels, S. (Creator), Gallas, B. D. (Creator), Chen, W. (Creator), van de Vijver, K. K. (Contributor), Goel, S. (Creator), Adams, S. (Creator), Demaria, S. (Creator), Viale, G. (Creator), Nielsen, T. O. (Creator), Badve, S. S. (Creator), Symmans, W. F. (Creator), Sotiriou, C. (Creator), Rimm, D. L. (Creator), Hewitt, S. (Creator), Denkert, C. (Creator), Loibl, S. (Creator), Luen, S. J. (Creator), Bartlett, J. M. S. (Creator), Savas, P. (Creator), Pruneri, G. (Creator), Dillon, D. A. (Creator), Cheang, M. C. U. (Creator), Tutt, A. (Creator), Hall, J. A. (Creator), Kok, M. (Creator), Horlings, H. M. (Creator), Madabhushi, A. (Creator), van der Laak, J. (Contributor), Ciompi, F. (Creator), Laenkholm, A.-V. (Creator), Bellolio, E. (Creator), Gruosso, T. (Creator), Fox, S. B. (Creator), Araya, J. C. (Creator), Floris, G. (Creator), Hudeček, J. (Creator), Voorwerk, L. (Creator), Beck, A. H. (Creator), Kerner, J. (Creator), Larsimont, D. (Creator), Declercq, S. (Creator), Van den Eynden, G. (Contributor), Pusztai, L. (Creator), Ehinger, A. (Creator), Yang, W. (Creator), AbdulJabbar, K. (Creator), Yuan, Y. (Creator), Singh, R. (Creator), Hiley, C. (Creator), Bakir, M. A. (Creator), Lazar, A. J. (Creator), Naber, S. (Creator), Wienert, S. (Creator), Castillo, M. (Creator), Curigliano, G. (Creator), Dieci, M.-V. (Creator), André, F. (Creator), Swanton, C. (Creator), Reis-Filho, J. (Creator), Sparano, J. (Creator), Balslev, E. (Creator), Chen, I.-C. (Creator), Stovgaard, E. I. S. (Creator), Pogue-Geile, K. (Creator), Blenman, K. R. M. (Creator), Penault-Llorca, F. (Creator), Schnitt, S. (Creator), Lakhani, S. R. (Creator), Vincent-Salomon, A. (Creator), Rojo, F. (Creator), Braybrooke, J. P. (Creator), Hanna, M. G. (Creator), Bethmann, D. (Creator), Castaneda, C. A. (Creator), Willard-Gallo, K. (Creator), Sharma, A. (Creator), Lien, H.-C. (Creator), Fineberg, S. (Creator), Thagaard, J. (Creator), Comerma, L. (Creator), Gonzalez-Ericsson, P. (Creator), Brogi, E. (Creator), Loi, S. (Creator), Saltz, J. (Creator), Klaushen, F. (Creator), Cooper, L. (Creator), Amgad, M. (Creator), Moore, D. A. (Creator) & Soler, T. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.11907768.v1, https://springernature.figshare.com/articles/figure/Metadata_supporting_data_files_in_the_published_article_Pitfalls_in_Assessing_Stromal_Tumor_Infiltrating_Lymphocytes_sTILs_in_Breast_Cancer/11907768/1
Dataset
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Additional file 1 of High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients
Yang, X. (Creator), Amgad, M. (Creator), Cooper, L. A. D. (Creator), Du, Y. (Contributor), Fu, H. (Contributor) & Ivanov, A. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12904788, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_High_expression_of_MKK3_is_associated_with_worse_clinical_outcomes_in_African_American_breast_cancer_patients/12904788
Dataset
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High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients
Yang, X. (Creator), Amgad, M. (Creator), Cooper, L. A. D. (Creator), Du, Y. (Contributor), Fu, H. (Contributor) & Ivanov, A. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.5109639, https://springernature.figshare.com/collections/High_expression_of_MKK3_is_associated_with_worse_clinical_outcomes_in_African_American_breast_cancer_patients/5109639
Dataset