Grants per year
Personal profile
Research Interests
Dr. Cooper received his PhD in Electrical and Computer Engineering from Ohio State University in 2009. He joined the Biomedical Informatics faculty at Emory University in 2012 where he was jointly appointed with Biomedical Engineering at Georgia Institute of Technology. He joined the department of pathology at Northwestern in 2019 as an Associate Professor and Director of Computational Pathology.
My lab focuses on the applications of machine learning in cancer and fundamental research in machine learning. We develop algorithms to predict clinical outcomes from genomic, imaging, and histopathology data, and to extract quantitative descriptions of tissue microenvironments from digital pathology images. Our work has produced a number of software tools that enable researchers to manage large and complex datasets and to interact with these data using machine learning algorithms. Our goal is to improve the quality of predictions used in clinical management and to provide investigators with new insights in cancer biology. Our research has been funded by NLM, NCI, NIBIB, NINDS, and industry and foundation sources.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Electrical Engineering and Computer Science, Ohio State University
… → 2009
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A retrospective observational study of cell type-specific TLlA expression as a predictor of lung and skin fibrosis and response to therapy in patients with systemic sclerosis
Misharin, A. (PD/PI), Cooper, L. A. D. (Co-Investigator) & Richardson, C. L. (Co-Investigator)
1/1/25 → 12/31/25
Project: Research project
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Element B + Subcontracts
Becker, S. (PD/PI), D'Aquila, R. T. (PD/PI), Yancy, C. W. (PD/PI), Alshurafa, N. (Other), Ameer, G. A. (Other), Beidas, R. S. (Other), Blanco, I. (Other), Bradley, C. D. (Other), Brawley, C. (Other), Brown, O. E. (Other), Brown, C. H. (Other), Cameron, K. A. (Other), Carnethon, M. R. (Other), Cooper, L. A. D. (Other), Feinstein, M. J. (Other), Franklin, P. D. (Other), Helseth, S. A. (Other), Hill, V. B. (Other), Holmes, K. (Other), Kalhan, R. (Other), Khan, S. S. (Other), Kho, A. N. (Other), Li, D. H. (Other), Liebovitz, D. M. (Other), Luo, Y. (Other), Macapagal, K. (Other), O'Brien, M. J. (Other), Passman, R. S. (Other), Perreault, E. (Other), Peters, A. T. (Other), Pickens, C. I. (Other), Rasmussen-Torvik, L. J. (Other), Rivnay, J. (Other), Rosenberg, S. R. (Other), Schauer, J. M. (Other), Scott, K. (Other), Scott, E. A. (Other), Simon, M. A. (Other), Skolarus, L. E. (Other), Spring, B. (Other), Starren, J. (Other), Tandon, D. (Other), Walunas, T. L. (Other), Welty, L. J. (Other), Woitowich, N. C. (Other) & Wolf, M. (Other)
National Center for Advancing Translational Sciences
9/1/24 → 7/31/31
Project: Research project
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Spatiotemporal analyses of human tumor-immune interactome
Liu, H. (PD/PI) & Cooper, L. A. D. (Co-Investigator)
6/1/24 → 5/31/27
Project: Research project
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Brain Digital Slide Archive: An Open Source Platform for data sharing and analysis of digital neuropathology
Cooper, L. A. D. (PD/PI) & Cooper, L. A. D. (PD/PI)
Emory University, National Institute of Neurological Disorders and Stroke
9/19/23 → 8/31/25
Project: Research project
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Atlascope: Composable Visualization Tools for Multiscale Integrative Biology
Cooper, L. A. D. (PD/PI)
Kitware, Inc, National Cancer Institute
9/15/23 → 9/14/25
Project: Research project
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An Accelerated Spectroscopic MRI Metabolite Quantification Based on a Deep Learning Method for Radiation Therapy Planning in Brain Tumor Patients
Giuffrida, A. S., Ramesh, K., Sheriff, S., Maudsley, A. A., Weinberg, B. D., Cooper, L. A. D. & Shim, H., Feb 2025, In: Cancers. 17, 3, 423.Research output: Contribution to journal › Article › peer-review
Open Access -
An Artificial Intelligence-Digital Pathology Algorithm Predicts Survival After Radical Prostatectomy From the Prostate, Lung, Colorectal, and Ovarian Cancer Trial
Li, E. V., Ren, Y., Griffin, J., Han, C., Yamashita, R., Mitani, A., Zhou, R., Huang, H. C., Yang, X., Feng, F. Y., Esteva, A., Patel, H. D., Schaeffer, E. M., Cooper, L. A. D. & Ross, A. E., May 1 2025, In: Journal of Urology. 213, 5, p. 600-607 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
NNFit: A Self-Supervised Deep Learning Method for Accelerated Quantification of High-Resolution Short-Echo-Time MR Spectroscopy Datasets
Giuffrida, A. S., Sheriff, S., Huang, V., Weinberg, B. D., Cooper, L. A. D., Liu, Y., Soher, B. J., Treadway, M., Maudsley, A. A. & Shim, H., Mar 2025, In: Radiology: Artificial Intelligence. 7, 2, e230579.Research output: Contribution to journal › Article › peer-review
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A panoptic segmentation dataset and deep-learning approach for explainable scoring of tumor-infiltrating lymphocytes
Liu, S., Amgad, M., More, D., Rathore, M. A., Salgado, R. & Cooper, L. A. D., Dec 2024, In: npj Breast Cancer. 10, 1, 52.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
A population-level digital histologic biomarker for enhanced prognosis of invasive breast cancer
Amgad, M., Hodge, J. M., Elsebaie, M. A. T., Bodelon, C., Puvanesarajah, S., Gutman, D. A., Siziopikou, K. P., Goldstein, J. A., Gaudet, M. M., Teras, L. R. & Cooper, L. A. D., Jan 2024, In: Nature Medicine. 30, 1, p. 85-97 13 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations
Datasets
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High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients
Yang, X. (Creator), Amgad, M. (Creator), Cooper, L. A. D. (Creator), Du, Y. (Contributor), Fu, H. (Contributor) & Ivanov, A. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.5109639, https://springernature.figshare.com/collections/High_expression_of_MKK3_is_associated_with_worse_clinical_outcomes_in_African_American_breast_cancer_patients/5109639
Dataset
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Metadata supporting data files in the published article: Pitfalls in Assessing Stromal Tumor Infiltrating Lymphocytes (sTILs) in Breast Cancer
Kos, Z. (Creator), Roblin, E. (Creator), Kim, R. S. (Creator), Michiels, S. (Creator), Gallas, B. D. (Creator), Chen, W. (Creator), van de Vijver, K. K. (Contributor), Goel, S. (Creator), Adams, S. (Creator), Demaria, S. (Creator), Viale, G. (Creator), Nielsen, T. O. (Creator), Badve, S. S. (Creator), Symmans, W. F. (Creator), Sotiriou, C. (Creator), Rimm, D. L. (Creator), Hewitt, S. (Creator), Denkert, C. (Creator), Loibl, S. (Creator), Luen, S. J. (Creator), Bartlett, J. M. S. (Creator), Savas, P. (Creator), Pruneri, G. (Creator), Dillon, D. A. (Creator), Cheang, M. C. U. (Creator), Tutt, A. (Creator), Hall, J. A. (Creator), Kok, M. (Creator), Horlings, H. M. (Creator), Madabhushi, A. (Creator), van der Laak, J. (Contributor), Ciompi, F. (Creator), Laenkholm, A.-V. (Creator), Bellolio, E. (Creator), Gruosso, T. (Creator), Fox, S. B. (Creator), Araya, J. C. (Creator), Floris, G. (Creator), Hudeček, J. (Creator), Voorwerk, L. (Creator), Beck, A. H. (Creator), Kerner, J. (Creator), Larsimont, D. (Creator), Declercq, S. (Creator), Van den Eynden, G. (Contributor), Pusztai, L. (Creator), Ehinger, A. (Creator), Yang, W. (Creator), AbdulJabbar, K. (Creator), Yuan, Y. (Creator), Singh, R. (Creator), Hiley, C. (Creator), Bakir, M. A. (Creator), Lazar, A. J. (Creator), Naber, S. (Creator), Wienert, S. (Creator), Castillo, M. (Creator), Curigliano, G. (Creator), Dieci, M.-V. (Creator), André, F. (Creator), Swanton, C. (Creator), Reis-Filho, J. (Creator), Sparano, J. (Creator), Balslev, E. (Creator), Chen, I.-C. (Creator), Stovgaard, E. I. S. (Creator), Pogue-Geile, K. (Creator), Blenman, K. R. M. (Creator), Penault-Llorca, F. (Creator), Schnitt, S. (Creator), Lakhani, S. R. (Creator), Vincent-Salomon, A. (Creator), Rojo, F. (Creator), Braybrooke, J. P. (Creator), Hanna, M. G. (Creator), Bethmann, D. (Creator), Castaneda, C. A. (Creator), Willard-Gallo, K. (Creator), Sharma, A. (Creator), Lien, H.-C. (Creator), Fineberg, S. (Creator), Thagaard, J. (Creator), Comerma, L. (Creator), Gonzalez-Ericsson, P. (Creator), Brogi, E. (Creator), Loi, S. (Creator), Saltz, J. (Creator), Klaushen, F. (Creator), Cooper, L. (Creator), Amgad, M. (Creator), Moore, D. A. (Creator) & Soler, T. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.11907768.v1, https://springernature.figshare.com/articles/figure/Metadata_supporting_data_files_in_the_published_article_Pitfalls_in_Assessing_Stromal_Tumor_Infiltrating_Lymphocytes_sTILs_in_Breast_Cancer/11907768/1
Dataset
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Additional file 1 of High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients
Yang, X. (Creator), Amgad, M. (Creator), Cooper, L. A. D. (Creator), Du, Y. (Contributor), Fu, H. (Contributor) & Ivanov, A. A. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12904788, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_High_expression_of_MKK3_is_associated_with_worse_clinical_outcomes_in_African_American_breast_cancer_patients/12904788
Dataset