Lee Alex Donald Cooper

  • 3336 Citations
1984 …2020

Research output per year

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Personal profile

Research Interests

Dr. Cooper received his PhD in Electrical and Computer Engineering from Ohio State University in 2009. He joined the Biomedical Informatics faculty at Emory University in 2012 where he was jointly appointed with Biomedical Engineering at Georgia Institute of Technology. He joined the department of pathology at Northwestern in 2019 as an Associate Professor and Director of Computational Pathology.

My lab focuses on the applications of machine learning in cancer and fundamental research in machine learning. We develop algorithms to predict clinical outcomes from genomic, imaging, and histopathology data, and to extract quantitative descriptions of tissue microenvironments from digital pathology images. Our work has produced a number of software tools that enable researchers to manage large and complex datasets and to interact with these data using machine learning algorithms. Our goal is to improve the quality of predictions used in clinical management and to provide investigators with new insights in cancer biology. Our research has been funded by NLM, NCI, NIBIB, NINDS, and industry and foundation sources.

Education/Academic qualification

PhD, Ohio State University

… → 2009

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Research Output

Machine-based detection and classification for bone marrow aspirate differential counts: initial development focusing on nonneoplastic cells

Chandradevan, R., Aljudi, A. A., Drumheller, B. R., Kunananthaseelan, N., Amgad, M., Gutman, D. A., Cooper, L. A. D. & Jaye, D. L., Jan 1 2020, In : Laboratory Investigation. 100, 1, p. 98-109 12 p.

Research output: Contribution to journalArticle

  • 3 Scopus citations

    An Ensemble-based Active Learning for Breast Cancer Classification

    Lee, S., Amgad, M., Masoud, M., Subramanian, R., Gutman, D. & Cooper, L., Nov 2019, Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. Yoo, I., Bi, J. & Hu, X. T. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 2549-2553 5 p. 8983317. (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  • Incorporation of a spectral model in a convolutional neural network for accelerated spectral fitting

    Gurbani, S. S., Sheriff, S., Maudsley, A. A., Shim, H. & Cooper, L. A. D., May 2019, In : Magnetic resonance in medicine. 81, 5, p. 3346-3357 12 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Joint region and nucleus segmentation for characterization of tumor infiltrating lymphocytes in breast cancer

    Amgad, M., Sarkar, A., Srinivas, C., Redman, R., Ratra, S., Bechert, C. J., Calhoun, B. C., Mrazeck, K., Kurkure, U., Cooper, L. A. D. & Barnes, M., Jan 1 2019, Medical Imaging 2019: Digital Pathology. Tomaszewski, J. E. & Ward, A. D. (eds.). SPIE, 109560M. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10956).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  • Phosphoinositide 3-kinase signaling can modulate MHC Class i and II expression

    Chandrasekaran, S., Sasaki, M., Scharer, C. D., Kissick, H. T., Patterson, D. G., Magliocca, K. R., Seykora, J. T., Sapkota, B., Gutman, D. A., Cooper, L. A., Lesinski, G. B., Waller, E. K., Thomas, S. N., Kotenko, S. V., Boss, J. M., Moreno, C. S., Swerlick, R. A. & Pollack, B. P., Jan 1 2019, In : Molecular Cancer Research. 17, 12, p. 2395-2409 15 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations