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Personal profile

Research Interests

The three fundamental goals of my research are the following: 1) To understand the nature of the brain's own signals -- the "language" in which movement commands are expressed by neurons in the central nervous system. 2) To understand the mechanisms by which these signals are produced -- the nature of the connections among networks of neurons, and the transformations that occur in the signals as they propagate throughout these networks. 3) To develop applications of these basic principles that could be of therapeutic value to human patients. Much of this work is done in collaboration with students and faculty from the Biomedical Engineering Department and the Interdepartmental Neuroscience Program (NUIN).

Training Experience

1992Postdoctoral Fellowship, University of Nijmegen

Education/Academic qualification

PhD, Northwestern University

… → 1990


  • Movement Control
  • Neural Engineering
  • Neuroscience
  • Spinal Cord Injury

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Grants 2002 2023

Motor Cortex
Nervous System Diseases
Research Personnel
Brain computer interface
Prostheses and Implants

Research Output 1984 2019

Cortically Controlled FES for Restoration and Rehabilitation of Function Following SCI in Rats

Barroso, F. O., Yoder, B., Wallner, J., Jantz, M., Tostado, P., Pei, E., Tysseling, V. M., Miller, L. E. & Tresch, M. C., Jan 1 2019, Biosystems and Biorobotics. Springer International Publishing, p. 931-934 4 p. (Biosystems and Biorobotics; vol. 21).

Research output: Chapter in Book/Report/Conference proceedingChapter

Patient rehabilitation

Cortical population activity within a preserved neural manifold underlies multiple motor behaviors

Gallego, J. A., Perich, M. G., Naufel, S. N., Ethier, C., Solla, S. A. & Miller, L. E., Dec 1 2018, In : Nature communications. 9, 1, 4233.

Research output: Contribution to journalArticle

Motor Cortex

Evaluation of high-density, multi-contact nerve cuffs for activation of grasp muscles in monkeys

Brill, N. A., Naufel, S. N., Polasek, K., Ethier, C., Cheesborough, J., Agnew, S., Miller, L. E. & Tyler, D. J., Feb 27 2018, In : Journal of Neural Engineering. 15, 3, 036003.

Research output: Contribution to journalArticle

Hand Strength
Chemical activation

Latent factors and dynamics in motor cortex and their application to brain–machine interfaces

Pandarinath, C., Ames, K. C., Russo, A. A., Farshchian, A., Miller, L. E., Dyer, E. L. & Kao, J. C., Oct 31 2018, In : Journal of Neuroscience. 38, 44, p. 9390-9401 12 p.

Research output: Contribution to journalArticle

Brain-Computer Interfaces
Motor Cortex

Linear-nonlinear-time-warp-poisson models of neural activity

Lawlor, P. N., Perich, M. G., Miller, L. E. & Kording, K. P., Jan 1 2018, (Accepted/In press) In : Journal of Computational Neuroscience.

Research output: Contribution to journalArticle

Nonlinear Dynamics
Motor Cortex