Leena Bhattacharya Mithal

  • 64 Citations
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Personal profile

Research Interests

I am a Pediatric Infectious Diseases specialist at the Ann and Robert H. Lurie Children’s Hospital of Chicago, with a particular academic interest and clinical expertise in infections affecting newborns and infants. I am passionate about improving accurate diagnosis of sepsis and appropriate antibiotic use in infants through research and education.

My clinical-translational research focus is to improve early, reliable identification of neonatal sepsis. Through several collaborative projects, I study aspects of neonatal sepsis diagnostics including biomarkers of immune response and molecular pathogen detection using proteomics and metagenomics techniques in umbilical cord blood. I am also interested in perinatal management of maternal infection risk, including intrapartum antibiotic prophylaxis. By understanding sepsis mechanisms and microbe-host interactions and applying this knowledge to development of novel clinical approaches, we can improve neonatal outcomes and judicious use of antimicrobials. My other research interests include congenital cytomegalovirus, the link between perinatal microbiome and neurobehavioral development, and molecular diagnostics.

As an Infectious Diseases physician, I diagnose and treat a variety of severe and atypical infections in infants and children. I have a special interest in infants and complex infections in the neonatal intensive care unit. I also lead the evaluation and treatment of neonates with congenital cytomegalovirus infection at Lurie Children’s. Other clinical interests include bacterial sepsis, bone and joint infections, device-related infections, and tuberculosis.

Training Experience

2011Residency, Baylor College of Medicine

Education/Academic qualification

MSCI, Northwestern University

… → 2016

MD, Northwestern University Feinberg School of Medicine

… → 2008

Research interests

  • Clinical Research
  • Infectious Diseases
  • Infectious Diseases in Children
  • Microbiome
  • Neonatology
  • Premature Infants
  • Sepsis
  • Translational Research

Fingerprint Dive into the research topics where Leena Bhattacharya Mithal is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Sepsis Medicine & Life Sciences
Vital Signs Medicine & Life Sciences
Premature Infants Medicine & Life Sciences
Pediatrics Medicine & Life Sciences
Vaccines Medicine & Life Sciences
Infection Medicine & Life Sciences
Blood Safety Medicine & Life Sciences
Gadolinium Medicine & Life Sciences

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Grants 2017 2018

Research Output 2011 2019

  • 64 Citations
  • 11 Article
  • 2 Chapter

Physeal separation in pediatric osteomyelitis

Wyers, M., Samet, J. D. & Mithal, L. B., Jan 1 2019, In : Pediatric radiology.

Research output: Contribution to journalArticle

Wounds and Injuries

Infectious Related to Prosthetic or Artificial Devices

Cherry, J., Tan, TQ., Demmler-Harrison, GJ., Mithal, LB., Kaplan, SL., Steinbach, WJ. & Hotez, P., 2018, Feigin and Cherry Textbook of Pediatric Infectious Diseases, 8th edition. Philadelphia: Elsevier

Research output: Chapter in Book/Report/Conference proceedingChapter

Initial Management of Fever and Neutropenia: A Practical Approach

Rossoff, J. & Mithal, L. B., Jun 1 2018, In : Clinical Pediatric Emergency Medicine. 19, 2, p. 145-152 8 p.

Research output: Contribution to journalArticle

Signs and Symptoms
Hospital Emergency Service
2 Citations (Scopus)

Vital signs analysis algorithm detects inflammatory response in premature infants with late onset sepsis and necrotizing enterocolitis

Mithal, L. B., Yogev, R., Palac, H. L., Kaminsky, D., Gur, I. & Mestan, K. K. L., Feb 1 2018, In : Early Human Development. 117, p. 83-89 7 p.

Research output: Contribution to journalArticle

Necrotizing Enterocolitis
Vital Signs
Premature Infants
Anti-Bacterial Agents
12 Citations (Scopus)

Cord blood acute phase reactants predict early onset neonatal sepsis in preterm infants

Mithal, L. B., Palac, H. L., Yogev, R., Ernst, L. M. & Mestan, K. K. L., Jan 1 2017, In : PloS one. 12, 1, e0168677.

Research output: Contribution to journalArticle

Serum Amyloid A Protein
sepsis (infection)
acute phase proteins
Acute-Phase Proteins