Grants per year
Personal profile
Research Interests
I am a Pediatric Infectious Diseases specialist at the Ann and Robert H. Lurie Children’s Hospital of Chicago, with a particular academic interest and clinical expertise in infections affecting newborns and infants. I am passionate about improving accurate diagnosis of sepsis and appropriate antibiotic use in infants through research and education.
My clinical-translational research focus is to improve early, reliable identification of neonatal sepsis. Through several collaborative projects, I study aspects of neonatal sepsis diagnostics including biomarkers of immune response and molecular pathogen detection using proteomics and metagenomics techniques in umbilical cord blood. I am also interested in perinatal management of maternal infection risk, including intrapartum antibiotic prophylaxis. By understanding sepsis mechanisms and microbe-host interactions and applying this knowledge to development of novel clinical approaches, we can improve neonatal outcomes and judicious use of antimicrobials. My other research interests include congenital cytomegalovirus, the link between perinatal microbiome and neurobehavioral development, and molecular diagnostics.
As an Infectious Diseases physician, I diagnose and treat a variety of severe and atypical infections in infants and children. I have a special interest in infants and complex infections in the neonatal intensive care unit. I also lead the evaluation and treatment of neonates with congenital cytomegalovirus infection at Lurie Children’s. Other clinical interests include bacterial sepsis, bone and joint infections, device-related infections, and tuberculosis.
Training Experience
2011 | Residency, Baylor College of Medicine |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MSCI, Clinical Investigation, Northwestern University
… → 2016
Medicine, MD, Northwestern University
… → 2008
Research interests keywords
- Clinical Research
- Infectious Diseases
- Infectious Diseases in Children
- Microbiome
- Neonatology
- Premature Infants
- Sepsis
- Translational Research
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Collaborations and top research areas from the last five years
Grants
- 9 Finished
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OPTIMIZING CONGENITAL CMV DIAGNOSIS THROUGH EDUCATION AND PROCESS
Mithal, L. B. (PD/PI)
8/15/19 → 2/28/21
Project: Research project
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Molecular Signatures of Early Onset Neonatal Sepsis in Umbilical Cord Blood
Mithal, L. B. (PD/PI)
National Institute of Allergy and Infectious Diseases
2/4/19 → 3/31/24
Project: Research project
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Molecular Signatures of Early Onset Neonatal Sepsis in Umbilical Cord Blood
Mithal, L. B. (PD/PI)
National Institute of Allergy and Infectious Diseases
2/4/19 → 3/31/24
Project: Research project
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Biomarker Signatures for Diagnosis of Neonatal Sepsis in Umbilical Cord Blood
Mithal, L. B. (PD/PI)
The Gerber Companies Foundation
8/13/18 → 12/31/21
Project: Research project
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Umbilical Cord Blood Biomarkers to Diagnosis Sepsis in Premature Infants
Mithal, L. B. (PD/PI)
Northwestern Memorial Foundation
9/1/17 → 12/31/20
Project: Research project
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Northwestern University resource and education development initiatives to advance collaborative artificial intelligence across the learning health system
Luo, Y., Mao, C., Sanchez-Pinto, L. N., Ahmad, F. S., Naidech, A., Rasmussen, L., Pacheco, J. A., Schneider, D., Mithal, L. B., Dresden, S., Holmes, K., Carson, M., Shah, S. J., Khan, S., Clare, S., Wunderink, R. G., Liu, H., Walunas, T., Cooper, L. & Yue, F. & 14 others, , Jul 2024, In: Learning Health Systems. 8, 3, e10417.Research output: Contribution to journal › Article › peer-review
Open Access -
Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes
Snider, J. B., Mithal, L. B., Kwah, J. H., Rhodes, N. J. & Son, M., Dec 2023, In: BMC Pregnancy and Childbirth. 23, 1, 400.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Enhancing Automatic Placenta Analysis Through Distributional Feature Recomposition in Vision-Language Contrastive Learning
Pan, Y., Cai, T., Mehta, M., Gernand, A. D., Goldstein, J. A., Mithal, L., Mwinyelle, D., Gallagher, K. & Wang, J. Z., 2023, Medical Image Computing and Computer Assisted Intervention – MICCAI 2023 - 26th International Conference, Proceedings. Greenspan, H., Greenspan, H., Madabhushi, A., Mousavi, P., Salcudean, S., Duncan, J., Syeda-Mahmood, T. & Taylor, R. (eds.). Springer Science and Business Media Deutschland GmbH, p. 116-126 11 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 14225 LNCS).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Open Access -
Lability of prenatal stress during the COVID-19 pandemic links to negative affect in infancy
MacNeill, L. A., Matras, S. A., Zhang, Y., Giase, G., Edwards, R. C., Petitclerc, A., Mithal, L. B., Mestan, K. K. L., Grobman, W. A., Norton, E. S., Alshurafa, N., Moskowitz, J. T., Tandon, S. D. & Wakschlag, L. S., Jan 1 2023, In: Infancy. 28, 1, p. 136-157 22 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Maternal Antibody Response and Transplacental Transfer Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection or Vaccination in Pregnancy
Otero, S., Miller, E. S., Sunderraj, A., Shanes, E. D., Sakowicz, A., Goldstein, J. A. & Mithal, L. B., Jan 15 2023, In: Clinical Infectious Diseases. 76, 2, p. 220-228 9 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations
Datasets
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Placental Pathology After SARS-CoV-2 Infection in the Pre-Variant of Concern, Alpha / Gamma, Delta, or Omicron Eras
Shanes, E. D. (Creator), Miller, E. S. (Creator), Otero, S. (Creator), Ebbott, R. (Creator), Aggarwal, R. (Creator), Willnow, A. S. (Creator), Ozer, E. A. (Creator), Mithal, L. B. (Creator) & Goldstein, J. A. (Creator), SAGE Journals, 2022
DOI: 10.25384/sage.c.6021478, https://sage.figshare.com/collections/Placental_Pathology_After_SARS-CoV-2_Infection_in_the_Pre-Variant_of_Concern_Alpha_Gamma_Delta_or_Omicron_Eras/6021478
Dataset
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Placental Pathology After SARS-CoV-2 Infection in the Pre-Variant of Concern, Alpha / Gamma, Delta, or Omicron Eras
Shanes, E. D. (Creator), Miller, E. S. (Creator), Otero, S. (Creator), Ebbott, R. (Creator), Aggarwal, R. (Creator), Willnow, A. S. (Creator), Ozer, E. A. (Creator), Mithal, L. B. (Creator) & Goldstein, J. A. (Creator), SAGE Journals, 2022
DOI: 10.25384/sage.c.6021478, https://sage.figshare.com/collections/Placental_Pathology_After_SARS-CoV-2_Infection_in_the_Pre-Variant_of_Concern_Alpha_Gamma_Delta_or_Omicron_Eras/6021478
Dataset