Leena Bhattacharya Mithal

  • 74 Citations

Research output per year

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Personal profile

Research Interests

I am a Pediatric Infectious Diseases specialist at the Ann and Robert H. Lurie Children’s Hospital of Chicago, with a particular academic interest and clinical expertise in infections affecting newborns and infants. I am passionate about improving accurate diagnosis of sepsis and appropriate antibiotic use in infants through research and education.

My clinical-translational research focus is to improve early, reliable identification of neonatal sepsis. Through several collaborative projects, I study aspects of neonatal sepsis diagnostics including biomarkers of immune response and molecular pathogen detection using proteomics and metagenomics techniques in umbilical cord blood. I am also interested in perinatal management of maternal infection risk, including intrapartum antibiotic prophylaxis. By understanding sepsis mechanisms and microbe-host interactions and applying this knowledge to development of novel clinical approaches, we can improve neonatal outcomes and judicious use of antimicrobials. My other research interests include congenital cytomegalovirus, the link between perinatal microbiome and neurobehavioral development, and molecular diagnostics.

As an Infectious Diseases physician, I diagnose and treat a variety of severe and atypical infections in infants and children. I have a special interest in infants and complex infections in the neonatal intensive care unit. I also lead the evaluation and treatment of neonates with congenital cytomegalovirus infection at Lurie Children’s. Other clinical interests include bacterial sepsis, bone and joint infections, device-related infections, and tuberculosis.

Training Experience

2011Residency, Baylor College of Medicine

Education/Academic qualification

MSCI, Northwestern University

… → 2016

MD, Northwestern University Feinberg School of Medicine

… → 2008

Research interests

  • Clinical Research
  • Infectious Diseases
  • Infectious Diseases in Children
  • Microbiome
  • Neonatology
  • Premature Infants
  • Sepsis
  • Translational Research

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Research Output

  • 74 Citations
  • 11 Article
  • 2 Chapter

Physeal separation in pediatric osteomyelitis

Wyers, M., Samet, J. D. & Mithal, L. B., Jan 1 2019, In : Pediatric radiology.

Research output: Contribution to journalArticle

  • Infectious Related to Prosthetic or Artificial Devices

    Cherry, J., Tan, TQ., Demmler-Harrison, GJ., Mithal, LB., Kaplan, SL., Steinbach, WJ. & Hotez, P., 2018, Feigin and Cherry Textbook of Pediatric Infectious Diseases, 8th edition. Philadelphia: Elsevier

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Initial Management of Fever and Neutropenia: A Practical Approach

    Rossoff, J. & Mithal, L. B., Jun 2018, In : Clinical Pediatric Emergency Medicine. 19, 2, p. 145-152 8 p.

    Research output: Contribution to journalArticle

  • Vital signs analysis algorithm detects inflammatory response in premature infants with late onset sepsis and necrotizing enterocolitis

    Mithal, L. B., Yogev, R., Palac, H. L., Kaminsky, D., Gur, I. & Mestan, K. K. L., Feb 1 2018, In : Early Human Development. 117, p. 83-89 7 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Cord blood acute phase reactants predict early onset neonatal sepsis in preterm infants

    Mithal, L. B., Palac, H. L., Yogev, R., Ernst, L. M. & Mestan, K. K., Jan 2017, In : PloS one. 12, 1, e0168677.

    Research output: Contribution to journalArticle

  • 14 Scopus citations