Grants per year
Personal profile
Research Interests
The overarching goals of Dr. Sharma’s research program are to develop novel approaches to prevent disease and disability development and progression in persons at high risk for or with knee osteoarthritis. Through large-scale, longitudinal studies of persons at high risk, she and her team seek to shift the initiation of disability prevention efforts to earlier stages, when individuals are well enough to execute them, before the whole-organ, downward osteoarthritic disease progression spiral. Her interdisciplinary team has examined the role in osteoarthritis disease progression and functional decline of an array of factors, including varus-valgus alignment, frontal and sagittal plane instability, joint proprioceptive acuity, quantitative characteristics of gait, knee and hip muscle strength, meniscal damage, other tissue factors by MRI, self-efficacy, and pain catastrophizing.
Certifications and Licenses
Internal Medicine | |
Rheumatology |
Training Experience
1987 | Residency, University of Texas Medical Branch Hospital |
1989 | Fellowship, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, Medical College of Wisconsin
… → 1984
Research interests keywords
- Disability
- Epidemiology
- Health Services Research
- Osteoarthritis
- Public Health
- Rheumatology
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Collaborations and top research areas from the last five years
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Core Center for Clinical Research at Northwestern University
Sharma, L., Holmes, K., Kershaw, K. N., Pope, R. M. & Lee, Y. C.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/21/22 → 8/31/27
Project: Research project
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Kyle MacQuarrie (KL2, GY7)
National Center for Advancing Translational Sciences
7/15/19 → 6/30/24
Project: Research project
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Sadiya, Khan
National Center for Advancing Translational Sciences
7/15/19 → 6/30/24
Project: Research project
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Carol Haywood (KL2, GY8)
National Center for Advancing Translational Sciences
7/15/19 → 6/30/24
Project: Research project
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Northwestern University Clinical and Translational Science Institute (NUCATS)
Pope, R. M., Sharma, L., Pope, R. M. & Yanez, B. R.
National Center for Advancing Translational Sciences
7/15/19 → 6/30/24
Project: Research project
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Ambulatory support moment contribution patterns and MRI-detected tibiofemoral and patellofemoral disease worsening in adults with knee osteoarthritis: A preliminary study
Chang, A. H., Almagor, O., Muhammad, L. N., Guermazi, A., Prasad, P. V., Chmiel, J. S., Moisio, K. C., Lee, J. & Sharma, L., Jun 2023, In: Journal of Orthopaedic Research. 41, 6, p. 1206-1216 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Comparison of evaluation metrics of deep learning for imbalanced imaging data in osteoarthritis studies
Liu, S., Roemer, F., Ge, Y., Bedrick, E. J., Li, Z. M., Guermazi, A., Sharma, L., Eaton, C., Hochberg, M. C., Hunter, D. J., Nevitt, M. C., Wirth, W., Kent Kwoh, C. & Sun, X., Sep 2023, In: Osteoarthritis and Cartilage. 31, 9, p. 1242-1248 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The Association Between Severity of Radiographic Knee OA and Recurrent Falls in Middle and Older Aged Adults: The Osteoarthritis Initiative
Harris, R., Strotmeyer, E. S., Sharma, L., Kwoh, C. K., Brach, J. S., Boudreau, R. & Cauley, J. A., Jan 26 2023, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 78, 1, p. 97-103 7 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
The Natural History of Knee Osteoarthritis Pain Experience and Risk Profiles
Chang, A. H-I., Almagor, O., Lee, J., Song, J., Muhammad, L. N., Chmiel, J. S., Moisio, K. C. & Sharma, L., 2023, (Accepted/In press) In: Journal of Pain.Research output: Contribution to journal › Article › peer-review
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Which risk factors determine cartilage thickness and composition change in radiographically normal knees? – Data from the Osteoarthritis Initiative
Eckstein, F., Maschek, S., Culvenor, A., Sharma, L., Roemer, F. W., Duda, G. N. & Wirth, W., Sep 2023, In: Osteoarthritis and Cartilage Open. 5, 3, 100365.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Is Laminar Cartilage Composition as Determined by T2 Relaxometry Associated with Incident and Worsening of Cartilage or Bone Marrow Abnormalities?
Roemer, F. W. (Creator), Eckstein, F. (Creator), Duda, G. (Creator), Guermazi, A. (Creator), Maschek, S. (Creator), Sharma, L. (Creator), Wirth, W. (Creator) & Eckstein, F. (Creator), SAGE Journals, 2020
DOI: 10.25384/sage.c.5020553.v1, https://sage.figshare.com/collections/Is_Laminar_Cartilage_Composition_as_Determined_by_T2_Relaxometry_Associated_with_Incident_and_Worsening_of_Cartilage_or_Bone_Marrow_Abnormalities_/5020553/1
Dataset