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Personal profile

Research Interests

Dr. Lei Wang's lab research is focused on the development of multidimensional and multimodal neuroimaging biomarkers using the tools of computational anatomy. Working with collaborators from engineering, mathematics, psychology and clinical specialties, the team focuses on the following major areas: Mapping of Brain Structures using MRI. Dr. Wang develops automated pipelines to delineate brain structures based on simultaneous mappings of multiple structures from multiple atlases. This includes deep brain structures (such as the hippocampus, amygdala, thalamus, and basal ganglia) and cortical structures.Complex Neuroimaging Biomarkers. They develop modeling and statistical approaches for the analysis of these maps and frameworks for joint, integrated analyses of multidimensional, multimodal information based on the structural mapping of the brain. These include: • Multimodal MRI analysis: structural MRI, functional MRI, diffusion MRI, perfusion MRI, PET • Network analysis • Structure-function relationship • Subtyping and dimensional analysis • Prediction and longitudinal analysis Clinical Applications We are interested in developing neuroimaging markers to characterize neuropsychiatric disorders, disease progression and prediction, and monitoring of treatment:
• Mild cognitive impairment (MCI), dementia • Breast cancer-related MCI • Psychosis/Schizophrenia/Mood Disorders • Imaging Genetics Neuroinformatics • Data sharing • Data mediation Preclinical Applications Neuroimaging of Animal Models • Schizophrenia, Dementia, Mood Disorders, Memory • Mouse, rat, rabbit

Education/Academic qualification

PhD, Harvard University

… → 1995

Research interests

  • Aging
  • Alzheimer's Disease
  • Bioengineering
  • Bioinformatics
  • Psychiatry
  • Psychology
  • Radiology
  • Schizophrenia

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Grants

  • Research Output

    Open Access
  • Subcortical structural variations associated with low socioeconomic status in adolescents

    Jenkins, L. M., Chiang, J. J., Vause, K., Hoffer, L., Alpert, K., Parrish, T. B., Wang, L. & Miller, G. E., Jan 1 2020, In : Human Brain Mapping. 41, 1, p. 162-171 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Circuit activity underlying a distinct modulator of prepulse inhibition

    Heidinger, L., Reilly, J. L., Wang, L. & Goldman, M. B., Jun 30 2019, In : Psychiatry research. Neuroimaging. 288, p. 1-11 11 p.

    Research output: Contribution to journalArticle

  • Common brain disorders are associated with heritable patterns of apparent aging of the brain

    Karolinska Schizophrenia Project (KaSP), Oct 1 2019, In : Nature Neuroscience. 22, 10, p. 1617-1623 7 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Exposure to violence and low family income are associated with heightened amygdala responsiveness to threat among adolescents

    White, S. F., Voss, J. L., Chiang, J. J., Wang, L., McLaughlin, K. A. & Miller, G. E., Dec 2019, In : Developmental Cognitive Neuroscience. 40, 100709.

    Research output: Contribution to journalReview article

    Open Access