Lena Burbulla

  • 3470 Citations
20102021
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Personal profile

Research Interests

My research focus is to define key molecular pathways in the pathogenesis of neurodegeneration by studying rare genetic diseases with a goal of identifying converging pathways and specific targets for therapeutic development. Utilizing genetic forms of Parkinson’s disease as a model, the overall objective of my work is to evaluate disease mechanisms in specific subtypes of human neurons in an age-dependent manner. For that I am studying long-term cultures of vulnerable midbrain dopaminergic neurons generated from induced pluripotent stem cells by a combination of genomic approaches and functional physiological assays. One major theme is the investigation of the role of oxidative stress as one possible initiating factor contributing to neurodegeneration in Parkinson’s disease. My goal is to evaluate the consequences of oxidative stress in disease progression by studying associated pathogenic mechanisms such as accumulation of aggregation-prone-proteins and toxic dopamine by-products as well as deficient autophagy and lysosomal degradation. This work also includes identifying specific targets for effective therapeutic intervention in Parkinson's disease.

Training Experience

2013Postdoctoral Fellowship, Massachusetts General Hospital, Harvard Medical School
2018Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, University of Tuebingen, Germany

… → 2011

Research interests

  • Aging
  • Cell Biology
  • Metabolism
  • Neuroscience
  • Parkinson’s Disease
  • Stem Cells

Fingerprint Dive into the research topics where Lena Burbulla is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 21 Similar Profiles
Parkinson Disease Medicine & Life Sciences
Glucosylceramidase Medicine & Life Sciences
Induced Pluripotent Stem Cells Medicine & Life Sciences
Synucleins Medicine & Life Sciences
Neurons Medicine & Life Sciences
Autophagy Medicine & Life Sciences
Mitochondria Medicine & Life Sciences
Mitochondrial Dynamics Medicine & Life Sciences

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Grants 2019 2021

Research Output 2010 2019

  • 3470 Citations
  • 17 Article
  • 3 Comment/debate
  • 3 Review article
  • 1 Chapter
Glucosylceramidase
Parkinson Disease
Phenotype
Mutation
Synucleins
1 Citation (Scopus)

Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase

Zheng, J., Jeon, S., Jiang, W., Burbulla, L., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1218-1230 13 p.

Research output: Contribution to journalArticle

Glucosylceramidase
Quinazolines
Parkinson Disease
Mutant Proteins
Structure-Activity Relationship

Corrigendum: Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells (Brain (2018) 141 (3052-3064) DOI: 10.1093/brain/awy230)

Seibler, P., Burbulla, L., Dulovic, M., Zittel, S., Heine, J., Schmidt, T., Rudolph, F., Westenberger, A., Rakovic, A., Munchau, A., Krainc, D. & Klein, C., Mar 1 2019, In : Brain. 142, 3, p. E10

Research output: Contribution to journalComment/debate

Open Access
Iron Overload
Osteogenesis Imperfecta
Ferritins
Brain
Data Display

The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease

Burbulla, L. F. & Krainc, D., Dec 2019, In : Neurobiology of Disease. 132, 104545.

Research output: Contribution to journalReview article

Parkinson Disease
Dopamine
Substantia Nigra
Rodentia
Nerve Degeneration