Grants per year
Personal profile
Research Interests
My research focus is to define key molecular pathways in the pathogenesis of neurodegeneration by studying rare genetic diseases with a goal of identifying converging pathways and specific targets for therapeutic development. Utilizing genetic forms of Parkinson’s disease as a model, the overall objective of my work is to evaluate disease mechanisms in specific subtypes of human neurons in an age-dependent manner. For that I am studying long-term cultures of vulnerable midbrain dopaminergic neurons generated from induced pluripotent stem cells by a combination of genomic approaches and functional physiological assays. One major theme is the investigation of the role of oxidative stress as one possible initiating factor contributing to neurodegeneration in Parkinson’s disease. My goal is to evaluate the consequences of oxidative stress in disease progression by studying associated pathogenic mechanisms such as accumulation of aggregation-prone-proteins and toxic dopamine by-products as well as deficient autophagy and lysosomal degradation. This work also includes identifying specific targets for effective therapeutic intervention in Parkinson's disease.
Training Experience
| 2013 | Postdoctoral Fellowship, Massachusetts General Hospital, Harvard Medical School |
| 2018 | Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine |
Education/Academic qualification
PhD, University of Tübingen
… → 2011
Research interests
- Aging
- Cell Biology
- Metabolism
- Neuroscience
- Parkinson’s Disease
- Stem Cells
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Grants
- 1 Active
Research Output
Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain (Nature Neuroscience, (2020), 23, 1, (15-20), 10.1038/s41593-019-0556-3)
Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Feb 1 2020, In : Nature Neuroscience. 23, 2, 1 p.Research output: Contribution to journal › Comment/debate
Open Access
Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain
Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, In : Nature neuroscience. 23, 1, p. 15-20 6 p.Research output: Contribution to journal › Article
3
Scopus
citations
Gelator Length Precisely Tunes Supramolecular Hydrogel Stiffness and Neuronal Phenotype in 3D Culture
Godbe, J. M., Freeman, R., Burbulla, L. F., Lewis, J., Krainc, D. & Stupp, S. I., Feb 10 2020, In : ACS Biomaterials Science and Engineering. 6, 2, p. 1196-1207 12 p.Research output: Contribution to journal › Article
1
Scopus
citations
A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease
Burbulla, L. F., Jeon, S., Zheng, J., Song, P., Silverman, R. B. & Krainc, D., Oct 16 2019, In : Science translational medicine. 11, 514, eaau6870.Research output: Contribution to journal › Article
7
Scopus
citations
Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase
Zheng, J., Jeon, S., Jiang, W., Burbulla, L. F., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1218-1230 13 p.Research output: Contribution to journal › Article
4
Scopus
citations