Grants per year
Personal profile
Research Interests
My research focus is to define key molecular pathways in the pathogenesis of neurodegeneration by studying rare genetic diseases with a goal of identifying converging pathways and specific targets for therapeutic development. Utilizing genetic forms of Parkinson’s disease as a model, the overall objective of my work is to evaluate disease mechanisms in specific subtypes of human neurons in an age-dependent manner. For that I am studying long-term cultures of vulnerable midbrain dopaminergic neurons generated from induced pluripotent stem cells by a combination of genomic approaches and functional physiological assays. One major theme is the investigation of the role of oxidative stress as one possible initiating factor contributing to neurodegeneration in Parkinson’s disease. My goal is to evaluate the consequences of oxidative stress in disease progression by studying associated pathogenic mechanisms such as accumulation of aggregation-prone-proteins and toxic dopamine by-products as well as deficient autophagy and lysosomal degradation. This work also includes identifying specific targets for effective therapeutic intervention in Parkinson's disease.
Training Experience
2013 | Postdoctoral Fellowship, Massachusetts General Hospital, Harvard Medical School |
2018 | Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine |
Education/Academic qualification
PhD, University of Tuebingen, Germany
… → 2011
Research interests
- Aging
- Cell Biology
- Metabolism
- Neuroscience
- Parkinson’s Disease
- Stem Cells
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Grants 2019 2021
- 1 Active
Mechanistic Insights into Iron Accumulation in WDR45 Mutant Neurons Linked to β-propeller-Associated Neurodegeneration
Associazione Italiana Sindromi Neurodegenerative da Accumulo di Ferro
10/1/19 → 3/31/21
Project: Research project
Research Output 2010 2019
A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease
Burbulla, L. F., Jeon, S., Zheng, J., Song, P., Silverman, R. B. & Krainc, D., Oct 16 2019, In : Science translational medicine. 11, 514Research output: Contribution to journal › Article
Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase
Zheng, J., Jeon, S., Jiang, W., Burbulla, L., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1218-1230 13 p.Research output: Contribution to journal › Article
Correction to: Conversion of quinazoline modulators from inhibitors to activators of β-glucocerebrosidase (Journal of Medical Chemistry (2019) 62: 3 (1218-1230) DOI: 10.1021/acs.jmedchem.8b01294)
Zheng, J., Jeon, S., Jiang, W., Burbulla, L. F., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, 1 p.Research output: Contribution to journal › Comment/debate
Corrigendum: Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells (Brain (2018) 141 (3052-3064) DOI: 10.1093/brain/awy230)
Seibler, P., Burbulla, L., Dulovic, M., Zittel, S., Heine, J., Schmidt, T., Rudolph, F., Westenberger, A., Rakovic, A., Munchau, A., Krainc, D. & Klein, C., Mar 1 2019, In : Brain. 142, 3, p. E10Research output: Contribution to journal › Comment/debate
The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease
Burbulla, L. F. & Krainc, D., Dec 2019, In : Neurobiology of Disease. 132, 104545.Research output: Contribution to journal › Review article