Lena Burbulla

  • 3830 Citations
20102020

Research output per year

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Research Output

  • 3830 Citations
  • 19 Article
  • 4 Comment/debate
  • 3 Review article
  • 1 Chapter
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Article
2020

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, In : Nature neuroscience. 23, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Gelator Length Precisely Tunes Supramolecular Hydrogel Stiffness and Neuronal Phenotype in 3D Culture

Godbe, J. M., Freeman, R., Burbulla, L. F., Lewis, J., Krainc, D. & Stupp, S. I., Feb 10 2020, In : ACS Biomaterials Science and Engineering. 6, 2, p. 1196-1207 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2019
8 Scopus citations

Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase

Zheng, J., Jeon, S., Jiang, W., Burbulla, L. F., Ysselstein, D., Oevel, K., Krainc, D. & Silverman, R. B., Feb 14 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1218-1230 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function

Kim, M. J., Jeon, S., Burbulla, L. F. & Krainc, D., Jun 1 2018, In : Human molecular genetics. 27, 11, p. 1972-1988 17 p.

Research output: Contribution to journalArticle

19 Scopus citations

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells

Seibler, P., Burbulla, L. F., Dulovic, M., Zittel, S., Heine, J., Schmidt, T., Rudolph, F., Westenberger, A., Rakovic, A., Münchau, A., Krainc, D. & Klein, C., Oct 1 2018, In : Brain. 141, 10, p. 3052-3064 13 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., Savas, J. N., Kiskinis, E., Zhuang, X., Krüger, R., Surmeier, D. J. & Krainc, D., Sep 22 2017, In : Science. 357, 6357, p. 1255-1261 7 p.

Research output: Contribution to journalArticle

214 Scopus citations
2016

Activation of β-glucocerebrosidase reduces pathological α-synuclein and restores lysosomal function in Parkinson’s patient midbrain neurons

Mazzulli, J. R., Zunke, F., Tsunemi, T., Toker, N. J., Jeon, S., Burbulla, L. F., Patnaik, S., Sidransky, E., Marugan, J. J., Sue, C. M. & Krainc, D., Jul 20 2016, In : Journal of Neuroscience. 36, 29, p. 7693-7706 14 p.

Research output: Contribution to journalArticle

100 Scopus citations

Detection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence

Mazzulli, J. R., Burbulla, L. F., Krainc, D. & Ischiropoulos, H., Feb 16 2016, In : Analytical Chemistry. 88, 4, p. 2399-2405 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease

Hsieh, C. H., Shaltouki, A., Gonzalez, A. E., Bettencourt da Cruz, A., Burbulla, L. F., St. Lawrence, E., Schüle, B., Krainc, D., Palmer, T. D. & Wang, X., Dec 1 2016, In : Cell stem cell. 19, 6, p. 709-724 16 p.

Research output: Contribution to journalArticle

137 Scopus citations
12 Scopus citations
2014

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1

Burbulla, L. F., Fitzgerald, J. C., Stegen, K., Westermeier, J., Thost, A. K., Kato, H., Mokranjac, D., Sauerwald, J., Martins, L. M., Woitalla, D., Rapaport, D., Riess, O., Proikas-Cezanne, T., Rasse, T. M. & Krüger, R., Apr 2014, In : Cell Death and Disease. 5, 4, e1180.

Research output: Contribution to journalArticle

53 Scopus citations
2013

A novel heterozygous OPA3 mutation located in the mitochondrial target sequence results in altered steady-state levels and fragmented mitochondrial network

Grau, T., Burbulla, L. F., Engl, G., Delettre, C., Delprat, B., Oexle, K., Leo-Kottler, B., Roscioli, T., Krüger, R., Rapaport, D., Wissinger, B. & Schimpf-Linzenbold, S., 2013, In : Journal of medical genetics. 50, 12, p. 848-858 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Genetic correction of a lrrk2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression

Reinhardt, P., Schmid, B., Burbulla, L. F., Schöndorf, D. C., Wagner, L., Glatza, M., Höing, S., Hargus, G., Heck, S. A., Dhingra, A., Wu, G., Müller, S., Brockmann, K., Kluba, T., Maisel, M., Krüger, R., Berg, D., Tsytsyura, Y., Thiel, C. S., Psathaki, O. E. & 7 others, Klingauf, J., Kuhlmann, T., Klewin, M., Müller, H., Gasser, T., Schöler, H. R. & Sterneckert, J., Mar 7 2013, In : Cell Stem Cell. 12, 3, p. 354-367 14 p.

Research output: Contribution to journalArticle

293 Scopus citations

Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model

Zhu, J. Y., Vereshchagina, N., Sreekumar, V., Burbulla, L. F., Costa, A. C., Daub, K. J., Woitalla, D., Martins, L. M., Krüger, R. & Rasse, T. M., Dec 30 2013, In : PloS one. 8, 12, e83714.

Research output: Contribution to journalArticle

27 Scopus citations
2012
13 Scopus citations
2011

Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease

Burbulla, L. F. & Krüger, R., Jul 15 2011, In : Journal of the Neurological Sciences. 306, 1-2, p. 1-8 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2010

Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: Functional impact of disease-related variants on mitochondrial homeostasis

Burbulla, L. F., Schelling, C., Kato, H., Rapaport, D., Woitalla, D., Schiesling, C., Schulte, C., Sharma, M., Illig, T., Bauer, P., Jung, S., Nordheim, A., Schöls, L., Riess, O. & Krüger, R., Nov 2010, In : Human molecular genetics. 19, 22, p. 4437-4452 16 p.

Research output: Contribution to journalArticle

89 Scopus citations

Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

Krebiehl, G., Ruckerbauer, S., Burbulla, L. F., Kieper, N., Maurer, B., Waak, J., Wolburg, H., Gizatullina, Z., Gellerich, F. N., Woitalla, D., Riess, O., Kahle, P. J., Proikas-Cezanne, T. & Krüger, R., Feb 23 2010, In : PloS one. 5, 2, e9367.

Research output: Contribution to journalArticle

239 Scopus citations