Leo I Gordon

Personal profile

Research Interests

The overarching goal of my involvement in translational research is to improve the outcome of patients with lymphoma. With scientists in the US and abroad, we are currently investigating novel signaling pathways in lymphoma, using cell lines and animal model systems. More specifically, our research focuses on the biology of reactive oxygen species signaling pathways in lymphoma. Active investigations include: 1) the biology of the lactone diterpenoids in lymphoma; 2) the development of all trans retinoic acid (ATRA) and curcumin loaded nanodisks as a drug delivery vehicle in mantle cell lymphoma (MCL), in collaboration with investigators from the Children’s Hospital Research Institute (CHORI) in Oakland, CA 3) The characterization of cholesterol efflux pumps as a target in lymphoma, in collaboration with Dr Colby Shad Thaxton from the Department of Urology and the Northwestern University Center of Cancer Nanotechnology excellence; 4) the study of hypoxia inducible factor (HIF) in lymphoma, in collaboration with Dr. Paul Schumacker. Clinical research interests include the study of novel immune stimulatory strategies following stem cell transplant in lymphoma with collaborators in Israel, Europe and the US, new approaches to the use of radioimmunotherapy (RIT) in lymphoma, and new treatment paradigms based on the basic investigations described above Clinical research studies are carried out through the Northwestern University Lymphoma Program and through national co-operative groups such as the Eastern Cooperative Oncology Group (ECOG), SPORE programs in lymphoma and through the NCI Phase II Consortium in collaboration with investigators at the University of Chicago.

Certifications and Licenses

	Internal Medicine
	Medical Oncology
	Hematology

Training Experience

1974	Internship, University of Chicago Hospitals
1976	Residency, University of Chicago Hospitals
1978	Fellowship, Univ. of Minnesota Hospital
1979	Fellowship, University of Chicago Hospitals

Education/Academic qualification

MD, University of Cincinnati

… → 1973

Research interests

Apoptosis
Blood Cancer (leukemia and lymphomas)
Cancer Biology
Stem Cells
Transplantation

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Grants

7 Active
46 Finished

Prot #017006: A Phase 2 Study of Lisocabtagene Maraleucel (JCAR017) as Second-Line Therapy in Adult Patients with Aggressive B-cell NHL

Gordon, L. I.

DrugDev Inc., Juno Therapeutics, Inc.

8/8/19 → 8/8/22

Project: Research project

Enhancing apoptosis and immunotherapy with CpG coated hollow gold nanoshells for aggressive B cell lymphoma

Gordon, L. I.

American Society of Hematology

7/1/19 → 6/30/20

Project: Research project

The Robert H. Lurie Comprehensive Cancer Center

Agulnik, M., Awatramani, R., Backman, V., Benson III, A. B., Carthew, R. W., Cella, D., Chakravarti, D., Chandel, N., Crispino, J. D., Cristofanilli, M., Eklund, E. A., Frankfurt, O., Gordon, L. I., Green, K. J., Hahn, E. A., Horbinski, C. M., Horvath, C. M., Hussain, M., James, C. D., Kelleher, N. L., Khan, S. A., LaBonne, C., Larson, A. C., Matei, D. E., Meade, T. J., Mondragon, A., Mrksich, M., Munshi, H. G., Murphy, A. B., Penedo, F. J., Perlman, H. R., Peter, M. E., Platanias, L. C., Rademaker, A. W., Rappoport, J. Z., Rosenzweig, A. C., Scheidt, K. A., Simon, M. A., Sosman, J. A., Spring, B., Wei, J., Weiss, E. L. & Woloschak, G. E.

National Cancer Institute

8/10/18 → 7/31/23

Project: Research project

Novel safe GR-targeted therapy for hematological malignancies

Budunova, I. & Gordon, L. I.

ILSI Health and Environmental Sciences Institute

1/23/17 → 7/22/20

Project: Research project

Prot #017001: A Phase 1, Multicenter, Open-Label Study of JCAR017, CD19-targeted Chimeric Antigen Receptor (CAR) T Cells, for Relapsed and Refractory (R/R) B-cell Non-Hodgkin Lymphoma (NHL)

Gordon, L. I.

Juno Therapeutics, Inc.

3/11/16 → 3/11/22

Project: Research project