Grants per year
Personal profile
Research Interests
The overarching goal of my involvement in translational research is to improve the outcome of patients with lymphoma. With scientists in the US and abroad, we are currently investigating novel signaling pathways in lymphoma, using cell lines and animal model systems. More specifically, our research focuses on the biology of reactive oxygen species signaling pathways in lymphoma. Active investigations include: 1) the biology of the lactone diterpenoids in lymphoma; 2) the development of all trans retinoic acid (ATRA) and curcumin loaded nanodisks as a drug delivery vehicle in mantle cell lymphoma (MCL), in collaboration with investigators from the Children’s Hospital Research Institute (CHORI) in Oakland, CA 3) The characterization of cholesterol efflux pumps as a target in lymphoma, in collaboration with Dr Colby Shad Thaxton from the Department of Urology and the Northwestern University Center of Cancer Nanotechnology excellence; 4) the study of hypoxia inducible factor (HIF) in lymphoma, in collaboration with Dr. Paul Schumacker. Clinical research interests include the study of novel immune stimulatory strategies following stem cell transplant in lymphoma with collaborators in Israel, Europe and the US, new approaches to the use of radioimmunotherapy (RIT) in lymphoma, and new treatment paradigms based on the basic investigations described above Clinical research studies are carried out through the Northwestern University Lymphoma Program and through national co-operative groups such as the Eastern Cooperative Oncology Group (ECOG), SPORE programs in lymphoma and through the NCI Phase II Consortium in collaboration with investigators at the University of Chicago.
Certifications and Licenses
Internal Medicine | |
Medical Oncology | |
Hematology |
Training Experience
1974 | Internship, University of Chicago Hospitals |
1976 | Residency, University of Chicago Hospitals |
1978 | Fellowship, Univ. of Minnesota Hospital |
1979 | Fellowship, University of Chicago Hospitals |
Education/Academic qualification
MD, University of Cincinnati
… → 1973
Research interests
- Apoptosis
- Blood Cancer (leukemia and lymphomas)
- Cancer Biology
- Stem Cells
- Transplantation
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Network
Grants
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Engineering CpG Deoxynucleotide-Conjugated Gold Nanoparticles for Enhanced Anti-Lymphoma Effects
7/1/20 → 6/30/22
Project: Research project
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The Robert H. Lurie Comprehensive Cancer Center
Agulnik, M., Awatramani, R., Backman, V., Benson III, A. B., Carthew, R. W., Cella, D., Chakravarti, D., Chandel, N., Crispino, J. D., Cristofanilli, M., Eklund, E. A., Frankfurt, O., Gordon, L. I., Green, K. J., Hahn, E. A., Horbinski, C. M., Horvath, C. M., Hussain, M., James, C. D., Kelleher, N. L., Khan, S. A., LaBonne, C., Larson, A. C., Matei, D. E., Meade, T. J., Mondragon, A., Mrksich, M., Munshi, H. G., Murphy, A. B., Penedo, F. J., Perlman, H. R., Peter, M. E., Platanias, L. C., Rademaker, A. W., Rappoport, J. Z., Rosenzweig, A. C., Scheidt, K. A., Simon, M. A., Sosman, J. A., Spring, B., Wei, J., Weiss, E. L., Woloschak, G. E., Obeng, R. & Hitsman, B. L.
8/10/18 → 7/31/23
Project: Research project
Research Output
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Aggressive morphologic variants of mantle cell lymphoma characterized with high genomic instability showing frequent chromothripsis, CDKN2A/B loss, and TP53 mutations: A multi-institutional study
Streich, L., Sukhanova, M., Lu, X., Chen, Y. H., Venkataraman, G., Mathews, S., Zhang, S., Kelemen, K., Segal, J., Gao, J., Gordon, L., Chen, Q. & Behdad, A., Aug 1 2020, In: Genes Chromosomes and Cancer. 59, 8, p. 484-494 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Hodgkin lymphoma, version 2.2020
Hoppe, R. T., Advani, R. H., Ai, W. Z., Ambinder, R. F., Armand, P., Bello, C. M., Benitez, C. M., Bierman, P. J., Boughan, K. M., Dabaja, B., Gordon, L. I., Hernandez-Ilizaliturri, F. J., Herrera, A. F., Hochberg, E. P., Huang, J., Johnston, P. B., Kaminski, M. S., Kenkre, V. P., Khan, N., Lynch, R. C. & 14 others, , Jun 2020, In: JNCCN Journal of the National Comprehensive Cancer Network. 18, 6, p. 755-781 27 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study
Abramson, J. S., Palomba, M. L., Gordon, L. I., Lunning, M. A., Wang, M., Arnason, J., Mehta, A., Purev, E., Maloney, D. G., Andreadis, C., Sehgal, A., Solomon, S. R., Ghosh, N., Albertson, T. M., Garcia, J., Kostic, A., Mallaney, M., Ogasawara, K., Newhall, K., Kim, Y. & 2 others, , Sep 19 2020, In: The Lancet. 396, 10254, p. 839-852 14 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Lymphoma 101: The plot thickens
Gordon, L. I., Dec 2020, In: JNCCN Journal of the National Comprehensive Cancer Network. 18, 125, p. 1742-1743 2 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Phase I Study of TAK-659, an Investigational, Dual SYK/FLT3 Inhibitor, in Patients with B-Cell Lymphoma
Gordon, L. I., Kaplan, J. B., Popat, R., Burris, H. A., Ferrari, S., Madan, S., Patel, M. R., Gritti, G., El-Sharkawi, D., Chau, I., Radford, J. A., Pérez de Oteyza, J., Zinzani, P. L., Iyer, S., Townsend, W., Karmali, R., Miao, H., Proscurshim, I., Wang, S., Wu, Y. & 4 others, , Jul 15 2020, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 26, 14, p. 3546-3556 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations