Leo I Gordon

  • 15780 Citations
1978 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research Interests

The overarching goal of my involvement in translational research is to improve the outcome of patients with lymphoma. With scientists in the US and abroad, we are currently investigating novel signaling pathways in lymphoma, using cell lines and animal model systems. More specifically, our research focuses on the biology of reactive oxygen species signaling pathways in lymphoma. Active investigations include: 1) the biology of the lactone diterpenoids in lymphoma; 2) the development of all trans retinoic acid (ATRA) and curcumin loaded nanodisks as a drug delivery vehicle in mantle cell lymphoma (MCL), in collaboration with investigators from the Children’s Hospital Research Institute (CHORI) in Oakland, CA 3) The characterization of cholesterol efflux pumps as a target in lymphoma, in collaboration with Dr Colby Shad Thaxton from the Department of Urology and the Northwestern University Center of Cancer Nanotechnology excellence; 4) the study of hypoxia inducible factor (HIF) in lymphoma, in collaboration with Dr. Paul Schumacker. Clinical research interests include the study of novel immune stimulatory strategies following stem cell transplant in lymphoma with collaborators in Israel, Europe and the US, new approaches to the use of radioimmunotherapy (RIT) in lymphoma, and new treatment paradigms based on the basic investigations described above Clinical research studies are carried out through the Northwestern University Lymphoma Program and through national co-operative groups such as the Eastern Cooperative Oncology Group (ECOG), SPORE programs in lymphoma and through the NCI Phase II Consortium in collaboration with investigators at the University of Chicago.

Certifications and Licenses

Internal Medicine
Medical Oncology

Training Experience

1974Internship, University of Chicago Hospitals
1976Residency, University of Chicago Hospitals
1978Fellowship, Univ. of Minnesota Hospital
1979Fellowship, University of Chicago Hospitals

Education/Academic qualification

MD, University of Cincinnati

… → 1973

Research interests

  • Apoptosis
  • Blood Cancer (leukemia and lymphomas)
  • Cancer Biology
  • Stem Cells
  • Transplantation

Fingerprint Dive into the research topics where Leo I Gordon is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 33 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.


  • Research Output

    Aggressive morphologic variants of mantle cell lymphoma characterized with high genomic instability showing frequent chromothripsis, CDKN2A/B loss, and TP53 mutations: A multi-institutional study

    Streich, L., Sukhanova, M., Lu, X., Chen, Y. H., Venkataraman, G., Mathews, S., Zhang, S., Kelemen, K., Segal, J., Gao, J., Gordon, L., Chen, Q. & Behdad, A., Jan 1 2020, (Accepted/In press) In : Genes Chromosomes and Cancer. 59, 8, p. 484-494 11 p.

    Research output: Contribution to journalArticle

  • B-cell lymphomas, version 3.2019: Featured updates to the NCCN Guidelines

    Zelenetz, A. D., Gordon, L. I., Abramson, J. S., Advani, R. H., Bartlett, N. L., Caimi, P. F., Chang, J. E., Chavez, J. C., Christian, B., Fayad, L. E., Glenn, M. J., Habermann, T. M., Harris, N. L., Hernandez-Ilizaliturri, F., Kaminski, M. S., Kelsey, C. R., Khan, N., Krivacic, S., LaCasce, A. S., Mehta, A. & 11 others, Nademanee, A., Rabinovitch, R., Reddy, N., Reid, E., Roberts, K. B., Smith, S. D., Snyder, E. D., Swinnen, L. J., VoseA, J. M., Dwyer, M. A. & Sundar, H., Jan 1 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 6, p. 650-661 12 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Biomimetic Magnetic Nanostructures: A Theranostic Platform Targeting Lipid Metabolism and Immune Response in Lymphoma

    Singh, A., Nandwana, V., Rink, J. S., Ryoo, S. R., Chen, T. H., Allen, S. D., Scott, E. A., Gordon, L. I., Thaxton, C. S. & Dravid, V. P., Sep 24 2019, In : ACS nano. 13, 9, p. 10301-10311 11 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Brentuximab Vedotin plus Chemotherapy in North American Subjects with Newly Diagnosed Stage III or IV Hodgkin Lymphoma

    Ramchandren, R., Advani, R. H., Ansell, S. M., Bartlett, N. L., Chen, R., Connors, J. M., Feldman, T., Forero-Torres, A., Friedberg, J. W., Gopal, A. K., Gordon, L. I., Kuruvilla, J., Savage, K. J., Younes, A., Engley, G., Manley, T. J., Fenton, K. & Straus, D. J., Jan 1 2019, In : Clinical Cancer Research. 25, 6, p. 1718-1726 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 12 Scopus citations

    Evaluation of the impact of cachexia on clinical outcomes in aggressive lymphoma

    Burkart, M., Schieber, M., Basu, S., Shah, P., Venugopal, P., Borgia, J. A., Gordon, L. I. & Karmali, R., Jul 2019, In : British Journal of Haematology. 186, 1, p. 45-53 9 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations