Leo I Gordon

  • 14847 Citations
1978 …2023
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Personal profile

Research Interests

The overarching goal of my involvement in translational research is to improve the outcome of patients with lymphoma. With scientists in the US and abroad, we are currently investigating novel signaling pathways in lymphoma, using cell lines and animal model systems. More specifically, our research focuses on the biology of reactive oxygen species signaling pathways in lymphoma. Active investigations include: 1) the biology of the lactone diterpenoids in lymphoma; 2) the development of all trans retinoic acid (ATRA) and curcumin loaded nanodisks as a drug delivery vehicle in mantle cell lymphoma (MCL), in collaboration with investigators from the Children’s Hospital Research Institute (CHORI) in Oakland, CA 3) The characterization of cholesterol efflux pumps as a target in lymphoma, in collaboration with Dr Colby Shad Thaxton from the Department of Urology and the Northwestern University Center of Cancer Nanotechnology excellence; 4) the study of hypoxia inducible factor (HIF) in lymphoma, in collaboration with Dr. Paul Schumacker. Clinical research interests include the study of novel immune stimulatory strategies following stem cell transplant in lymphoma with collaborators in Israel, Europe and the US, new approaches to the use of radioimmunotherapy (RIT) in lymphoma, and new treatment paradigms based on the basic investigations described above Clinical research studies are carried out through the Northwestern University Lymphoma Program and through national co-operative groups such as the Eastern Cooperative Oncology Group (ECOG), SPORE programs in lymphoma and through the NCI Phase II Consortium in collaboration with investigators at the University of Chicago.

Certifications and Licenses

Internal Medicine
Medical Oncology
Hematology

Training Experience

1974Internship, University of Chicago Hospitals
1976Residency, University of Chicago Hospitals
1978Fellowship, Univ. of Minnesota Hospital
1979Fellowship, University of Chicago Hospitals

Education/Academic qualification

MD, University of Cincinnati

… → 1973

Research interests

  • Apoptosis
  • Blood Cancer (leukemia and lymphomas)
  • Cancer Biology
  • Stem Cells
  • Transplantation

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  • 28 Similar Profiles
Non-Hodgkin's Lymphoma Medicine & Life Sciences
Lymphoma Medicine & Life Sciences
Hodgkin Disease Medicine & Life Sciences
Radioimmunotherapy Medicine & Life Sciences
Follicular Lymphoma Medicine & Life Sciences
Lymphoma, Large B-Cell, Diffuse Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Mantle-Cell Lymphoma Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 1996 2023

Nanoshells
B-Cell Lymphoma
Gold
Immunotherapy
Lymphoma
Nanotechnology
Cardiovascular Diseases
HDL Lipoproteins
Nanoparticles
Nanomedicine

Research Output 1978 2019

3 Citations (Scopus)

Brentuximab Vedotin plus Chemotherapy in North American Subjects with Newly Diagnosed Stage III or IV Hodgkin Lymphoma

Ramchandren, R., Advani, R. H., Ansell, S. M., Bartlett, N. L., Chen, R., Connors, J. M., Feldman, T., Forero-Torres, A., Friedberg, J. W., Gopal, A. K., Gordon, L. I., Kuruvilla, J., Savage, K. J., Younes, A., Engley, G., Manley, T. J., Fenton, K. & Straus, D. J., Jan 1 2019, In : Clinical Cancer Research. 25, 6, p. 1718-1726 9 p.

Research output: Contribution to journalArticle

Open Access
North America
Hodgkin Disease
Drug Therapy
Disease-Free Survival
Febrile Neutropenia

Evaluation of the impact of cachexia on clinical outcomes in aggressive lymphoma

Burkart, M., Schieber, M., Basu, S., Shah, P., Venugopal, P., Borgia, J. A., Gordon, L. I. & Karmali, R., Jul 1 2019, In : British Journal of Haematology. 186, 1, p. 45-53 9 p.

Research output: Contribution to journalArticle

Cachexia
Lymphoma
Insulin-Like Growth Factor Binding Protein 6
Sarcopenia
Lymphotoxin-alpha
Lymphatic Irradiation
transplantation
stem cells
Stem Cell Transplantation
refractories
1 Citation (Scopus)

Beyond Chemotherapy: Checkpoint Inhibition and Cell-Based Therapy in Non-Hodgkin Lymphoma

Strati, P., Patel, S., Nastoupil, L., Fanale, M. A., Bollard, C. M., Lin, A. Y. & Gordon, L. I., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 592-603 12 p.

Research output: Contribution to journalReview article

Cell- and Tissue-Based Therapy
Non-Hodgkin's Lymphoma
T-Cell Antigen Receptor
Drug Therapy
Antigen Receptors

Consolidation and maintenance in follicular lymphoma: radioimmunotherapy revisited?

Gordon, L. I., Mar 1 2018, In : The Lancet Haematology. 5, 3, p. e96-e97

Research output: Contribution to journalComment/debate

Radioimmunotherapy
Follicular Lymphoma
Maintenance