Leon G Epstein

  • 14957 Citations
1971 …2020

Research output per year

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Personal profile

Research Interests

Dr. Epstein’s research interest is the study of the impact of viral infections on the developing nervous system. Currently we are investigating the role of Human Herpesvirus 6, and 7 (HHV-6 and HHV-7) as potential causes of hippocampal injury during febrile status epilpepticus (FSE). Dr. Epstein is the site PI and the study neurovirologist for the 15 year NINDS funded multicenter longitudinal FEBSTAT study of 200 children with FSE. To date we have found that HHV-6B is the most common cause of FSE in children accounting for nearly 30% of the infants that present with FSE. This longitudinal study will allow us to determine if FSE caused by HHV-6B or HHV-7 is more likely to result in mesial temporal sclerosis and temporal lobe seizures. Intractable temporal lobe seizures are the most common reason for epilepsy surgery in adolescents and young adults. If HHV-6B or HHV-7 prove to be responsible for hippocampal damage it is possible that the injury could be prevented by treatment with anti-viral or anti-infammatory medications at the time of presentation with FSE.

Dr. Epstein is a child neurologist who has over 30 years experience caring for pediatric patients with complex neurologic disorder. He has worked exclusively in major pediatric academic centers seeing patients in both an inpatient and outpatient setting. He has special interest in viral infections of the nervous system, auto-immune encephalitis, and migraine headaches. He frequently sees pediatric patients for additional neurologic consultation.

Certifications and Licenses

Child Neurology

Training Experience

1974Internship, Saint Joseph's Mercy, Ann Arbor
1976Residency, University of Arizona Health Science Center
1978Fellowship, Columbia Presbyterian Medical Center

Education/Academic qualification

MD, Wayne State University School of Medicine

… → 1973

Research interests

  • Infectious Diseases: Viral
  • Pediatric Neurology

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Research Output

Practical Bioethics during the Exceptional Circumstances of a Pandemic

Graf, W. D., Epstein, L. G. & Pearl, P. L., Jan 1 2020, (Accepted/In press) In : Pediatric neurology.

Research output: Contribution to journalEditorial

Open Access

Brain death, the determination of brain death, and member guidance for brain death accommodation requests

Russell, J. A., Epstein, L. G., Greer, D. M., Kirschen, M., Rubin, M. A. & Lewis, A., Jan 29 2019, In : Neurology. 92, 5, p. 228-232 5 p.

Research output: Contribution to journalArticle

Open Access
  • 16 Scopus citations

    Determination of Death by Neurologic Criteria in the United States: The Case for Revising the Uniform Determination of Death Act

    Lewis, A., Bonnie, R. J., Pope, T., Epstein, L. G., Greer, D. M., Kirschen, M. P., Rubin, M. & Russell, J. A., Dec 1 2019, In : Journal of Law, Medicine and Ethics. 47, 4_suppl, p. 9-24 16 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Remote poststroke headache in children: Characteristics and association with stroke recurrence

    Chelse, A. B., Kurz, J. E., Gorman, K. M., Epstein, L. G., Balmert, L. C., Ciolino, J. D. & Wainwright, M., Jun 1 2019, In : Neurology: Clinical Practice. 9, 3, p. 194-200 7 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    SLC35A2-CDG: Functional characterization, expanded molecular, clinical, and biochemical phenotypes of 30 unreported Individuals

    Ng, B. G., Sosicka, P., Agadi, S., Almannai, M., Bacino, C. A., Barone, R., Botto, L. D., Burton, J. E., Carlston, C., Chung, B. H. Y., Cohen, J. S., Coman, D., Dipple, K. M., Dorrani, N., Dobyns, W. B., Elias, A. F., Epstein, L., Gahl, W. A., Garozzo, D., Hammer, T. B. & 49 others, Haven, J., Héron, D., Herzog, M., Hoganson, G. E., Hunter, J. M., Jain, M., Juusola, J., Lakhani, S., Lee, H., Lee, J., Lewis, K., Longo, N., Lourenço, C. M., Mak, C. C. Y., McKnight, D., Mendelsohn, B. A., Mignot, C., Mirzaa, G., Mitchell, W., Muhle, H., Nelson, S. F., Olczak, M., Palmer, C. G. S., Partikian, A., Patterson, M. C., Pierson, T. M., Quinonez, S. C., Regan, B. M., Ross, M. E., Guillen Sacoto, M. J., Scaglia, F., Scheffer, I. E., Segal, D., Singhal, N. S., Striano, P., Sturiale, L., Symonds, J. D., Tang, S., Vilain, E., Willis, M., Wolfe, L. A., Yang, H., Yano, S., Powis, Z., Suchy, S. F., Rosenfeld, J. A., Edmondson, A. C., Grunewald, S. & Freeze, H. H., Jul 2019, In : Human mutation. 40, 7, p. 908-925 18 p.

    Research output: Contribution to journalArticle

    Open Access
  • 8 Scopus citations