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Lewis J Smith

  • 5564 Citations
1977 …2023
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Personal profile

Research Interests

My current research interests include the role of diet in asthma pathogenesis, novel treatments for asthma and COPD, and the development of novel clinical research study designs to improve the translation of clinical research results into better health outcomes.

Certifications and Licenses

Internal Medicine
Pulmonary Disease

Training Experience

1974Internship, Strong Memorial Hospital
1976Residency, Strong Memorial Hospital
1978Fellowship, Boston City Hospital

Education/Academic qualification

MD, University of Rochester

… → 1973

Research interests

  • Asthma
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Clinical Research
  • Drugs (clinical pharmacology)

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 1992 2023

Azithromycin and the airway microbiome in asthma

Rosenberg, S. R., Smith, L. J. & Rosenberg, S. R.

University of Chicago, National Heart, Lung, and Blood Institute

4/1/18 → 3/31/20

Project: Research project

Azithromycin
Microbiota
Bronchoscopy
Asthma

Chronic Refractory Cough Cohort Study (COCO)

Smith, L. J.

American Lung Association, National Heart, Lung, and Blood Institute

11/1/17 → 10/31/19

Project: Research project

Chicago Metropolitan Asthma Consortium for severe/exacerbation-prone asthma

Kalhan, R., Rosenberg, S. R. & Smith, L. J.

University of Chicago, National Heart, Lung, and Blood Institute

9/23/17 → 6/30/23

Project: Research project

Asthma
Research Personnel

Losartan Effects on Emphysema Progression Trial (LEEP)

Kalhan, R. & Smith, L. J.

American Lung Association, National Heart, Lung, and Blood Institute

2/1/17 → 1/31/21

Project: Research project

Illinois Consortium

Kalhan, R., Smith, L. J. & Kalhan, R.

American Lung Association

7/1/16 → 6/30/20

Project: Research project

Asthma
Chronic Obstructive Pulmonary Disease
Morbidity
Mortality
Population

Research Output 1977 2019

Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?

Tang, M., Henderson, R. J., Holbrook, J. T., Que, L. G., Mathews, A. M., Wise, R. A., Dixon, A. E., Peters, S. P., Rogers, L., Smith, L. J., Teague, W. G. & Lang, J. E., Mar 1 2019, In : Journal of Allergy and Clinical Immunology: In Practice. 7, 3, p. 954-961.e6

Research output: Contribution to journal › Article

Respiratory Tract Infections
Asthma
Obesity
Body Mass Index
Steroids
1 Citation (Scopus)

Loss of bronchoprotection with ICS plus LABA treatment, β-receptor dynamics, and the effect of alendronate

AsthmaNet Investigators, Aug 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 416-425.e7

Research output: Contribution to journal › Article

Alendronate
Adrenal Cortex Hormones
Adrenergic Receptors
Placebos
Methacholine Chloride
3 Citations (Scopus)

Mometasone or tiotropium in mild asthma with a low sputum eosinophil level

Lazarus, S. C., Krishnan, J. A., King, T. S., Lang, J. E., Blake, K. V., Covar, R., Lugogo, N., Wenzel, S., Chinchilli, V. M., Mauger, D. T., Dyer, A. M., Boushey, H. A., Fahy, J. V., Woodruff, P. G., Bacharier, L. B., Cabana, M. D., Cardet, J. C., Castro, M., Chmiel, J., Denlinger, L. & 24 others, DiMango, E., Fitzpatrick, A. M., Gentile, D., Hastie, A., Holguin, F., Israel, E., Jackson, D., Kraft, M., LaForce, C., Lemanske, R. F., Martinez, F. D., Moore, W., Morgan, W. J., Moy, J. N., Myers, R., Peters, S. P., Phipatanakul, W., Pongracic, J. A., Que, L., Ross, K., Smith, L. J., Szefler, S. J., Wechsler, M. E. & Sorkness, C. A., May 23 2019, In : New England Journal of Medicine. 380, 21, p. 2009-2019 11 p.

Research output: Contribution to journal › Article

Mometasone Furoate
Sputum
Eosinophils
Asthma
Placebos
2 Citations (Scopus)

Omega-3 fatty acids and genome-wide interaction analyses reveal DPP10–pulmonary function association

Xu, J., Gaddis, N. C., Bartz, T. M., Hou, R., Manichaikul, A. W., Pankratz, N., Smith, A. V., Sun, F., Terzikhan, N., Markunas, C. A., Patchen, B. K., Schu, M., Beydoun, M. A., Brusselle, G. G., Eiriksdottir, G., Zhou, X., Wood, A. C., Graff, M., Harris, T. B., Arfan Ikram, M. & 30 others, Jacobs, D. R., Launer, L. J., Lemaitre, R. N., O’Connor, G. T., Oelsner, E. C., Psaty, B. M., Vasan, R. S., Rohde, R. R., Rich, S. S., Rotter, J. I., Seshadri, S., Smith, L. J., Tiemeier, H., Tsai, M. Y., Uitterlinden, A. G., Saroja Voruganti, V., Xu, H., Zilhão, N. R., Fornage, M., Carola Zillikens, M., London, S. J., Graham Barr, R., Dupuis, J., Gharib, S. A., Gudnason, V., Lahousse, L., North, K. E., Steffen, L. M., Cassano, P. A. & Hancock, D. B., Mar 1 2019, In : American journal of respiratory and critical care medicine. 199, 5, p. 631-642 12 p.

Research output: Contribution to journal › Article

Omega-3 Fatty Acids
Genome
Single Nucleotide Polymorphism
Docosahexaenoic Acids
Respiratory Function Tests

Soy isoflavones reduce asthma exacerbation in asthmatic patients with high PAI-1–producing genotypes

Cho, S. H., Jo, A., Casale, T., Jeong, S. J., Hong, S. J., Cho, J. K., Holbrook, J. T., Kumar, R. & Smith, L. J., Jul 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 1, p. 109-117.e4

Research output: Contribution to journal › Article

Isoflavones
Plasminogen Activator Inhibitor 1
Asthma
Genotype
Genistein