Grants per year
Personal profile
Research Interests
Lifang Hou, MD, MS, PhD is a Professor of Preventive Medicine. With a multidisciplinary background in medicine, basic science, and epidemiology, Dr. Hou’s research interest lies in integrating traditional epidemiologic methods with the ever-advancing molecular techniques in multi-disciplinary research focusing on identifying key molecular markers and understanding their potential impact on disease etiology, detection, and prevention. Dr. Hou’s major research efforts to date have focused on two areas: 1) identification of risk factors that may cause chronic diseases; and 2) identification of biomarkers that serve as indicators of an individual’s past exposure to disease risk factors and/or predict future disease risks and/or prognosis. The environmental/lifestyle risk factors that Dr. Hou has studied include air pollution, pesticides, overweight, physical inactivity, and reproductive factors in relation to chronic diseases. The biomarkers that Dr. Hou has investigated include genetic factors (i.e., polymorphisms, telomere length shortening, mitochondria DNA copy number variations); and epigenetic factors (i.e., DNA methylation, histone modifications, and microRNA profiling). Her over-arching research goal is to understand the biological mechanisms linking environmental risk factors with subclinical or clinical disease development, which ultimately lead to development of effective strategies for prevention of chronic diseases. In addition to being a PI of several NIH funded grants, Dr. Hou is the co-director and Co-PI of the Northwestern Consortium for Early Phase Cancer Prevention Trials of the Division of Cancer Prevention (DCP) Consortia, National Cancer Institute (http://prevention.cancer.gov/clinicaltrials/management/consortia).
Education/Academic qualification
MD, PhD, University of Tsukuba
… → 2001
Research interests
- Cardiovascular Diseases
- Environmental Health
- Epidemiology
- Prostate Cancer
- Digestive Cancer (esophagus, stomach, colon, rectum)
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Grants
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The Fragile Families Cardiovascular Health Follow Up Study
Allen, N. B., Hou, L., Lloyd-Jones, D. M., Van Horn, L. & Zheng, Y.
Princeton University, National Heart, Lung, and Blood Institute
8/1/20 → 7/31/24
Project: Research project
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Blood mitochondrial DNA biomarkers of midlife cognitive decline and adverse brain imaging changes – A longitudinal investigation in the CARDIA population‐based cohort study.
Hou, L., Wang, J., Zheng, Y. & Gao, T.
Columbia University, National Institute on Aging
7/15/20 → 4/30/25
Project: Research project
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The Center for Innovation in Point-of-Care Technologies for HIV/AIDS at Northwestern University (C-THAN) RADx Supplemental Request
Achenbach, C. J., D'Aquila, R. T., Fisher, M. J., Glucksberg, M. R., Hawkins, C. A., Hirschhorn, L. R., Hou, L., Huffman, M. D., Loffler, A., Maiga, M., McFall, S. M., Murphy, R. L., Palamountain, K., Taiwo, B. O. & Zembower, T. R.
National Institute of Biomedical Imaging and Bioengineering
5/21/20 → 5/22/21
Project: Research project
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Epigenetic Determinants of Lipoproteins Across the Early Adult Life Course
Allen, N. B., Hou, L., Lloyd-Jones, D. M., Wilkins, J. T., Zhao, L. & Zheng, Y.
National Heart, Lung, and Blood Institute
3/1/20 → 2/29/24
Project: Research project
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Urban Exposome and Cardiovascular Health in the CARDIA Longitudinal Study
University of Texas Health Science Center at Houston, American Heart Association
7/1/19 → 6/30/21
Project: Research project
Research Output
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Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies
Breen, M., Nwanaji-Enwerem, J. C., Karrasch, S., Flexeder, C., Schulz, H., Waldenberger, M., Kunze, S., Ollert, M., Weidinger, S., Colicino, E., Gao, X., Wang, C., Shen, J., Just, A. C., Vokonas, P., Sparrow, D., Hou, L., Schwartz, J. D., Baccarelli, A. A., Peters, A. & 1 others, , Aug 31 2020, In: Aging. 12, 16, p. 16539-16554 16 p.Research output: Contribution to journal › Article › peer-review
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Association of Neutrophil to Lymphocyte Ratio With Pulmonary Function in a 30-Year Longitudinal Study of US Veterans
Gao, X., Coull, B., Lin, X., Vokonas, P., Sparrow, D., Hou, L., DeMeo, D. L., Litonjua, A. A., Schwartz, J. & Baccarelli, A. A., Jul 1 2020, In: JAMA network open. 3, 7, p. e2010350Research output: Contribution to journal › Article › peer-review
Open Access -
Association of PIN3 16-bp duplication polymorphism of TP53 with breast cancer risk in Mali and a meta-analysis
Diakite, B., Kassogue, Y., Dolo, G., Kassogue, O., Keita, M. L., Joyce, B., Neuschler, E., Wang, J., Musa, J., Traore, C. B., Kamate, B., Dembele, E., Nadifi, S., Isichei, M., Holl, J. L., Murphy, R., Doumbia, S., Hou, L. & Maiga, M., Jul 3 2020, In: BMC Medical Genetics. 21, 1, 142.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Association of the V122I Transthyretin Amyloidosis Genetic Variant with Cardiac Structure and Function in Middle-Aged Black Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study
Sinha, A., Zheng, Y., Nannini, D., Qu, Y., Hou, L., Shah, S. J., Yancy, C. W., McNally, E. M., Fornage, M., Lima, J., Lloyd-Jones, D. M., Rasmussen-Torvik, L. J. & Khan, S. S., 2020, (Accepted/In press) In: JAMA cardiology.Research output: Contribution to journal › Article › peer-review
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Associations of smoking and air pollution with peripheral blood RNA N6-methyladenosine in the Beijing truck driver air pollution study
Kupsco, A., Gonzalez, G., Baker, B. H., Knox, J. M., Zheng, Y., Wang, S., Chang, D., Schwartz, J., Hou, L., Wang, Y. & Baccarelli, A. A., Nov 2020, In: Environment International. 144, 106021.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations