• 6568 Citations
20002023
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Personal profile

Research Interests

Lifang Hou, MD, MS, PhD is an Associate Professor in Preventive Medicine. With a multidisciplinary background in medicine, basic science, and epidemiology, Dr. Hou’s research interest lies in integrating traditional epidemiologic methods with the ever-advancing molecular techniques in multi-disciplinary research focusing on identifying key molecular markers and understanding their potential impact on disease etiology, detection, and prevention. Dr. Hou’s major research efforts to date have focused on two areas: 1) identification of risk factors that may cause chronic diseases; and 2) identification of biomarkers that serve as indicators of an individual’s past exposure to disease risk factors and/or predict future disease risks and/or prognosis. The environmental/lifestyle risk factors that Dr. Hou has studied include air pollution, pesticides, overweight, physical inactivity, and reproductive factors in relation to chronic diseases. The biomarkers that Dr. Hou has investigated include genetic factors (i.e., polymorphisms, telomere length shortening, mitochondria DNA copy number variations); and epigenetic factors (i.e., DNA methylation, histone modifications, and microRNA profiling). Her over-arching research goal is to understand the biological mechanisms linking environmental risk factors with subclinical or clinical disease development, which ultimately lead to development of effective strategies for prevention of chronic diseases. In addition to being a PI of several NIH funded grants, Dr. Hou is the co-director and Co-PI of the Northwestern Consortium for Early Phase Cancer Prevention Trials of the Division of Cancer Prevention (DCP) Consortia, National Cancer Institute (http://prevention.cancer.gov/clinicaltrials/management/consortia).

Research Interests

Lifang Hou, MD, MS, PhD is a Professor of Preventive Medicine. With a multidisciplinary background in medicine, basic science, and epidemiology, Dr. Hou’s research interest lies in integrating traditional epidemiologic methods with the ever-advancing molecular techniques in multi-disciplinary research focusing on identifying key molecular markers and understanding their potential impact on disease etiology, detection, and prevention. Dr. Hou’s major research efforts to date have focused on two areas: 1) identification of risk factors that may cause chronic diseases; and 2) identification of biomarkers that serve as indicators of an individual’s past exposure to disease risk factors and/or predict future disease risks and/or prognosis. The environmental/lifestyle risk factors that Dr. Hou has studied include air pollution, pesticides, overweight, physical inactivity, and reproductive factors in relation to chronic diseases. The biomarkers that Dr. Hou has investigated include genetic factors (i.e., polymorphisms, telomere length shortening, mitochondria DNA copy number variations); and epigenetic factors (i.e., DNA methylation, histone modifications, and microRNA profiling). Her over-arching research goal is to understand the biological mechanisms linking environmental risk factors with subclinical or clinical disease development, which ultimately lead to development of effective strategies for prevention of chronic diseases. In addition to being a PI of several NIH funded grants, Dr. Hou is the co-director and Co-PI of the Northwestern Consortium for Early Phase Cancer Prevention Trials of the Division of Cancer Prevention (DCP) Consortia, National Cancer Institute (http://prevention.cancer.gov/clinicaltrials/management/consortia).

Education/Academic qualification

MD, PhD, University of Tsukuba, Japan

… → 2001

Keywords

  • Cardiovascular Diseases
  • Digestive Cancer (esophagus / stomach / colon / rectum)
  • Environmental Health
  • Epidemiology
  • Prostate Cancer

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Grants 2001 2023

Research Output 2000 2019

Predictors of urinary phthalate biomarker concentrations in postmenopausal women

Reeves, K. W., Santana, M. D., Manson, J. A. E., Hankinson, S. E., Zoeller, R. T., Bigelow, C., Hou, L., Wactawski-Wende, J., Liu, S., Tinker, L. & Calafat, A. M., Feb 1 2019, In : Environmental Research. 169, p. 122-130 9 p.

Research output: Contribution to journalArticle

phthalate
Biomarkers
biomarker
Metabolites
metabolite
16 Citations

An epigenetic biomarker of aging for lifespan and healthspan

Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., Hou, L., Baccarelli, A. A., Stewart, J. D., Li, Y., Whitsel, E. A., Wilson, J. G., Reiner1, A. P., Aviv1, A., Lohman, K., Liu, Y., Ferrucci, L. & Horvath, S., Apr 1 2018, In : Aging. 10, 4, p. 573-591 19 p.

Research output: Contribution to journalArticle

Epigenomics
Biomarkers
Interferons
Transcriptional Activation
DNA Damage

Corrigendum to “APOE ε4 allele modifies the association of lead exposure with age-related cognitive decline in older individuals” [Environ. Res. 151 (2016) 101–105] (S0013935116303218) (10.1016/j.envres.2016.07.034))

Prada, D., Colicino, E., Power, M. C., Weisskopf, M. G., Zhong, J., Hou, L., Spiro, A., Vokonas, P., Brennan, K., Herrera, L. A., Schwartz, J., Wright, R., Hu, H. & Baccarelli, A. A., Aug 1 2018, In : Environmental Research. 165, 1 p.

Research output: Contribution to journalComment/debate

allele
Emotions
Alleles
corrigendum
Environ

Cost effectiveness of human papilloma virus vaccination in low and middle income countries: a systematic review of literature

Silas, O. A., Achenbach, C. J., Murphy, R. L., Hou, L., Sagay, S. A., Banwat, E., Adoga, A. A., Musa, J. & French, D. D., Jan 2 2018, In : Expert Review of Vaccines. 17, 1, p. 91-98 8 p.

Research output: Contribution to journalReview article

Papillomaviridae
Cost-Benefit Analysis
Vaccination
Uterine Cervical Neoplasms
Costs and Cost Analysis

DNA methylation of telomere-related genes and cancer risk

Joyce, B. T., Zheng, Y., Nannini, D., Zhang, Z., Liu, L., Gao, T., Kocherginsky, M., Murphy, R. L., Yang, H., Achenbach, C. J., Roberts, L. R., Hoxha, M., Shen, J., Vokonas, P., Schwartz, J., Baccarelli, A. & Hou, L., Aug 1 2018, In : Cancer Prevention Research. 11, 8, p. 511-522 12 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Telomere
DNA Methylation
Neoplasms
Leukocytes