• 6865 Citations
20002023
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

Lifang Hou, MD, MS, PhD is a Professor of Preventive Medicine. With a multidisciplinary background in medicine, basic science, and epidemiology, Dr. Hou’s research interest lies in integrating traditional epidemiologic methods with the ever-advancing molecular techniques in multi-disciplinary research focusing on identifying key molecular markers and understanding their potential impact on disease etiology, detection, and prevention. Dr. Hou’s major research efforts to date have focused on two areas: 1) identification of risk factors that may cause chronic diseases; and 2) identification of biomarkers that serve as indicators of an individual’s past exposure to disease risk factors and/or predict future disease risks and/or prognosis. The environmental/lifestyle risk factors that Dr. Hou has studied include air pollution, pesticides, overweight, physical inactivity, and reproductive factors in relation to chronic diseases. The biomarkers that Dr. Hou has investigated include genetic factors (i.e., polymorphisms, telomere length shortening, mitochondria DNA copy number variations); and epigenetic factors (i.e., DNA methylation, histone modifications, and microRNA profiling). Her over-arching research goal is to understand the biological mechanisms linking environmental risk factors with subclinical or clinical disease development, which ultimately lead to development of effective strategies for prevention of chronic diseases. In addition to being a PI of several NIH funded grants, Dr. Hou is the co-director and Co-PI of the Northwestern Consortium for Early Phase Cancer Prevention Trials of the Division of Cancer Prevention (DCP) Consortia, National Cancer Institute (http://prevention.cancer.gov/clinicaltrials/management/consortia).

Education/Academic qualification

MD, PhD, University of Tsukuba, Japan

… → 2001

Keywords

  • Cardiovascular Diseases
  • Environmental Health
  • Epidemiology
  • Prostate Cancer
  • Digestive Cancer (esophagus, stomach, colon, rectum)

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 13 Similar Profiles
DNA Methylation Medicine & Life Sciences
Methylation Medicine & Life Sciences
Women's Health Medicine & Life Sciences
Telomere Medicine & Life Sciences
Confidence Intervals Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Particulate Matter Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2001 2023

Research Output 2000 2019

Association of clinical outcomes in metastatic breast cancer patients with circulating tumour cell and circulating cell-free DNA

Ye, Z., Wang, C., Wan, S., Mu, Z., Zhang, Z., Abu-Khalaf, M. M., Fellin, F. M., Silver, D. P., Neupane, M., Jaslow, R. J., Bhattacharya, S., Tsangaris, T. N., Chervoneva, I., Berger, A., Austin, L., Palazzo, J. P., Myers, R. E., Pancholy, N., Toorkey, D., Yao, K. & 10 othersKrall, M., Li, X., Chen, X., Fu, X., Xing, J., Hou, L., Wei, Q., Li, B., Cristofanilli, M. & Yang, H., Jan 1 2019, In : European Journal of Cancer. 106, p. 133-143 11 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Breast Neoplasms
DNA
Disease-Free Survival
Survival

DNA methylation GrimAge strongly predicts lifespan and healthspan

Lu, A. T., Quach, A., Wilson, J. G., Reiner, A. P., Aviv, A., Raj, K., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D., Whitsel, E. A., Assimes, T. L., Ferrucci, L. & Horvath, S., Jan 1 2019, In : Aging. 11, 2, p. 303-327 25 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Biomarkers
Plasminogen Activator Inhibitor 1
Comorbidity

Predictors of urinary phthalate biomarker concentrations in postmenopausal women

Reeves, K. W., Santana, M. D., Manson, J. A. E., Hankinson, S. E., Zoeller, R. T., Bigelow, C., Hou, L., Wactawski-Wende, J., Liu, S., Tinker, L. & Calafat, A. M., Feb 1 2019, In : Environmental Research. p. 122-130 9 p.

Research output: Contribution to journalArticle

phthalate
Biomarkers
biomarker
Metabolites
metabolite

Accelerated DNA methylation age and the use of antihypertensive medication among older adults

Gao, X., Colicino, E., Shen, J., Just, A. C., Nwanaji-Enwerem, J. C., Coull, B., Lin, X., Vokonas, P., Zheng, Y., Hou, L., Schwartz, J. & Baccarelli, A. A., Nov 1 2018, In : Aging. 10, 11, p. 3210-3228 19 p.

Research output: Contribution to journalArticle

DNA Methylation
Antihypertensive Agents
Hypertension
Interviews
Physicians

Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction

Ward-Caviness, C. K., Agha, G., Chen, B. H., Pfeiffer, L., Wilson, R., Wolf, P., Gieger, C., Schwartz, J., Vokonas, P. S., Hou, L., Just, A. C., Bandinelli, S., Hernandez, D. G., Singleton, A. B., Prokisch, H., Meitinger, T., Kastenmüller, G., Ferrucci, L., Baccarelli, A. A., Waldenberger, M. & 1 othersPeters, A., Dec 27 2018, In : Clinical Epigenetics. 10, 1, 161.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Leukocytes
Myocardial Infarction
Dermatoglyphics