• 7618 Citations
20002024
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Personal profile

Research Interests

Lifang Hou, MD, MS, PhD is a Professor of Preventive Medicine. With a multidisciplinary background in medicine, basic science, and epidemiology, Dr. Hou’s research interest lies in integrating traditional epidemiologic methods with the ever-advancing molecular techniques in multi-disciplinary research focusing on identifying key molecular markers and understanding their potential impact on disease etiology, detection, and prevention. Dr. Hou’s major research efforts to date have focused on two areas: 1) identification of risk factors that may cause chronic diseases; and 2) identification of biomarkers that serve as indicators of an individual’s past exposure to disease risk factors and/or predict future disease risks and/or prognosis. The environmental/lifestyle risk factors that Dr. Hou has studied include air pollution, pesticides, overweight, physical inactivity, and reproductive factors in relation to chronic diseases. The biomarkers that Dr. Hou has investigated include genetic factors (i.e., polymorphisms, telomere length shortening, mitochondria DNA copy number variations); and epigenetic factors (i.e., DNA methylation, histone modifications, and microRNA profiling). Her over-arching research goal is to understand the biological mechanisms linking environmental risk factors with subclinical or clinical disease development, which ultimately lead to development of effective strategies for prevention of chronic diseases. In addition to being a PI of several NIH funded grants, Dr. Hou is the co-director and Co-PI of the Northwestern Consortium for Early Phase Cancer Prevention Trials of the Division of Cancer Prevention (DCP) Consortia, National Cancer Institute (http://prevention.cancer.gov/clinicaltrials/management/consortia).

Education/Academic qualification

MD, PhD, University of Tsukuba, Japan

… → 2001

Research interests

  • Cardiovascular Diseases
  • Environmental Health
  • Epidemiology
  • Prostate Cancer
  • Digestive Cancer (esophagus, stomach, colon, rectum)

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DNA Methylation Medicine & Life Sciences
Methylation Medicine & Life Sciences
Women's Health Medicine & Life Sciences
Telomere Medicine & Life Sciences
Confidence Intervals Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Particulate Matter Medicine & Life Sciences

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Grants 2001 2024

Plasminogen Activator Inhibitor 1
Fibrosis
Mutation
Cardiomyopathies
Cardiac Myocytes

Research Output 2000 2019

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis

Liu, J., Carnero-Montoro, E., van Dongen, J., Lent, S., Nedeljkovic, I., Ligthart, S., Tsai, P. C., Martin, T. C., Mandaviya, P. R., Jansen, R., Peters, M. J., Duijts, L., Jaddoe, V. W. V., Tiemeier, H., Felix, J. F., Willemsen, G., de Geus, E. J. C., Chu, A. Y., Levy, D., Hwang, S. J. & 37 others, Bressler, J., Gondalia, R., Salfati, E. L., Herder, C., Hidalgo, B. A., Tanaka, T., Moore, A. Z., Lemaitre, R. N., Jhun, M. A., Smith, J. A., Sotoodehnia, N., Bandinelli, S., Ferrucci, L., Arnett, D. K., Grallert, H., Assimes, T. L., Hou, L., Baccarelli, A., Whitsel, E. A., van Dijk, K. W., Amin, N., Uitterlinden, A. G., Sijbrands, E. J. G., Franco, O. H., Dehghan, A., Spector, T. D., Dupuis, J., Hivert, M. F., Rotter, J. I., Meigs, J. B., Pankow, J. S., van Meurs, J. B. J., Isaacs, A., Boomsma, D. I., Bell, J. T., Demirkan, A. & van Duijn, C. M., Dec 1 2019, In : Nature communications. 10, 1, 2581.

Research output: Contribution to journalArticle

Open Access
homeostasis
insulin
methylation
Methylation
DNA Methylation

A peripheral blood DNA methylation signature of hepatic fat reveals a potential causal pathway for nonalcoholic fatty liver disease

Ma, J., Nano, J., Ding, J., Zheng, Y., Hennein, R., Liu, C., Speliotes, E. K., Huan, T., Song, C., Mendelson, M. M., Joehanes, R., Long, M. T., Liang, L., Smith, J. A., Reynolds, L. M., Ghanbari, M., Muka, T., Van Meurs, J. B. J., Alferink, L. J. M., Franco, O. H. & 17 others, Dehghan, A., Ratliff, S., Zhao, W., Bielak, L., Kardia, S. L. R., Peyser, P. A., Ning, H., VanWagner, L. B., Lloyd-Jones, D. M., Carr, J. J., Greenland, P., Lichtenstein, A. H., Hu, F. B., Liu, Y., Hou, L., Murad, S. D. & Levy, D., Jan 1 2019, In : Diabetes. 68, 5, p. 1073-1083 11 p.

Research output: Contribution to journalArticle

DNA Methylation
Fats
Liver
Type 2 Diabetes Mellitus
Mendelian Randomization Analysis

Association of clinical outcomes in metastatic breast cancer patients with circulating tumour cell and circulating cell-free DNA

Ye, Z., Wang, C., Wan, S., Mu, Z., Zhang, Z., Abu-Khalaf, M. M., Fellin, F. M., Silver, D. P., Neupane, M., Jaslow, R. J., Bhattacharya, S., Tsangaris, T. N., Chervoneva, I., Berger, A., Austin, L., Palazzo, J. P., Myers, R. E., Pancholy, N., Toorkey, D., Yao, K. & 10 others, Krall, M., Li, X., Chen, X., Fu, X., Xing, J., Hou, L., Wei, Q., Li, B., Cristofanilli, M. & Yang, H., Jan 1 2019, In : European Journal of Cancer. 106, p. 133-143 11 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Breast Neoplasms
DNA
Disease-Free Survival
Survival

Author Correction: Magnesium intake and mortality due to liver diseases: Results from the Third National Health and Nutrition Examination Survey Cohort (Scientific Reports, (2017), 7, 1, (17913), 10.1038/s41598-017-18076-5)

Wu, L., Zhu, X., Fan, L., Kabagambe, E. K., Song, Y., Tao, M., Zhong, X., Hou, L., Shrubsole, M. J., Liu, J. & Dai, Q., Dec 1 2019, In : Scientific Reports. 9, 1, 6983.

Research output: Contribution to journalComment/debate

Open Access
Nutrition Surveys
Magnesium
Liver Diseases
Mortality

Correction: Accelerated DNA methylation age and the use of antihypertensive medication among older adults [Aging, (Albany NY), 10, (2018), (3210-3228)] doi: 10.18632/aging.10162

Gao, X., Colicino, E., Shen, J., Just, A. C., Nwanaji-Enwerem, J. C., Coull, B., Lin, X., Vokonas, P., Zheng, Y., Hou, L., Schwartz, J. & Baccarelli, A. A., May 15 2019, In : Aging. 11, 9, 1 p.

Research output: Contribution to journalComment/debate

DNA Methylation
Antihypertensive Agents