Grants per year
Personal profile
Research Interests
Prion proteins are capable of existing in multiple stable conformations, at least one of which is infectious. It is generally accepted that prion (PrPSc) is the responsible agent for the devastating neurodegenerative disorders known as transmissible spongiform encephalopathies or prion diseases. Our laboratory is interested in using yeast and other model organisms to understand how a prion protein acquires its infectious prion conformations and how such conformations are maintained in vivo. Our ultimate goal is to dissect the initiation and propagation processes of prionogenesis, and to identify important cellular factors required in each of these processes
Training Experience
| 1997 | Postdoctoral Fellowship, Harvard University |
| 2002 | Postdoctoral Fellowship, University of Chicago |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of California, Davis
… → 1992
Research interests keywords
- Aging
- Biochemistry: Proteins
- Genetics: Microbial
- Infectious Diseases
- Microbiology
- Molecular Genetics
- Nervous System Diseases
- Proteins / Macromolecules
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Understanding prion-mediated transcriptional modifications and cellular phenotypes: insights into the role of Swi1 prion and prion-like behaviors of BAF proteins
Du, Z. (PD/PI), Bartom, E. T. (Co-Investigator) & Li, L. (Co-Investigator)
National Institute of General Medical Sciences
8/1/24 → 5/31/28
Project: Research project
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Investigating the role of prion-mediated epigenetic regulation in yeast using an integrative approach of multi-omics
Li, L. (PD/PI) & Gao, R. (Co-Investigator)
4/1/24 → 3/31/27
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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Prion-mediated protein aggregation/co-aggregation and cellular consequence
Du, Z. (PD/PI), Li, L. (Co-Investigator) & Savas, J. N. (Co-Investigator)
National Institute of General Medical Sciences
8/1/18 → 7/31/24
Project: Research project
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Northwestern University Interdepartmental Neuroscience Postbaccalaureate Research Education Program
Disterhoft, J. F. (PD/PI), McLean, D. (Co-Investigator), Acosta, A. (Other), Allada, R. (Other), Apkarian, A. (Other), Awatramani, R. (Other), Beeman, M. (Other), Bevan, M. D. (Other), Bozza, T. (Other), Cang, J. (Other), Chetkovich, D. M. (Other), Cobia, D. J. (Other), Contractor, A. (Other), Corcos, D. M. (Other), DeVries, S. H. (Other), Dewald, J. P. A. (Other), Dhar, S. (Other), Dombeck, D. A. (Other), Elliott, J. M. (Other), Feng, Y. (Other), Ferreira, A. B. (Other), Gallio, M. (Other), Garcia-Anoveros, J. (Other), George, A. L. (Other), Geula, C. (Other), Gordon, K. E. (Other), Gottfried, J. A. (Other), Grafman, J. H. (Other), Hartmann, M. J. (Other), Heckman, C. (Other), Hespos, S. J. (Other), Jayaraman, A. (Other), Kahnt, T. (Other), Kearney, J. A. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kohtz, J. D. (Other), Kording, K. P. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Larson, C. (Other), Lee, S. S. M. (Other), Li, L. (Other), Losh, M. C. (Other), MacIver, M. A. (Other), Maccaferri, G. (Other), Martina, M. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, L. E. (Other), Mussa Ivaldi, F. (Other), Nusslock, R. (Other), Opal, P. (Other), Ozdinler, H. (Other), Paller, K. (Other), Parrish, T. B. (Other), Prakriya, M. (Other), Radulovic, J. (Other), Raman, I. M. (Other), Reber, P. J. (Other), Redei, E. E. (Other), Rogalski, E. (Other), Sanchez, J. T. (Other), Sanz-Clemente, A. (Other), Savas, J. N. (Other), Schmidt, T. M. (Other), Schwartz, G. W. (Other), Segraves, M. (Other), Shepherd, G. M. G. (Other), Siddique, T. (Other), Solla, S. A. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Topczewski, J. (Other), Tresch, M. C. (Other), Tysseling, V. M. (Other), Vassar, R. J. (Other), Voss, J. L. (Other), Wainwright, D. A. (Other), Wang, L. (Other), Weintraub, S. (Other), Woolley, C. S. (Other) & Wright, B. A. (Other)
National Institute of General Medical Sciences
5/1/17 → 5/12/22
Project: Research project
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Iron drives anabolic metabolism through active histone demethylation and mTORC1
Shapiro, J. S., Chang, H. C., Tatekoshi, Y., Zhao, Z., Waxali, Z. S., Hong, B. J., Chen, H., Geier, J. A., Bartom, E. T., De Jesus, A., Nejad, F. K., Mahmoodzadeh, A., Sato, T., Ramos-Alonso, L., Romero, A. M., Martinez-Pastor, M. T., Jiang, S. C., Sah-Teli, S. K., Li, L. & Bentrem, D. & 8 others, , Oct 2023, In: Nature Cell Biology. 25, 10, p. 1478-1494 17 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Identifying Endogenous Cellular Proteins Destabilizing the Propagation of Swi1 Prion upon Overproduction
Du, Z., Cho, B. & Li, L., Jul 2022, In: Viruses. 14, 7, 1366.Research output: Contribution to journal › Article › peer-review
Open Access -
Defining key residues of the Swi1 prion domain in prion formation and maintenance
Goncharoff, D. K., Cabral, R., Applebey, S. V., Pagadala, M., Du, Z. & Li, L., Jun 2021, In: Molecular and cellular biology. 41, 7, e00044-21.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Elucidating the regulatory mechanism of Swi1 prion in global transcription and stress responses
Du, Z., Regan, J., Bartom, E., Wu, W. S., Zhang, L., Goncharoff, D. K. & Li, L., Dec 2020, In: Scientific reports. 10, 1, 21838.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System
Du, Z., Valtierra, S., Cardona, L. R., Dunne, S. F., Luan, C. H. & Li, L., Dec 19 2019, In: Cell Chemical Biology. 26, 12, p. 1664-1680.e4Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations