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Personal profile

Research Interests

Prion proteins are capable of existing in multiple stable conformations, at least one of which is infectious. It is generally accepted that prion (PrPSc) is the responsible agent for the devastating neurodegenerative disorders known as transmissible spongiform encephalopathies or prion diseases. Our laboratory is interested in using yeast and other model organisms to understand how a prion protein acquires its infectious prion conformations and how such conformations are maintained in vivo. Our ultimate goal is to dissect the initiation and propagation processes of prionogenesis, and to identify important cellular factors required in each of these processes

Training Experience

1997Postdoctoral Fellowship, Harvard University
2002Postdoctoral Fellowship, University of Chicago

Education/Academic qualification

PhD, University of California, Davis

… → 1992

Research interests

  • Aging
  • Biochemistry: Proteins
  • Genetics: Microbial
  • Infectious Diseases
  • Microbiology
  • Molecular Genetics
  • Nervous System Diseases
  • Proteins / Macromolecules

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Grants

  • Research Output

    Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System

    Du, Z., Valtierra, S., Cardona, L. R., Dunne, S. F., Luan, C. H. & Li, L., Dec 19 2019, In : Cell Chemical Biology. 26, 12, p. 1664-1680.e4

    Research output: Contribution to journalArticle

  • A brief overview of the Swi1 prion—[SWI+]

    Goncharoff, D. K., Du, Z. & Li, L., Sep 1 2018, In : FEMS yeast research. 18, 6, foy061.

    Research output: Contribution to journalReview article

  • 6 Scopus citations

    Analysis of [SWI+] formation and propagation events

    Du, Z., Goncharoff, D. K., Cheng, X. & Li, L., Apr 1 2017, In : Molecular Microbiology. 104, 1, p. 105-124 20 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Analysis of small critical regions of Swi1 conferring prion formation, maintenance, and transmission

    Valtierra, S., Du, Z. & Li, L., Oct 1 2017, In : Molecular and cellular biology. 37, 20, e00206-17.

    Research output: Contribution to journalArticle

  • 4 Scopus citations
  • 22 Scopus citations