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Research Interests

Prion proteins are capable of existing in multiple stable conformations, at least one of which is infectious. It is generally accepted that prion (PrPSc) is the responsible agent for the devastating neurodegenerative disorders known as transmissible spongiform encephalopathies or prion diseases. Our laboratory is interested in using yeast and other model organisms to understand how a prion protein acquires its infectious prion conformations and how such conformations are maintained in vivo. Our ultimate goal is to dissect the initiation and propagation processes of prionogenesis, and to identify important cellular factors required in each of these processes

Training Experience

1997Postdoctoral Fellowship, Harvard University
2002Postdoctoral Fellowship, University of Chicago

Education/Academic qualification

PhD, University of California-Davis

… → 1992

Keywords

  • Aging
  • Biochemistry: Proteins
  • Genetics: Microbial
  • Infectious Diseases
  • Microbiology
  • Molecular Genetics
  • Nervous System Diseases
  • Proteins / Macromolecules

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Grants 2001 2023

Prions
Prion Diseases
Proteostasis Deficiencies
Yeasts
Amyloid
Prions
Prion Diseases
Uracil
Yeasts
PrPC Proteins

Research Output 1991 2018

2 Citations (Scopus)

A brief overview of the Swi1 prion-[SWI+

Goncharoff, D. K., Du, Z. & Li, L., Sep 1 2018, In : FEMS yeast research. 18, 6

Research output: Contribution to journalArticle

Prions
Yeasts
Protein Conformation
Saccharomycetales
Chromatin Assembly and Disassembly
5 Citations (Scopus)

Analysis of [SWI+] formation and propagation events

Du, Z., Goncharoff, D. K., Cheng, X. & Li, L., Apr 1 2017, In : Molecular Microbiology. 104, 1, p. 105-124 20 p.

Research output: Contribution to journalArticle

Prions
Molecular Chaperones
Protein Conformation
Saccharomycetales
Chromatin Assembly and Disassembly
3 Citations (Scopus)

Analysis of small critical regions of Swi1 conferring prion formation, maintenance, and transmission

Valtierra, S., Du, Z. & Li, L., Oct 1 2017, In : Molecular and cellular biology. 37, 20, e00206-17.

Research output: Contribution to journalArticle

Prions
Maintenance
Amino Acids
Protein Conformation
Asparagine
17 Citations (Scopus)
Prions
Gene expression
Yeast
Yeasts
Gene Expression
1 Citation (Scopus)

An insight into the complex prion-prion interaction network in the budding yeast Saccharomyces cerevisiae

Du, Z., Valtierra, S. & Li, L., Nov 1 2014, In : Prion. 8, 6, p. 387-392 6 p.

Research output: Contribution to journalReview article

Saccharomycetales
Prions
Yeast
Saccharomyces cerevisiae
Yeasts