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Research Output

2019

Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System

Du, Z., Valtierra, S., Cardona, L. R., Dunne, S. F., Luan, C. H. & Li, L., Dec 19 2019, In : Cell Chemical Biology. 26, 12, p. 1664-1680.e4

Research output: Contribution to journalArticle

2018

A brief overview of the Swi1 prion—[SWI+]

Goncharoff, D. K., Du, Z. & Li, L., Sep 1 2018, In : FEMS yeast research. 18, 6, foy061.

Research output: Contribution to journalReview article

6 Scopus citations
2017

Analysis of [SWI+] formation and propagation events

Du, Z., Goncharoff, D. K., Cheng, X. & Li, L., Apr 1 2017, In : Molecular Microbiology. 104, 1, p. 105-124 20 p.

Research output: Contribution to journalArticle

7 Scopus citations

Analysis of small critical regions of Swi1 conferring prion formation, maintenance, and transmission

Valtierra, S., Du, Z. & Li, L., Oct 1 2017, In : Molecular and cellular biology. 37, 20, e00206-17.

Research output: Contribution to journalArticle

4 Scopus citations
2015
22 Scopus citations
2014

An insight into the complex prion-prion interaction network in the budding yeast Saccharomyces cerevisiae

Du, Z., Valtierra, S. & Li, L., Nov 1 2014, In : Prion. 8, 6, p. 387-392 6 p.

Research output: Contribution to journalReview article

3 Scopus citations

Environmental regulation of prions in yeast

Li, L. & Kowal, A. S., Jan 1 2014, Investigations in Yeast Functional Genomics and Molecular Biology. Apple Academic Press, p. 155-163 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Investigating the interactions of yeast prions: [SWI+], [PSI+], and [PIN+]

Du, Z. & Li, L., Jan 1 2014, In : Genetics. 197, 2, p. 685-700 16 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013

Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans

Nussbaum-Krammer, C. I., Park, K. W., Li, L., Melki, R. & Morimoto, R. I., 2013, In : PLoS genetics. 9, 3, e1003351.

Research output: Contribution to journalArticle

34 Scopus citations
2012

Environmental Regulation of Prions in Yeast

Li, L. & Kowal, A. S., Nov 2012, In : PLoS pathogens. 8, 11, e1002973.

Research output: Contribution to journalArticle

14 Scopus citations
2011

[SWI+], the prion formed by the chromatin remodeling factor Swi1, is highly sensitive to alterations in hsp70 chaperone system activity

Hines, J. K., Li, X., Du, Z., Higurashi, T., Li, L. & Craig, E. A., Feb 1 2011, In : PLoS genetics. 7, 2, e1001309.

Research output: Contribution to journalArticle

53 Scopus citations

A small, glutamine-free domain propagates the [SWI+] prion in budding yeast

Crow, E. T., Du, Z. & Li, L., Aug 1 2011, In : Molecular and Cellular Biology. 31, 16, p. 3436-3444 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

A special focus on microbial models for amyloids and prions: Letter from the editors

Zhouravleva, G. & Li, L., Oct 1 2011, In : Prion. 5, 4, 1 p.

Research output: Contribution to journalEditorial

Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy

Fushimi, K., Long, C., Jayaram, N., Chen, X., Li, L. & Wu, J. Y., Feb 2011, In : Protein and Cell. 2, 2, p. 141-149 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Newly identified prions in budding yeast, and their possible functions

Crow, E. T. & Li, L., Jan 1 2011, In : Seminars in Cell and Developmental Biology. 22, 5, p. 452-459 8 p.

Research output: Contribution to journalReview article

54 Scopus citations

Prion protein in Caenorhabditis elegans: Distinct models of anti-BAX and neuropathology

Park, K. W. & Li, L., Jan 1 2011, In : Prion. 5, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

Distinct subregions of Swi1 manifest striking differences in prion transmission and SWI/SNF function

Du, Z., Crow, E. T., Kang, H. S. & Li, L., Oct 1 2010, In : Molecular and cellular biology. 30, 19, p. 4644-4655 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Evolution of enzymatic activities of testis-specific short-chain dehydrogenase/reductase in drosophila

Zhang, J., Yang, H., Long, M., Li, L. & Dean, A. M., Oct 1 2010, In : Journal of Molecular Evolution. 71, 4, p. 241-249 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2008

Cytoplasmic expression of mouse prion protein causes severe toxicity in Caenorhabditis elegans

Park, K. W. & Li, L., Aug 8 2008, In : Biochemical and Biophysical Research Communications. 372, 4, p. 697-702 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

New insights into prion biology from the novel [SWI+] system.

Crow, E., Du, Z. & Li, L., Oct 2008, In : Prion. 2, 4, p. 141-144 4 p.

Research output: Contribution to journalReview article

9 Scopus citations

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae

Du, Z., Park, K. W., Yu, H., Fan, Q. & Li, L., Apr 1 2008, In : Nature Genetics. 40, 4, p. 460-465 6 p.

Research output: Contribution to journalArticle

218 Scopus citations
2007

The role of Sse1 in the de novo formation and variant determination of the [PSI+] prion

Fan, Q., Park, K. W., Du, Z., Morano, K. A. & Li, L., Nov 1 2007, In : Genetics. 177, 3, p. 1583-1593 11 p.

Research output: Contribution to journalArticle

65 Scopus citations
2006

De novo appearance and "strain" formation of yeast prion [PSI+] are regulated by the heat-shock transcription factor

Park, K. W., Hahn, J. S., Fan, Q., Thiele, D. J. & Li, L., May 1 2006, In : Genetics. 173, 1, p. 35-47 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2005

Translational effects of differential codon usage among intragenic domains of new genes in Drosophila

Zhang, J., Long, M. & Li, L., May 1 2005, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1728, 3, p. 135-142 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2001

Investigating protein conformation-based inheritance and disease in yeast

Lindquist, S., Krobitsch, S., Li, L., Sondheimer, N., Peto, H., Dobson, C. M., Perutz, M. F., Pepys, M. & Goldberg, M. E., Feb 28 2001, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 356, 1406, p. 169-176 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

N-terminal intramolecularly conserved histidines of three domains in Gonylaulax luciferase are responsible for loss of activity in the alkaline region

Li, L., Liu, L., Hong, R., Robertson, D. & Hastings, J. W., Feb 13 2001, In : Biochemistry. 40, 6, p. 1844-1849 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2000

Creating a protein-based element of inheritance

Li, L. & Lindquist, S., Jan 28 2000, In : Science. 287, 5453, p. 661-664 4 p.

Research output: Contribution to journalArticle

141 Scopus citations

Gonyaulax luciferase: Gene structure, protein expression, and purification from recombinant sources

Li, L., 2000, In : Methods in enzymology. 305, p. 249-258 10 p.

Research output: Contribution to journalReview article

2 Scopus citations
1998

The circadian rhythm of bioluminescence in Pyrocystis is not due to differences in the amount of luciferase: A comparative study of the three bioluminescent marine dinoflagellates

Knaust, R., Urbig, T., Li, L., Taylor, W. & Hastings, J. W., Jan 1 1998, In : Journal of Phycology. 34, 1, p. 167-172 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

The mRNA level of the circadian regulated Gonyaulax luciferase remains constant over the cycle

Mittag, M., Li, L. & Woodland Hastings, J., Jan 1 1998, In : Chronobiology International. 15, 1, p. 93-98 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

The structure and organization of the luciferase gene in the photosynthetic dinoflagellate Gonyaulax polyedra

Li, L. & Hastings, J. W., Jan 1 1998, In : Plant Molecular Biology. 36, 2, p. 275-284 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
1997

Three functional luciferase domains in a single polypeptide chain

Li, L., Hong, R. & Hastings, J. W., Aug 19 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 17, p. 8954-8958 5 p.

Research output: Contribution to journalArticle

52 Scopus citations
1995

Continuous Fluorescence Assay of Phytochrome Assembly in Vitro

Li, L., Murphy, J. T. & Lagarias, J. C., Jan 1 1995, In : Biochemistry. 34, 24, p. 7923-7930 8 p.

Research output: Contribution to journalArticle

45 Scopus citations
1994

Phytochrome assembly in living cells of the yeast Saccharomyces cerevisiae

Li, L. & Lagarias, J. C., Dec 20 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 26, p. 12535-12539 5 p.

Research output: Contribution to journalArticle

30 Scopus citations
1992

Phytochrome assembly: Defining chromophore structural requirements for covalent attachment and photoreversibility

Li, L. & Lagarias, J. C., Sep 25 1992, In : Journal of Biological Chemistry. 267, 27, p. 19204-19210 7 p.

Research output: Contribution to journalArticle

89 Scopus citations
1991

Cloning of a cDNA encoding 1-aminocyclopropane-1-carboxylate synthase and expression of its mRNA in ripening apple fruit

Dong, J. G., Kim, W. T., Yip, W. K., Thompson, G. A., Li, L., Bennett, A. B. & Yang, S. F., Aug 1 1991, In : Planta. 185, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

Expression and assembly of spectrally active recombinant holophytochrome

Wahleithner, J. A., Liming, L. & Lagarias, J. C., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 23, p. 10387-10391 5 p.

Research output: Contribution to journalArticle

68 Scopus citations