Lin Qi

  • 539 Citations
20112019
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Research Output 2011 2019

  • 539 Citations
  • 19 Article
  • 3 Review article
  • 1 Comment/debate
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Article
2019
2 Citations (Scopus)

Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma

Dobson, T. H. W., Tao, R. H., Swaminathan, J., Maegawa, S., Shaik, S., Bravo-Alegria, J., Sharma, A., Kennis, B., Yang, Y., Callegari, K., Haltom, A. R., Taylor, P., Kogiso, M., Qi, L., Khatua, S., Goldman, S., Lulla, R. R., Fangusaro, J., MacDonald, T. J., Li, X. & 3 others, Hawkins, C., Rajaram, V. & Gopalakrishnan, V., Jan 22 2019, In : Science Signaling. 12, 565, aan8680.

Research output: Contribution to journalArticle

Medulloblastoma
Hedgehogs
Chromatin
Compaction
Chemical activation
2018
2 Citations (Scopus)

Concurrent inhibition of neurosphere and monolayer cells of pediatric glioblastoma by aurora a inhibitor mln8237 predicted survival extension in pdox models

Kogiso, M., Qi, L., Braun, F. K., Injac, S. G., Zhang, L., Du, Y., Zhang, H., Lin, F. Y., Zhao, S., Lindsay, H., Su, J. M., Baxter, P. A., Adesina, A. M., Liao, D., Qian, M. G., Berg, S., Muscal, J. A. & Li, X. N., May 1 2018, In : Clinical Cancer Research. 24, 9, p. 2159-2170 12 p.

Research output: Contribution to journalArticle

Aurora Kinase A
Glioblastoma
Pediatrics
Survival
Heterografts
1 Citation (Scopus)

IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma

Berlow, N. E., Svalina, M. N., Quist, M. J., Settelmeyer, T. P., Zherebitskiy, V., Kogiso, M., Qi, L., Du, Y., Hawkins, C. E., Hulleman, E., Li, X. N., Gultekin, S. H. & Keller, C., Apr 2018, In : PloS one. 13, 4, e0193565.

Research output: Contribution to journalArticle

Interleukin-13 Receptors
Interleukin-13
Glioma
Interleukin-4
Interleukin-2

Involvement of acid-sensing ion channel 1a in gastric carcinoma cell migration and invasion

Chen, X., Sun, X., Wang, Z., Zhou, X., Xu, L., Li, FE., Zhang, X., Pan, JA., Qi, L., Qian, H. & Mao, Z., May 1 2018, In : Acta biochimica et biophysica Sinica. 50, 5, p. 440-446 7 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channels
Cell Movement
Stomach
Cells
Carcinoma
6 Citations (Scopus)

Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma

Huang, L., Injac, S. G., Cui, K., Braun, F., Qi, L., Du, Y., Zhang, H., Kogiso, M., Lindsay, H., Zhao, S., Baxter, P., Adekunle, A., Man, T. K., Zhao, H., Li, X., Lau, C. C. & Wong, S. T. C., Oct 24 2018, In : Science translational medicine. 10, 464, eaat0150.

Research output: Contribution to journalArticle

Drug Repositioning
Medulloblastoma
Systems Biology
Digoxin
Group Psychotherapy
2017

Live kinase B1 maintains CD34+CD38 AML cell proliferation and self-renewal

Wang, H., Wang, X., Xin, N., Qi, L., Liao, A., Yang, W., Liu, Z. & Zhao, C., Oct 1 2017, In : Molecular and Cellular Biochemistry. 434, 1-2, p. 25-32 8 p.

Research output: Contribution to journalArticle

Cell proliferation
Myeloid Cells
Acute Myeloid Leukemia
Phosphotransferases
Stem cells
5 Citations (Scopus)

Next-generation sequencing of Chinese stage IV lung cancer patients reveals an association between EGFR mutation status and survival outcome

Li, F., Du, X., Zhang, H., Ju, T., Chen, C., Qu, Q., Zhang, X., Qi, L. & Lizée, G., Mar 1 2017, In : Clinical Genetics. 91, 3, p. 488-493 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Lung Neoplasms
Mutation
Survival
Non-Small Cell Lung Carcinoma
12 Citations (Scopus)

The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a TH-MYCN transgenic neuroblastoma mouse model

Lu, J., Guan, S., Zhao, Y., Yu, Y., Woodfield, S. E., Zhang, H., Yang, K. L., Bieerkehazhi, S., Qi, L., Li, X., Gu, J., Xu, X., Jin, J., Muscal, J. A., Yang, T., Xu, G. T. & Yang, J., Aug 1 2017, In : Cancer Letters. 400, p. 61-68 8 p.

Research output: Contribution to journalArticle

Neuroblastoma
Transgenic Mice
Apoptosis
Growth
Neoplasms
2 Citations (Scopus)

Xenotransplantation of pediatric low grade gliomas confirms the enrichment of BRAF V600E mutation and preservation of CDKN2A deletion in a novel orthotopic xenograft mouse model of progressive pleomorphic xanthoastrocytoma

Kogiso, M., Qi, L., Lindsay, H., Huang, Y., Zhao, X., Liu, Z., Braun, F. K., Du, Y., Zhang, H., Bae, G., Zhao, S., Injac, S. G., Sobieski, M., Brunell, D., Mehta, V., Tran, D., Murray, J., Baxter, P. A., Yuan, X. J., Su, J. M. & 8 others, Adesina, A., Perlaky, L., Chintagumpala, M., Williams Parsons, D., Lau, C. C., Stephan, C. C., Lu, X. & Li, X. N., Jan 1 2017, In : Oncotarget. 8, 50, p. 87455-87471 17 p.

Research output: Contribution to journalArticle

Heterologous Transplantation
Heterografts
Glioma
Pediatrics
Mutation
2016
69 Citations (Scopus)

HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma

Pei, Y., Liu, K. W., Wang, J., Garancher, A., Tao, R., Esparza, L. A., Maier, D. L., Udaka, Y. T., Murad, N., Morrissy, S., Seker-Cin, H., Brabetz, S., Qi, L., Kogiso, M., Schubert, S., Olson, J. M., Cho, Y. J., Li, X. N., Crawford, J. R., Levy, M. L. & 4 others, Kool, M., Pfister, S. M., Taylor, M. D. & Wechsler-Reya, R. J., Mar 14 2016, In : Cancer Cell. 29, 3, p. 311-323 13 p.

Research output: Contribution to journalArticle

Medulloblastoma
Phosphatidylinositol 3-Kinases
Histone Deacetylase Inhibitors
Growth
Phosphatidylinositol 3-Kinase
4 Citations (Scopus)

Preservation of KIT genotype in a novel pair of patient-derived orthotopic xenograft mouse models of metastatic pediatric CNS germinoma

Lindsay, H., Huang, Y., Du, Y., Braun, F. K., Teo, W. Y., Kogiso, M., Qi, L., Zhang, H., Zhao, S., Mao, H., Lin, F., Baxter, P., Su, J. M., Terashima, K., Perlaky, L., Chintagumpala, M., Adesina, A., Lau, C. C., Williams Parsons, D. & Li, X. N., Jan 1 2016, In : Journal of Neuro-Oncology. 128, 1, p. 47-56 10 p.

Research output: Contribution to journalArticle

Germinoma
Heterografts
Genotype
Pediatrics
Neoplasms
2015
6 Citations (Scopus)

Cytogenetic landscape of paired neurospheres and traditional monolayer cultures in pediatric malignant brain tumors

Zhao, X., Zhao, Y. J., Lin, Q., Yu, L., Liu, Z., Lindsay, H., Kogiso, M., Rao, P., Li, X. N. & Lu, X., Jul 1 2015, In : Neuro-oncology. 17, 7, p. 965-977 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Medulloblastoma
Brain Neoplasms
Glioma
Cytogenetics
192 Citations (Scopus)

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

Grasso, C. S., Tang, Y., Truffaux, N., Berlow, N. E., Liu, L., Debily, M. A., Quist, M. J., Davis, L. E., Huang, E. C., Woo, P. J., Ponnuswami, A., Chen, S., Johung, T. B., Sun, W., Kogiso, M., Du, Y., Qi, L., Huang, Y., Hütt-Cabezas, M., Warren, K. E. & 20 others, Le Dret, L., Meltzer, P. S., Mao, H., Quezado, M., Van Vuurden, D. G., Abraham, J., Fouladi, M., Svalina, M. N., Wang, N., Hawkins, C., Nazarian, J., Alonso, M. M., Raabe, E. H., Hulleman, E., Spellman, P. T., Li, X. N., Keller, C., Pal, R., Grill, J. & Monje, M., Jun 9 2015, In : Nature Medicine. 21, 6, p. 555-559 5 p.

Research output: Contribution to journalArticle

Glioma
Histone Demethylases
Histone Deacetylase Inhibitors
Heterografts
RNA
54 Citations (Scopus)

Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells

Toledo, C. M., Ding, Y., Hoellerbauer, P., Davis, R. J., Basom, R., Girard, E. J., Lee, E., Corrin, P., Hart, T., Bolouri, H., Davison, J., Zhang, Q., Hardcastle, J., Aronow, B. J., Plaisier, C. L., Baliga, N. S., Moffat, J., Lin, Q., Li, X. N., Nam, D. H. & 7 others, Lee, J., Pollard, S. M., Zhu, J., Delrow, J. J., Clurman, B. E., Olson, J. M. & Paddison, P. J., Dec 22 2015, In : Cell reports. 13, 11, p. 2425-2439 15 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Glioblastoma
Redundancy
Stem Cells
Genes
8 Citations (Scopus)

Postoperative adjuvant arterial chemoembolization improves the survival of hepatitis B virus-related hepatocellular carcinoma: a retrospective control study

Li, F., Guo, Z., Zhang, Y., Wang, H., Zhang, X., Si, T., Yu, H. & Qi, L., Dec 1 2015, In : Irish Journal of Medical Science. 184, 4, p. 753-759 7 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Hepatocellular Carcinoma
Retrospective Studies
Survival
Survival Rate
2014
9 Citations (Scopus)

A patient tumor-derived orthotopic xenograft mouse model replicating the group 3 supratentorial primitive neuroectodermal tumor in children

Liu, Z., Zhao, X., Wang, Y., Mao, H., Huang, Y., Kogiso, M., Qi, L., Baxter, P. A., Man, T. K., Adesina, A., Su, J. M., Picard, D., Ching Ho, K., Huang, A., Perlaky, L., Lau, C. C., Chintagumpala, M. & Li, X. N., Jan 1 2014, In : Neuro-Oncology. 16, 6, p. 787-799 13 p.

Research output: Contribution to journalArticle

Primitive Neuroectodermal Tumors
Heterografts
Neoplastic Stem Cells
Neoplasms
Preclinical Drug Evaluations
2013
7 Citations (Scopus)

Expression of acid-sensing ion channels in nucleus pulposus cells of the human intervertebral disk is regulated by non-steroid anti-inflammatory drugs

Sun, X., Jin, J., Zhang, J. G., Qi, L., Braun, F. K., Zhang, X. D. & Xu, F., Dec 26 2013, In : Acta Biochimica et Biophysica Sinica. 46, 9, p. 774-781 8 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channels
Intervertebral Disc
Anti-Inflammatory Agents
Cells
Amiloride
2012
24 Citations (Scopus)

The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1

Wu, J. C., Qi, L., Wang, Y., Kegel, K. B., Yoder, J., Difiglia, M., Qin, Z. H. & Lin, F., Jun 1 2012, In : Acta Pharmacologica Sinica. 33, 6, p. 743-751 9 p.

Research output: Contribution to journalArticle

Autophagy
PC12 Cells
Cathepsin L
Cathepsin B
Proteasome Inhibitors
2011
34 Citations (Scopus)

Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice

Qi, L., Liu, C. Y., Wu, W. Q., Gu, Z. L. & Guo, C. Y., Apr 1 2011, In : Fitoterapia. 82, 3, p. 383-392 10 p.

Research output: Contribution to journalArticle

Flavonoids
Radiation
DNA Damage
Seeds
High Pressure Liquid Chromatography