Grants per year
Personal profile
Research Interests
Dr. Wilsbacher's research focuses on cardiac development and cardiomyocyte maintenance in the setting of pathological stress. Currently, the laboratory investigates the G protein-coupled receptor sphingosine-1-phosphate receptor 1 (S1Pr1) and its unexpected role in cardiomyocyte proliferation and cardiac development. Her research aims to identify the signaling mechanisms that underlie these cardiac developmental effects and to investigate whether S1Pr1 signaling contributes to cardiac remodeling in the adult heart.
Training Experience
| 2004 | Internship, University of California- San Francisco Medical Center |
| 2007 | Residency, University of California- San Francisco Medical Center |
| 2009 | Fellowship, University of California- San Francisco Medical Center |
Education/Academic qualification
Medicine, MD, Northwestern University Feinberg School of Medicine
… → 2003
PhD, Northwestern University
… → 2001
Research interests
- Cardiomyopathy
- Developmental Biology
- Fibrosis
- Gene Regulation
- Genomic Medicine/Personalized Medicine
- Molecular Biology
- Phospholipids
- TGF-beta
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CardioExcyte 96 System for Pharmacology Research at Northwestern University
George Jr., A. L., Abdulkadir, S. A., Ardehali, H., Arora, R. K., Burridge, P., Kearney, J. A., McNally, E. M., Schiltz, G. E., Silverman, R. B., Watterson, D. M. & Wilsbacher, L. D.
Office of the Director, National Institutes of Health
6/15/20 → 6/30/25
Project: Research project
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Exploring the roles of Gi and S1Pr1 in endothelial barrier function in vivo
National Heart, Lung, and Blood Institute
3/2/15 → 2/29/16
Project: Research project
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Complete Regional Absence of Vasa Vasorum in an Ascending Aortic Aneurysm
Son, A. Y., Demarais, N. M., Malaisrie, S. C., Lomasney, J. W., Pradella, M., Wilsbacher, L. D., Allen, B. A., Markl, M. & Avery, R., 2021, (Accepted/In press) In: Circulation: Cardiovascular Imaging. p. 565-567 3 p., e012312.Research output: Contribution to journal › Comment/debate › peer-review
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Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair
DeBerge, M., Lantz, C., Dehn, S., Sullivan, D. P., van der Laan, A. M., Niessen, H. W. M., Flanagan, M. E., Brat, D. J., Feinstein, M. J., Kaushal, S., Wilsbacher, L. D. & Thorp, E. B., Sep 6 2021, In: The Journal of experimental medicine. 218, 9Research output: Contribution to journal › Article › peer-review
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Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction
DeBerge, M., Glinton, K., Subramanian, M., Wilsbacher, L. D., Rothlin, C. V., Tabas, I. & Thorp, E. B., Mar 15 2021, In: Journal of Clinical Investigation. 131, 6, e139576.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Clinical Implications of the Genetic Architecture of Dilated Cardiomyopathy
Wilsbacher, L. D., Dec 1 2020, In: Current Cardiology Reports. 22, 12, 170.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
Desmoplakin Cardiomyopathy, a Fibrotic and Inflammatory Form of Cardiomyopathy Distinct from Typical Dilated or Arrhythmogenic Right Ventricular Cardiomyopathy
Smith, E. D., Lakdawala, N. K., Papoutsidakis, N., Aubert, G., Mazzanti, A., McCanta, A. C., Agarwal, P. P., Arscott, P., Dellefave-Castillo, L. M., Vorovich, E. E., Nutakki, K., Wilsbacher, L. D., Priori, S. G., Jacoby, D. L., McNally, E. M. & Helms, A. S., Jun 9 2020, In: Circulation. 141, 23, p. 1872-1884 13 p.Research output: Contribution to journal › Article › peer-review
41 Scopus citations