Grants per year
Personal profile
Research Interests
Dr. Wilsbacher's research focuses on cardiac development and cardiomyocyte maintenance in the setting of pathological stress. Currently, the laboratory investigates the G protein-coupled receptor sphingosine-1-phosphate receptor 1 (S1Pr1) and its unexpected role in cardiomyocyte proliferation and cardiac development. Her research aims to identify the signaling mechanisms that underlie these cardiac developmental effects and to investigate whether S1Pr1 signaling contributes to cardiac remodeling in the adult heart.
Training Experience
| 2004 | Internship, University of California- San Francisco Medical Center |
| 2007 | Residency, University of California- San Francisco Medical Center |
| 2009 | Fellowship, University of California- San Francisco Medical Center |
Education/Academic qualification
Medicine, MD, Northwestern University
… → 2003
PhD, Northwestern University
… → 2001
Research interests
- Cardiomyopathy
- Developmental Biology
- Fibrosis
- Gene Regulation
- Genomic Medicine/Personalized Medicine
- Molecular Biology
- Phospholipids
- TGF-beta
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Evolutionary Advantage of Heterozygous PAI-1 Deficiency in Humans
Vaughan, D. E., Duncan, F. E., Eren, M., Richter, C. & Wilsbacher, L. D.
9/15/22 → 8/31/23
Project: Research project
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CardioExcyte 96 System for Pharmacology Research at Northwestern University
George, A. L., Abdulkadir, S. A., Ardehali, H., Arora, R. K., Burridge, P., Kearney, J. A., McNally, E. M., Schiltz, G. E., Silverman, R. B., Watterson, D. M. & Wilsbacher, L. D.
Office of the Director, National Institutes of Health
6/15/20 → 6/30/25
Project: Research project
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Efferocytosis-Directed Inflammation Resolution and Repair in the Hypoxic Heart
Thorp, E. B. & Wilsbacher, L. D.
National Heart, Lung, and Blood Institute
12/20/19 → 11/30/23
Project: Research project
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Spontaneous cardiac fibrosis in PAI-1-deficient mice and men: A rare mutation informs a common molecular pathophysiology
Vaughan, D. E., Burridge, P., Carr, J., Eren, M., Flevaris, P. D., Ghosh, A. K., Hou, L., Khan, S. S., Shah, S. J., Wilsbacher, L. D. & Winter, D. R.
National Heart, Lung, and Blood Institute
4/15/19 → 3/31/23
Project: Research project
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Combined modality PET/MR for the detection of severe large vessel vasculitis
Cerne, J. W., Liu, S., Umair, M., Pathrose, A., Moore, J. E., Allen, B. D., Markl, M., Carr, J., Savas, H., Wilsbacher, L. & Avery, R. J., Dec 2022, In: European Journal of Hybrid Imaging. 6, 1, 16.Research output: Contribution to journal › Article › peer-review
Open Access -
Ischemic dual papillary muscle rupture in a postpartum patient with vascular Ehlers-Danlos syndrome
Erfe, J. M., Devlin, P., Rich, J., Wilsbacher, L., Schimmel, D., McCarthy, P. & Pawale, A. A., 2022, (Accepted/In press) In: JTCVS Techniques.Research output: Contribution to journal › Article › peer-review
Open Access -
Valve-sparing versus valve-replacing aortic root replacement in patients with aortic root aneurysm
Malaisrie, S. C., Kislitsina, O. N., Wilsbacher, L., Mendelson, M., Puthumana, J. J., Vassallo, P., Kruse, J., Andrei, A. C. & McCarthy, P. M., Jul 2022, In: Journal of Cardiac Surgery. 37, 7, p. 1947-1956 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
COL3A1 Missense Variant in a Patient Presenting With Hemoptysis
Riaz, A., Portocarrero, J. P., Hoel, A., Yeldandi, A., Dellefave-Castillo, L., Paparello, J., D Amico, J. D. M. & Wilsbacher, L. D., Oct 1 2021, In: Circulation. Genomic and precision medicine. 14, 5, p. e003386Research output: Contribution to journal › Article › peer-review
Open Access -
Complete Regional Absence of Vasa Vasorum in an Ascending Aortic Aneurysm
Son, A. Y., Demarais, N. M., Malaisrie, S. C., Lomasney, J. W., Pradella, M., Wilsbacher, L. D., Allen, B. A., Markl, M. & Avery, R., Jun 1 2021, In: Circulation: Cardiovascular Imaging. 14, 6, p. E012312Research output: Contribution to journal › Article › peer-review
Open Access