Grants per year
Personal profile
Research Interests
Dr. Wilsbacher's research focuses on cardiac development and cardiomyocyte maintenance in the setting of pathological stress. Currently, the laboratory investigates the G protein-coupled receptor sphingosine-1-phosphate receptor 1 (S1Pr1) and its unexpected role in cardiomyocyte proliferation and cardiac development. Her research aims to identify the signaling mechanisms that underlie these cardiac developmental effects and to investigate whether S1Pr1 signaling contributes to cardiac remodeling in the adult heart.
Training Experience
| 2004 | Internship, University of California- San Francisco Medical Center |
| 2007 | Residency, University of California- San Francisco Medical Center |
| 2009 | Fellowship, University of California- San Francisco Medical Center |
Education/Academic qualification
MD, Northwestern University Feinberg School of Medicine
… → 2003
PhD, Northwestern University
… → 2001
Research interests
- Cardiomyopathy
- Developmental Biology
- Fibrosis
- Gene Regulation
- Genomic Medicine/Personalized Medicine
- Molecular Biology
- Phospholipids
- TGF-beta
Fingerprint Dive into the research topics where Lisa D Wilsbacher is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 5 Similar Profiles
Cardiac Myocytes
Medicine & Life Sciences
Circadian Clocks
Medicine & Life Sciences
Lysosphingolipid Receptors
Medicine & Life Sciences
CLOCK Proteins
Medicine & Life Sciences
Genes
Medicine & Life Sciences
Transcription Factors
Medicine & Life Sciences
Circadian Rhythm
Medicine & Life Sciences
Clocks
Chemical Compounds
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2015 2017
- 2 Finished
Exploring the roles of Gi and S1Pr1 in endothelial barrier function in vivo
National Heart, Lung, and Blood Institute
3/2/15 → 2/29/16
Project: Research project
Lysosphingolipid Receptors
Endothelium
Blood Vessels
Caveolae
Research Personnel
Research Output 1997 2019
Macrophages in Heart Failure with Reduced versus Preserved Ejection Fraction
DeBerge, M., Shah, S. J., Wilsbacher, L. D. & Thorp, E. B., Jan 1 2019, In : Trends in Molecular Medicine.Research output: Contribution to journal › Review article
Heart Failure
Macrophages
Biomarkers
Inflammation
Incidence
3
Citations
(Scopus)
Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation
Liu, P., Wysocki, J., Souma, T., Ye, M., Ramirez, V., Zhou, B., Wilsbacher, L. D., Quaggin, S. E., Batlle, D. & Jin, J., Jul 1 2018, In : Kidney international. 94, 1, p. 114-125 12 p.Research output: Contribution to journal › Article
Renin-Angiotensin System
Angiotensin II
Hypertension
Blood Pressure
Transgenic Mice
5
Citations
(Scopus)
A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis
Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.Research output: Contribution to journal › Article
Fibrosis
Hypertension
Kidney
Podocytes
Mesangial Cells
9
Citations
(Scopus)
Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament Component in Arrhythmia and Dilated Cardiomyopathy
Barefield, D. Y., Roy-Puckelwartz, M. J., Kim, E. Y., Wilsbacher, L. D., Vo, A. H., Waters, E. A., Earley, J. U., Hadhazy, M., Castillo, L. M., Pesce, L. L. & McNally, E. M., Oct 17 2017, In : Circulation. 136, 16, p. 1477-1491 15 p.Research output: Contribution to journal › Article
Myofibrils
Dilated Cardiomyopathy
Myosins
Cardiac Arrhythmias
Carrier Proteins
21
Citations
(Scopus)
Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2
Yang, X., Park, S. H., Chang, H. C., Shapiro, J. S., Vasilopoulos, A., Sawicki, K. T., Chen, C., Shang, M., Burridge, P., Epting, C. L., Wilsbacher, L. D., Jenkitkasemwong, S., Knutson, M., Gius, D. R. & Ardehali, H., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1505-1516 12 p.Research output: Contribution to journal › Article
Sirtuin 2
Homeostasis
Transcription Factors
Iron
Lysine