Lisa D Wilsbacher

  • 4297 Citations
19972019
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Personal profile

Research Interests

Dr. Wilsbacher's research focuses on cardiac development and cardiomyocyte maintenance in the setting of pathological stress. Currently, the laboratory investigates the G protein-coupled receptor sphingosine-1-phosphate receptor 1 (S1Pr1) and its unexpected role in cardiomyocyte proliferation and cardiac development. Her research aims to identify the signaling mechanisms that underlie these cardiac developmental effects and to investigate whether S1Pr1 signaling contributes to cardiac remodeling in the adult heart.

Training Experience

2004Internship, University of California- San Francisco Medical Center
2007Residency, University of California- San Francisco Medical Center
2009Fellowship, University of California- San Francisco Medical Center

Education/Academic qualification

MD, Northwestern University Feinberg School of Medicine

… → 2003

PhD, Northwestern University

… → 2001

Research interests

  • Cardiomyopathy
  • Developmental Biology
  • Fibrosis
  • Gene Regulation
  • Genomic Medicine/Personalized Medicine
  • Molecular Biology
  • Phospholipids
  • TGF-beta

Fingerprint Dive into the research topics where Lisa D Wilsbacher is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Cardiac Myocytes Medicine & Life Sciences
Circadian Clocks Medicine & Life Sciences
Lysosphingolipid Receptors Medicine & Life Sciences
CLOCK Proteins Medicine & Life Sciences
Genes Medicine & Life Sciences
Transcription Factors Medicine & Life Sciences
Circadian Rhythm Medicine & Life Sciences
Clocks Chemical Compounds

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Grants 2015 2017

Lysosphingolipid Receptors
Endothelium
Blood Vessels
Caveolae
Research Personnel

Research Output 1997 2019

  • 4297 Citations
  • 18 Article
  • 2 Review article
  • 1 Comment/debate
Heart Failure
Macrophages
Biomarkers
Inflammation
Incidence
3 Citations (Scopus)
Renin-Angiotensin System
Angiotensin II
Hypertension
Blood Pressure
Transgenic Mice
5 Citations (Scopus)

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis

Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

Fibrosis
Hypertension
Kidney
Podocytes
Mesangial Cells
9 Citations (Scopus)

Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament Component in Arrhythmia and Dilated Cardiomyopathy

Barefield, D. Y., Roy-Puckelwartz, M. J., Kim, E. Y., Wilsbacher, L. D., Vo, A. H., Waters, E. A., Earley, J. U., Hadhazy, M., Castillo, L. M., Pesce, L. L. & McNally, E. M., Oct 17 2017, In : Circulation. 136, 16, p. 1477-1491 15 p.

Research output: Contribution to journalArticle

Myofibrils
Dilated Cardiomyopathy
Myosins
Cardiac Arrhythmias
Carrier Proteins
21 Citations (Scopus)

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

Yang, X., Park, S. H., Chang, H. C., Shapiro, J. S., Vasilopoulos, A., Sawicki, K. T., Chen, C., Shang, M., Burridge, P., Epting, C. L., Wilsbacher, L. D., Jenkitkasemwong, S., Knutson, M., Gius, D. R. & Ardehali, H., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1505-1516 12 p.

Research output: Contribution to journalArticle

Sirtuin 2
Homeostasis
Transcription Factors
Iron
Lysine