Grants per year
Personal profile
Research Interests
Dr. Wilsbacher's research focuses on cardiac development and cardiomyocyte maintenance in the setting of pathological stress. Currently, the laboratory investigates the G protein-coupled receptor sphingosine-1-phosphate receptor 1 (S1Pr1) and its unexpected role in cardiomyocyte proliferation and cardiac development. Her research aims to identify the signaling mechanisms that underlie these cardiac developmental effects and to investigate whether S1Pr1 signaling contributes to cardiac remodeling in the adult heart.
Training Experience
| 2004 | Internship, University of California- San Francisco Medical Center |
| 2007 | Residency, University of California- San Francisco Medical Center |
| 2009 | Fellowship, University of California- San Francisco Medical Center |
Education/Academic qualification
MD, Northwestern University Feinberg School of Medicine
… → 2003
PhD, Northwestern University
… → 2001
Research interests
- Cardiomyopathy
- Developmental Biology
- Fibrosis
- Gene Regulation
- Genomic Medicine/Personalized Medicine
- Molecular Biology
- Phospholipids
- TGF-beta
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Grants
CardioExcyte 96 System for Pharmacology Research at Northwestern University
Abdulkadir, S. A., Ardehali, H., Arora, R. K., Burridge, P., George Jr, A. L., Kearney, J. A., McNally, E. M., Schiltz, G. E., Silverman, R. B., Watterson, D. M. & Wilsbacher, L. D.
6/15/20 → 6/14/21
Project: Research project
Exploring the roles of Gi and S1Pr1 in endothelial barrier function in vivo
National Heart, Lung, and Blood Institute
3/2/15 → 2/29/16
Project: Research project
Research Output
Desmoplakin Cardiomyopathy, a Fibrotic and Inflammatory Form of Cardiomyopathy Distinct From Typical Dilated or Arrhythmogenic Right Ventricular Cardiomyopathy
Smith, E. D., Lakdawala, N. K., Papoutsidakis, N., Aubert, G., Mazzanti, A., McCanta, A. C., Agarwal, P. P., Arscott, P., Castillo, L. M., Vorovich, E. E., Nutakki, K., Wilsbacher, L. D., Priori, S. G., Jacoby, D. L., McNally, E. M. & Helms, A. S., Jun 9 2020, In : Circulation. 141, 23, p. 1872-1884 13 p.Research output: Contribution to journal › Article
Macrophages in Heart Failure with Reduced versus Preserved Ejection Fraction
DeBerge, M., Shah, S. J., Wilsbacher, L. & Thorp, E. B., Apr 2019, In : Trends in Molecular Medicine. 25, 4, p. 328-340 13 p.Research output: Contribution to journal › Review article
2
Scopus
citations
Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation
Liu, P., Wysocki, J., Souma, T., Ye, M., Ramirez, V., Zhou, B., Wilsbacher, L. D., Quaggin, S. E., Batlle, D. & Jin, J., Jul 2018, In : Kidney international. 94, 1, p. 114-125 12 p.Research output: Contribution to journal › Article
9
Scopus
citations
A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis
Rai, R., Verma, S. K., Kim, D., Ramirez, V., Lux, E., Li, C., Sahoo, S., Wilsbacher, L. D., Vaughan, D. E., Quaggin, S. E. & Ghosh, A. K., Nov 2 2017, In : Epigenetics. 12, 11, p. 1004-1013 10 p.Research output: Contribution to journal › Article
7
Scopus
citations
Experimental Modeling Supports a Role for MyBP-HL as a Novel Myofilament Component in Arrhythmia and Dilated Cardiomyopathy
Barefield, D. Y., Puckelwartz, M. J., Kim, E. Y., Wilsbacher, L. D., Vo, A. H., Waters, E. A., Earley, J. U., Hadhazy, M., Dellefave-Castillo, L., Pesce, L. L. & McNally, E. M., Oct 17 2017, In : Circulation. 136, 16, p. 1477-1491 15 p.Research output: Contribution to journal › Article
14
Scopus
citations