Grants per year
Personal profile
Research Interests
Dr. Wilsbacher's research focuses on cardiac development and cardiomyocyte maintenance in the setting of pathological stress. Currently, the laboratory investigates the G protein-coupled receptor sphingosine-1-phosphate receptor 1 (S1Pr1) and its unexpected role in cardiomyocyte proliferation and cardiac development. Her research aims to identify the signaling mechanisms that underlie these cardiac developmental effects and to investigate whether S1Pr1 signaling contributes to cardiac remodeling in the adult heart.
Training Experience
| 2004 | Internship, University of California- San Francisco Medical Center |
| 2007 | Residency, University of California- San Francisco Medical Center |
| 2009 | Fellowship, University of California- San Francisco Medical Center |
Education/Academic qualification
Medicine, MD, Northwestern University
… → 2003
PhD, Neuroscience, Northwestern University
… → 2001
Research interests keywords
- Cardiomyopathy
- Developmental Biology
- Fibrosis
- Gene Regulation
- Genomic Medicine/Personalized Medicine
- Molecular Biology
- Phospholipids
- TGF-beta
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Spatial Compartmentalization of Plasminogen Activator Inhibitor-1 in Senescence and Cardiovascular Aging
Vaughan, D. E. (PD/PI) & Wilsbacher, L. D. (Other)
1/1/25 → 12/31/26
Project: Research project
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Linking in vivo hemodynamics with outcomes in Type B aortic dissection using 4D flow MRI
Allen, B. D. (PD/PI), Bagci, U. (Co-Investigator), Hoel, A. W. (Co-Investigator), Markl, M. (Co-Investigator), Mehta, C. (Co-Investigator), Ragin, A. (Co-Investigator) & Wilsbacher, L. D. (Co-Investigator)
National Heart, Lung, and Blood Institute
2/15/24 → 1/31/29
Project: Research project
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Heterozygous SERPINE1 Deficiency Confers Durable Cardiovascular Fitness in Humans
Vaughan, D. E. (PD/PI), Abdala-Valencia, H. (Co-Investigator), Burridge, P. (Co-Investigator), Cuda, C. M. (Co-Investigator), Eren, M. (Co-Investigator), Ghosh, A. K. (Co-Investigator), Hayes, M. G. (Co-Investigator), Kelleher, N. L. (Co-Investigator), Khan, S. S. (Co-Investigator), Stoeger, T. (Co-Investigator), Wilsbacher, L. D. (Co-Investigator) & Zhang, W. (Co-Investigator)
National Heart, Lung, and Blood Institute
1/1/24 → 12/31/30
Project: Research project
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SHaRe: Sarcomeric Human Cardiomyopathy Registry
Wilsbacher, L. D. (PD/PI) & Khan, S. S. (Co-Investigator)
1/1/22 → 12/31/27
Project: Research project
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CardioExcyte 96 System for Pharmacology Research at Northwestern University
George, A. L. (PD/PI), Abdulkadir, S. A. (Other), Ardehali, H. (Other), Arora, R. K. (Other), Burridge, P. (Other), Kearney, J. A. (Other), McNally, E. M. (Other), Schiltz, G. E. (Other), Silverman, R. B. (Other), Watterson, D. M. (Other) & Wilsbacher, L. D. (Other)
Office of the Director, National Institutes of Health
6/15/20 → 6/30/25
Project: Research project
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Dilated Cardiomyopathy Presentation, Early Outcomes, and Female Sex: A Paradox Revealed
Wilsbacher, L. D., Feb 2024, In: JACC: Heart Failure. 12, 2, p. 364-365 2 p.Research output: Contribution to journal › Editorial › peer-review
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Prioritizing the primary prevention of heart failure: Measuring, modifying and monitoring risk
Patel, R., Peesay, T., Krishnan, V., Wilcox, J., Wilsbacher, L. & Khan, S. S., Jan 1 2024, In: Progress in Cardiovascular Diseases. 82, p. 2-14 13 p.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias
Ohiri, J. C., Dellefave-Castillo, L., Tomar, G., Wilsbacher, L., Choudhury, L., Barefield, D. Y., Fullenkamp, D., Gacita, A. M., Monroe, T. O., Pesce, L., Blancard, M., Vaught, L., George, A. L., Demonbreun, A. R., Puckelwartz, M. J. & McNally, E. M., 2024, In: Journal of the American Heart Association. 13, 10, e030467.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Hypertrophic Cardiomyopathy Secondary to RAF1 Cysteine-Rich Domain Variants
Fullenkamp, D. E., Jorgensen, R. M., Leach, D. F., Sinha, A., Salamone, I. M., Johnston, J. R., Dellefave-Castillo, L. M., Choudhury, L., McNally, E. M. & Wilsbacher, L. D., Dec 1 2023, In: Circulation: Genomic and Precision Medicine. 16, 6, p. E004262Research output: Contribution to journal › Article › peer-review
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Cardiomyocyte PAI-1 influences the cardiac transcriptome and limits the extent of cardiac fibrosis in response to left ventricular pressure overload
Ghosh, A. K., Kalousdian, A. A., Shang, M., Lux, E., Eren, M., Keating, A., Wilsbacher, L. D. & Vaughan, D. E., Nov 27 2022, (E-pub ahead of print) In: Cellular Signalling. p. 110555Research output: Contribution to journal › Article › peer-review
3 Scopus citations