Grants per year
Personal profile
Research Interests
My clinical practice involves the medical treatment of breast cancer in women and men with a particular interest in young women with breast cancer. My clinical research endeavors involve chemotherapy, endocrine therapy, and novel therapies for the treatment of breast cancer. I am interested in ways to optimize and individualize breast cancer treatment based on patient characteristics as well as tumor specific molecular profiles.
Certifications and Licenses
| Medical Oncology | |
| Hematology |
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Georgetown University
… → 1998
Research interests
- Breast Cancer
- Cancer Genetics
- Cancer Survivorship
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Grants
- 8 Finished
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Prot# M02-446: A Phase II Study of ABT-751 in Subjects with Refractory Colorectal Carcinoma
Benson III, A. B., Flaum, L. E., Frankfurt, O. & Zakarija, A.
4/29/04 → 4/29/06
Project: Research project
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Prot# MNTX 301: A Double-Blind Placebo Controlled Study of Methylnaltrexone (MNTX) for the Relief of Symptomatic Constipation Due to Chronic Opioid Therapy in Patients with Advanced Medical Illness
Flaum, L. E., Frankfurt, O. & Zakarija, A.
Progenics Pharmaceuticals, Inc.
4/7/04 → 4/5/07
Project: Research project
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Prot# NCI R03L1: A Phase 2 Study of OSI 774 (IND# 63383) in Combination with Celecoxib (Celebrex, Pharmacia) as Second-Line Therapy in Advanced Non-Small Cell Lung Cancer (NCI prot# 5416) (Rush prot# Lung 2002-1)
Patel, J. D., Flaum, L. E., Frankfurt, O. & Zakarija, A.
Rush University Medical Center, Pfizer Inc.
3/22/04 → 1/1/08
Project: Research project
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Prot# PSIND011: Mltctr Phz 1-2 Trial to Evaluate E&S of IDEC-Y2B8 (Zevalin) Radioimmunotherapy in Low-Grade, Follicular or Transformed B-Cell Non-Hodgkin's Lymphoma Patients Following Initial Response & Subsequent Relapse from Previous (NU Prot# UAB 0153)
Gordon, L. I., Flaum, L. E., Frankfurt, O. & Zakarija, A.
University of Alabama Medical School, Biogen Inc.
3/4/04 → 2/28/06
Project: Research project
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Prot# 9238IL/0048: Rndmzd, Dbl-Bld, Mltctr Study to Compare Effic & Tolrblty of Fulvestrant (FASLODEX?) vs Exemestane (AROMASIN?) in Postmenopausal Women w/ Hormone Receptor Positive Advanced Breast Cancer w/ Disease Progression after Prior Non-Steroidal
Gradishar, W. J., Flaum, L. E., Frankfurt, O. & Zakarija, A.
2/18/04 → 11/21/11
Project: Research project
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Longitudinal dynamics of circulating tumor cells and circulating tumor DNA for treatment monitoring in metastatic breast cancer
Gerratana, L., Davis, A. A., Zhang, Q., Basile, D., Rossi, G., Strickland, K., Franzoni, A., Allegri, L., Mu, Z., Zhang, Y., Flaum, L. E., Damante, G., Gradishar, W. J., Platanias, L. C., Behdad, A., Yang, H., Puglisi, F. & Cristofanilli, M., 2021, In: JCO Precision Oncology. 5, p. 943-952 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The use of serial circulating tumor DNA to detect resistance alterations in progressive metastatic breast cancer
Jacob, S., Davis, A. A., Gerratana, L., Velimirovic, M., Shah, A. N., Wehbe, F., Katam, N., Zhang, Q., Flaum, L., Siziopikou, K. P., Platanias, L. C., Gradishar, W. J., Behdad, A., Bardia, A. & Cristofanilli, M., Mar 1 2021, In: Clinical Cancer Research. 27, 5, p. 1361-1370 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Landscape of circulating tumour DNA in metastatic breast cancer
Davis, A. A., Jacob, S., Gerratana, L., Shah, A. N., Wehbe, F., Katam, N., Zhang, Q., Flaum, L., Siziopikou, K. P., Platanias, L. C., Gradishar, W. J., Behdad, A. & Cristofanilli, M., Aug 2020, In: EBioMedicine. 58, 102914.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Performance of a novel Next Generation Sequencing circulating tumor DNA (ctDNA) platform for the evaluation of samples from patients with metastatic breast cancer (MBC)
Gerratana, L., Zhang, Q., Shah, A. N., Davis, A. A., Zhang, Y., Wehbe, F., Qiang, W., Flaum, L., Finkelman, B. S., Gradishar, W. J., Platanias, L. C., Behdad, A. & Cristofanilli, M., Jan 2020, In: Critical Reviews in Oncology/Hematology. 145, 102856.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
Phase II study of pembrolizumab and capecitabine for triple negative and hormone receptor-positive, HER2-negative endocrine-refractory metastatic breast cancer
Shah, A. N., Flaum, L., Helenowski, I., Santa-Maria, C. A., Jain, S., Rademaker, A., Nelson, V., Tsarwhas, D., Cristofanilli, M. & Gradishar, W., Feb 13 2020, In: Journal for immunotherapy of cancer. 8, 1, e000173.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations