Grants per year
Personal profile
Research Interests
My clinical practice involves the medical treatment of breast cancer in women and men with a particular interest in young women with breast cancer. My clinical research endeavors involve chemotherapy, endocrine therapy, and novel therapies for the treatment of breast cancer. I am interested in ways to optimize and individualize breast cancer treatment based on patient characteristics as well as tumor specific molecular profiles.
Certifications and Licenses
| Medical Oncology | |
| Hematology |
Education/Academic qualification
MD, Georgetown University
… → 1998
Research interests
- Breast Cancer
- Cancer Genetics
- Cancer Survivorship
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Network
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Grants
- 8 Finished
Prot# M02-446: A Phase II Study of ABT-751 in Subjects with Refractory Colorectal Carcinoma
Benson III, A. B., Flaum, L. E., Frankfurt, O. & Zakarija, A.
4/29/04 → 4/29/06
Project: Research project
Prot# MNTX 301: A Double-Blind Placebo Controlled Study of Methylnaltrexone (MNTX) for the Relief of Symptomatic Constipation Due to Chronic Opioid Therapy in Patients with Advanced Medical Illness
Flaum, L. E., Frankfurt, O. & Zakarija, A.
Progenics Pharmaceuticals, Inc.
4/7/04 → 4/5/07
Project: Research project
Prot# NCI R03L1: A Phase 2 Study of OSI 774 (IND# 63383) in Combination with Celecoxib (Celebrex, Pharmacia) as Second-Line Therapy in Advanced Non-Small Cell Lung Cancer (NCI prot# 5416) (Rush prot# Lung 2002-1)
Flaum, L. E., Frankfurt, O., Patel, J. D. & Zakarija, A.
Rush University Medical Center, Pfizer Inc.
3/22/04 → 1/1/08
Project: Research project
Prot# PSIND011: Mltctr Phz 1-2 Trial to Evaluate E&S of IDEC-Y2B8 (Zevalin) Radioimmunotherapy in Low-Grade, Follicular or Transformed B-Cell Non-Hodgkin's Lymphoma Patients Following Initial Response & Subsequent Relapse from Previous (NU Prot# UAB 0153)
Flaum, L. E., Frankfurt, O., Gordon, L. I. & Zakarija, A.
University of Alabama Medical School, Biogen Inc.
3/4/04 → 2/28/06
Project: Research project
Prot# 9238IL/0048: Rndmzd, Dbl-Bld, Mltctr Study to Compare Effic & Tolrblty of Fulvestrant (FASLODEX?) vs Exemestane (AROMASIN?) in Postmenopausal Women w/ Hormone Receptor Positive Advanced Breast Cancer w/ Disease Progression after Prior Non-Steroidal
Flaum, L. E., Frankfurt, O., Gradishar, W. J. & Zakarija, A.
2/18/04 → 11/21/11
Project: Research project
Research Output
Performance of a novel Next Generation Sequencing circulating tumor DNA (ctDNA) platform for the evaluation of samples from patients with metastatic breast cancer (MBC)
Gerratana, L., Zhang, Q., Shah, A. N., Davis, A. A., Zhang, Y., Wehbe, F., Qiang, W., Flaum, L., Finkelman, B. S., Gradishar, W. J., Platanias, L. C., Behdad, A. & Cristofanilli, M., Jan 2020, In : Critical Reviews in Oncology/Hematology. 145, 102856.Research output: Contribution to journal › Review article
Open Access
1
Scopus
citations
Phase II study of pembrolizumab and capecitabine for triple negative and hormone receptor-positive, HER2-negative endocrine-refractory metastatic breast cancer
Shah, A. N., Flaum, L., Helenowski, I., Santa-Maria, C. A., Jain, S., Rademaker, A., Nelson, V., Tsarwhas, D., Cristofanilli, M. & Gradishar, W., Feb 13 2020, In : Journal for immunotherapy of cancer. 8, 1, e000173.Research output: Contribution to journal › Article
Open Access
Association of a novel circulating tumor DNA next-generating sequencing platform with circulating tumor cells (CTCs) and CTC clusters in metastatic breast cancer
Davis, A. A., Zhang, Q., Gerratana, L., Shah, A. N., Zhan, Y., Qiang, W., Finkelman, B. S., Flaum, L., Behdad, A., Gradishar, W. J., Platanias, L. C. & Cristofanilli, M., Dec 4 2019, In : Breast Cancer Research. 21, 1, 137.Research output: Contribution to journal › Article
Open Access
2
Scopus
citations
Relationship of pathological features and a 21 gene expression assay in younger versus older women with node-negative endocrine receptor-positive breast cancer
Mutonga, M., Speedy, S., Rademaker, A., Liu, D., Uthe, R., Jain, S., Gradishar, W. J., Flaum, L. & Santa-Maria, C. A., Jul 15 2019, In : Breast Cancer Research and Treatment. 176, 1, p. 95-100 6 p.Research output: Contribution to journal › Article
1
Scopus
citations
Advances in endocrine therapy for postmenopausal metastatic breast cancer
Flaum, L. E. & Gradishar, W. J., Jan 1 2018, Cancer Treatment and Research. Springer International Publishing, p. 141-154 14 p. (Cancer Treatment and Research; vol. 173).Research output: Chapter in Book/Report/Conference proceeding › Chapter
5
Scopus
citations