Grants per year
Personal profile
Research Interests
intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis.
I am interested in the regulation of the intercellular adhesive junction, the desmosome, during processes such as wound healing and morphogenesis. Currently my studies are focused on the plakin protein, desmoplakin, an obligate member of the desmosomal plaque, which mediates the interaction between the plaque and the intermediate filament network. This interaction with the intermediate filament network is required for maintaining tissue integrity, particularly those tissues undergoing large amounts of stress, such as the heart and skin. The importance of desmoplakin in maintaining adhesive strength is highlighted by cardiomyopathies and skin diseases, which result from desmoplakin mutations. Utilizing biochemistry and fixed and live cell imaging techniques we are analyzing the dynamics of desmoplakin during desmosome formation and the roles the intermediate filament and microfilament networks play in that process.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Northwestern University
… → 1997
Research interests
- Cell Adhesion Mechanisms
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Desmoplakin Assembly and Function in Epidermis
Green, K. J., Broussard, J. A. & Godsel, L. M.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
6/1/21 → 5/31/26
Project: Research project
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Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and Melanoma
Green, K. J., Godsel, L. M. & Johnson, J. L. P.
2/1/19 → 1/31/24
Project: Research project
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Inter-junctional signaling in epithelial junctional complex
Troyanovsky, S. M., Godsel, L. M. & Green, K. J.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/1/16 → 7/31/22
Project: Research project
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Inter-junctional signaling in epithelial junctional complex
Troyanovsky, S. M., Godsel, L. M. & Green, K. J.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/1/15 → 8/31/16
Project: Research project
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The Role of the Desmosome Protein, Plakophilin 2, in Cancer
4/1/12 → 3/31/13
Project: Research project
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Acral peeling in Nagashima type palmo-plantar keratosis patients reveals the role of serine protease inhibitor B 7 in keratinocyte adhesion
Cohen-Barak, E., Azzam, W., Koetsier, J. L., Danial-Farran, N., Barcan, M., Hriesh, M., Khayat, M., Edison, N., Krausz, J., Gafni-Amsalem, C., Kubo, A., Godsel, L. M., Ziv, M. & Allon-Shalev, S., Feb 2022, In: Experimental Dermatology. 31, 2, p. 214-222 9 p.Research output: Contribution to journal › Article › peer-review
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Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor
Godsel, L. M., Roth-Carter, Q. R., Koetsier, J. L., Tsoi, L. C., Huffine, A. L., Broussard, J. A., Fitz, G. N., Lloyd, S. M., Kweon, J., Burks, H. E., Hegazy, M., Amagai, S., Harms, P. W., Xing, X., Kirma, J., Johnson, J. L., Urciuoli, G., Doglio, L. T., Swindell, W. R., Awatramani, R. & 6 others, , Feb 1 2022, In: Journal of Clinical Investigation. 132, 3, 144363.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2
Raya-Sandinoa, A., Luissint, A. C., Kusters, D. H. M., Narayanan, V., Flemming, S., Garcia-Hernandez, V., Godsel, L. M., Green, K. J., Hagen, S. J., Conway, D. E., Parkos, C. A. & Nusrat, A., Apr 15 2021, In: Molecular biology of the cell. 32, 8, p. 753-768 16 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Proximity Ligation Assay for Detecting Protein-Protein Interactions and Protein Modifications in Cells and Tissues in Situ
Hegazy, M., Cohen-Barak, E., Koetsier, J. L., Najor, N. A., Arvanitis, C., Sprecher, E., Green, K. J. & Godsel, L. M., Dec 1 2020, In: Current Protocols in Cell Biology. 89, 1, p. e115Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
The Role of Desmoglein 1 in Gap Junction Turnover Revealed through the Study of SAM Syndrome
Cohen-Barak, E., Godsel, L. M., Koetsier, J. L., Hegazy, M., Kushnir-Grinbaum, D., Hammad, H., Danial-Farran, N., Harmon, R., Khayat, M., Bochner, R., Peled, A., Rozenblat, M., Krausz, J., Sarig, O., Johnson, J. L., Ziv, M., Shalev, S. A., Sprecher, E. & Green, K. J., Mar 2020, In: Journal of Investigative Dermatology. 140, 3, p. 556-567.e9Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations