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Lisa Marie Godsel

  • 1806 Citations
19952020

Research output per year

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Personal profile

Research Interests

intercellular junctions, adhesion, desmosomes, adherens junctions, signal transduction, cell motility, skin disease, cadherins, cancer metastasis.

I am interested in the regulation of the intercellular adhesive junction, the desmosome, during processes such as wound healing and morphogenesis. Currently my studies are focused on the plakin protein, desmoplakin, an obligate member of the desmosomal plaque, which mediates the interaction between the plaque and the intermediate filament network. This interaction with the intermediate filament network is required for maintaining tissue integrity, particularly those tissues undergoing large amounts of stress, such as the heart and skin. The importance of desmoplakin in maintaining adhesive strength is highlighted by cardiomyopathies and skin diseases, which result from desmoplakin mutations. Utilizing biochemistry and fixed and live cell imaging techniques we are analyzing the dynamics of desmoplakin during desmosome formation and the roles the intermediate filament and microfilament networks play in that process.

Education/Academic qualification

PhD, Northwestern University

… → 1997

Research interests

  • Cell Adhesion Mechanisms

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Grants

Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and Melanoma

Godsel, L. M., Green, K. J. & Johnson, J. L. P.

National Cancer Institute

2/1/19 → 1/31/24

Project: Research project

    • Inter-junctional signaling in epithelial junctional complex

    Godsel, L. M., Green, K. J. & Troyanovsky, S. M.

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    9/1/16 → 7/31/21

    Project: Research project

    • Inter-junctional signaling in epithelial junctional complex

    Godsel, L. M., Green, K. J. & Troyanovsky, S. M.

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    9/1/15 → 8/31/16

    Project: Research project

    • The Role of the Desmosome Protein, Plakophilin 2, in Cancer

    Godsel, L. M.

    Skin Cancer Foundation

    4/1/12 → 3/31/13

    Project: Research project

    Desmoplakin Assembly and Function in Epidermis

    Godsel, L. M. & Green, K. J.

    National Institute of Arthritis and Musculoskeletal and Skin Diseases

    4/1/11 → 3/31/16

    Project: Research project

    Research Output

    The Role of Desmoglein 1 in Gap Junction Turnover Revealed through the Study of SAM Syndrome

    Cohen-Barak, E., Godsel, L. M., Koetsier, J. L., Hegazy, M., Kushnir-Grinbaum, D., Hammad, H., Danial-Farran, N., Harmon, R., Khayat, M., Bochner, R., Peled, A., Rozenblat, M., Krausz, J., Sarig, O., Johnson, J. L., Ziv, M., Shalev, S. A., Sprecher, E. & Green, K. J., Mar 2020, In : Journal of Investigative Dermatology. 140, 3, p. 556-567.e9

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Desmoglein 1 regulates invadopodia by suppressing EGFR/ERK signaling in an ERBIN-dependent manner

    Valenzuela-Iglesias, A., Burks, H. E., Arnette, C. R., Yalamanchili, A., Nekrasova, O., Godsel, L. M. & Green, K. J., May 2019, In : Molecular Cancer Research. 17, 5, p. 1195-1206 12 p.

    Research output: Contribution to journal › Article

    • 5 Scopus citations

    Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination

    Nekrasova, O., Harmon, R. M., Broussard, J. A., Koetsier, J. L., Godsel, L. M., Fitz, G. N., Gardel, M. L. & Green, K. J., Dec 1 2018, In : Nature communications. 9, 1, 1053.

    Research output: Contribution to journal › Article

    • 17 Scopus citations

    Epithelial barrier dysfunction in desmoglein-1 deficiency

    Polivka, L., Hadj-Rabia, S., Bal, E., Leclerc-Mercier, S., Madrange, M., Hamel, Y., Bonnet, D., Mallet, S., Lepidi, H., Ovaert, C., Barbet, P., Dupont, C., Neven, B., Munnich, A., Godsel, L. M., Campeotto, F., Weil, R., Laplantine, E., Marchetto, S., Borg, J. P. & 6 others, Weis, W. I., Casanova, J. L., Puel, A., Green, K. J., Bodemer, C. & Smahi, A., Aug 2018, In : Journal of Allergy and Clinical Immunology. 142, 2, p. 702-706.e7

    Research output: Contribution to journal › Article

    10 Scopus citations

    Filaggrin 2 Deficiency Results in Abnormal Cell-Cell Adhesion in the Cornified Cell Layers and Causes Peeling Skin Syndrome Type A

    Mohamad, J., Sarig, O., Godsel, L. M., Peled, A., Malchin, N., Bochner, R., Vodo, D., Rabinowitz, T., Pavlovsky, M., Taiber, S., Fried, M., Eskin-Schwartz, M., Assi, S., Shomron, N., Uitto, J., Koetsier, J. L., Bergman, R., Green, K. J. & Sprecher, E., Aug 2018, In : Journal of Investigative Dermatology. 138, 8, p. 1736-1743 8 p.

    Research output: Contribution to journal › Article

    • 16 Scopus citations