Grants per year
Personal profile
Research Interests
Our research focuses on the elucidation of the cellular and molecular events by which mutations in genes linked to Parkinson’s disease (PD) contribute to disease pathology. PD has been classically considered a sporadic disease, however, it is now recognized to have a substantial genetic component. Interestingly, the same genes involved in the autosomal-dominantly inherited forms of PD such as SNCA (a-synuclein), and LRRK2 can act as risk factors in sporadic PD, as well. Given the relevance of LRRK2 and a-synuclein with the sporadic forms of PD, our long-term research goal by interrogating a-synuclein and mainly LRRK2-dependent alterations at the cellular, network and behavioral levels is to understand the pathophysiology of PD. The gained knowledge will provide useful insights towards the development of mechanism-based therapeutic opportunities for a disease that is currently addressed symptomatically.
Education/Academic qualification
PhD, National and Kapodistrian University of Athens
… → 2006
Research interests
- Aging
- Neurobiology
- Neurogenetics
- Neurology
- Neuroscience
- Parkinson’s Disease
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Grants
LRRK2-mediated molecular and synaptic events in the striatum
National Institute of Neurological Disorders and Stroke
8/15/16 → 7/31/21
Project: Research project
Inhibition of PKA in the striatum as a mechanism to reverse LRRK2 mutant-induced phenotype
Michael J. Fox Foundation for Parkinson's Research
11/24/14 → 2/23/16
Project: Research project
Research Output
Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course
Tayebi, N., Parisiadou, L., Berhe, B., Gonzalez, A. N., Serra-Vinardell, J., Tamargo, R. J., Maniwang, E., Sorrentino, Z., Fujiwara, H., Grey, R. J., Hassan, S., Blech-Hermoni, Y. N., Chen, C., McGlinchey, R., Makariou-Pikis, C., Brooks, M., Ginns, E. I., Ory, D. S., Giasson, B. I. & Sidransky, E., Dec 2017, In : Molecular Genetics and Metabolism. 122, 4, p. 198-208 11 p.Research output: Contribution to journal › Article
8
Scopus
citations
Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy
Liu, G., Park, S. H., Imbesi, M., Nathan, W. J., Zou, X., Zhu, Y., Jiang, H., Parisiadou, L. & Gius, D., May 20 2017, In : Antioxidants and Redox Signaling. 26, 15, p. 846-863 18 p.Research output: Contribution to journal › Article
34
Scopus
citations
Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression
Liu, G., Sgobio, C., Gu, X., Sun, L., Lin, X., Yu, J., Parisiadou, L., Xie, C., Sastry, N., Ding, J., Lohr, K. M., Miller, G. W., Mateo, Y., Lovinger, D. M. & Cai, H., Apr 9 2015, In : Human molecular genetics. 24, 18, p. 5299-5312 14 p.Research output: Contribution to journal › Article
17
Scopus
citations
A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons
Luo, J., Sun, L., Lin, X., Liu, G., Yu, J., Parisiadou, L., Xie, C., Ding, J. & Cai, H., Dec 15 2014, In : Human molecular genetics. 23, 24, p. 6567-6574 8 p.Research output: Contribution to journal › Article
28
Scopus
citations
Erratum: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity (Nature Neuroscience (2014) 17 (367-376)
Parisiadou, L., Yu, J., Sgobio, C., Xie, C., Liu, G., Sun, L., Gu, X. L., Lin, X., Crowley, N. A., Lovinger, D. M. & Cai, H., Jan 1 2014, In : Nature Neuroscience. 17, 9, 1 p.Research output: Contribution to journal › Comment/debate