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Personal profile

Research Interests

Our research focuses on the elucidation of the cellular and molecular events by which mutations in genes linked to Parkinson’s disease (PD) contribute to disease pathology. PD has been classically considered a sporadic disease, however, it is now recognized to have a substantial genetic component. Interestingly, the same genes involved in the autosomal-dominantly inherited forms of PD such as SNCA (a-synuclein), and LRRK2 can act as risk factors in sporadic PD, as well. Given the relevance of LRRK2 and a-synuclein with the sporadic forms of PD, our long-term research goal by interrogating a-synuclein and mainly LRRK2-dependent alterations at the cellular, network and behavioral levels is to understand the pathophysiology of PD. The gained knowledge will provide useful insights towards the development of mechanism-based therapeutic opportunities for a disease that is currently addressed symptomatically.

Education/Academic qualification

PhD, National and Kapodistrian University of Athens

… → 2006

Research interests

  • Aging
  • Neurobiology
  • Neurogenetics
  • Neurology
  • Neuroscience
  • Parkinson’s Disease

Fingerprint Dive into the research topics where Loukia Parisiadou is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 20 Similar Profiles
Parkinson Disease Medicine & Life Sciences
Synucleins Medicine & Life Sciences
Leucine Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
Dopamine Receptors Medicine & Life Sciences
Mesencephalon Medicine & Life Sciences
Amyloid beta-Protein Precursor Medicine & Life Sciences

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Grants 2014 2021

Parkinson Disease
Corpus Striatum
Mutation
Viral Genes
Neurodegenerative Diseases
Corpus Striatum
Parkinson Disease
Dopaminergic Neurons
Mesencephalon
Phenotype

Research Output 2004 2017

  • 1293 Citations
  • 15 Article
  • 2 Comment/debate
  • 2 Review article
7 Citations (Scopus)

Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course

Tayebi, N., Parisiadou, L., Berhe, B., Gonzalez, A. N., Serra-Vinardell, J., Tamargo, R. J., Maniwang, E., Sorrentino, Z., Fujiwara, H., Grey, R. J., Hassan, S., Blech-Hermoni, Y. N., Chen, C., McGlinchey, R., Makariou-Pikis, C., Brooks, M., Ginns, E. I., Ory, D. S., Giasson, B. I. & Sidransky, E., Dec 1 2017, In : Molecular Genetics and Metabolism. 122, 4, p. 198-208 11 p.

Research output: Contribution to journalArticle

Synucleins
Glucosylceramidase
Haploinsufficiency
Gaucher Disease
Hemizygote
31 Citations (Scopus)

Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy

Liu, G., Park, S. H., Imbesi, M., Nathan, W. J., Zou, X., Zhu, Y., Jiang, H., Parisiadou, L. & Gius, D., May 20 2017, In : Antioxidants and Redox Signaling. 26, 15, p. 846-863 18 p.

Research output: Contribution to journalArticle

Sirtuin 2
Mitochondrial Degradation
Acetylation
Mitochondrial Proteins
NAD
16 Citations (Scopus)

Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression

Liu, G., Sgobio, C., Gu, X., Sun, L., Lin, X., Yu, J., Parisiadou, L., Xie, C., Sastry, N., Ding, J., Lohr, K. M., Miller, G. W., Mateo, Y., Lovinger, D. M. & Cai, H., Apr 9 2015, In : Human molecular genetics. 24, 18, p. 5299-5312 14 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Missense Mutation
Mesencephalon
Leucine
Parkinson Disease
26 Citations (Scopus)

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons

Luo, J., Sun, L., Lin, X., Liu, G., Yu, J., Parisiadou, L., Xie, C., Ding, J. & Cai, H., Dec 15 2014, In : Human molecular genetics. 23, 24, p. 6567-6574 8 p.

Research output: Contribution to journalArticle

Synucleins
NFATC Transcription Factors
Calcineurin
Dopaminergic Neurons
Mesencephalon

Erratum: LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity (Nature Neuroscience (2014) 17 (367-376)

Parisiadou, L., Yu, J., Sgobio, C., Xie, C., Liu, G., Sun, L., Gu, X. L., Lin, X., Crowley, N. A., Lovinger, D. M. & Cai, H., Jan 1 2014, In : Nature Neuroscience. 17, 9, 1 p.

Research output: Contribution to journalComment/debate

Dopamine Receptors
Neurosciences