Grants per year
Personal profile
Research Interests
Our research focuses on the elucidation of the cellular and molecular events by which mutations in genes linked to Parkinson’s disease (PD) contribute to disease pathology. PD has been classically considered a sporadic disease, however, it is now recognized to have a substantial genetic component. Interestingly, the same genes involved in the autosomal-dominantly inherited forms of PD such as SNCA (a-synuclein), and LRRK2 can act as risk factors in sporadic PD, as well. Given the relevance of LRRK2 and a-synuclein with the sporadic forms of PD, our long-term research goal by interrogating a-synuclein and mainly LRRK2-dependent alterations at the cellular, network and behavioral levels is to understand the pathophysiology of PD. The gained knowledge will provide useful insights towards the development of mechanism-based therapeutic opportunities for a disease that is currently addressed symptomatically.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biology, PhD, National and Kapodistrian University of Athens
… → 2006
Research interests keywords
- Aging
- Neurobiology
- Neurogenetics
- Neurology
- Neuroscience
- Parkinson’s Disease
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Parisiadou Subproject
Parisiadou, L. (Co-Investigator)
Michael J. Fox Foundation for Parkinson's Research
11/1/24 → 10/31/26
Project: Research project
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The Role of Striatal Astrocytic Dopamine D2 Receptor Signaling in the Pathogenesis of LRRK2-Mediated Parkinson's Disease
Parisiadou, L. (PD/PI)
8/15/24 → 5/31/26
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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Redefining PD pathophysiology mechanisms in the context of heterogeneous substantia nigra neuron subtypes
Awatramani, R. (PD/PI), Awatramani, R. (PD/PI), Bevan, M. D. (Co-Investigator), Bevan, M. D. (Co-Investigator), Dombeck, D. A. (Co-Investigator), Dombeck, D. A. (Co-Investigator), Parisiadou, L. (Co-Investigator), Parisiadou, L. (Co-Investigator), Surmeier Jr, D. J. (Co-Investigator) & Surmeier Jr, D. J. (Co-Investigator)
Michael J. Fox Foundation for Parkinson's Research
11/1/21 → 10/31/24
Project: Research project
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LRRK2-mediated molecular and synaptic events in the striatum
Parisiadou, L. (PD/PI) & Chan, S. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
8/15/16 → 7/31/22
Project: Research project
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LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
Chen, C., Masotti, M., Shepard, N., Promes, V., Tombesi, G., Arango, D., Manzoni, C., Greggio, E., Hilfiker, S., Kozorovitskiy, Y. & Parisiadou, L., 2025, (Accepted/In press) In: Molecular Psychiatry. 204.Research output: Contribution to journal › Article › peer-review
Open Access -
Closing the structure-to-function gap for LRRK2
Tokars, V., Chen, C. & Parisiadou, L., Mar 2022, In: Trends in Biochemical Sciences. 47, 3, p. 187-188 2 p.Research output: Contribution to journal › Short survey › peer-review
Open Access4 Scopus citations -
Genetic association of primary nonresponse to anti-TNFα therapy in patients with inflammatory bowel disease
De, T., Zhang, H., Alarcon, C., Lec, B., Avitia, J., Smithberger, E., Chen, C., Horvath, M., Kwan, S., Young, M., Adhikari, S., Kwon, J., Pacheco, J., Jarvik, G., Wei, W. Q., Mentch, F., Hakonarson, H., Sleiman, P., Gordon, A. & Harley, J. & 4 others, , Jan 1 2022, In: Pharmacogenetics and genomics. 32, 1, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights
Skelton, P. D., Tokars, V. & Parisiadou, L., Jan 1 2022, In: Cells. 11, 1, 169.Research output: Contribution to journal › Review article › peer-review
Open Access9 Scopus citations -
R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
Xenias, H. S., Chen, C., Kang, S., Cherian, S., Situ, X., Shanmugasundaram, B., Liu, G., Scesa, G., Savio Chan, C. & Parisiadou, L., Dec 2022, In: Communications Biology. 5, 1, 1211.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations