Grants per year
Personal profile
Research Interests
Our research focuses on the elucidation of the cellular and molecular events by which mutations in genes linked to Parkinson’s disease (PD) contribute to disease pathology. PD has been classically considered a sporadic disease, however, it is now recognized to have a substantial genetic component. Interestingly, the same genes involved in the autosomal-dominantly inherited forms of PD such as SNCA (a-synuclein), and LRRK2 can act as risk factors in sporadic PD, as well. Given the relevance of LRRK2 and a-synuclein with the sporadic forms of PD, our long-term research goal by interrogating a-synuclein and mainly LRRK2-dependent alterations at the cellular, network and behavioral levels is to understand the pathophysiology of PD. The gained knowledge will provide useful insights towards the development of mechanism-based therapeutic opportunities for a disease that is currently addressed symptomatically.
Education/Academic qualification
PhD, National and Kapodistrian University of Athens
… → 2006
Research interests
- Aging
- Neurobiology
- Neurogenetics
- Neurology
- Neuroscience
- Parkinson’s Disease
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Grants
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LRRK2-mediated molecular and synaptic events in the striatum
National Institute of Neurological Disorders and Stroke
8/15/16 → 7/31/21
Project: Research project
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Inhibition of PKA in the striatum as a mechanism to reverse LRRK2 mutant-induced phenotype
The Michael J Fox Foundation for Parkinson's Research
11/24/14 → 2/23/16
Project: Research project
Research Output
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Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations
Chen, C., Soto, G., Dumrongprechachan, V., Bannon, N., Kang, S., Kozorovitskiy, Y. & Parisiadou, L., Oct 2020, In: eLife. 9, p. 1-26 26 p., e58997.Research output: Contribution to journal › Article › peer-review
Open Access -
Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course
Tayebi, N., Parisiadou, L., Berhe, B., Gonzalez, A. N., Serra-Vinardell, J., Tamargo, R. J., Maniwang, E., Sorrentino, Z., Fujiwara, H., Grey, R. J., Hassan, S., Blech-Hermoni, Y. N., Chen, C., McGlinchey, R., Makariou-Pikis, C., Brooks, M., Ginns, E. I., Ory, D. S., Giasson, B. I. & Sidransky, E., Dec 2017, In: Molecular Genetics and Metabolism. 122, 4, p. 198-208 11 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy
Liu, G., Park, S. H., Imbesi, M., Nathan, W. J., Zou, X., Zhu, Y., Jiang, H., Parisiadou, L. & Gius, D., May 20 2017, In: Antioxidants and Redox Signaling. 26, 15, p. 846-863 18 p.Research output: Contribution to journal › Article › peer-review
41 Scopus citations -
Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression
Liu, G., Sgobio, C., Gu, X., Sun, L., Lin, X., Yu, J., Parisiadou, L., Xie, C., Sastry, N., Ding, J., Lohr, K. M., Miller, G. W., Mateo, Y., Lovinger, D. M. & Cai, H., Apr 9 2015, In: Human molecular genetics. 24, 18, p. 5299-5312 14 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons
Luo, J., Sun, L., Lin, X., Liu, G., Yu, J., Parisiadou, L., Xie, C., Ding, J. & Cai, H., Dec 15 2014, In: Human molecular genetics. 23, 24, p. 6567-6574 8 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations