Ludmilla A Shuvalova

  • 602 Citations
1986 …2019
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Research Output 1986 2019

  • 602 Citations
  • 40 Article
  • 2 Comment/debate
2019
1 Citation (Scopus)

Pyrimidine biosynthesis in pathogens – Structures and analysis of dihydroorotases from Yersinia pestis and Vibrio cholerae

Lipowska, J., Miks, C. D., Kwon, K., Shuvalova, L. A., Zheng, H., Lewiński, K., Cooper, D. R., Shabalin, I. G. & Minor, W., Sep 1 2019, In : International Journal of Biological Macromolecules. 136, p. 1176-1187 12 p.

Research output: Contribution to journalArticle

Dihydroorotase
Yersinia pestis
Vibrio cholerae
Biosynthesis
Pathogens
4-Hydroxybenzoate-3-Monooxygenase
Oxygenases
Pseudomonas putida
pseudomonas
adenines
2018
2 Citations (Scopus)

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii

Lykins, J. D., Filippova, E. V., Halavaty, A. S., Minasov, G., Zhou, Y., Dubrovska, I., Flores, K. J., Shuvalova, L. A., Ruan, J., El Bissati, K., Dovgin, S., Roberts, C. W., Woods, S., Moulton, J. D., Moulton, H., McPhillie, M. J., Muench, S. P., Fishwick, C. W. G., Sabini, E., Shanmugam, D. & 4 others, Roos, D. S., McLeod, R., Anderson, W. F. & Ngô, H. M., Jan 1 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 1 p.

Research output: Contribution to journalArticle

Toxoplasma
Racemases and Epimerases
Parasites
Phenotype
Crystallography

Structural and immunological characterization of E. coli derived recombinant CRM197 protein used as carrier in conjugate vaccines

Mishra, R. P. N., Yadav, R. S. P., Jones, C., Nocadello, S., Minasov, G., Shuvalova, L. A., Anderson, W. F. & Goel, A., Sep 25 2018, In : Bioscience Reports. 38, 5, BSR20180238.

Research output: Contribution to journalArticle

Recombinant proteins
Conjugate Vaccines
Recombinant Proteins
Escherichia coli
Carrier Proteins
2016
5 Citations (Scopus)

Crystal structures of the components of the Staphylococcus aureus leukotoxin ED

Nocadello, S., Minasov, G., Shuvalova, L. A., Dubrovska, I., Sabini, E., Bagnoli, F., Grandi, G. & Anderson, W. F., Jan 1 2016, In : Acta Crystallographica Section D: Structural Biology. 72, 1, p. 113-120 8 p.

Research output: Contribution to journalArticle

Staphylococcus aureus
Leukocidins
Exotoxins
Protein Subunits
Methicillin-Resistant Staphylococcus aureus
11 Citations (Scopus)

Crystal structures of the spoiid lytic transglycosylases essential for bacterial sporulation

Nocadello, S., Minasov, G., Shuvalova, L. A., Dubrovska, I., Sabini, E. & Anderson, W. F., Jul 15 2016, In : Journal of Biological Chemistry. 291, 29, p. 14915-14926 12 p.

Research output: Contribution to journalArticle

Crystal structure
Pathogens
Bacterial Physiological Phenomena
Bioterrorism
Bacterial Spores
10 Citations (Scopus)

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis

Kuhn, M. L., Alexander, E., Minasov, G., Page, H. J., Warwrzak, Z., Shuvalova, L. A., Flores, K. J., Wilson, D. J., Shi, C., Aldrich, C. C. & Anderson, W. F., Aug 12 2016, In : ACS Infectious Diseases. 2, 8, p. 579-591 13 p.

Research output: Contribution to journalArticle

Mycolic Acids
Adenosine Monophosphate
Ligases
Mycobacterium tuberculosis
Tuberculosis
2015

Erratum: Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates

Light, S. H., Minasov, G., Shuvalova, L., Duban, M. E., Caffrey, M., Anderson, W. F. & Lavie, A., Jul 31 2015, In : Journal of Biological Chemistry. 290, 31, 1 p.

Research output: Contribution to journalComment/debate

Hydro-Lyases
Reaction intermediates
8 Citations (Scopus)

Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus

Halavaty, A. S., Rich, R. L., Chen, C., Joo, J. C., Minasov, G., Dubrovska, I., Winsor, J. R., Myszka, D. G., Duban, M., Shuvalova, L. A., Yakunin, A. F. & Anderson, W. F., May 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 1159-1175 17 p.

Research output: Contribution to journalArticle

Betaine-Aldehyde Dehydrogenase
NAD
Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
Betaine
2014
8 Citations (Scopus)

Mechanisms of allosteric activation and inhibition of the deoxyribonucleoside triphosphate triphosphohydrolase from Enterococcus faecalis

Vorontsov, I. I., Wu, Y., Delucia, M., Minasov, G., Mehrens, J., Shuvalova, L. A., Anderson, W. F. & Ahn, J., Jan 31 2014, In : Journal of Biological Chemistry. 289, 5, p. 2815-2824 10 p.

Research output: Contribution to journalArticle

Deoxyribonucleosides
Enterococcus faecalis
Allosteric Site
Chemical activation
Crystal structure
2 Citations (Scopus)

Parallel protein purification

Shuvalova, L., Jan 1 2014, In : Methods in Molecular Biology. 1140, p. 137-143 7 p.

Research output: Contribution to journalArticle

Genomics
Proteins
Technology
caN protocol
2 Citations (Scopus)
Staphylococcal Protein A
Metabolism
Proteins
Actinobacteria
Protein Sequence Analysis
12 Citations (Scopus)

Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP

Kuhn, M. L., Prachi, P., Minasov, G., Shuvalova, L., Ruan, J., Dubrovska, I., Winsor, J., Giraldi, M., Biagini, M., Liberatori, S., Savino, S., Bagnoli, F., Anderson, W. F. & Grandi, G., Apr 2014, In : FASEB Journal. 28, 4, p. 1780-1793 14 p.

Research output: Contribution to journalArticle

Staphylococcus aureus
Peptide Hydrolases
Vaccines
Crystal structure
Proteins
2013
41 Citations (Scopus)

Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae

Seo, H. S., Minasov, G., Seepersaud, R., Doran, K. S., Dubrovska, I., Shuvalova, L. A., Anderson, W. F., Iverson, T. M. & Sullam, P. M., Dec 13 2013, In : Journal of Biological Chemistry. 288, 50, p. 35982-35996 15 p.

Research output: Contribution to journalArticle

Streptococcus agalactiae
Fibrinogen
Glycoproteins
Mutagenesis
Docks
16 Citations (Scopus)

Large scale structural rearrangement of a serine hydrolase from francisella tularensis facilitates catalysis

Filippova, E. V., Weston, L. A., Kuhn, M. L., Geissler, B., Gehring, A. M., Armoush, N., Adkins, C. T., Minasov, G., Dubrovska, I., Shuvalova, L., Winsor, J. R., Lavis, L. D., Satchell, K. J. F., Becker, D. P., Anderson, W. F. & Johnson, R. J., Apr 12 2013, In : Journal of Biological Chemistry. 288, 15, p. 10522-10535 14 p.

Research output: Contribution to journalArticle

Francisella tularensis
Hydrolases
Catalysis
Serine
Membranes
2012
19 Citations (Scopus)

Structural analysis of a 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with an N-terminal chorismate mutase-like regulatory domain

Light, S. H., Halavaty, A. S., Minasov, G., Shuvalova, L. A. & Anderson, W. F., Jun 1 2012, In : Protein Science. 21, 6, p. 887-895 9 p.

Research output: Contribution to journalArticle

3-Deoxy-7-Phosphoheptulonate Synthase
Chorismate Mutase
Structural analysis
Biosynthesis
Phenylalanine
4 Citations (Scopus)

Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria

Halavaty, A. S., Kim, Y., Minasov, G., Shuvalova, L., Dubrovska, I., Winsor, J., Zhou, M., Onopriyenko, O., Skarina, T., Papazisi, L., Kwon, K., Peterson, S. N., Joachimiak, A., Savchenko, A. & Anderson, W. F., Oct 1 2012, In : Acta Crystallographica Section D: Biological Crystallography. 68, 10, p. 1359-1370 12 p.

Research output: Contribution to journalArticle

holo-(acyl-carrier-protein) synthase
Adenosine Diphosphate
Bacteria
Coenzyme A
Acyl Carrier Protein
23 Citations (Scopus)

Structure of the Type III Secretion Effector Protein ExoU in Complex with Its Chaperone SpcU

Halavaty, A. S., Borek, D., Tyson, G. H., Veesenmeyer, J. L., Shuvalova, L. A., Minasov, G., Otwinowski, Z., Hauser, A. R. & Anderson, W. F., Nov 14 2012, In : PLoS One. 7, 11, e49388.

Research output: Contribution to journalArticle

type III secretion system
secretion
Bacteria
Proteins
proteins
2011
12 Citations (Scopus)

A conserved surface loop in type i dehydroquinate dehydratases positions an active site arginine and functions in substrate binding

Light, S. H., Minasov, G., Shuvalova, L. A., Peterson, S. N., Caffrey, M., Anderson, W. F. & Lavie, A., Mar 29 2011, In : Biochemistry. 50, 12, p. 2357-2363 7 p.

Research output: Contribution to journalArticle

Hydro-Lyases
Arginine
Catalytic Domain
Substrates
Salmonella
27 Citations (Scopus)
Enterococcus faecalis
Hydrolysis
Catalytic Domain
Crystal structure
Substrates
8 Citations (Scopus)
Thermoplasma
Acetyltransferases
Crystal structure
Acetyl Coenzyme A
Spermidine
20 Citations (Scopus)

Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates

Light, S. H., Minasov, G., Shuvalova, L. A., Duban, M. E., Caffrey, M., Anderson, W. F. & Lavie, A., Feb 4 2011, In : Journal of Biological Chemistry. 286, 5, p. 3531-3539 9 p.

Research output: Contribution to journalArticle

Hydro-Lyases
Reaction intermediates
Dehydration
Conformations
Schiff Bases
2009
58 Citations (Scopus)

Crystal structures of Ykul and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains

Minasov, G., Padavattan, S., Shuvalova, L., Brunzelle, J. S., Miller, D. J., Baslé, A., Massa, C., Collart, F. R., Schirmer, T. & Anderson, W. F., May 8 2009, In : Journal of Biological Chemistry. 284, 19, p. 13174-13184 11 p.

Research output: Contribution to journalArticle

Second Messenger Systems
Crystal structure
Phosphoric Diester Hydrolases
Catalytic Domain
Triose-Phosphate Isomerase
48 Citations (Scopus)

Structural and molecular mechanism for autoprocessing of MARTX toxin of vibrio cholerae at multiple sites

Prochazkova, K., Shuvalova, L. A., Minasov, G., Voburka, Z., Anderson, W. F. & Satchell, K. J. F., Sep 25 2009, In : Journal of Biological Chemistry. 284, 39, p. 26557-26568 12 p.

Research output: Contribution to journalArticle

Vibrio cholerae
Cysteine Proteases
Leucine
Actins
rho GTP-Binding Proteins
2007
27 Citations (Scopus)

Crystal structure of an apo form of Shigella flexneri ArsH protein with an NADPH-dependent FMN reductase activity

Vorontsov, I. I., Minasov, G., Brunzelle, J. S., Shuvalova, L., Kiryukhina, O., Collart, F. R. & Anderson, W. F., Nov 1 2007, In : Protein Science. 16, 11, p. 2483-2490 8 p.

Research output: Contribution to journalArticle

FMN Reductase
Shigella flexneri
NADP
Flavin Mononucleotide
Crystal structure
20 Citations (Scopus)

Structural and biochemical characterization of a novel Mn 2+-dependent phosphodiesterase encoded by the yfcE gene

Miller, D. J., Shuvalova, L. A., Evdokimova, E., Savchenko, A., Yakunin, A. F. & Anderson, W. F., Jul 1 2007, In : Protein Science. 16, 7, p. 1338-1348 11 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Catalytic Domain
Genes
Escherichia coli
Substrates
13 Citations (Scopus)

The 2.2 Å resolution crystal structure of Bacillus cereus Nif3-family protein YqfO reveals a conserved dimetal-binding motif and a regulatory domain

Godsey, M. H., Minasov, G., Shuvalova, L., Brunzelle, J. S., Vorontsov, I. I., Collart, F. R. & Anderson, W. F., Jul 1 2007, In : Protein Science. 16, 7, p. 1285-1293 9 p.

Research output: Contribution to journalArticle

Bacillus cereus
Crystal structure
Conservation
Catalytic Domain
Proteins
2006
8 Citations (Scopus)

Crystal structure of YfiR, an unusual TetR/CamR-type putative transcriptional regulator from Bacillus subtilis

Rajan, S. S., Yang, X., Shuvalova, L. A., Collart, F. & Anderson, W. F., Oct 1 2006, In : Proteins: Structure, Function and Genetics. 65, 1, p. 255-257 3 p.

Research output: Contribution to journalArticle

Helix-Turn-Helix Motifs
Molecular Models
Bacterial Proteins
X ray crystallography
X Ray Crystallography
2004
14 Citations (Scopus)

YfiT from Bacillus subtilis is a probable metal-dependent hydrolase with an unusual four-helix bundle topology

Rajan, S. S., Yang, X., Shuvalova, L. A., Collart, F. & Anderson, W. F., Dec 14 2004, In : Biochemistry. 43, 49, p. 15472-15479 8 p.

Research output: Contribution to journalArticle

Hydrolases
Bacilli
Bacillus subtilis
Metals
Topology
2003
25 Citations (Scopus)

Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases

Gardberg, A., Shuvalova, L., Monnerjahn, C., Konrad, M. & Lavie, A., Oct 1 2003, In : Structure. 11, 10, p. 1265-1277 13 p.

Research output: Contribution to journalArticle

dTMP kinase
Thymidine Kinase
nucleoside phosphotransferase
Thymidine
Equid Herpesvirus 4

Structure of the Bacillus subtilis YYCN Protein: A Putative N-Acetyltransferase

Taneja, B., Maar, S., Shuvalova, L. A., Collart, F., Anderson, W. F. & Mondragon, A., Dec 1 2003, In : Proteins: Structure, Function and Genetics. 53, 4, p. 950-952 3 p.

Research output: Contribution to journalArticle

Arylamine N-Acetyltransferase
Acetyltransferases
Molecular Models
Bacterial Proteins
X ray crystallography
2002
55 Citations (Scopus)

Structural characterization of the closed conformation of mouse guanylate kinase.

Sekulic, N., Shuvalova, L., Spangenberg, O., Konrad, M. & Lavie, A., Jan 1 2002, In : The Journal of biological chemistry. 277, 33, p. 30236-30243 8 p.

Research output: Contribution to journalArticle

Guanylate Kinases
Nucleoside-Phosphate Kinase
Conformations
carbovir
Prodrugs
1999
29 Citations (Scopus)
Calmodulin
Calcium
Peptides
Ligands
Ligation
7 Citations (Scopus)
Biochemistry
Calmodulin
Calcium
Peptides
1992
13 Citations (Scopus)

A hypothalamic activator of calmodulin-dependent enzymes is thymosin β4 (1-39)

Galoyan, A. A., Gurvits, B. Y., Shuvalova, L. A., Davis, M. T., Shively, J. E. & Lee, T. D., Aug 1 1992, In : Neurochemical Research. 17, 8, p. 773-777 5 p.

Research output: Contribution to journalArticle

Thymosin
Calmodulin
Enzymes
Hypothalamus
Mass spectrometry
1991
39 Citations (Scopus)

Vliianie slabogo magnitnogo polia v rezhime parametricheskogo rezonansa na skorost' kal'modulinzavisimogo fosforilirovaniia miozina v rastvore.

Translated title of the contribution: The effect of a weak magnetic field in the paramagnetic resonance mode on the rate of the calmodulin-dependent phosphorylation of myosin in solutionShuvalova, L. A., Ostrovskaia, M. V., Sosunov, E. A. & Lednev, V. V., Jan 1 1991, In : Doklady Akademii nauk SSSR. 317, 1, p. 227-230 4 p.

Research output: Contribution to journalArticle

Calmodulin
Electron spin resonance spectroscopy
Myosin-Light-Chain Kinase
Phosphorylation
Electromagnetic Fields
1987
1 Citation (Scopus)

Izmenenie strukturnogo sostoianiia miozinovykh niteǐ v glitserinizirovannykh voloknakh skeletnykh myshts krolika, indutsiruemye fosforilirovaniem legkikh tsepeǐ miozina.

Translated title of the contribution: Changes in the structural state of myosin filaments in glycerol-treated fibers of rabbit skeletal muscles induced by phosphorylation of myosin light chainsBorovikov, I. S., Levitskiǐ, D. I., Shuvalova, L. A., Lebedeva, N. N. & Poglazov, B. F., Dec 1 1987, In : Biokhimiya. 52, 12, p. 2061-2065 5 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Phosphorylation
Myosins
Glycerol
Muscle
5 Citations (Scopus)

Ordered assemblies of myosin minifilaments

Podlubnaya, Z. A., Levitsky, D. I., Shuvalova, L. A. & Poglazov, B. F., Aug 5 1987, In : Journal of Molecular Biology. 196, 3, p. 729-732 4 p.

Research output: Contribution to journalArticle

Myosins
Myosin Light Chains
Magnesium Chloride
Citric Acid
Buffers
3 Citations (Scopus)

Poluchenie glitserinizirovannykh modeleǐ myshechnykh volokon s fosforilirovannymi legkimi tsepiami miozina.

Translated title of the contribution: Production of glycerinated models of muscle fibers with phosphorylated myosin light chainsLebedeva, N. N., Wrotek, M., Shuvalova, L. A., Konkol, I. & Borovikov, I. S., Aug 1 1987, In : Tsitologiya. 29, 8, p. 973-975 3 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Phosphorylation
Muscles
Myosins
Phosphoric Monoester Hydrolases
3 Citations (Scopus)

The effect of myosin light chain phosphorylation on the actin-stimulated ATPase activity of myosin minifilaments

Levitsky, D. I., Shuvalova, L. A. & Poglazov, B. F., Aug 31 1987, In : FEBS Letters. 221, 1, p. 77-80 4 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Phosphorylation
Myosins
Adenosine Triphosphatases
Actins
1 Citation (Scopus)

Vliianie fosforilirovaniia legkikh tsepeǐ miozina na vzaimodeǐstvie miozinovykh minifilamentov s F-aktinom.

Translated title of the contribution: Effect of phosphorylation of myosin light chains on the interaction of myosin minifilaments with F-actinLevitskiǐ, D. I., Shuvalova, L. A., Kalmykov, P. V. & Poglazov, B. F., May 1 1987, In : Biokhimiya. 52, 5, p. 813-824 12 p.

Research output: Contribution to journalArticle

Myosin Light Chains
Phosphorylation
Myosins
Ca(2+) Mg(2+)-ATPase
Actins
1986
2 Citations (Scopus)

Uporiadochennaia samosborka miozinovykh minifilamentov: vliianie Mg2+ i fosforilirovaniia legkikh tsepeǐ miozina.

Translated title of the contribution: Regulated self-assembly of myosin minifilaments: the effect of Mg2+ and phosphorylation of myosin light chainsPodlubnaia, Z. A., Levitskiǐ, D. I., Shuvalova, L. A. & Poglazov, B. F., Dec 1 1986, In : Doklady Akademii nauk SSSR. 290, 4, p. 1015-1017 3 p.

Research output: Contribution to journalArticle

Myosin Subfragments
Myosin Light Chains
Protein Conformation
Peptide Fragments
Myosins