• 15858 Citations
1989 …2019

Research output per year

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Research Output

2019

A focus on vascular malformations

Iruela-Arispe, M. L., May 1 2019, In : Current opinion in hematology. 26, 3, p. 152-153 2 p.

Research output: Contribution to journalComment/debate

Angiopoietin-2 predicts morbidity in adults with Fontan physiology

Shirali, A. S., Lluri, G., Guihard, P. J., Conrad, M. B., Kim, H., Pawlikowska, L., Boström, K. I., Iruela-Arispe, M. L. & Aboulhosn, J. A., Dec 1 2019, In : Scientific reports. 9, 1, 18328.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Keklikoglou, I., Cianciaruso, C., Güç, E., Squadrito, M. L., Spring, L. M., Tazzyman, S., Lambein, L., Poissonnier, A., Ferraro, G. B., Baer, C., Cassará, A., Guichard, A., Iruela-Arispe, M. L., Lewis, C. E., Coussens, L. M., Bardia, A., Jain, R. K., Pollard, J. W. & De Palma, M., Feb 1 2019, In : Nature Cell Biology. 21, 2, p. 190-202 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Emerging molecular mechanisms of vascular dementia

Romay, M. C., Toro, C. & Iruela-Arispe, M. L., May 1 2019, In : Current opinion in hematology. 26, 3, p. 199-206 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Noninvasive Quantification of Cell Density in Three-Dimensional Gels by MRI

Archer, B. J., Uberruck, T., Mack, J. J., Youssef, K., Jarenwattananon, N. N., Rall, D., Wypysek, D., Wiese, M., Blumich, B., Wessling, M., Iruela-Arispe, M. L. & Bouchard, L. S., Mar 2019, In : IEEE Transactions on Biomedical Engineering. 66, 3, p. 821-830 10 p., 8412441.

Research output: Contribution to journalArticle

2018

A dual origin for blood vessels

Iruela-Arispe, M. L., Oct 11 2018, In : Nature. 562, 7726, p. 195-197 3 p.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis

Ziyad, S., Riordan, J. D., Cavanaugh, A. M., Su, T., Hernandez, G. E., Hilfenhaus, G., Morselli, M., Huynh, K., Wang, K., Chen, J. N., Dupuy, A. J. & Iruela-Arispe, M. L., Jan 30 2018, In : Cell reports. 22, 5, p. 1211-1224 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

A multi-step transcriptional cascade underlies vascular regeneration in vivo

Shirali, A. S., Romay, M. C., McDonald, A. I., Su, T., Steel, M. E. & Iruela-Arispe, M. L., Dec 1 2018, In : Scientific reports. 8, 1, 5430.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Analysis of cardiomyocyte clonal expansion during mouse heart development and injury

Sereti, K. I., Nguyen, N. B., Kamran, P., Zhao, P., Ranjbarvaziri, S., Park, S., Sabri, S., Engel, J. L., Sung, K., Kulkarni, R. P., Ding, Y., Hsiai, T. K., Plath, K., Ernst, J., Sahoo, D., Mikkola, H. K. A., Iruela-Arispe, M. L. & Ardehali, R., Dec 1 2018, In : Nature communications. 9, 1, 754.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells

Jumabay, M., Zhumabai, J., Mansurov, N., Niklason, K. C., Guihard, P. J., Cubberly, M. R., Fogelman, A. M., Iruela-Arispe, L., Yao, Y., Saparov, A. & Boström, K. I., Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 1812-1822 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Consensus guidelines for the use and interpretation of angiogenesis assays

Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A. C., Auerbach, R., Augustin, H. G., Bates, D. O., van Beijnum, J. R., Bender, R. H. F., Bergers, G., Bikfalvi, A., Bischoff, J., Böck, B. C., Brooks, P. C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D., Cimpean, A. M. & 66 others, Cleaver, O., Coukos, G., Davis, G. E., De Palma, M., Dimberg, A., Dings, R. P. M., Djonov, V., Dudley, A. C., Dufton, N. P., Fendt, S. M., Ferrara, N., Fruttiger, M., Fukumura, D., Ghesquière, B., Gong, Y., Griffin, R. J., Harris, A. L., Hughes, C. C. W., Hultgren, N. W., Iruela-Arispe, M. L., Irving, M., Jain, R. K., Kalluri, R., Kalucka, J., Kerbel, R. S., Kitajewski, J., Klaassen, I., Kleinmann, H. K., Koolwijk, P., Kuczynski, E., Kwak, B. R., Marien, K., Melero-Martin, J. M., Munn, L. L., Nicosia, R. F., Noel, A., Nurro, J., Olsson, A. K., Petrova, T. V., Pietras, K., Pili, R., Pollard, J. W., Post, M. J., Quax, P. H. A., Rabinovich, G. A., Raica, M., Randi, A. M., Ribatti, D., Ruegg, C., Schlingemann, R. O., Schulte-Merker, S., Smith, L. E. H., Song, J. W., Stacker, S. A., Stalin, J., Stratman, A. N., Van de Velde, M., van Hinsbergh, V. W. M., Vermeulen, P. B., Waltenberger, J., Weinstein, B. M., Xin, H., Yetkin-Arik, B., Yla-Herttuala, S., Yoder, M. C. & Griffioen, A. W., Aug 1 2018, In : Angiogenesis. 21, 3, p. 425-532 108 p.

Research output: Contribution to journalReview article

Open Access
114 Scopus citations

Endothelial permeability, LDL deposition, and cardiovascular risk factors-A review

Mundi, S., Massaro, M., Scoditti, E., Carluccio, M. A., Van Hinsbergh, V. W. M., Iruela-Arispe, M. L. & De Caterina, R., Jan 1 2018, In : Cardiovascular research. 114, 1, p. 35-52 18 p.

Research output: Contribution to journalReview article

Open Access
35 Scopus citations

Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities

McDonald, A. I., Shirali, A. S., Aragón, R., Ma, F., Hernandez, G., Vaughn, D. A., Mack, J. J., Lim, T. Y., Sunshine, H., Zhao, P., Kalinichenko, V., Hai, T., Pelegrini, M., Ardehali, R. & Iruela-Arispe, M. L., Aug 2 2018, In : Cell stem cell. 23, 2, p. 210-225.e6

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth

Li, L., Zeng, Q., Bhutkar, A., Galván, J. A., Karamitopoulou, E., Noordermeer, D., Peng, M. W., Piersigilli, A., Perren, A., Zlobec, I., Robinson, H., Iruela-Arispe, M. L. & Hanahan, D., Apr 9 2018, In : Cancer Cell. 33, 4, p. 736-751.e5

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

HIF-1α Deletion in the Endothelium, but Not in the Epithelium, Protects From Radiation-Induced Enteritis

Toullec, A., Buard, V., Rannou, E., Tarlet, G., Guipaud, O., Robine, S., Iruela-Arispe, M. L., François, A. & Milliat, F., 2018, In : CMGH. 5, 1, p. 15-30 16 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Mapping metabolism: Monitoring lactate dehydrogenase activity directly in tissue

Jelinek, D., Flores, A., Uebelhoer, M., Pasque, V., Plath, K., Iruela-Arispe, M. L., Christofk, H. R., Lowry, W. E. & Coller, H. A., Jun 21 2018, In : Journal of Visualized Experiments. 2018, 136, e57760.

Research output: Contribution to journalArticle

5 Scopus citations

Metastasis of Circulating Tumor Cells: Speed Matters

Freitas, V. M., Hilfenhaus, G. & Iruela-Arispe, M. L., Apr 9 2018, In : Developmental Cell. 45, 1, p. 3-5 3 p.

Research output: Contribution to journalShort survey

Open Access
2 Scopus citations

NOTCH regulation of the endothelial cell phenotype

MacK, J. J. & Luisa Iruela-Arispe, M., May 1 2018, In : Current Opinion in Hematology. 25, 3, p. 212-218 7 p.

Research output: Contribution to journalReview article

20 Scopus citations

NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot

Duran, I., Tenney, J., Warren, C. M., Sarukhanov, A., Csukasi, F., Skalansky, M., Iruela-Arispe, M. L. & Krakow, D., Mar 2018, In : American Journal of Medical Genetics, Part A. 176, 3, p. 649-656 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pumping blood with self-reliance and cooperation

Iruela-Arispe, M. L., Oct 1 2018, In : The Journal of experimental medicine. 215, 10, p. 2480-2482 3 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer

Chattopadhyay, A., Yang, X., Mukherjee, P., Sulaiman, D., Fogelman, H. R., Grijalva, V., Dubinett, S., Wasler, T. C., Paul, M. K., Salehi-Rad, R., Mack, J. J., Iruela-Arispe, M. L., Navab, M., Fogelman, A. M. & Reddy, S. T., Dec 1 2018, In : Scientific reports. 8, 1, 9032.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers

Hilfenhaus, G., Nguyen, D. P., Freshman, J., Prajapati, D., Ma, F., Song, D., Ziyad, S., Cuadrado, M., Pellegrini, M., Bustelo, X. R. & Luisa Iruela‑Arispe, M., Aug 1 2018, In : Journal of Cell Biology. 217, 8, p. 2813-2830 18 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2017

4-D flow control in porous scaffolds: Toward a next generation of bioreactors

Youssef, K., Jarenwattananon, N. N., Archer, B. J., Mack, J., Iruela-Arispe, M. L. & Bouchard, L. S., Jan 2017, In : IEEE Transactions on Biomedical Engineering. 64, 1, p. 61-69 9 p., 7423746.

Research output: Contribution to journalArticle

2 Scopus citations

Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart

Rose, B. A., Yokota, T., Chintalgattu, V., Ren, S., Iruela-Arispe, L., Khakoo, A. Y., Minamisawa, S. & Wang, Y., Aug 4 2017, In : Journal of Biological Chemistry. 292, 31, p. 12787-12800 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice

Mintet, E., Lavigne, J., Paget, V., Tarlet, G., Buard, V., Guipaud, O., Sabourin, J. C., Iruela-Arispe, M. L., Milliat, F. & François, A., Dec 1 2017, In : Scientific reports. 7, 1, 4933.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Membrane lipids and cell signaling

Sunshine, H. & Iruela-Arispe, M. L., Oct 1 2017, In : Current opinion in lipidology. 28, 5, p. 408-413 6 p.

Research output: Contribution to journalReview article

31 Scopus citations

Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum

Mukherjee, P., Hough, G., Chattopadhyay, A., Navab, M., Fogelman, H. R., Meriwether, D., Williams, K., Bensinger, S., Moller, T., Faull, K. F., Lusis, A. J., Iruela-Arispe, M. L., Bostrom, K. I., Tontonoz, P., Reddy, S. T. & Fogelman, A. M., Aug 1 2017, In : Journal of lipid research. 58, 8, p. 1636-1647 12 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2016

Cross-talk between signaling and metabolism in the vasculature

Uebelhoer, M. & Iruela-Arispe, M. L., Aug 1 2016, In : Vascular Pharmacology. 83, p. 4-9 6 p.

Research output: Contribution to journalReview article

12 Scopus citations

Endothelial-mesenchymal transition in vascular calcification of Ins2Akita/+ Mice

Guihard, P. J., Yao, J., Blazquez-Medela, A. M., Iruela-Arispe, L., Boström, K. I. & Yao, Y., Dec 2016, In : PloS one. 11, 12, e0167936.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Notch, lipids, and endothelial cells

Briot, A., Bouloumie, A. & Iruela-Arispe, M. L., Oct 1 2016, In : Current opinion in lipidology. 27, 5, p. 513-520 8 p.

Research output: Contribution to journalReview article

17 Scopus citations

Perivascular Macrophages Limit Permeability

He, H., Mack, J. J., Güç, E., Warren, C. M., Squadrito, M. L., Kilarski, W. W., Baer, C., Freshman, R. D., McDonald, A. I., Ziyad, S., Swartz, M. A., De Palma, M. & Iruela-Arispe, M. L., Nov 1 2016, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 11, p. 2203-2212 10 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Reproducible arterial denudation injury by infrarenal abdominal aortic clamping in a murine model

Shirali, A. S., McDonald, A. I., Mack, J. J. & Iruela-Arispe, M. L., Nov 24 2016, In : Journal of Visualized Experiments. 2016, 117, e54755.

Research output: Contribution to journalArticle

3 Scopus citations
2015

ADAMTS proteases in vascular biology

Rodríguez-Manzaneque, J. C., Fernández-Rodríguez, R., Rodríguez-Baena, F. J. & Iruela-Arispe, M. L., May 1 2015, In : Matrix Biology. 44-46, p. 38-45 8 p.

Research output: Contribution to journalReview article

Open Access
28 Scopus citations

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

Domigan, C. K., Warren, C. M., Antanesian, V., Happel, K., Ziyad, S., Lee, S., Krall, A., Duan, L., Torres-Collado, A. X., Castellani, L. W., Elashoff, D., Christofk, H. R., Van Der Bliek, A. M., Potente, M. & Iruela-Arispe, M. L., Jun 1 2015, In : Journal of cell science. 128, 12, p. 2236-2248 13 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Blockade of specific NOTCH ligands: A new promising approach in cancer therapy

Briot, A. & Iruela-Arispe, M. L., Feb 1 2015, In : Cancer discovery. 5, 2, p. 112-114 3 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
Open Access
34 Scopus citations

Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis

Briot, A., Civelek, M., Seki, A., Hoi, K., Mack, J. J., Lee, S. D., Kim, J., Hong, C., Yu, J., Fishbein, G. A., Vakili, L., Fogelman, A. M., Fishbein, M. C., Lusis, A. J., Tontonoz, P., Navab, M., Berliner, J. A. & Iruela-Arispe, M. L., Nov 16 2015, In : Journal of Experimental Medicine. 212, 12, p. 2147-2163 17 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells

Hernández-García, R., Iruela-Arispe, M. L., Reyes-Cruz, G. & Vázquez-Prado, J., Nov 2015, In : Vascular Pharmacology. 74, p. 60-72 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Healing arterial ulcers: Endothelial lining regeneration upon vascular denudation injury

McDonald, A. I. & Iruela-Arispe, M. L., Sep 1 2015, In : Vascular Pharmacology. 72, p. 9-15 7 p.

Research output: Contribution to journalReview article

15 Scopus citations

In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury

Rannou, E., François, A., Toullec, A., Guipaud, O., Buard, V., Tarlet, G., Mintet, E., Jaillet, C., Iruela-Arispe, M. L., Benderitter, M., Sabourin, J. C. & Milliat, F., Oct 29 2015, In : Scientific reports. 5, 15738.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Macrophage blockade using CSF1R inhibitors reverses the vascular leakage underlying malignant ascites in late-stage epithelial ovarian cancer

Moughon, D. L., He, H., Schokrpur, S., Jiang, Z. K., Yaqoob, M., David, J., Lin, C., Iruela-Arispe, M. L., Dorigo, O. & Wu, L., Nov 15 2015, In : Cancer Research. 75, 22, p. 4742-4752 11 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

State-of-the-art methods for evaluation of angiogenesis and tissue vascularization: A scientific statement from The American Heart Association

Simons, M., Alitalo, K., Annex, B. H., Augustin, H. G., Beam, C., Berk, B. C., Byzova, T., Carmeliet, P., Chilian, W., Cooke, J. P., Davis, G. E., Eichmann, A., Iruela-Arispe, M. L., Keshet, E., Sinusas, A. J., Ruhrberg, C., Woo, Y. J. & Dimmeler, S., May 22 2015, In : Circulation research. 116, 11, p. e99-e132

Research output: Contribution to journalReview article

Open Access
64 Scopus citations
2014

A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes

Warren, C. M., Ziyad, S., Briot, A., Der, A. & Iruela-Arispe, M. L., Jan 7 2014, In : Science Signaling. 7, 307, p. ra1

Research output: Contribution to journalArticle

58 Scopus citations

Erratum: Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation (ChemBioChem (2014) 15 (233-242) DOI: 10.1002/cbic.201300687)

Griffin, D. R., Borrajo, J., Soon, A., Acosta-Vélez, G. F., Oshita, V., Darling, N., MacK, J., Barker, T., Iruela-Arispe, M. L. & Segura, T., Mar 3 2014, In : ChemBioChem. 15, 4, p. 485-486 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation

Griffin, D. R., Borrajo, J., Soon, A., Acosta-Vélez, G. F., Oshita, V., Darling, N., MacK, J., Barker, T., Iruela-Arispe, M. L. & Segura, T., Jan 24 2014, In : ChemBioChem. 15, 2, p. 233-242 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye

Michael, I. P., Westenskow, P. D., Hacibekiroglu, S., Greenwald, A. C., Ballios, B. G., Kurihara, T., Li, Z., Warren, C. M., Zhang, P., Aguilar, E., Donaldson, L., Marchetti, V., Baba, T., Hussein, S. M., Sung, H. K., Iruela-Arispe, M. L., Rini, J. M., Van der Kooy, D., Friedlander, M. & Nagy, A., May 2014, In : EMBO Molecular Medicine. 6, 5, p. 604-623 20 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Podosome rosettes precede vascular sprouts in tumour angiogenesis

Warren, C. M. & Iruela-Arispe, M. L., Jan 1 2014, In : Nature Cell Biology. 16, 10, p. 928-930 3 p.

Research output: Contribution to journalReview article

8 Scopus citations

Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation

Goddard, L. M., Murphy, T. J., Org, T., Enciso, J. M., Hashimoto-Partyka, M. K., Warren, C. M., Domigan, C. K., McDonald, A. I., He, H., Sanchez, L. A., Allen, N. C., Orsenigo, F., Chao, L. C., Dejana, E., Tontonoz, P., Mikkola, H. K. A. & Iruela-Arispe, M. L., Jan 30 2014, In : Cell. 156, 3, p. 549-562 14 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells

Briot, A., Jaroszewicz, A., Warren, C. M., Lu, J., Touma, M., Rudat, C., Hofmann, J. J., Airik, R., Weinmaster, G., Lyons, K., Wang, Y., Kispert, A., Pellegrini, M. & Iruela-Arispe, M. L., Dec 22 2014, In : Developmental Cell. 31, 6, p. 707-721 15 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations