• 15858 Citations
1989 …2019

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2019

Angiopoietin-2 predicts morbidity in adults with Fontan physiology

Shirali, A. S., Lluri, G., Guihard, P. J., Conrad, M. B., Kim, H., Pawlikowska, L., Boström, K. I., Iruela-Arispe, M. L. & Aboulhosn, J. A., Dec 1 2019, In : Scientific reports. 9, 1, 18328.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Keklikoglou, I., Cianciaruso, C., Güç, E., Squadrito, M. L., Spring, L. M., Tazzyman, S., Lambein, L., Poissonnier, A., Ferraro, G. B., Baer, C., Cassará, A., Guichard, A., Iruela-Arispe, M. L., Lewis, C. E., Coussens, L. M., Bardia, A., Jain, R. K., Pollard, J. W. & De Palma, M., Feb 1 2019, In : Nature Cell Biology. 21, 2, p. 190-202 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Noninvasive Quantification of Cell Density in Three-Dimensional Gels by MRI

Archer, B. J., Uberruck, T., Mack, J. J., Youssef, K., Jarenwattananon, N. N., Rall, D., Wypysek, D., Wiese, M., Blumich, B., Wessling, M., Iruela-Arispe, M. L. & Bouchard, L. S., Mar 2019, In : IEEE Transactions on Biomedical Engineering. 66, 3, p. 821-830 10 p., 8412441.

Research output: Contribution to journalArticle

2018

A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis

Ziyad, S., Riordan, J. D., Cavanaugh, A. M., Su, T., Hernandez, G. E., Hilfenhaus, G., Morselli, M., Huynh, K., Wang, K., Chen, J. N., Dupuy, A. J. & Iruela-Arispe, M. L., Jan 30 2018, In : Cell reports. 22, 5, p. 1211-1224 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

A multi-step transcriptional cascade underlies vascular regeneration in vivo

Shirali, A. S., Romay, M. C., McDonald, A. I., Su, T., Steel, M. E. & Iruela-Arispe, M. L., Dec 1 2018, In : Scientific reports. 8, 1, 5430.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Analysis of cardiomyocyte clonal expansion during mouse heart development and injury

Sereti, K. I., Nguyen, N. B., Kamran, P., Zhao, P., Ranjbarvaziri, S., Park, S., Sabri, S., Engel, J. L., Sung, K., Kulkarni, R. P., Ding, Y., Hsiai, T. K., Plath, K., Ernst, J., Sahoo, D., Mikkola, H. K. A., Iruela-Arispe, M. L. & Ardehali, R., Dec 1 2018, In : Nature communications. 9, 1, 754.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells

Jumabay, M., Zhumabai, J., Mansurov, N., Niklason, K. C., Guihard, P. J., Cubberly, M. R., Fogelman, A. M., Iruela-Arispe, L., Yao, Y., Saparov, A. & Boström, K. I., Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 1812-1822 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities

McDonald, A. I., Shirali, A. S., Aragón, R., Ma, F., Hernandez, G., Vaughn, D. A., Mack, J. J., Lim, T. Y., Sunshine, H., Zhao, P., Kalinichenko, V., Hai, T., Pelegrini, M., Ardehali, R. & Iruela-Arispe, M. L., Aug 2 2018, In : Cell stem cell. 23, 2, p. 210-225.e6

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth

Li, L., Zeng, Q., Bhutkar, A., Galván, J. A., Karamitopoulou, E., Noordermeer, D., Peng, M. W., Piersigilli, A., Perren, A., Zlobec, I., Robinson, H., Iruela-Arispe, M. L. & Hanahan, D., Apr 9 2018, In : Cancer Cell. 33, 4, p. 736-751.e5

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

HIF-1α Deletion in the Endothelium, but Not in the Epithelium, Protects From Radiation-Induced Enteritis

Toullec, A., Buard, V., Rannou, E., Tarlet, G., Guipaud, O., Robine, S., Iruela-Arispe, M. L., François, A. & Milliat, F., 2018, In : CMGH. 5, 1, p. 15-30 16 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Mapping metabolism: Monitoring lactate dehydrogenase activity directly in tissue

Jelinek, D., Flores, A., Uebelhoer, M., Pasque, V., Plath, K., Iruela-Arispe, M. L., Christofk, H. R., Lowry, W. E. & Coller, H. A., Jun 21 2018, In : Journal of Visualized Experiments. 2018, 136, e57760.

Research output: Contribution to journalArticle

5 Scopus citations

NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot

Duran, I., Tenney, J., Warren, C. M., Sarukhanov, A., Csukasi, F., Skalansky, M., Iruela-Arispe, M. L. & Krakow, D., Mar 2018, In : American Journal of Medical Genetics, Part A. 176, 3, p. 649-656 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer

Chattopadhyay, A., Yang, X., Mukherjee, P., Sulaiman, D., Fogelman, H. R., Grijalva, V., Dubinett, S., Wasler, T. C., Paul, M. K., Salehi-Rad, R., Mack, J. J., Iruela-Arispe, M. L., Navab, M., Fogelman, A. M. & Reddy, S. T., Dec 1 2018, In : Scientific reports. 8, 1, 9032.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers

Hilfenhaus, G., Nguyen, D. P., Freshman, J., Prajapati, D., Ma, F., Song, D., Ziyad, S., Cuadrado, M., Pellegrini, M., Bustelo, X. R. & Luisa Iruela‑Arispe, M., Aug 1 2018, In : Journal of Cell Biology. 217, 8, p. 2813-2830 18 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2017

4-D flow control in porous scaffolds: Toward a next generation of bioreactors

Youssef, K., Jarenwattananon, N. N., Archer, B. J., Mack, J., Iruela-Arispe, M. L. & Bouchard, L. S., Jan 2017, In : IEEE Transactions on Biomedical Engineering. 64, 1, p. 61-69 9 p., 7423746.

Research output: Contribution to journalArticle

2 Scopus citations

Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart

Rose, B. A., Yokota, T., Chintalgattu, V., Ren, S., Iruela-Arispe, L., Khakoo, A. Y., Minamisawa, S. & Wang, Y., Aug 4 2017, In : Journal of Biological Chemistry. 292, 31, p. 12787-12800 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice

Mintet, E., Lavigne, J., Paget, V., Tarlet, G., Buard, V., Guipaud, O., Sabourin, J. C., Iruela-Arispe, M. L., Milliat, F. & François, A., Dec 1 2017, In : Scientific reports. 7, 1, 4933.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum

Mukherjee, P., Hough, G., Chattopadhyay, A., Navab, M., Fogelman, H. R., Meriwether, D., Williams, K., Bensinger, S., Moller, T., Faull, K. F., Lusis, A. J., Iruela-Arispe, M. L., Bostrom, K. I., Tontonoz, P., Reddy, S. T. & Fogelman, A. M., Aug 1 2017, In : Journal of lipid research. 58, 8, p. 1636-1647 12 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2016

Endothelial-mesenchymal transition in vascular calcification of Ins2Akita/+ Mice

Guihard, P. J., Yao, J., Blazquez-Medela, A. M., Iruela-Arispe, L., Boström, K. I. & Yao, Y., Dec 2016, In : PloS one. 11, 12, e0167936.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Perivascular Macrophages Limit Permeability

He, H., Mack, J. J., Güç, E., Warren, C. M., Squadrito, M. L., Kilarski, W. W., Baer, C., Freshman, R. D., McDonald, A. I., Ziyad, S., Swartz, M. A., De Palma, M. & Iruela-Arispe, M. L., Nov 1 2016, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 11, p. 2203-2212 10 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Reproducible arterial denudation injury by infrarenal abdominal aortic clamping in a murine model

Shirali, A. S., McDonald, A. I., Mack, J. J. & Iruela-Arispe, M. L., Nov 24 2016, In : Journal of Visualized Experiments. 2016, 117, e54755.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

Domigan, C. K., Warren, C. M., Antanesian, V., Happel, K., Ziyad, S., Lee, S., Krall, A., Duan, L., Torres-Collado, A. X., Castellani, L. W., Elashoff, D., Christofk, H. R., Van Der Bliek, A. M., Potente, M. & Iruela-Arispe, M. L., Jun 1 2015, In : Journal of cell science. 128, 12, p. 2236-2248 13 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Blockade of specific NOTCH ligands: A new promising approach in cancer therapy

Briot, A. & Iruela-Arispe, M. L., Feb 1 2015, In : Cancer discovery. 5, 2, p. 112-114 3 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis

Briot, A., Civelek, M., Seki, A., Hoi, K., Mack, J. J., Lee, S. D., Kim, J., Hong, C., Yu, J., Fishbein, G. A., Vakili, L., Fogelman, A. M., Fishbein, M. C., Lusis, A. J., Tontonoz, P., Navab, M., Berliner, J. A. & Iruela-Arispe, M. L., Nov 16 2015, In : Journal of Experimental Medicine. 212, 12, p. 2147-2163 17 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells

Hernández-García, R., Iruela-Arispe, M. L., Reyes-Cruz, G. & Vázquez-Prado, J., Nov 2015, In : Vascular Pharmacology. 74, p. 60-72 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury

Rannou, E., François, A., Toullec, A., Guipaud, O., Buard, V., Tarlet, G., Mintet, E., Jaillet, C., Iruela-Arispe, M. L., Benderitter, M., Sabourin, J. C. & Milliat, F., Oct 29 2015, In : Scientific reports. 5, 15738.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Macrophage blockade using CSF1R inhibitors reverses the vascular leakage underlying malignant ascites in late-stage epithelial ovarian cancer

Moughon, D. L., He, H., Schokrpur, S., Jiang, Z. K., Yaqoob, M., David, J., Lin, C., Iruela-Arispe, M. L., Dorigo, O. & Wu, L., Nov 15 2015, In : Cancer Research. 75, 22, p. 4742-4752 11 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations
2014

A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes

Warren, C. M., Ziyad, S., Briot, A., Der, A. & Iruela-Arispe, M. L., Jan 7 2014, In : Science Signaling. 7, 307, p. ra1

Research output: Contribution to journalArticle

58 Scopus citations

Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation

Griffin, D. R., Borrajo, J., Soon, A., Acosta-Vélez, G. F., Oshita, V., Darling, N., MacK, J., Barker, T., Iruela-Arispe, M. L. & Segura, T., Jan 24 2014, In : ChemBioChem. 15, 2, p. 233-242 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye

Michael, I. P., Westenskow, P. D., Hacibekiroglu, S., Greenwald, A. C., Ballios, B. G., Kurihara, T., Li, Z., Warren, C. M., Zhang, P., Aguilar, E., Donaldson, L., Marchetti, V., Baba, T., Hussein, S. M., Sung, H. K., Iruela-Arispe, M. L., Rini, J. M., Van der Kooy, D., Friedlander, M. & Nagy, A., May 2014, In : EMBO Molecular Medicine. 6, 5, p. 604-623 20 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation

Goddard, L. M., Murphy, T. J., Org, T., Enciso, J. M., Hashimoto-Partyka, M. K., Warren, C. M., Domigan, C. K., McDonald, A. I., He, H., Sanchez, L. A., Allen, N. C., Orsenigo, F., Chao, L. C., Dejana, E., Tontonoz, P., Mikkola, H. K. A. & Iruela-Arispe, M. L., Jan 30 2014, In : Cell. 156, 3, p. 549-562 14 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells

Briot, A., Jaroszewicz, A., Warren, C. M., Lu, J., Touma, M., Rudat, C., Hofmann, J. J., Airik, R., Weinmaster, G., Lyons, K., Wang, Y., Kispert, A., Pellegrini, M. & Iruela-Arispe, M. L., Dec 22 2014, In : Developmental Cell. 31, 6, p. 707-721 15 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations
2013

Cellular and molecular regulation of vascular permeability

Goddard, L. M. & Luisa Iruela-Arispe, M., Feb 7 2013, In : Thrombosis and Haemostasis. 109, 3, p. 407-415 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Dll4-notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models

Cristofaro, B., Shi, Y., Faria, M., Suchting, S., Leroyer, A. S., Trindade, A., Duarte, A., Zovein, A. C., Luisa Iruela-Arispe, M., Nih, L. R., Kubis, N., Henrion, D., Loufrani, L., Todiras, M., Schleifenbaum, J., Gollasch, M., Zhuang, Z. W., Simons, M., Eichmann, A. & le Noble, F., Apr 1 2013, In : Development (Cambridge). 140, 8, p. 1720-1729 10 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy

Janzen, D. M., Rosales, M. A., Paik, D. Y., Lee, D. S., Smith, D. A., Witte, O. N., Iruela-Arispe, M. L. & Memarzadeh, S., Aug 1 2013, In : Cancer Research. 73, 15, p. 4697-4710 14 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Real-time maps of fluid flow fields in porous biomaterials

Mack, J. J., Youssef, K., Noel, O. D. V., Lake, M. P., Wu, A., Iruela-Arispe, M. L. & Bouchard, L. S., Mar 2013, In : Biomaterials. 34, 8, p. 1980-1986 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Selective suppression of endothelial cytokine production by progesterone receptor

Goddard, L. M., Ton, A. N., Org, T., Mikkola, H. K. A. & Iruela-Arispe, M. L., Jul 1 2013, In : Vascular Pharmacology. 59, 1-2, p. 36-43 8 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Sox17 is indispensable for acquisition and maintenance of arterial identity

Corada, M., Orsenigo, F., Morini, M. F., Pitulescu, M. E., Bhat, G., Nyqvist, D., Breviario, F., Conti, V., Briot, A., Iruela-Arispe, M. L., Adams, R. H. & Dejana, E., Nov 4 2013, In : Nature communications. 4, 2609.

Research output: Contribution to journalArticle

Open Access
116 Scopus citations

Testosterone levels influence mouse fetal leydig cell progenitors through notch signaling

DeFalco, T., Saraswathula, A., Briot, A., Iruela-Arispe, M. L. & Capel, B., Apr 1 2013, In : Biology of reproduction. 88, 4, 91.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations

The mouse retina in 3D: Quantification of vascular growth and remodeling

Milde, F., Lauw, S., Koumoutsakos, P. & Iruela-Arispe, M. L., Dec 2013, In : Integrative Biology (United Kingdom). 5, 12, p. 1426-1438 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

β1-integrin is essential for vasoregulation and smooth muscle survival in vivo

Turlo, K. A., Scapa, J., Bagher, P., Jones, A. W., Feil, R., Korthuis, R. J., Segal, S. S. & Iruela-Arispe, M. L., Oct 1 2013, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 10, p. 2325-2335 11 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2012

An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall

Turlo, K. A., Noel, O. D. V., Vora, R., LaRussa, M., Fassler, R., Hall-Glenn, F. & Iruela-Arispe, M. L., May 1 2012, In : Developmental Biology. 365, 1, p. 23-35 13 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1

Avraham-Davidi, I., Ely, Y., Pham, V. N., Castranova, D., Grunspan, M., Malkinson, G., Gibbs-Bar, L., Mayseless, O., Allmog, G., Lo, B., Warren, C. M., Chen, T. T., Ungos, J., Kidd, K., Shaw, K., Rogachev, I., Wan, W., Murphy, P. M., Farber, S. A., Carmel, L. & 4 others, Shelness, G. S., Iruela-Arispe, M. L., Weinstein, B. M. & Yaniv, K., Jun 1 2012, In : Nature Medicine. 18, 6, p. 967-973 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

CCN2/Connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis

Hall-Glenn, F., de Young, R. A., Huang, B. L., van Handel, B., Hofmann, J. J., Chen, T. T., Choi, A., Ong, J. R., Benya, P. D., Mikkola, H., Iruela-Arispe, M. L. & Lyons, K. M., Feb 20 2012, In : PloS one. 7, 2, e30562.

Research output: Contribution to journalArticle

Open Access
78 Scopus citations

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages

He, H., Xu, J., Warren, C. M., Duan, D., Li, X., Wu, L. & Iruela-Arispe, M. L., Oct 11 2012, In : Blood. 120, 15, p. 3152-3162 11 p.

Research output: Contribution to journalArticle

88 Scopus citations

Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome

Hofmann, J. J., Briot, A., Enciso, J., Zovein, A. C., Ren, S., Zhang, Z. W., Radtke, F., Simons, M., Wang, Y. & Luisa Iruela-Arispe, M., Dec 1 2012, In : Development (Cambridge). 139, 23, p. 4449-4460 12 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation

Cooley, M. A., Fresco, V. M., Dorlon, M. E., Twal, W. O., Lee, N. V., Barth, J. L., Kern, C. B., Iruela-Arispe, M. L. & Argraves, W. S., Feb 1 2012, In : Developmental Dynamics. 241, 2, p. 303-314 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Macro-scale topology optimization for controlling internal shear stress in a porous scaffold bioreactor

Youssef, K., Mack, J. J., Iruela-Arispe, M. L. & Bouchard, L. S., Jul 1 2012, In : Biotechnology and Bioengineering. 109, 7, p. 1844-1854 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane

Scheppke, L., Murphy, E. A., Zarpellon, A., Hofmann, J. J., Merkulova, A., Shields, D. J., Weis, S. M., Byzova, T. V., Ruggeri, Z. M., Iruela-Arispe, M. L. & Cheresh, D. A., Mar 1 2012, In : Blood. 119, 9, p. 2149-2158 10 p.

Research output: Contribution to journalArticle

Open Access
73 Scopus citations