M Matthew Oh

  • 1370 Citations
1995 …2021
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Personal profile

Research Interests

I am interested in identifying why learning becomes progressively more difficult with normal aging. With this broad goal in mind, I am studying the cellular properties of principle neurons of the hippocampus as an animal ages and after an animal has learned a task that involve the hippocampus. Thus far, my colleagues and I have identified that hippocampal pyramidal neurons (the principle output neurons of the hippocampus) become more excitable (that is, they are able to fire more action potentials) following successful learning. More importantly, the same population of neurons become less excitable with normal aging. Thus, it is our working hypothesis that the reduced excitability levels of the hippocampal pyramidal neurons with normal aging is a cause of the learning deficits observed in the aging population. We are currently using state of the art calcium imaging techniques to further characterize the changes in the hippocampal pyramidal neurons following learning and with normal aging. By systematically examining these cellular changes that occur following successful learning and with normal aging, a goal is to identify potential pharmacological targets to ameliorate and/or reverse the normal aging-related cognitive deficits. In addition, given that incidence of Alzheimer's disease increases with age, it is another goal of our research to translate our findings and approach to identify the cellular changes that occur in this debilitating condition.

Training Experience

2008Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Northwestern University

… → 2002

Research interests

  • Aging
  • Alzheimer's Disease
  • Behavioral Biology
  • Cell Imaging
  • Cellular Electrophysiology
  • Neuroscience

Fingerprint Dive into the research topics where M Matthew Oh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Grants 2004 2021

Memory Disorders
Dendrites
Ion Channels
Photons
Maze Learning
Hippocampus
Learning
Neurons
Proteins
CREB-Binding Protein
Hippocampus
Learning
Neurons
Aptitude
Potassium

Research Output 1995 2018

  • 1370 Citations
  • 26 Article
  • 7 Review article
  • 1 Chapter
3 Citations (Scopus)

Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease

Musial, T. F., Molina-Campos, E., Bean, L. A., Ybarra, N., Borenstein, R., Russo, M. L., Buss, E. W., Justus, D., Neuman, K. M., Ayala, G. D., Mullen, S. A., Voskobiynyk, Y., Tulisiak, C. T., Fels, J. A., Corbett, N. J., Carballo, G., Kennedy, C. D., Popovic, J., Ramos-Franco, J., Fill, M. & 13 others, Pergande, M. R., Borgia, J. A., Corbett, G. T., Pahan, K., Han, Y., Chetkovich, D. M., Vassar, R. J., Byrne, R. W., Oh, M. M., Stoub, T. R., Remy, S., Disterhoft, J. F. & Nicholson, D. A., Oct 1 2018, In : Neurobiology of Learning and Memory. 154, p. 141-157 17 p.

Research output: Contribution to journalArticle

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Channelopathies
Alzheimer Disease
Cyclic Nucleotides
Nervous System Diseases
16 Citations (Scopus)

CREB, cellular excitability, and cognition: Implications for aging

Yu, X. W., Oh, M. M. & Disterhoft, J. F., Mar 30 2017, In : Behavioural Brain Research. 322, p. 206-211 6 p.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Cognition
Laboratory Animals
Young Adult
Transcription Factors
12 Citations (Scopus)

CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats

Yu, X. W., Curlik, D. M., Oh, M. M., Yin, J. C. P. & Disterhoft, J. F., Jan 4 2017, In : eLife. 6, e19358.

Research output: Contribution to journalArticle

Cyclic AMP Response Element-Binding Protein
Long-Term Memory
Memory Disorders
Rats
Data storage equipment
19 Citations (Scopus)
Pyramidal Cells
Hippocampus
Neurons
Action Potentials
Cognitive Aging
37 Citations (Scopus)

Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression

Simkin, D., Hattori, S., Ybarra, N., Musia, T. F., Buss, E. W., Richter, H., Oh, M. M., Nicholson, D. A. & Disterhoft, J. F., Sep 23 2015, In : Journal of Neuroscience. 35, 38, p. 13206-13218 13 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Action Potentials
Cognition
Hippocampus
Western Blotting