M Matthew Oh

  • 1497 Citations
19952020

Research output per year

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Personal profile

Research Interests

I am interested in identifying why learning becomes progressively more difficult with normal aging. With this broad goal in mind, I am studying the cellular properties of principle neurons of the hippocampus as an animal ages and after an animal has learned a task that involve the hippocampus. Thus far, my colleagues and I have identified that hippocampal pyramidal neurons (the principle output neurons of the hippocampus) become more excitable (that is, they are able to fire more action potentials) following successful learning. More importantly, the same population of neurons become less excitable with normal aging. Thus, it is our working hypothesis that the reduced excitability levels of the hippocampal pyramidal neurons with normal aging is a cause of the learning deficits observed in the aging population. We are currently using state of the art calcium imaging techniques to further characterize the changes in the hippocampal pyramidal neurons following learning and with normal aging. By systematically examining these cellular changes that occur following successful learning and with normal aging, a goal is to identify potential pharmacological targets to ameliorate and/or reverse the normal aging-related cognitive deficits. In addition, given that incidence of Alzheimer's disease increases with age, it is another goal of our research to translate our findings and approach to identify the cellular changes that occur in this debilitating condition.

Training Experience

2008Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Northwestern University

… → 2002

Research interests

  • Aging
  • Alzheimer's Disease
  • Behavioral Biology
  • Cell Imaging
  • Cellular Electrophysiology
  • Neuroscience

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Grants

  • Research Output

    • 1497 Citations
    • 26 Article
    • 7 Review article
    • 1 Chapter

    Learning and aging affect neuronal excitability and learning

    Oh, M. M. & Disterhoft, J. F., Jan 2020, In : Neurobiology of Learning and Memory. 167, 107133.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease

    Musial, T. F., Molina-Campos, E., Bean, L. A., Ybarra, N., Borenstein, R., Russo, M. L., Buss, E. W., Justus, D., Neuman, K. M., Ayala, G. D., Mullen, S. A., Voskobiynyk, Y., Tulisiak, C. T., Fels, J. A., Corbett, N. J., Carballo, G., Kennedy, C. D., Popovic, J., Ramos-Franco, J., Fill, M. & 13 others, Pergande, M. R., Borgia, J. A., Corbett, G. T., Pahan, K., Han, Y., Chetkovich, D. M., Vassar, R. J., Byrne, R. W., Matthew Oh, M., Stoub, T. R., Remy, S., Disterhoft, J. F. & Nicholson, D. A., Oct 2018, In : Neurobiology of Learning and Memory. 154, p. 141-157 17 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    CREB, cellular excitability, and cognition: Implications for aging

    Yu, X. W., Oh, M. M. & Disterhoft, J. F., Mar 30 2017, In : Behavioural Brain Research. 322, p. 206-211 6 p.

    Research output: Contribution to journalArticle

  • 18 Scopus citations

    CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats

    Yu, X. W., Curlik, D. M., Oh, M. M., Yin, J. C. P. & Disterhoft, J. F., Jan 4 2017, In : eLife. 6, e19358.

    Research output: Contribution to journalArticle

  • 18 Scopus citations
  • 29 Scopus citations