Grants per year
Personal profile
Research Interests
Ribosomes are protein manufacturers that are essential for all cells and viruses. Our lab applies genetic, structural and biochemical principles to understand how ribosome composition and associations, antibiotics and stressors affect the translation of genetic codes and, in turn, give rise to phenotypic variations and differential manifestations of infection. Our focus spans fundamental basic biology and extends to understanding bacterial physiology and human and plant diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Plant Pathology, University of Wisconsin-Madison
… → 2006
Research interests keywords
- Bacterial Pathogenesis
- Biochemistry: Nucleic Acid
- Biochemistry: Proteins
- Genomics
- Infectious Diseases: Bacteria
- Microbiome
- Molecular Biology
- Proteins / Macromolecules
- Sepsis
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Regulation and function of bacterial hibernating 100S ribosome
Yap, M.-N. F. (PD/PI) & Yap, M.-N. F. (PD/PI)
National Institute of General Medical Sciences
9/12/22 → 7/31/26
Project: Research project
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Role of translational fidelity in cellular physiology of oral streptococci
Yap, M.-N. F. (PD/PI) & Yap, M.-N. F. (PD/PI)
University of Kansas Medical Center Research Institute, Inc., National Institute of Dental and Craniofacial Research
3/1/22 → 2/28/27
Project: Research project
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Evolution and consequences of multidrug resistant ribosome
Yap, M.-N. F. (PD/PI) & Yap, M.-N. F. (PD/PI)
National Institute of Allergy and Infectious Diseases
9/16/20 → 8/31/25
Project: Research project
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29th Annual Midwest Microbial Pathogenesis Conference (MMPC)
Yap, M.-N. F. (PD/PI)
National Institute of Allergy and Infectious Diseases
7/20/23 → 6/30/24
Project: Research project
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Support of the 29th Annual Midwest Microbial Pathogenesis Conference (MMPC)
Satchell, K. J. (PD/PI), Seifert, H. S. (Co-Investigator) & Yap, M.-N. F. (Co-Investigator)
3/1/23 → 12/31/23
Project: Research project
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Epitranscriptional m6A modification of rRNA negatively impacts translation and host colonization in Staphylococcus aureus
Shields, K. E., Ranava, D., Tan, Y., Zhang, D. & Yap, M. N. F., Jan 2024, In: PLoS pathogens. 20, 1, e1011968.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Machine learning-based classification reveals distinct clusters of non-coding genomic allelic variations associated with Ermmediated antibiotic resistance
Tan, Y., Le Scornet, A., Yap, M. N. F. & Zhang, D., Jul 2024, In: mSystems. 9, 7Research output: Contribution to journal › Article › peer-review
Open Access -
Staphylococcal exoribonuclease YhaM destabilizes ribosomes by targeting the mRNA of a hibernation factor
Lipońska, A., Lee, H. & Yap, M. N. F., Aug 27 2024, In: Nucleic acids research. 52, 15, p. 8998-9013 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Bidirectional sequestration between a bacterial hibernation factor and a glutamate metabolizing protein
Ranava, D., Scheidler, C. M., Pfanzelt, M., Fiedler, M., Sieber, S. A., Schneider, S. & Yap, M. N. F., Sep 27 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 39, e2207257119.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
The Identity of the Constriction Region of the Ribosomal Exit Tunnel Is Important to Maintain Gene Expression in Escherichia coli
Worthan, S. B., Franklin, E. A., Pham, C., Yap, M. N. F. & Cruz-Vera, L. R., Apr 2022, In: Microbiology Spectrum. 10, 2Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Structure of YwlG (Q2FF14) from Staphylococcus aureus
Ranava, D. (Contributor), Scheidler, C. M. (Contributor), Pfanzelt, M. (Contributor), Fiedler, M. (Contributor), Sieber, S. A. (Contributor), Schneider, S. (Contributor) & Yap, M.-N. F. (Contributor), Protein Data Bank (PDB), Sep 21 2022
DOI: 10.2210/pdb7Z06/pdb, https://www.wwpdb.org/pdb?id=pdb_00007z06
Dataset