Grants per year
Personal profile
Research Interests
My clinical and research interests focus on neurosurgical management of patients with brain and spinal cord tumors. I take care of patients with both benign as well as malignant cancer of the brain/spinal cord. In addition, part of my practice is devoted to the care of neurovascular patients, including aneurysms and arteriovenous malformations.
Training Experience
| 1997 | Internship, Johns Hopkins Hospital |
| 2002 | Fellowship, Johns Hopkins Hospital |
| 2002 | Residency, Johns Hopkins Hospital |
Education/Academic qualification
MS, Harvard University
… → 2010
MD, Johns Hopkins University
… → 1996
Research interests
- Acoustic Neuroma
- Biologic Therapies
- Brain Aneurysm
- Brain Arteriovenous Malformation
- Brain Cancer / Nervous System Cancer
- Neuro-Oncology
- Neurosurgery
- Skull Base Surgery
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Grants
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Gene Silencing and NK Cell Therapy as a Nano-Immunotherapy for Glioblastoma
9/1/20 → 8/31/23
Project: Research project
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Developing a patient-derived B-cell-based vaccine, a novel therapeutic agent for glioblastomas
Neurosurgery Research and Education Foundation
7/1/20 → 6/30/21
Project: Research project
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Arginine Metabolism Regulates Myeloid Immune Suppression in Glioblastoma
National Institute of Neurological Disorders and Stroke
5/1/20 → 1/31/25
Project: Research project
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Genetic Approaches to Optimize CAR T cells for Glioblastoma Therapy
Balyasnikova, I. V., Horbinski, C. M. & Lesniak, M. S.
National Institute of Neurological Disorders and Stroke
9/30/18 → 8/31/23
Project: Research project
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SPORE for Translational Approaches to Brain Cancer
Ahmed, A. U., Balyasnikova, I. V., Bartom, E. T., Brat, D. J., Chandler, J. P., Cheng, S., Horbinski, C. M., Hu, B., James, C. D., Kumthekar, P. U., Lesniak, M. S., Liu, B. P., Lukas, R. V., Sachdev, S., Scholtens, D. M., Stegh, A. H., Stupp, R., Wainwright, D. A., Leikin, R. G. & Platanias, L. C.
8/17/18 → 7/31/23
Project: Research project
Research Output
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Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma
Lee-Chang, C., Miska, J., Hou, D., Rashidi, A., Zhang, P., Burga, R. A., Jusúe, I. T., Xiao, T., Arrieta, V. A., Zhang, D. Y., Lopez-Rosas, A., Han, Y., Sonabend, A. M., Horbinski, C. M., Stupp, R., Balyasnikova, I. V. & Lesniak, M. S., Jan 4 2021, In: Journal of Experimental Medicine. 218, 1Research output: Contribution to journal › Article › peer-review
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Metabolome-driven regulation of adenovirus-induced cell death
Laevskaya, A., Borovjagin, A., Timashev, P. S., Lesniak, M. S. & Ulasov, I., Jan 1 2021, In: International journal of molecular sciences. 22, 1, p. 1-14 14 p., 464.Research output: Contribution to journal › Review article › peer-review
Open Access -
A Neutrophil-Inspired Supramolecular Nanogel for Magnetocaloric–Enzymatic Tandem Therapy
Zhang, Q., Wu, J., Wang, J., Wang, X., Wu, C., Chen, M., Wu, Q., Lesniak, M. S., Mi, Y., Cheng, Y. & Wang, Q., Feb 24 2020, In: Angewandte Chemie - International Edition. 59, 9, p. 3732-3738 7 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine
Kanojia, D., Panek, W. K., Cordero, A., Fares, J., Xiao, A., Savchuk, S., Kumar, K., Xiao, T., Pituch, K. C., Miska, J., Zhang, P., Kam, K. L., Horbinski, C., Balyasnikova, I. V., Ahmed, A. U. & Lesniak, M. S., Aug 2020, In: Science translational medicine. 12, 558, eaax2879.Research output: Contribution to journal › Article › peer-review
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CD8+ T-cell-Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas
Kane, J. R., Zhao, J., Tsujiuchi, T., Laffleur, B., Arrieta, V. A., Mahajan, A., Rao, G., Mela, A., Dmello, C., Chen, L., Zhang, D. Y., González-Buendia, E., Lee-Chang, C., Xiao, T., Rothschild, G., Basu, U., Horbinski, C., Lesniak, M. S., Heimberger, A. B., Rabadan, R. & 2 others, , Aug 15 2020, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 26, 16, p. 4390-4401 12 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations