Grants per year
Personal profile
Research Interests
My clinical and research interests focus on neurosurgical management of patients with brain and spinal cord tumors. I take care of patients with both benign as well as malignant cancer of the brain/spinal cord. In addition, part of my practice is devoted to the care of neurovascular patients, including aneurysms and arteriovenous malformations.
Training Experience
| 1997 | Internship, Johns Hopkins Hospital |
| 2002 | Fellowship, Johns Hopkins Hospital |
| 2002 | Residency, Johns Hopkins Hospital |
Education/Academic qualification
MS, Harvard University
… → 2010
MD, Johns Hopkins University
… → 1996
Keywords
- Acoustic Neuroma
- Biologic Therapies
- Brain Aneurysm
- Brain Arteriovenous Malformation
- Brain Cancer / Nervous System Cancer
- Neuro-Oncology
- Neurosurgery
- Skull Base Surgery
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2011 2023
Neural Stem Cell Carriers for Glioblastoma Immunotherapy
Balyasnikova, I. V., Horbinski, C. M., James, C. D. & Lesniak, M. S.
National Institute of Neurological Disorders and Stroke
6/1/19 → 5/31/20
Project: Research project
Genetic Approaches to Optimize CAR T cells for Glioblastoma Therapy
Balyasnikova, I. V., Horbinski, C. M. & Lesniak, M. S.
National Institute of Neurological Disorders and Stroke
9/30/18 → 8/31/23
Project: Research project
Antigen Receptors
Glioblastoma
Cell- and Tissue-Based Therapy
T-Cell Antigen Receptor
Glioma
Developmental Research 4 Subproject for Institution # SP0045923
8/17/18 → 7/31/23
Project: Research project
Glioblastoma
Brain Neoplasms
Research
Therapeutics
Neoplasms
Paclitaxel delivery through ultrasound based blood brain barrier disruption: Setting the stage for Phase 1 2 clinical trial
Lesniak, M. S. & Sonabend Worthalter, A. M.
8/17/18 → 7/31/23
Project: Research project
Clinical Trials, Phase I
Paclitaxel
Blood-Brain Barrier
Glioblastoma
Brain Neoplasms
Career Enhancement 4 Subproject for Institution # SP0045923
8/17/18 → 7/31/23
Project: Research project
Glioblastoma
Brain Neoplasms
Therapeutics
Neoplasms
Survival
Research Output 1999 2019
Cathepsin B: A sellsword of cancer progression
Mijanović, O., Branković, A., Panin, A. N., Savchuk, S., Timashev, P., Ulasov, I. & Lesniak, M. S., May 1 2019, In : Cancer Letters. 449, p. 207-214 8 p.Research output: Contribution to journal › Short survey
Cathepsin B
Cathepsins
Peptide Hydrolases
Neoplasms
Neoplasm Metastasis
Correlation of post-contrast T1-weighted MRI surface regularity, tumor bulk, and necrotic volume with Ki67 and p53 in glioblastomas
Hasse, A., Dapash, M., Jeong, Y., Ansari, S. A., Carroll, T. J., Lesniak, M. S. & Ginat, D. T., Jan 1 2019, In : Neuroradiology.Research output: Contribution to journal › Review article
Glioblastoma
Area Under Curve
Neoplasms
ROC Curve
Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer
Mooney, R., Majid, A. A., Batalla-Covello, J., Machado, D., Liu, X., Gonzaga, J., Tirughana, R., Hammad, M., Lesniak, M. S., Curiel, D. T. & Aboody, K. S., Mar 29 2019, In : Molecular Therapy - Oncolytics. 12, p. 79-92 14 p.Research output: Contribution to journal › Article
Neural Stem Cells
Adenoviridae
Ovarian Neoplasms
Cisplatin
Neoplasms
1
Citation
(Scopus)
HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
Miska, J. M., Lee Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. & Lesniak, M. S., Apr 2 2019, In : Cell reports. 27, 1, p. 226-237.e4Research output: Contribution to journal › Article
Open Access
Hypoxia-Inducible Factor 1
Oxidative Phosphorylation
Glioblastoma
Immunosuppression
Switches
2
Citations
(Scopus)
Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod
Lukas, R. V., Juhász, C., Wainwright, D. A., James, C. D., Kennedy, E., Stupp, R. & Lesniak, M. S., Jan 15 2019, In : Journal of Neuro-Oncology. 141, 1, p. 111-120 10 p.Research output: Contribution to journal › Article
Indoleamine-Pyrrole 2,3,-Dioxygenase
Glioblastoma
Tryptophan
Positron-Emission Tomography
temozolomide