Maciej S Lesniak

  • 9141 Citations
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Personal profile

Research Interests

My clinical and research interests focus on neurosurgical management of patients with brain and spinal cord tumors. I take care of patients with both benign as well as malignant cancer of the brain/spinal cord. In addition, part of my practice is devoted to the care of neurovascular patients, including aneurysms and arteriovenous malformations.

Training Experience

1997Internship, Johns Hopkins Hospital
2002Fellowship, Johns Hopkins Hospital
2002Residency, Johns Hopkins Hospital

Education/Academic qualification

MS, Harvard University

… → 2010

MD, Johns Hopkins University

… → 1996


  • Acoustic Neuroma
  • Biologic Therapies
  • Brain Aneurysm
  • Brain Arteriovenous Malformation
  • Brain Cancer / Nervous System Cancer
  • Neuro-Oncology
  • Neurosurgery
  • Skull Base Surgery

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Therapeutics Medicine & Life Sciences
Oncolytic Virotherapy Medicine & Life Sciences

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Grants 2011 2023

Antigen Receptors
Cell- and Tissue-Based Therapy
T-Cell Antigen Receptor
Brain Neoplasms
Clinical Trials, Phase I
Blood-Brain Barrier
Brain Neoplasms
Brain Neoplasms

Research Output 1999 2019

Cathepsin B: A sellsword of cancer progression

Mijanović, O., Branković, A., Panin, A. N., Savchuk, S., Timashev, P., Ulasov, I. & Lesniak, M. S., May 1 2019, In : Cancer Letters. 449, p. 207-214 8 p.

Research output: Contribution to journalShort survey

Cathepsin B
Peptide Hydrolases
Neoplasm Metastasis

Correlation of post-contrast T1-weighted MRI surface regularity, tumor bulk, and necrotic volume with Ki67 and p53 in glioblastomas

Hasse, A., Dapash, M., Jeong, Y., Ansari, S. A., Carroll, T. J., Lesniak, M. S. & Ginat, D. T., Jan 1 2019, In : Neuroradiology.

Research output: Contribution to journalReview article

Area Under Curve
ROC Curve

Enhanced Delivery of Oncolytic Adenovirus by Neural Stem Cells for Treatment of Metastatic Ovarian Cancer

Mooney, R., Majid, A. A., Batalla-Covello, J., Machado, D., Liu, X., Gonzaga, J., Tirughana, R., Hammad, M., Lesniak, M. S., Curiel, D. T. & Aboody, K. S., Mar 29 2019, In : Molecular Therapy - Oncolytics. 12, p. 79-92 14 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Ovarian Neoplasms
1 Citation (Scopus)

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

Miska, J. M., Lee Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. & Lesniak, M. S., Apr 2 2019, In : Cell reports. 27, 1, p. 226-237.e4

Research output: Contribution to journalArticle

Open Access
Hypoxia-Inducible Factor 1
Oxidative Phosphorylation
2 Citations (Scopus)

Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod

Lukas, R. V., Juhász, C., Wainwright, D. A., James, C. D., Kennedy, E., Stupp, R. & Lesniak, M. S., Jan 15 2019, In : Journal of Neuro-Oncology. 141, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Positron-Emission Tomography