Grants per year
Personal profile
Research Interests
This is an exciting time to be studying organismal development. In spite of the progress in molecular biology built up over the last 3 decades, we are still searching for the mechanisms that couple the chemical and physical forms of organism. A misshaped hand, even with the right proportions of different cell types, wouldn't be of much use in gripping a cup of coffee. What are the collective cellular and tissue level mechanisms that generate the complex multicellular patterns of cellular differentiation and morphology in organisms? Recent advance in live fluorescent imaging provide us with a dynamic and spatially resolved view of organismal development, and what is needed now is the development of mathematical tools and models that can help ushering in a new, and physical, understanding of organismal biology.
In close collaboration with experimental labs around the world, my group develops quantitative image-analysis tools and mathematical models that guide the construction of inverse modeling schemes to make new and better measurements of live imaging data. When required, forward mathematical models are constructed to make sense of emergent phenomena, and more importantly, to generate predictions and hypotheses that guide future experimentation.
Education/Academic qualification
Applied Mathematics, PhD, Harvard University
2007 → 2010
Engineering Sciences, SM, Harvard University
2006 → 2007
Mathematics and Theoretical Physics (Part 3), Masters of Advanced Studies, University of Cambridge
2005 → 2006
Mathematics and Theoretical Physics, MA, University of Cambridge
2004 → 2005
Mathematics and Theoretical Physics, BA, University of Cambridge
2002 → 2005
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Grants
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Reconstructing positional information in the eye from scRNA-seq and relating it to signal transduction
Kennedy Institute - National Eye Clinic
1/1/21 → 12/31/22
Project: Research project
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Northwestern University Quantitative Biology Center (NUQuB)
Allada, R., Allada, R., Amaral, L. A. N., Amaral, L. A. N., Andersen, E. C., Andersen, E. C., Auffinger, A. C., Bagheri, N., Braun, R. I., Carthew, R. W., Kath, W. L., LaBonne, C., Mangan, N. M., Mani, M., Wang, J. & Wang, X.
7/1/18 → 6/30/23
Project: Research project
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Northwestern University Quantitative Biology Center (NUQuB)
Allada, R., Amaral, L. A. N., Andersen, E. C., Auffinger, A. C., Bagheri, N., Braun, R. I., Carthew, R. W., Goldberg, B. B., Kath, W. L., LaBonne, C., Mangan, N. M., Mani, M., Wang, J. & Wang, X.
7/1/18 → 6/30/23
Project: Research project
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RTG: Interdisciplinary Training in Quantitative Biological Modeling
Abrams, D. M., Kath, W. L., Mangan, N. M., Mani, M., Riecke, H. E., Abrams, D. M., Allada, R., Braun, R. I., Carthew, R. W., Dombeck, D. A., Luijten, E., Mani, M., Packman, A., Riecke, H. E., Schwab, D. J. & Silber, M. C.
9/1/16 → 8/31/21
Project: Research project
Research Output
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Evolution of Generalists by Phenotypic Plasticity
Fraebel, D. T., Gowda, K., Mani, M. & Kuehn, S., Nov 20 2020, In: iScience. 23, 11, 101678.Research output: Contribution to journal › Article › peer-review
Open Access -
Ordered patterning of the sensory system is susceptible to stochastic features of gene expression
Giri, R., Papadopoulos, D. K., Posadas, D. M., Potluri, H. K., Tomancak, P., Mani, M. & Carthew, R. W., Feb 2020, In: eLife. 9, e53638.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
The WG and DPP morphogens regulate gene expression by modulating the frequency of transcriptional bursts
Bakker, R., Mani, M. & Carthew, R. W., Jun 2020, In: eLife. 9, p. 1-26 26 p., e56076.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
A Jump-Distance-Based Parameter Inference Scheme for Particulate Trajectories
Menssen, R. & Mani, M., Jul 9 2019, In: Biophysical Journal. 117, 1, p. 143-156 14 p.Research output: Contribution to journal › Article › peer-review
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Erratum: A Jump-Distance-Based Parameter Inference Scheme for Particulate Trajectories (Biophysical Journal (2019) 117(1) (143–156), (S0006349519304503), (10.1016/j.bpj.2019.06.004))
Menssen, R. & Mani, M., Aug 6 2019, In: Biophysical Journal. 117, 3, 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access