If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

This is an exciting time to be studying organismal development. In spite of the progress in molecular biology built up over the last 3 decades, we are still searching for the mechanisms that couple the chemical and physical forms of organism. A misshaped hand, even with the right proportions of different cell types, wouldn't be of much use in gripping a cup of coffee. What are the collective cellular and tissue level mechanisms that generate the complex multicellular patterns of cellular differentiation and morphology in organisms? Recent advance in live fluorescent imaging provide us with a dynamic and spatially resolved view of organismal development, and what is needed now is the development of mathematical tools and models that can help ushering in a new, and physical, understanding of organismal biology.

In close collaboration with experimental labs around the world, my group develops quantitative image-analysis tools and mathematical models that guide the construction of inverse modeling schemes to make new and better measurements of live imaging data. When required, forward mathematical models are constructed to make sense of emergent phenomena, and more importantly, to generate predictions and hypotheses that guide future experimentation.

Education/Academic qualification

Applied Mathematics, PhD, Harvard University

20072010

Engineering Sciences, SM, Harvard University

20062007

Mathematics and Theoretical Physics (Part 3), Masters of Advanced Studies, University of Cambridge

20052006

Mathematics and Theoretical Physics, MA, University of Cambridge

20042005

Mathematics and Theoretical Physics, BA, University of Cambridge

20022005

Fingerprint Dive into the research topics where Madhav Mani is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

splashing Physics & Astronomy
Cadherins Medicine & Life Sciences
solid surfaces Physics & Astronomy
liquids Physics & Astronomy
impact velocity Physics & Astronomy
Morphogenesis Medicine & Life Sciences
Fats Medicine & Life Sciences
Drosophila Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2016 2023

Environmental engineering
Biomedical engineering
Mechanical engineering
Civil engineering
Numerical methods
biophysics
furrows
eyes
ommatidia
image analysis

Research Output 2009 2019

  • 631 Citations
  • 15 Article
  • 1 Comment/debate

A Jump-Distance-Based Parameter Inference Scheme for Particulate Trajectories

Menssen, R. & Mani, M., Jul 9 2019, In : Biophysical Journal. 117, 1, p. 143-156 14 p.

Research output: Contribution to journalArticle

Aptitude
Chemotaxis
Bacteria
1 Citation (Scopus)

QuBiT: A quantitative tool for analyzing epithelial tubes reveals unexpected patterns of organization in the Drosophila trachea

Yang, R., Li, E., Kwon, Y. J., Mani, M. & Beitel, G. J., Jun 1 2019, In : Development (Cambridge). 146, 12, dev172759.

Research output: Contribution to journalArticle

Open Access
Trachea
Drosophila
Morphogenesis
Cell Shape
Periodicity

A scheme for 3-dimensional morphological reconstruction and force inference in the early c. Elegans embryo

Xu, M., Wu, Y., Shroff, H., Wu, M. & Mani, M., Jul 1 2018, In : PloS one. 13, 7, e0199151.

Research output: Contribution to journalArticle

Embryonic Structures
Membranes
reproducibility
Image analysis
Sensitivity analysis
5 Citations (Scopus)

Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis

Kale, G. R., Yang, X., Philippe, J. M., Mani, M., Lenne, P. F. & Lecuit, T., Dec 1 2018, In : Nature communications. 9, 1, 5021.

Research output: Contribution to journalArticle

Cadherins
tensile stress
Morphogenesis
Tensile stress
shear stress