Manu Jain

  • 3494 Citations
1992 …2020

Research output per year

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Personal profile

Research Interests

My primary research interest is in lung repair after acute injury with a focus on TGF-beta mediated signaling. We have identified mitochondrial generated reactive oxygen species as important in TGF-bête mediated gene expression and are working to identify novel therapeutic targets in this pathway. We are also interested in modulating the ubiquitin-proteosomal pathway as a therapeutic target for tissue fibrosis. I have a clinical translational interest in Cystic Fibrosis. I am the site co-PI for the CF Foundation sponsored clinical trial network, The Therapeutic Development Network. I am also interested in the CF outcomes, especially related to chronic infection with Pseudomonas aeruginosa.

Certifications and Licenses

Pulmonary Disease
Internal Medicine
Critical Care Medicine

Training Experience

1990Internship, University of Chicago Pritzker School of Medicine
1992Residency, Univ. of Chicago Hospital
1996Fellowship, University of Chicago

Education/Academic qualification

MD, The University of Chicago

… → 1989

Research interests

  • Critical Care
  • Cystic Fibrosis
  • Fibrosis
  • Lungs / Breathing Problems
  • TGF-beta

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Research Output

A Call for Rational Intensive Care in the Era of COVID-19

Singer, B. D., Jain, M., Budinger, G. R. S. & Wunderink, R. G., Jul 1 2020, In : American journal of respiratory cell and molecular biology. 63, 1, p. 132-133 2 p.

Research output: Contribution to journalLetter

Open Access
3 Scopus citations

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

Joshi, N., Watanabe, S., Verma, R., Jablonski, R. P., Chen, C. I., Cheresh, P., Markov, N. S., Reyfman, P. A., McQuattie-Pimentel, A. C., Sichizya, L., Lu, Z., Piseaux-Aillon, R., Kirchenbuechler, D., Flozak, A. S., Gottardi, C. J., Cuda, C. M., Perlman, H., Jain, M., Kamp, D. W., Budinger, G. R. S. & 1 others, Misharin, A. V., Jan 1 2020, In : The European respiratory journal. 55, 1

Research output: Contribution to journalArticle

Open Access
  • 4 Scopus citations

    Clinical pharmacokinetics of ceftolozane and tazobactam in an obese patient receiving continuous venovenous haemodiafiltration: A patient case and literature review

    Mahmoud, A., Shah, A., Nutley, K., Nicolau, D. P., Sutherland, C., Jain, M., Scheetz, M. H. & Rhodes, N. J., Jun 2020, In : Journal of Global Antimicrobial Resistance. 21, p. 83-85 3 p.

    Research output: Contribution to journalLetter

    Open Access
    1 Scopus citations
    Open Access

    Exploring the Relationship between FEV1 Loss and Recovery and Aminoglycoside Pharmacokinetics in Adult Patients with Cystic Fibrosis: Implications for Clinical Dosing Strategies

    Hoff, B. M., Scheetz, M. H., Jain, M., Cullina, J. F. & Rhodes, N. J., Jun 1 2020, In : Pharmacotherapy. 40, 6, p. 584-591 8 p.

    Research output: Contribution to journalArticle