Grants per year
Personal profile
Research Interests
My primary research interest is in lung repair after acute injury with a focus on TGF-beta mediated signaling. We have identified mitochondrial generated reactive oxygen species as important in TGF-bête mediated gene expression and are working to identify novel therapeutic targets in this pathway. We are also interested in modulating the ubiquitin-proteosomal pathway as a therapeutic target for tissue fibrosis. I have a clinical translational interest in Cystic Fibrosis. I am the site co-PI for the CF Foundation sponsored clinical trial network, The Therapeutic Development Network. I am also interested in the CF outcomes, especially related to chronic infection with Pseudomonas aeruginosa.
Certifications and Licenses
| Pulmonary Disease | |
| Internal Medicine | |
| Critical Care Medicine |
Training Experience
| 1990 | Internship, University of Chicago Pritzker School of Medicine |
| 1992 | Residency, Univ. of Chicago Hospital |
| 1996 | Fellowship, University of Chicago |
Education/Academic qualification
Medicine, MD, University of Chicago
… → 1989
Research interests keywords
- Critical Care
- Cystic Fibrosis
- Fibrosis
- Lungs / Breathing Problems
- TGF-beta
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Health Outcomes of Parents with Cystic Fibrosis (HOPe:CF)
Jain, M. (PD/PI)
University of Pittsburgh, Cystic Fibrosis Foundation
2/1/24 → 1/31/25
Project: Research project
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Prot #VX21‐522‐001: A Phase 1 Single Dose Escalation Study Evaluating the Safety and Tolerability of VX‐522 in Subjects 18 Years of Age and Older With Cystic Fibrosis and a CFTR Genotype Not Responsive to CFTR Modulator Therapy
Jain, M. (PD/PI)
Vertex Pharmaceuticals Incorporated
10/31/23 → 10/31/26
Project: Research project
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Characterization of the progression of CF-related airway disease via longitudinal transcriptomic analysis of nasal epithelium from children with CF
Jain, M. (Other)
7/1/23 → 6/30/25
Project: Research project
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Prot #VX20-121-104: A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis
Jain, M. (PD/PI)
Vertex Pharmaceuticals Incorporated
3/28/23 → 3/28/26
Project: Research project
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Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
The NU SCRIPT Study Investigators, 2024, (Accepted/In press) In: Nature Immunology. 25, 9, p. 1607-1622 16 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
ECFS standards of care on CFTR-related disorders: Towards a comprehensive program for affected individuals
ECFS Diagnostic Network Working Group, May 2024, In: Journal of Cystic Fibrosis. 23, 3, p. 388-397 10 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19
Bailey, J. I., Puritz, C. H., Senkow, K. J., Markov, N. S., Diaz, E., Jonasson, E., Yu, Z., Swaminathan, S., Lu, Z., Fenske, S., Grant, R. A., Abdala-Valencia, H., Mylvaganam, R. J., Ludwig, A., Miller, J., Cumming, R. I., Tighe, R. M., Gowdy, K. M., Kalhan, R. & Jain, M. & 12 others, , Nov 2024, In: Nature Immunology. 25, 11, p. 2097-2109 13 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Real-world effectiveness of elexacaftor/tezacaftor/ivacaftor on the burden of illness in adolescents and adults with cystic fibrosis
for the VX19-CFD-003 Study Group, Apr 15 2024, In: Heliyon. 10, 7, e28508.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Advancing the pipeline of cystic fibrosis clinical trials: a new roadmap with a global trial network perspective
Mayer-Hamblett, N., Clancy, J. P., Jain, R., Donaldson, S. H., Fajac, I., Goss, C. H., Polineni, D., Ratjen, F., Quon, B. S., Zemanick, E. T., Bell, S. C., Davies, J. C., Jain, M., Konstan, M. W., Kerper, N. R., LaRosa, T., Mall, M. A., McKone, E., Pearson, K. & Pilewski, J. M. & 6 others, , Oct 2023, In: The Lancet Respiratory Medicine. 11, 10, p. 932-944 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access22 Scopus citations
Datasets
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Additional file 2: of Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A. (Creator), Balderas-Martínez, Y. I. (Contributor), Buendía-Roldan, I. (Contributor), Abdala-Valencia, H. (Creator), Nam, K. (Contributor), Jain, M. (Creator), Bhorade, S. (Creator), Bharat, A. (Creator), Reyfman, P. A. (Creator), Ridge, K. M. (Creator), Pardo, A. (Creator), Sznajder, J. I. (Creator), Budinger, G. R. S. (Contributor), Misharin, A. V. (Creator) & Selman, M. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7386341, https://springernature.figshare.com/articles/Additional_file_2_of_Inflammatory_pathways_are_upregulated_in_the_nasal_epithelium_in_patients_with_idiopathic_pulmonary_fibrosis/7386341
Dataset
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Additional file 1: of Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A. (Creator), Balderas-Martínez, Y. I. (Contributor), Buendía-Roldan, I. (Contributor), Abdala-Valencia, H. (Creator), Nam, K. (Contributor), Jain, M. (Creator), Bhorade, S. (Creator), Bharat, A. (Creator), Reyfman, P. A. (Creator), Ridge, K. M. (Creator), Pardo, A. (Creator), Sznajder, J. I. (Creator), Budinger, G. R. S. (Contributor), Misharin, A. V. (Creator) & Selman, M. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7386323, https://springernature.figshare.com/articles/Additional_file_1_of_Inflammatory_pathways_are_upregulated_in_the_nasal_epithelium_in_patients_with_idiopathic_pulmonary_fibrosis/7386323
Dataset
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Additional file 9: of Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A. (Creator), Balderas-Martínez, Y. I. (Contributor), Buendía-Roldan, I. (Contributor), Abdala-Valencia, H. (Creator), Nam, K. (Contributor), Jain, M. (Creator), Bhorade, S. (Creator), Bharat, A. (Creator), Reyfman, P. A. (Creator), Ridge, K. M. (Creator), Pardo, A. (Creator), Sznajder, J. I. (Creator), Budinger, G. R. S. (Contributor), Misharin, A. V. (Creator) & Selman, M. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7386458, https://springernature.figshare.com/articles/Additional_file_9_of_Inflammatory_pathways_are_upregulated_in_the_nasal_epithelium_in_patients_with_idiopathic_pulmonary_fibrosis/7386458
Dataset
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Additional file 8: of Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A. (Creator), Balderas-Martínez, Y. I. (Contributor), Buendía-Roldan, I. (Contributor), Abdala-Valencia, H. (Creator), Nam, K. (Contributor), Jain, M. (Creator), Bhorade, S. (Creator), Bharat, A. (Creator), Reyfman, P. A. (Creator), Ridge, K. M. (Creator), Pardo, A. (Creator), Sznajder, J. I. (Creator), Budinger, G. R. S. (Contributor), Misharin, A. V. (Creator) & Selman, M. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7386437, https://springernature.figshare.com/articles/Additional_file_8_of_Inflammatory_pathways_are_upregulated_in_the_nasal_epithelium_in_patients_with_idiopathic_pulmonary_fibrosis/7386437
Dataset
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Additional file 6: of Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A. (Creator), Balderas-Martínez, Y. I. (Contributor), Buendía-Roldan, I. (Contributor), Abdala-Valencia, H. (Creator), Nam, K. (Contributor), Jain, M. (Creator), Bhorade, S. (Creator), Bharat, A. (Creator), Reyfman, P. A. (Creator), Ridge, K. M. (Creator), Pardo, A. (Creator), Sznajder, J. I. (Creator), Budinger, G. R. S. (Contributor), Misharin, A. V. (Creator) & Selman, M. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.7386401, https://springernature.figshare.com/articles/Additional_file_6_of_Inflammatory_pathways_are_upregulated_in_the_nasal_epithelium_in_patients_with_idiopathic_pulmonary_fibrosis/7386401
Dataset