Grants per year
Personal profile
Research Interests
My primary research interest is in lung repair after acute injury with a focus on TGF-beta mediated signaling. We have identified mitochondrial generated reactive oxygen species as important in TGF-bête mediated gene expression and are working to identify novel therapeutic targets in this pathway. We are also interested in modulating the ubiquitin-proteosomal pathway as a therapeutic target for tissue fibrosis. I have a clinical translational interest in Cystic Fibrosis. I am the site co-PI for the CF Foundation sponsored clinical trial network, The Therapeutic Development Network. I am also interested in the CF outcomes, especially related to chronic infection with Pseudomonas aeruginosa.
Certifications and Licenses
| Pulmonary Disease | |
| Internal Medicine | |
| Critical Care Medicine |
Training Experience
| 1990 | Internship, University of Chicago Pritzker School of Medicine |
| 1992 | Residency, Univ. of Chicago Hospital |
| 1996 | Fellowship, University of Chicago |
Education/Academic qualification
MD, University of Chicago
… → 1989
Research interests
- Critical Care
- Cystic Fibrosis
- Fibrosis
- Lungs / Breathing Problems
- TGF-beta
Fingerprint Dive into the research topics where Manu Jain is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 23 Similar Profiles
Cystic Fibrosis
Medicine & Life Sciences
Lung
Medicine & Life Sciences
Adult Respiratory Distress Syndrome
Medicine & Life Sciences
Acute Lung Injury
Medicine & Life Sciences
Pulmonary Fibrosis
Medicine & Life Sciences
Fibrosis
Medicine & Life Sciences
Transforming Growth Factors
Medicine & Life Sciences
Pseudomonas aeruginosa
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2002 2021
Cystic Fibrosis Lung Transplant Transition - Regional Dissemination Network
Dartmouth College, Cystic Fibrosis Foundation
1/1/19 → 12/31/19
Project: Research project
Advisory Committees
Clinical Protocols
Clinical Trials
Prot #MRT5005-101: A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Combined Single and Multiple Ascending Dose Study Evaluating the Safety, Tolerability, and Biological Activity of MRT5005 (CO-hCFTR mRNA/ICE LNP) Administered by Nebulization to
Rho, Inc., Translate Bio, Inc.
12/7/18 → 12/7/21
Project: Research project
Multicenter study of patient-reported gastrointestinal symptoms in people with Cystic Fibrosis (GALAXY)
Seattle Children's, Cystic Fibrosis Foundation
12/1/18 → 11/30/19
Project: Research project
Prot #PTI-428-06: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect of PTI-428 in Subjects with Cystic Fibrosis
MS Clinical Services, LLC, Proteostasis Therapeutics, Inc.
10/29/18 → 10/29/21
Project: Research project
Research Output 1992 2019
Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))
Soberanes, S., Misharin, A., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, , Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.Research output: Contribution to journal › Comment/debate
Metformin
Air Pollution
Electron Transport
Names
Publications
15
Citations
(Scopus)
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, , Jun 15 2019, In : American journal of respiratory and critical care medicine. 199, 12, p. 1517-1536 20 p.Research output: Contribution to journal › Article
Open Access
Single-Cell Analysis
Pulmonary Fibrosis
Lung
RNA Sequence Analysis
Alveolar Macrophages
5
Citations
(Scopus)
Association of body mass index with lung transplantation survival in the United States following implementation of the lung allocation score
Fernandez, R., Safaeinili, N., Kurihara, C., Odell, D. D., Jain, M., DeCamp Jr, M. M., Budinger, GR. S. & Bharat, A., Apr 1 2018, In : Journal of Thoracic and Cardiovascular Surgery. 155, 4, p. 1871-1879.e3Research output: Contribution to journal › Article
Lung Transplantation
Body Mass Index
Lung
Survival
Mortality
Bortezomib is safe in and stabilizes pulmonary function in patients with allo-HSCT-associated pulmonary CGVHD
Jain, M., Budinger, GRS., Jovanovic, B., Dematte, J., Duffey, S. & Mehta, J., Sep 1 2018, In : Bone Marrow Transplantation. 53, 9, p. 1124-1130 7 p.Research output: Contribution to journal › Article
Graft vs Host Disease
Lung
Safety
Multiple Myeloma
Bortezomib
Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
Sala, M. A., Balderas-Martínez, Y. I., Buendía-Roldan, I., Abdala-Valencia, H., Nam, K., Jain, M., Bhorade, S. M., Bharat, A., Reyfman, P. A., Ridge, K. M., Pardo, A., Sznajder, J. I., Budinger, GR. S., Misharin, A. & Selman, M., Nov 26 2018, In : Respiratory Research. 19, 1, 233.Research output: Contribution to journal › Article
Idiopathic Pulmonary Fibrosis
Nasal Mucosa
Nose
Up-Regulation
RNA Sequence Analysis