Manu Jain

Personal profile

Research Interests

My primary research interest is in lung repair after acute injury with a focus on TGF-beta mediated signaling. We have identified mitochondrial generated reactive oxygen species as important in TGF-bête mediated gene expression and are working to identify novel therapeutic targets in this pathway. We are also interested in modulating the ubiquitin-proteosomal pathway as a therapeutic target for tissue fibrosis. I have a clinical translational interest in Cystic Fibrosis. I am the site co-PI for the CF Foundation sponsored clinical trial network, The Therapeutic Development Network. I am also interested in the CF outcomes, especially related to chronic infection with Pseudomonas aeruginosa.

Certifications and Licenses

	Pulmonary Disease
	Internal Medicine
	Critical Care Medicine

Training Experience

1990	Internship, University of Chicago Pritzker School of Medicine
1992	Residency, Univ. of Chicago Hospital
1996	Fellowship, University of Chicago

Education/Academic qualification

MD, University of Chicago

… → 1989

Research interests

Critical Care
Cystic Fibrosis
Fibrosis
Lungs / Breathing Problems
TGF-beta

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26 Similar Profiles

Cystic Fibrosis Medicine & Life Sciences

Lung Medicine & Life Sciences

Adult Respiratory Distress Syndrome Medicine & Life Sciences

Acute Lung Injury Medicine & Life Sciences

Fibrosis Medicine & Life Sciences

Pulmonary Fibrosis Medicine & Life Sciences

Transforming Growth Factors Medicine & Life Sciences

Pseudomonas aeruginosa Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2002 2021

17 Active
61 Finished

Assessing the Transcriptional Response to Triple CFTR modulator Treatment of the Nasal Epithelium

Jain, M.

Cystic Fibrosis Foundation

1/1/20 → 12/31/21

Project: Research project

TDN Protocol Review Committee Chair

Jain, M.

Cystic Fibrosis Foundation

1/1/19 → 12/31/20

Project: Research project

Advisory Committees

Clinical Protocols

Clinical Trials

Prot #MRT5005-101: A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Combined Single and Multiple Ascending Dose Study Evaluating the Safety, Tolerability, and Biological Activity of MRT5005 (CO-hCFTR mRNA/ICE LNP) Administered by Nebulization to

Jain, M.

Rho, Inc., Translate Bio, Inc.

12/7/18 → 12/7/21

Project: Research project

Prot #PTI-428-06: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect of PTI-428 in Subjects with Cystic Fibrosis

Jain, M.

MS Clinical Services, LLC, Proteostasis Therapeutics, Inc.

10/29/18 → 10/29/21

Project: Research project

Prot #PTI-808-01: A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of PTI-808 in Healthy Adult Subjects and in Adults with Cystic Fibrosis

Jain, M.

Chiltern International, Inc., Proteostasis Therapeutics, Inc.

8/2/18 → 8/2/21

Project: Research project

Research Output 1992 2019

3123 Citations
51 Article
16 Review article
10 Letter
5 Editorial
4 More
- 3 Comment/debate
- 1 Chapter

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

Research output: Contribution to journal › Comment/debate

Metformin

Air Pollution

Electron Transport

Names

Publications

28 Citations (Scopus)

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journal › Article

Open Access

Single-Cell Analysis

Pulmonary Fibrosis

Lung

RNA Sequence Analysis

Alveolar Macrophages

6 Citations (Scopus)