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Manu Jain

  • 3331 Citations
1992 …2021

Research output per year

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Personal profile

Research Interests

My primary research interest is in lung repair after acute injury with a focus on TGF-beta mediated signaling. We have identified mitochondrial generated reactive oxygen species as important in TGF-bête mediated gene expression and are working to identify novel therapeutic targets in this pathway. We are also interested in modulating the ubiquitin-proteosomal pathway as a therapeutic target for tissue fibrosis. I have a clinical translational interest in Cystic Fibrosis. I am the site co-PI for the CF Foundation sponsored clinical trial network, The Therapeutic Development Network. I am also interested in the CF outcomes, especially related to chronic infection with Pseudomonas aeruginosa.

Certifications and Licenses

Pulmonary Disease
Internal Medicine
Critical Care Medicine

Training Experience

1990Internship, University of Chicago Pritzker School of Medicine
1992Residency, Univ. of Chicago Hospital
1996Fellowship, University of Chicago

Education/Academic qualification

MD, The University of Chicago

… → 1989

Research interests

  • Critical Care
  • Cystic Fibrosis
  • Fibrosis
  • Lungs / Breathing Problems
  • TGF-beta

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Grants

Assessing the Transcriptional Response to Triple CFTR modulator Treatment of the Nasal Epithelium

Jain, M.

Cystic Fibrosis Foundation

1/1/20 → 12/31/21

Project: Research project

TDN Protocol Review Committee Chair

Jain, M.

Cystic Fibrosis Foundation

1/1/19 → 12/31/20

Project: Research project

    • Cystic Fibrosis Lung Transplant Transition - Regional Dissemination Network

    Jain, M.

    Dartmouth College, Cystic Fibrosis Foundation

    1/1/19 → 5/31/20

    Project: Research project

    Prot #MRT5005-101: A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Combined Single and Multiple Ascending Dose Study Evaluating the Safety, Tolerability, and Biological Activity of MRT5005 (CO-hCFTR mRNA/ICE LNP) Administered by Nebulization to

    Jain, M.

    Rho, Inc., Translate Bio, Inc.

    12/7/18 → 12/7/21

    Project: Research project

    Prot #PTI-428-06: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect of PTI-428 in Subjects with Cystic Fibrosis

    Jain, M.

    MS Clinical Services, LLC, Proteostasis Therapeutics, Inc.

    10/29/18 → 10/29/21

    Project: Research project

    Research Output

    A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

    Joshi, N., Watanabe, S., Verma, R., Jablonski, R. P., Chen, C. I., Cheresh, P., Markov, N. S., Reyfman, P. A., McQuattie-Pimentel, A. C., Sichizya, L., Lu, Z., Piseaux-Aillon, R., Kirchenbuechler, D., Flozak, A. S., Gottardi, C. J., Cuda, C. M., Perlman, H., Jain, M., Kamp, D. W., Budinger, G. R. S. & 1 others, Misharin, A. V., Jan 1 2020, In : The European respiratory journal. 55, 1

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    Females with Cystic Fibrosis Demonstrate a Differential Response Profile to Ivacaftor Compared with Males

    Secunda, K. E., Guimbellot, J. S., Jovanovic, B., Heltshe, S. L., Sagel, S. D., Rowe, S. M. & Jain, M., Apr 15 2020, In : American journal of respiratory and critical care medicine. 201, 8, p. 996-998 3 p.

    Research output: Contribution to journal › Letter

    Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial

    VX17-445-103 Trial Group, Nov 23 2019, In : The Lancet. 394, 10212, p. 1940-1948 9 p.

    Research output: Contribution to journal › Article

    • 32 Scopus citations

    Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

    Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

    Research output: Contribution to journal › Comment/debate

    • 2 Scopus citations

    Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

    Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

    Research output: Contribution to journal › Article

    Open Access
    • 65 Scopus citations