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Manu Jain

  • 3494 Citations
1992 …2020

Research output per year

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Personal profile

Research Interests

My primary research interest is in lung repair after acute injury with a focus on TGF-beta mediated signaling. We have identified mitochondrial generated reactive oxygen species as important in TGF-bête mediated gene expression and are working to identify novel therapeutic targets in this pathway. We are also interested in modulating the ubiquitin-proteosomal pathway as a therapeutic target for tissue fibrosis. I have a clinical translational interest in Cystic Fibrosis. I am the site co-PI for the CF Foundation sponsored clinical trial network, The Therapeutic Development Network. I am also interested in the CF outcomes, especially related to chronic infection with Pseudomonas aeruginosa.

Certifications and Licenses

Pulmonary Disease
Internal Medicine
Critical Care Medicine

Training Experience

1990Internship, University of Chicago Pritzker School of Medicine
1992Residency, Univ. of Chicago Hospital
1996Fellowship, University of Chicago

Education/Academic qualification

MD, The University of Chicago

… → 1989

Research interests

  • Critical Care
  • Cystic Fibrosis
  • Fibrosis
  • Lungs / Breathing Problems
  • TGF-beta

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Grants

Assessing the Transcriptional Response to Triple CFTR modulator Treatment of the Nasal Epithelium

Jain, M.

Cystic Fibrosis Foundation

1/1/20 → 12/31/21

Project: Research project

TDN Protocol Review Committee Chair

Jain, M.

Cystic Fibrosis Foundation

1/1/19 → 12/31/20

Project: Research project

    • Prot #MRT5005-101: A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Combined Single and Multiple Ascending Dose Study Evaluating the Safety, Tolerability, and Biological Activity of MRT5005 (CO-hCFTR mRNA/ICE LNP) Administered by Nebulization to

    Jain, M.

    Rho, Inc., Translate Bio, Inc.

    12/7/18 → 12/7/21

    Project: Research project

    Prot #PTI-428-06: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect of PTI-428 in Subjects with Cystic Fibrosis

    Jain, M.

    MS Clinical Services, LLC, Proteostasis Therapeutics, Inc.

    10/29/18 → 10/29/21

    Project: Research project

    Sexual and Reproductive Health in Adult Women with Cystic Fibrosis

    Jain, M.

    University of Pittsburgh, Cystic Fibrosis Foundation

    10/1/18 → 9/30/20

    Project: Research project

    Research Output

    A Call for Rational Intensive Care in the Era of COVID-19

    Singer, B. D., Jain, M., Budinger, G. R. S. & Wunderink, R. G., Jul 1 2020, In : American journal of respiratory cell and molecular biology. 63, 1, p. 132-133 2 p.

    Research output: Contribution to journal › Letter

    Open Access
    3 Scopus citations

    A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

    Joshi, N., Watanabe, S., Verma, R., Jablonski, R. P., Chen, C. I., Cheresh, P., Markov, N. S., Reyfman, P. A., McQuattie-Pimentel, A. C., Sichizya, L., Lu, Z., Piseaux-Aillon, R., Kirchenbuechler, D., Flozak, A. S., Gottardi, C. J., Cuda, C. M., Perlman, H., Jain, M., Kamp, D. W., Budinger, G. R. S. & 1 others, Misharin, A. V., Jan 1 2020, In : The European respiratory journal. 55, 1

    Research output: Contribution to journal › Article

    Open Access
    • 4 Scopus citations

    Clinical pharmacokinetics of ceftolozane and tazobactam in an obese patient receiving continuous venovenous haemodiafiltration: A patient case and literature review

    Mahmoud, A., Shah, A., Nutley, K., Nicolau, D. P., Sutherland, C., Jain, M., Scheetz, M. H. & Rhodes, N. J., Jun 2020, In : Journal of Global Antimicrobial Resistance. 21, p. 83-85 3 p.

    Research output: Contribution to journal › Letter

    Open Access
    1 Scopus citations

    Combination therapy with lumacaftor–ivacaftor in cystic fibrosis keeping it real

    Sala, M. A. & Jain, M., Jan 15 2020, In : American journal of respiratory and critical care medicine. 201, 2, p. 133-134 2 p.

    Research output: Contribution to journal › Editorial

    Open Access

    Exploring the Relationship between FEV1 Loss and Recovery and Aminoglycoside Pharmacokinetics in Adult Patients with Cystic Fibrosis: Implications for Clinical Dosing Strategies

    Hoff, B. M., Scheetz, M. H., Jain, M., Cullina, J. F. & Rhodes, N. J., Jun 1 2020, In : Pharmacotherapy. 40, 6, p. 584-591 8 p.

    Research output: Contribution to journal › Article