Manu Jain

  • 2984 Citations
1992 …2021
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Personal profile

Research Interests

My primary research interest is in lung repair after acute injury with a focus on TGF-beta mediated signaling. We have identified mitochondrial generated reactive oxygen species as important in TGF-bête mediated gene expression and are working to identify novel therapeutic targets in this pathway. We are also interested in modulating the ubiquitin-proteosomal pathway as a therapeutic target for tissue fibrosis. I have a clinical translational interest in Cystic Fibrosis. I am the site co-PI for the CF Foundation sponsored clinical trial network, The Therapeutic Development Network. I am also interested in the CF outcomes, especially related to chronic infection with Pseudomonas aeruginosa.

Certifications and Licenses

Pulmonary Disease
Internal Medicine
Critical Care Medicine

Training Experience

1990Internship, University of Chicago Pritzker School of Medicine
1992Residency, Univ. of Chicago Hospital
1996Fellowship, University of Chicago

Education/Academic qualification

MD, University of Chicago

… → 1989

Research interests

  • Critical Care
  • Cystic Fibrosis
  • Fibrosis
  • Lungs / Breathing Problems
  • TGF-beta

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  • 23 Similar Profiles
Cystic Fibrosis Medicine & Life Sciences
Lung Medicine & Life Sciences
Adult Respiratory Distress Syndrome Medicine & Life Sciences
Acute Lung Injury Medicine & Life Sciences
Pulmonary Fibrosis Medicine & Life Sciences
Fibrosis Medicine & Life Sciences
Transforming Growth Factors Medicine & Life Sciences
Pseudomonas aeruginosa Medicine & Life Sciences

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Grants 2002 2021

Research Output 1992 2019

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H. R., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N., Mutlu, G. M. & Budinger, GR. S., Feb 5 2019, In : Cell Metabolism. 29, 2, 1 p.

Research output: Contribution to journalComment/debate

Metformin
Air Pollution
Electron Transport
Names
Publications
15 Citations (Scopus)

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American journal of respiratory and critical care medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
Single-Cell Analysis
Pulmonary Fibrosis
Lung
RNA Sequence Analysis
Alveolar Macrophages
5 Citations (Scopus)

Association of body mass index with lung transplantation survival in the United States following implementation of the lung allocation score

Fernandez, R., Safaeinili, N., Kurihara, C., Odell, D. D., Jain, M., DeCamp Jr, M. M., Budinger, GR. S. & Bharat, A., Apr 1 2018, In : Journal of Thoracic and Cardiovascular Surgery. 155, 4, p. 1871-1879.e3

Research output: Contribution to journalArticle

Lung Transplantation
Body Mass Index
Lung
Survival
Mortality
Graft vs Host Disease
Lung
Safety
Multiple Myeloma
Bortezomib

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis

Sala, M. A., Balderas-Martínez, Y. I., Buendía-Roldan, I., Abdala-Valencia, H., Nam, K., Jain, M., Bhorade, S. M., Bharat, A., Reyfman, P. A., Ridge, K. M., Pardo, A., Sznajder, J. I., Budinger, GR. S., Misharin, A. & Selman, M., Nov 26 2018, In : Respiratory Research. 19, 1, 233.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Nasal Mucosa
Nose
Up-Regulation
RNA Sequence Analysis