Manu Jain

  • 3605 Citations
1992 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020
5 Scopus citations

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

Joshi, N., Watanabe, S., Verma, R., Jablonski, R. P., Chen, C. I., Cheresh, P., Markov, N. S., Reyfman, P. A., McQuattie-Pimentel, A. C., Sichizya, L., Lu, Z., Piseaux-Aillon, R., Kirchenbuechler, D., Flozak, A. S., Gottardi, C. J., Cuda, C. M., Perlman, H., Jain, M., Kamp, D. W., Budinger, G. R. S. & 1 others, Misharin, A. V., Jan 1 2020, In : The European respiratory journal. 55, 1

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Clinical pharmacokinetics of ceftolozane and tazobactam in an obese patient receiving continuous venovenous haemodiafiltration: A patient case and literature review

Mahmoud, A., Shah, A., Nutley, K., Nicolau, D. P., Sutherland, C., Jain, M., Scheetz, M. H. & Rhodes, N. J., Jun 2020, In : Journal of Global Antimicrobial Resistance. 21, p. 83-85 3 p.

Research output: Contribution to journalLetter

Open Access
1 Scopus citations
Open Access

Exploring the Relationship between FEV1 Loss and Recovery and Aminoglycoside Pharmacokinetics in Adult Patients with Cystic Fibrosis: Implications for Clinical Dosing Strategies

Hoff, B. M., Scheetz, M. H., Jain, M., Cullina, J. F. & Rhodes, N. J., Jun 1 2020, In : Pharmacotherapy. 40, 6, p. 584-591 8 p.

Research output: Contribution to journalArticle

Females with Cystic Fibrosis Demonstrate a Differential Response Profile to Ivacaftor Compared with Males

Secunda, K. E., Guimbellot, J. S., Jovanovic, B., Heltshe, S. L., Sagel, S. D., Rowe, S. M. & Jain, M., Apr 15 2020, In : American journal of respiratory and critical care medicine. 201, 8, p. 996-998 3 p.

Research output: Contribution to journalLetter

1 Scopus citations
2019
83 Scopus citations

Erratum: Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis (Cell Metabolism (2019) 29(2) (335–347.e5), (S1550413118305862) (10.1016/j.cmet.2018.09.019))

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C. I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 503 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations
2018
8 Scopus citations
1 Scopus citations

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis

Sala, M. A., Balderas-Martínez, Y. I., Buendía-Roldan, I., Abdala-Valencia, H., Nam, K., Jain, M., Bhorade, S., Bharat, A., Reyfman, P. A., Ridge, K. M., Pardo, A., Sznajder, J. I., Budinger, G. R. S., Misharin, A. V. & Selman, M., Nov 26 2018, In : Respiratory Research. 19, 1, 233.

Research output: Contribution to journalArticle

Ivacaftor-treated patients with cystic fibrosis derive long-term benefit despite no short-term clinical improvement

Heltshe, S. L., Rowe, S. M., Skalland, M., Baines, A. & Jain, M., Jun 1 2018, In : American journal of respiratory and critical care medicine. 197, 11, p. 1483-1486 4 p.

Research output: Contribution to journalLetter

5 Scopus citations

Lumacaftor/ivacaftor in patients with cystic fibrosis and advanced lung disease homozygous for F508del-CFTR

VX14-809-106 Investigator Group, Mar 2018, In : Journal of Cystic Fibrosis. 17, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C-I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Oct 11 2018, In : Cell Metabolism.

Research output: Contribution to journalArticle

14 Scopus citations

Tezacaftor for the treatment of cystic fibrosis

Sala, M. A. & Jain, M., Sep 2 2018, In : Expert Review of Respiratory Medicine. 12, 9, p. 725-732 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

The relationship between sweat chloride levels and mortality in cystic fibrosis varies by individual genotype

Espel, J. C., Palac, H. L., Bharat, A., Cullina, J., Prickett, M., Sala, M., McColley, S. A. & Jain, M., Jan 2018, In : Journal of Cystic Fibrosis. 17, 1, p. 34-42 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene

Prickett, M. H., Hauser, A. R., McColley, S. A., Cullina, J., Potter, E., Powers, C. & Jain, M., Jan 1 2017, In : Thorax. 72, 1, p. 40-47 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

An official American thoracic society workshop report: Obesity and metabolism an emerging frontier in lung health and disease

Suratt, B. T., Ubags, N. D. J., Rastogi, D., Tantisira, K. G., Marsland, B. J., Petrache, I., Allen, J. B., Bates, J. H. T., Holguin, F., McCormack, M. C., Michelakis, E. D., Black, S. M., Jain, M., Mora, A. L., Natarajan, V., Miller, Y. I., Fessler, M. B., Birukov, K. G., Summer, R. S. & Shore, S. A., Jun 2017, In : Annals of the American Thoracic Society. 14, 6, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Antibiotic duration and changes in FEV1 are not associated with time until next exacerbation in adult cystic fibrosis: A single center study

Espel, J. C., Palac, H. L., Cullina, J. F., Clarke, A. P., McColley, S. A., Prickett, M. H. & Jain, M., Nov 29 2017, In : BMC Pulmonary Medicine. 17, 1, 160.

Research output: Contribution to journalArticle

Applying recent advances in the science of CFTR-based therapeutics to improve outcomes in patients with cystic fibrosis

Clancy, JP. P., Benitez, D. S., Fajac, I., Jain, M., Rowe, S. M. & Sawicki, G., Jan 1 2017, (Accepted/In press) In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

216 Scopus citations

Reactive oxygen species as signaling molecules in the development of lung fibrosis

Gonzalez-Gonzalez, F. J., Chandel, N. S., Jain, M. & Budinger, G. R. S., Dec 2017, In : Translational Research. 190, p. 61-68 8 p.

Research output: Contribution to journalReview article

27 Scopus citations
2016

Failure to improve the oxygenation index is a useful predictor of therapy failure in acute respiratory distress syndrome clinical trials

Go, L., Budinger, G. R. S., Kwasny, M. J., Peng, J., Forel, J. M., Papazian, L. & Jain, M., Jan 1 2016, In : Critical care medicine. 44, 1, p. e40-e44

Research output: Contribution to journalArticle

6 Scopus citations

New insights into disease progression for the CFTR modulator-treated cystic fibrosis patient

McColley, S. A., Davies, J., Ratjen, F. & Jain, M., Mar 1 2016, In : Journal of Cystic Fibrosis. 15, 2, p. e21

Research output: Contribution to journalArticle

2015

Driving pressure as a key ventilation variable

Morales-Nebreda, L., Jain, M. & Corbridge, T. C., May 21 2015, In : The New England journal of medicine. 372, 21, 1 p.

Research output: Contribution to journalLetter

Meropenem tolerance in a patient with probable fulminant piperacillin-induced immune hemolytic anemia

Prince, B. T., McMahon, B. J., Jain, M. & Peters, A. T., Jan 1 2015, In : Journal of Allergy and Clinical Immunology: In Practice. 3, 3, p. 452-453 2 p.

Research output: Contribution to journalArticle

4 Scopus citations

Protein repair: Cusp of a new era in cystic fibrosis

Espel, J. & Jain, M., Jan 1 2015, In : Clinical Pulmonary Medicine. 22, 5, p. 246-254 9 p.

Research output: Contribution to journalArticle

To the editor

Morales-Nebreda, L., Jain, M. & Corbridge, T. C., Jan 1 2015, In : New England Journal of Medicine. 372, 21, 1 p.

Research output: Contribution to journalLetter

2014

Fibroproliferative ARDS in the era of low-tidal-volume ventilation

Jain, M., Nov 1 2014, In : CHEST. 146, 5, p. 1140-1142 3 p.

Research output: Contribution to journalEditorial

Gene Therapy in Cystic Fibrosis

Prickett, M. & Jain, M., Nov 17 2014, Translating Gene Therapy to the Clinic: Techniques and Approaches. Elsevier Inc, p. 247-260 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Kadinfection prevention and control guideline for cystic fibrosis: 2013 update

Saiman, L., Siegel, J. D., LiPuma, J. J., Brown, R. F., Bryson, E. A., Chambers, M. J., Downer, V. S., Fliege, J., Hazle, L. A., Jain, M., Marshall, B. C., O'Malley, C., Pattee, S. R., Potter-Bynoe, G., Reid, S., Robinson, K. A., Sabadosa, K. A., Schmidt, H. J., Tullis, E., Webber, J. & 1 others, Weber, D. J., Aug 2014, In : Infection Control and Hospital Epidemiology. 35, SUPPL.1, p. S1-S67

Research output: Contribution to journalArticle

183 Scopus citations

Point: Does the risk of cross infection warrant exclusion of adults with cystic fibrosis from cystic fibrosis foundation events? Yes

Jain, M., Saiman, L. M., Sabadosa, K. & LiPuma, J. J., Apr 2014, In : CHEST. 145, 4, p. 678-680 3 p.

Research output: Contribution to journalEditorial

9 Scopus citations

Rebuttal from Dr Jain et al

Jain, M., Saiman, L. M., Sabadosa, K. & LiPuma, J. J., Apr 2014, In : CHEST. 145, 4, p. 683-684 2 p.

Research output: Contribution to journalEditorial

Reply: antioxidants in the intensive care unit.

Jain, M. & Chandel, N. S., Jan 1 2014, In : American Journal of Respiratory and Critical Care Medicine. 189, 8, 1 p.

Research output: Contribution to journalComment/debate

Reply

Jain, M. & Chandel, N., Apr 15 2014, In : American journal of respiratory and critical care medicine. 189, 8, 1 p.

Research output: Contribution to journalLetter

Update in cystic fibrosis 2013

Jain, M. & Goss, C. H., May 15 2014, In : American journal of respiratory and critical care medicine. 189, 10, p. 1181-1186 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Gene therapy in cystic fibrosis

Prickett, M. & Jain, M., Jan 1 2013, In : Translational Research. 161, 4, p. 255-264 10 p.

Research output: Contribution to journalReview article

31 Scopus citations

Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling

Jain, M., Rivera, S., Monclus, E. A., Synenki, L., Zirk, A., Eisenbart, J., Feghali-Bostwick, C., Mutlu, G. M., Budinger, G. R. S. & Chandel, N. S., Jan 11 2013, In : Journal of Biological Chemistry. 288, 2, p. 770-777 8 p.

Research output: Contribution to journalArticle

170 Scopus citations

Rethinking antioxidants in the intensive care unit

Jain, M. & Chandel, N., Dec 1 2013, In : American journal of respiratory and critical care medicine. 188, 11, p. 1283-1285 3 p.

Research output: Contribution to journalReview article

17 Scopus citations

The proteasome as a therapeutic target for lung fibrosis

Go, L. H. T., Gangar, J. K. & Jain, M., Aug 28 2013, In : Current Enzyme Inhibition. 9, 2, p. 161-167 7 p.

Research output: Contribution to journalArticle

2012

Diagnosis of cystic fibrosis in adults

Go, L. H. T. & Jain, M., Jul 1 2012, In : Clinical Pulmonary Medicine. 19, 4, p. 159-164 6 p.

Research output: Contribution to journalReview article

1 Scopus citations

Personalized medicine in cystic fibrosis: Dawning of a new era

Clancy, J. P. & Jain, M., Oct 1 2012, In : American journal of respiratory and critical care medicine. 186, 7, p. 593-597 5 p.

Research output: Contribution to journalReview article

72 Scopus citations

Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β1 signalling

Mutlu, G. M., Budinger, G. R. S., Wu, M., Lam, A. P., Zirk, A., Rivera, S., Urich, D., Chiarella, S. E., Go, L. H. T., Ghosh, A. K., Selman, M., Pardo, A., Varga, J., Kamp, D. W., Chandel, N. S., Sznajder, J. I. & Jain, M., Feb 2012, In : Thorax. 67, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
31 Scopus citations

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation

Clancy, J. P., Rowe, S. M., Accurso, F. J., Aitken, M. L., Amin, R. S., Ashlock, M. A., Ballmann, M., Boyle, M. P., Bronsveld, I., Campbell, P. W., De Boeck, K., Donaldson, S. H., Dorkin, H. L., Dunitz, J. M., Durie, P. R., Jain, M., Leonard, A., McCoy, K. S., Moss, R. B., Pilewski, J. M. & 10 others, Rosenbluth, D. B., Rubenstein, R. C., Schechter, M. S., Botfield, M., Ordoñez, C. L., Spencer-Green, G. T., Vernillet, L., Wisseh, S., Yen, K. & Konstan, M. W., Jan 2012, In : Thorax. 67, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

385 Scopus citations
2011

Clinical significance of microbial infection and adaptation in cystic fibrosis

Hauser, A. R., Jain, M., Bar-Meir, M. & McColley, S. A., Jan 2011, In : Clinical microbiology reviews. 24, 1, p. 29-70 42 p.

Research output: Contribution to journalArticle

221 Scopus citations

Epithelial cell death is an important contributor to oxidant-mediated acute lung injury

Budinger, G. R. S., Mutlu, G. M., Urich, D., Soberanes, S., Buccellato, L. J., Hawkins, K., Chiarella, S. E., Radigan, K. A., Eisenbart, J., Agrawal, H., Berkelhamer, S., Hekimi, S., Zhang, J., Perlman, H., Schumacker, P. T., Jain, M. & Chandel, N. S., Apr 15 2011, In : American journal of respiratory and critical care medicine. 183, 8, p. 1043-1054 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ

Jain, M., Budinger, G. R. S., Lo, A., Urich, D., Rivera, S. E., Ghosh, A. K., Gonzalez, A., Chiarella, S. E., Marks, K., Donnelly, H. K., Soberanes, S., Varga, J., Radigan, K. A., Chandel, N. S. & Mutlu, G. M., Jun 1 2011, In : American journal of respiratory and critical care medicine. 183, 11, p. 1490-1498 9 p.

Research output: Contribution to journalArticle

62 Scopus citations