Manu Jain

  • 3605 Citations
1992 …2020

Research output per year

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Article
2020

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

Joshi, N., Watanabe, S., Verma, R., Jablonski, R. P., Chen, C. I., Cheresh, P., Markov, N. S., Reyfman, P. A., McQuattie-Pimentel, A. C., Sichizya, L., Lu, Z., Piseaux-Aillon, R., Kirchenbuechler, D., Flozak, A. S., Gottardi, C. J., Cuda, C. M., Perlman, H., Jain, M., Kamp, D. W., Budinger, G. R. S. & 1 others, Misharin, A. V., Jan 1 2020, In : The European respiratory journal. 55, 1

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Exploring the Relationship between FEV1 Loss and Recovery and Aminoglycoside Pharmacokinetics in Adult Patients with Cystic Fibrosis: Implications for Clinical Dosing Strategies

Hoff, B. M., Scheetz, M. H., Jain, M., Cullina, J. F. & Rhodes, N. J., Jun 1 2020, In : Pharmacotherapy. 40, 6, p. 584-591 8 p.

Research output: Contribution to journalArticle

2019
83 Scopus citations

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations
2018
8 Scopus citations
1 Scopus citations

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis

Sala, M. A., Balderas-Martínez, Y. I., Buendía-Roldan, I., Abdala-Valencia, H., Nam, K., Jain, M., Bhorade, S., Bharat, A., Reyfman, P. A., Ridge, K. M., Pardo, A., Sznajder, J. I., Budinger, G. R. S., Misharin, A. V. & Selman, M., Nov 26 2018, In : Respiratory Research. 19, 1, 233.

Research output: Contribution to journalArticle

Lumacaftor/ivacaftor in patients with cystic fibrosis and advanced lung disease homozygous for F508del-CFTR

VX14-809-106 Investigator Group, Mar 2018, In : Journal of Cystic Fibrosis. 17, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., Chen, C-I., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Antalek, M., Abdala-Valencia, H., Chiarella, S. E., Sun, K. A., Woods, P. S., Ghio, A. J. & 12 others, Jain, M., Perlman, H., Ridge, K. M., Morimoto, R. I., Sznajder, J. I., Balch, W. E., Bhorade, S. M., Bharat, A., Prakriya, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Oct 11 2018, In : Cell Metabolism.

Research output: Contribution to journalArticle

14 Scopus citations

Tezacaftor for the treatment of cystic fibrosis

Sala, M. A. & Jain, M., Sep 2 2018, In : Expert Review of Respiratory Medicine. 12, 9, p. 725-732 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

The relationship between sweat chloride levels and mortality in cystic fibrosis varies by individual genotype

Espel, J. C., Palac, H. L., Bharat, A., Cullina, J., Prickett, M., Sala, M., McColley, S. A. & Jain, M., Jan 2018, In : Journal of Cystic Fibrosis. 17, 1, p. 34-42 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene

Prickett, M. H., Hauser, A. R., McColley, S. A., Cullina, J., Potter, E., Powers, C. & Jain, M., Jan 1 2017, In : Thorax. 72, 1, p. 40-47 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

An official American thoracic society workshop report: Obesity and metabolism an emerging frontier in lung health and disease

Suratt, B. T., Ubags, N. D. J., Rastogi, D., Tantisira, K. G., Marsland, B. J., Petrache, I., Allen, J. B., Bates, J. H. T., Holguin, F., McCormack, M. C., Michelakis, E. D., Black, S. M., Jain, M., Mora, A. L., Natarajan, V., Miller, Y. I., Fessler, M. B., Birukov, K. G., Summer, R. S. & Shore, S. A., Jun 2017, In : Annals of the American Thoracic Society. 14, 6, p. 1050-1059 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Antibiotic duration and changes in FEV1 are not associated with time until next exacerbation in adult cystic fibrosis: A single center study

Espel, J. C., Palac, H. L., Cullina, J. F., Clarke, A. P., McColley, S. A., Prickett, M. H. & Jain, M., Nov 29 2017, In : BMC Pulmonary Medicine. 17, 1, 160.

Research output: Contribution to journalArticle

Applying recent advances in the science of CFTR-based therapeutics to improve outcomes in patients with cystic fibrosis

Clancy, JP. P., Benitez, D. S., Fajac, I., Jain, M., Rowe, S. M. & Sawicki, G., Jan 1 2017, (Accepted/In press) In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

216 Scopus citations
2016

Failure to improve the oxygenation index is a useful predictor of therapy failure in acute respiratory distress syndrome clinical trials

Go, L., Budinger, G. R. S., Kwasny, M. J., Peng, J., Forel, J. M., Papazian, L. & Jain, M., Jan 1 2016, In : Critical care medicine. 44, 1, p. e40-e44

Research output: Contribution to journalArticle

6 Scopus citations

New insights into disease progression for the CFTR modulator-treated cystic fibrosis patient

McColley, S. A., Davies, J., Ratjen, F. & Jain, M., Mar 1 2016, In : Journal of Cystic Fibrosis. 15, 2, p. e21

Research output: Contribution to journalArticle

2015

Meropenem tolerance in a patient with probable fulminant piperacillin-induced immune hemolytic anemia

Prince, B. T., McMahon, B. J., Jain, M. & Peters, A. T., Jan 1 2015, In : Journal of Allergy and Clinical Immunology: In Practice. 3, 3, p. 452-453 2 p.

Research output: Contribution to journalArticle

4 Scopus citations

Protein repair: Cusp of a new era in cystic fibrosis

Espel, J. & Jain, M., Jan 1 2015, In : Clinical Pulmonary Medicine. 22, 5, p. 246-254 9 p.

Research output: Contribution to journalArticle

2014

Kadinfection prevention and control guideline for cystic fibrosis: 2013 update

Saiman, L., Siegel, J. D., LiPuma, J. J., Brown, R. F., Bryson, E. A., Chambers, M. J., Downer, V. S., Fliege, J., Hazle, L. A., Jain, M., Marshall, B. C., O'Malley, C., Pattee, S. R., Potter-Bynoe, G., Reid, S., Robinson, K. A., Sabadosa, K. A., Schmidt, H. J., Tullis, E., Webber, J. & 1 others, Weber, D. J., Aug 2014, In : Infection Control and Hospital Epidemiology. 35, SUPPL.1, p. S1-S67

Research output: Contribution to journalArticle

183 Scopus citations

Update in cystic fibrosis 2013

Jain, M. & Goss, C. H., May 15 2014, In : American journal of respiratory and critical care medicine. 189, 10, p. 1181-1186 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Mitochondrial reactive oxygen species regulate transforming growth factor-β signaling

Jain, M., Rivera, S., Monclus, E. A., Synenki, L., Zirk, A., Eisenbart, J., Feghali-Bostwick, C., Mutlu, G. M., Budinger, G. R. S. & Chandel, N. S., Jan 11 2013, In : Journal of Biological Chemistry. 288, 2, p. 770-777 8 p.

Research output: Contribution to journalArticle

170 Scopus citations

The proteasome as a therapeutic target for lung fibrosis

Go, L. H. T., Gangar, J. K. & Jain, M., Aug 28 2013, In : Current Enzyme Inhibition. 9, 2, p. 161-167 7 p.

Research output: Contribution to journalArticle

2012

Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β1 signalling

Mutlu, G. M., Budinger, G. R. S., Wu, M., Lam, A. P., Zirk, A., Rivera, S., Urich, D., Chiarella, S. E., Go, L. H. T., Ghosh, A. K., Selman, M., Pardo, A., Varga, J., Kamp, D. W., Chandel, N. S., Sznajder, J. I. & Jain, M., Feb 2012, In : Thorax. 67, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation

Clancy, J. P., Rowe, S. M., Accurso, F. J., Aitken, M. L., Amin, R. S., Ashlock, M. A., Ballmann, M., Boyle, M. P., Bronsveld, I., Campbell, P. W., De Boeck, K., Donaldson, S. H., Dorkin, H. L., Dunitz, J. M., Durie, P. R., Jain, M., Leonard, A., McCoy, K. S., Moss, R. B., Pilewski, J. M. & 10 others, Rosenbluth, D. B., Rubenstein, R. C., Schechter, M. S., Botfield, M., Ordoñez, C. L., Spencer-Green, G. T., Vernillet, L., Wisseh, S., Yen, K. & Konstan, M. W., Jan 2012, In : Thorax. 67, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

385 Scopus citations
2011

Clinical significance of microbial infection and adaptation in cystic fibrosis

Hauser, A. R., Jain, M., Bar-Meir, M. & McColley, S. A., Jan 2011, In : Clinical microbiology reviews. 24, 1, p. 29-70 42 p.

Research output: Contribution to journalArticle

221 Scopus citations

Epithelial cell death is an important contributor to oxidant-mediated acute lung injury

Budinger, G. R. S., Mutlu, G. M., Urich, D., Soberanes, S., Buccellato, L. J., Hawkins, K., Chiarella, S. E., Radigan, K. A., Eisenbart, J., Agrawal, H., Berkelhamer, S., Hekimi, S., Zhang, J., Perlman, H., Schumacker, P. T., Jain, M. & Chandel, N. S., Apr 15 2011, In : American journal of respiratory and critical care medicine. 183, 8, p. 1043-1054 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ

Jain, M., Budinger, G. R. S., Lo, A., Urich, D., Rivera, S. E., Ghosh, A. K., Gonzalez, A., Chiarella, S. E., Marks, K., Donnelly, H. K., Soberanes, S., Varga, J., Radigan, K. A., Chandel, N. S. & Mutlu, G. M., Jun 1 2011, In : American journal of respiratory and critical care medicine. 183, 11, p. 1490-1498 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

Lam, A. P., Flozak, A. S., Russell, S., Wei, J., Jain, M., Mutlu, G. M., Budinger, G. R. S., Feghali-Bostwick, C. A., Varga, J. & Gottardi, C. J., Nov 1 2011, In : American journal of respiratory cell and molecular biology. 45, 5, p. 915-922 8 p.

Research output: Contribution to journalArticle

100 Scopus citations

Pseudomonas aeruginosa Infection in Cystic Fibrosis: A Paradigm of Chronic Infection

Prickett, M. & Jain, M., Mar 1 2011, In : Clinical Pulmonary Medicine. 18, 2, p. 53-59 7 p.

Research output: Contribution to journalArticle

2010

Beyond mortality: Future clinical research in acute lung injury

Spragg, R. G., Bernard, G. R., Checkley, W., Curtis, J. R., Gajic, O., Guyatt, G., Hall, J., Israel, E., Jain, M., Needham, D. M., Randolph, A. G., Rubenfeld, G. D., Schoenfeld, D., Thompson, B. T., Ware, L. B., Young, D. & Harabin, A. L., May 15 2010, In : American journal of respiratory and critical care medicine. 181, 10, p. 1121-1127 7 p.

Research output: Contribution to journalArticle

201 Scopus citations

PPAR? Downregulation by TGF in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

Wei, J., Ghosh, A. K., Sargent, J. L., Komura, K., Wu, M., Huang, Q. Q., Jain, M., Whitfield, M. L., Feghali-Bostwick, C. & Varga, J., 2010, In : PloS one. 5, 11, e13778.

Research output: Contribution to journalArticle

116 Scopus citations

β-Catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells

Flozak, A. S., Lam, A. P., Russell, S., Jain, M., Peled, O. N., Sheppard, K. A., Beri, R., Mutlu, G. M., Budinger, G. R. S. & Gottardi, C. J., Jan 29 2010, In : Journal of Biological Chemistry. 285, 5, p. 3157-3167 11 p.

Research output: Contribution to journalArticle

70 Scopus citations
2009

BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK

Shroff, E. H., Snyder, C. M., Budinger, G. R. S., Jain, M., Chew, T. L., Khuon, S., Perlman, H. & Chandel, N. S., May 21 2009, In : PloS one. 4, 5, e5646.

Research output: Contribution to journalArticle

21 Scopus citations

Head CT is of limited diagnostic value in critically ill patients who remain unresponsive after discontinuation of sedation

Balachandran, J. S., Jaleel, M., Jain, M., Mahajan, N., Kalhan, R., Balagani, R., Donnelly, H. K., Greenstein, E. & Mutlu, G. M., May 7 2009, In : BMC Anesthesiology. 9, 3.

Research output: Contribution to journalArticle

5 Scopus citations

Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways

Chandel, N. S., Budinger, G. R. S., Mutlu, G. M., Varga, J., Synenki, L., Donnelly, H. K., Zirk, A., Eisenbart, J., Jovanovic, B. & Jain, M., May 2009, In : Critical care medicine. 37, 5, p. 1678-1684 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
2008

Evolution of Pseudomonas aeruginosa type III secretion in cystic fibrosis: a paradigm of chronic infection

Jain, M., Bar-Meir, M., McColley, S. A., Cullina, J., Potter, E., Powers, C., Prickett, M., Seshadri, R., Jovanovic, B., Petrocheilou, A., King, J. D. & Hauser, A. R., Jan 1 2008, In : Translational Research. 152, 6, p. 257-264 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2007

A 48-year-old woman with skin lesions, renal masses, and spontaneous pneumothorax

Kalhan, R., Yeldandi, A. V. & Jain, M., Jan 1 2007, In : Chest. 131, 2, p. 624-627 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Bronchoalveolar lavage fluid from patients with acute lung injury/acute respiratory distress syndrome induces myofibroblast differentiation

Synenki, L., Chandel, N. S., Budinger, G. R. S., Donnelly, H. K., Topin, J., Eisenbart, J., Jovanovic, B. & Jain, M., Mar 2007, In : Critical care medicine. 35, 3, p. 842-848 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death

Wang, H. L., Akinci, I. O., Baker, C. M., Urich, D., Bellmeyer, A., Jain, M., Chandel, N. S., Mutlu, G. M. & Budinger, G. R. S., Aug 1 2007, In : Journal of Immunology. 179, 3, p. 1834-1841 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
2005

Active transforming growth factor-β1 activates the procollagen I promoter in patients with acute lung injury

Budinger, G. R. S., Chandel, N. S., Donnelly, H. K., Eisenbart, J., Oberoi, M. & Jain, M., Jan 1 2005, In : Intensive Care Medicine. 31, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

52 Scopus citations

Cystic fibrosis patients have poor sleep quality despite normal sleep latency and efficiency

Jankelowitz, L., Reid, K. J., Wolfe, L., Cullina, J., Zee, P. C. & Jain, M., May 2005, In : CHEST. 127, 5, p. 1593-1599 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

Effects of hypoxia on the alveolar epithelium

Jain, M. & Sznajder, J. I., Oct 31 2005, In : Proceedings of the American Thoracic Society. 2, 3, p. 202-205 4 p.

Research output: Contribution to journalArticle

69 Scopus citations
2004

Type III secretion phenotypes of Pseudomonas aeruginosa strains change during infection of individuals with cystic fibrosis

Jain, M., Ramirez, D., Seshadri, R., Cullina, J. F., Powers, C. A., Schullert, G. S., Bar-Meir, M., Sullivan, C. L., McColley, S. A. & Hauser, A. R., Nov 2004, In : Journal of clinical microbiology. 42, 11, p. 5229-5237 9 p.

Research output: Contribution to journalArticle

110 Scopus citations
2003

Variability in interventions with pulmonary artery catheter data

Jain, M., Canham, M., Upadhyay, D. & Corbridge, T., Nov 1 2003, In : Intensive Care Medicine. 29, 11, p. 2059-2062 4 p.

Research output: Contribution to journalArticle

31 Scopus citations
2001

Managing acute, severe asthma: Part 1

Jain, M. & Corbridge, T., Jan 1 2001, In : Journal of Respiratory Diseases. 22, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Managing acute, severe asthma: Part 2

Jain, M. & Corbridge, T. C., Jan 1 2001, In : Journal of Respiratory Diseases. 22, 1, p. 45-48 4 p.

Research output: Contribution to journalArticle

Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa

Feltman, H., Schulert, G., Khan, S., Jain, M., Peterson, L. & Hauser, A. R., 2001, In : Microbiology. 147, 10, p. 2659-2669 11 p.

Research output: Contribution to journalArticle

293 Scopus citations
2000
6 Scopus citations